Article
Immunology
Sheila Dollard, Min-hsin Chen, Stephen Lindstrom, Mona Marin, Paul A. Rota
Summary: The decline in varicella cases due to vaccination has led to increased reliance on laboratory diagnosis. The atypical presentation in vaccinated individuals makes it challenging for providers to recognize the disease. Enhanced education and more sensitive diagnostic methods are critical for accurate diagnosis and testing of varicella immunity.
JOURNAL OF INFECTIOUS DISEASES
(2022)
Article
Immunology
Omid Rezahosseini, Soren Schwartz Sorensen, Michael Perch, Christina Ekenberg, Dina Leth Moller, Andreas Dehlbaek Knudsen, Nikolai Kirkby, Jens Lundgren, Isabelle P. Lodding, Neval Ete Wareham, Finn Gustafsson, Allan Rasmussen, Susanne Dam Nielsen
Summary: A significant proportion of adult solid organ transplant recipients are seronegative for at least one of the MMRV viruses. Post-transplant, some recipients may develop vaccine-related seroconversion. Vaccination is crucial for the health of SOT recipients.
CLINICAL INFECTIOUS DISEASES
(2021)
Article
Nutrition & Dietetics
Fumiko Okazaki, Hiroyuki Wakiguchi, Yuno Korenaga, Kazumasa Takahashi, Hiroki Yasudo, Ken Fukuda, Mototsugu Shimokawa, Shunji Hasegawa
Summary: Little is known about the clinical features of food protein-induced enterocolitis syndrome (FPIES) in patients with Down syndrome (DS). This study found that FPIES in DS patients is associated with greater severity and earlier onset of symptoms. Cow's milk formula and wheat were the main causative foods. The surgical history of colostomy and postoperative nutrition may contribute to the onset of FPIES. Therefore, the use of amino acid-based formula should be considered for DS children undergoing gastrointestinal surgeries, and FPIES should be considered when acute gastrointestinal disease is suspected in DS children.
Article
Clinical Neurology
Viktor Grut, Martin Bistrom, Jonatan Salzer, Pernilla Stridh, Daniel Jons, Rasmus Gustafsson, Anna Fogdell-Hahn, Jesse Huang, Nicole Brenner, Julia Butt, Noemi Bender, Anna Lindam, Lucia Alonso-Magdalena, Martin Gunnarsson, Magnus Vrethem, Tomas Bergstrom, Oluf Andersen, Ingrid Kockum, Tim Waterboer, Tomas Olsson, Peter Sundstrom
Summary: The study indicates that cytomegalovirus (CMV) seropositivity is associated with a decreased risk for multiple sclerosis (MS), and there are interactions between CMV seropositivity and seropositivity against EBV and HHV-6A.
EUROPEAN JOURNAL OF NEUROLOGY
(2021)
Article
Immunology
Marci Drees, David J. Weber
Summary: The varicella vaccination program in the United States has effectively reduced the incidence and hospitalizations of varicella by more than 90%, which has also decreased the risk of infection in healthcare settings. However, both patients and healthcare personnel can still introduce the varicella zoster virus into healthcare facilities. Robust occupational health and infection prevention programs that ensure the immunity of healthcare personnel and prompt recognition and isolation of patients with varicella or herpes zoster can significantly lower the risk of transmission and avoid the need to furlough exposed healthcare personnel and the associated costs.
JOURNAL OF INFECTIOUS DISEASES
(2022)
Article
Nutrition & Dietetics
Seyed Mohammad Mousavi, Mehdi Shayanfar, Somaye Rigi, Minoo Mohammad-Shirazi, Giuve Shari, Ahmad Esmaillzadeh
Summary: The study showed that high adherence to the Mediterranean diet was significantly associated with a lower risk of glioma. This association persisted even after adjusting for other potential confounders.
CLINICAL NUTRITION
(2021)
Article
Medicine, General & Internal
Yoshihiro Aoki, Toshiyuki Tanaka, Naoto Mizushiro, Katsuhiko Kitazawa
Summary: This is a case report of a pediatric patient with aseptic meningitis caused by Varicella-zoster virus (VZV) who did not have skin rash but showed a substantial increase in paired serum antibody. The study suggests that VZV infection and reactivations associated with vaccination should be considered in the differential diagnosis of pediatric aseptic meningitis even in the absence of skin rash.
CUREUS JOURNAL OF MEDICAL SCIENCE
(2022)
Article
Medicine, General & Internal
Wei Zhang, Biao Xie, Meina Liu, Yupeng Wang
Summary: This study assessed the associations between sensitization to common allergens and atopic dermatitis, allergic rhinitis, and allergic asthma in adults. The prevalence of allergen sensitization was higher in patients with these allergic diseases compared to healthy controls. There was a dose-response relationship between levels of allergen-specific IgE and the prevalence of allergic diseases, and multiple sensitizations increased the risk of these diseases.
Article
Agriculture, Dairy & Animal Science
Morena Di Tommaso, Alessia Luciani, Paolo Emidio Crisi, Marica Beschi, Paolo Rosi, Francesca Rocconi, Arianna Miglio
Summary: Canine atopic dermatitis (CAD) is a pruritic allergic skin disease associated with IgE-mediated hypersensitivity. The present study used Serum Allergen-Specific IgE test (SAT) to identify relevant environmental allergens in atopic dogs living in Northern Italy, primarily house dust mites, Rumex acetosa pollen, and grasses. Specific panels for geographical areas should be considered and re-evaluated at time intervals.
Article
Immunology
Zahra Bibi, Ahmed Daniyal Nawaz, Maha Al Kurbi, Shahad Fakhroo, Khaled Ferih, Noor Al-Jaber, Merin Alex, Khalid H. Elawad, Tawanda Chivese, Susu M. Zughaier
Summary: This study evaluated the real-world effectiveness of varicella vaccination in Qatar from 2017 to 2019. The results showed that two doses of varicella vaccination provided reasonable protection against varicella infection in the multicultural setting of Qatar.
Article
Infectious Diseases
M. E. Baarsma, A. Vrijlandt, J. Ursinus, H. L. Zaaijer, S. Jurriaans, A. P. van Dam, J. W. Hovius
Summary: This study compared the diagnostic parameters of the ZEUS Borrelia VlsE1/pepC10 assay and C6-ELISA in European patients with Lyme borreliosis, healthy blood donors, and potentially cross-reactive controls. The specificity of both assays was similar in healthy blood donors, but C6-ELISA appeared to have slightly higher sensitivity in patients with early localized or disseminated Lyme borreliosis. The VlsE1/pepC10 assay showed significantly higher specificity in sera with potentially cross-reactive antibodies.
EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES
(2022)
Article
Oncology
Tareq M. Haedenkamp, Michael F. Leitzmann, Ralf A. Linker, Christoph Meier, Claudia Becker, Susan Jick, Peter Hau, Corinna Seliger
Summary: This large case-control study investigated the association between antibiotic use and the risk of glioma. The results showed no significant increase in glioma risk after antibiotic use, and the use of polyenes may be weakly associated with a decreased risk of glioma.
Article
Infectious Diseases
Ana Atti, Ferdinando Insalata, Edward J. Carr, Ashley D. Otter, Sarah Foulkes, Mary Y. Wu, Michelle J. Crick COVID Immunity Pipeline, Michelle J. Cole, Ezra Linley, Amanda Semper, Tim Brooks, Susan Hopkins, Andre Charlett, Rupert Beale, SIREN Study Grp
Summary: This study investigates the serological correlates of protection against SARS-CoV-2 Delta infection after two vaccine doses. The research identifies differences in antibody levels and neutralizing antibody titers between Delta cases and controls. The study also demonstrates a correlation between antibody titers and the odds of Delta infection.
JOURNAL OF INFECTION
(2023)
Article
Immunology
L. Ludwig, T. Tsukui, M. Kageyama, M. Farias
Summary: The study observed allergen-specific IgE against D. farinae, Der f 2, and Zen 1 in dogs with atopic dermatitis, highlighting the association with house dust mite allergens. The results showed a higher positivity for crude D. farinae and Zen 1, indicating these allergens as major sensitizers in the dogs with atopic dermatitis, possibly due to unrestricted exposition to furniture and textile material. Zen 1 may play a crucial role in sensitization to crude D. farinae.
VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY
(2021)
Article
Pathology
Thomas Perkmann, Thomas Koller, Nicole Perkmann-Nagele, Maria Ozsvar-Kozma, David Eyre, Philippa Matthews, Abbie Bown, Nicole Stoesser, Marie-Kathrin Breyer, Robab Breyer-Kohansal, Otto C. Burghuber, Slyvia Hartl, Daniel Aletaha, Daniela Sieghart, Peter Quehenberger, Rodrig Marculescu, Patrick Mucher, Astrid Radakovics, Miriam Klausberger, Mark Duerkop, Barba Holzer, Boris Hartmann, Robert Strassl, Gerda Leitner, Florian Grebien, Wilhelm Gerner, Reingard Grabherr, Oswald F. Wagner, Christoph J. Binder, Helmuth Haslacher
Summary: A new testing strategy called SIT2 algorithm was proposed for SARS-CoV-2 serology, which involves retesting samples falling in a predefined zone with adjusted cut-offs to increase sensitivity. The results showed that SIT2 had superior specificity and maintained or even improved sensitivity compared to single tests or orthogonal testing, significantly reducing total test errors.
JOURNAL OF CLINICAL PATHOLOGY
(2022)
Article
Engineering, Civil
Kewei Liu, Megan Walske, Mi Zhou, Xihong Zhang
Summary: The use of rammed earth as a construction material has gained attention for its sustainability and low-cost potential. However, the mechanical performance of stabilized rammed earth, particularly under dynamic loading, is not well understood. This study experimentally investigates the quasi-static and dynamic material properties of cement and calcium carbonate residue stabilized rammed earth, and derives empirical formulae for the dynamic increase factor.
INTERNATIONAL JOURNAL OF PROTECTIVE STRUCTURES
(2023)
Article
Genetics & Heredity
Hongkyung Kim, Yeeun Shim, Taek Gyu Lee, Dongju Won, Jong Rak Choi, Saeam Shin, Seung-Tae Lee
Summary: This study introduces a visualization tool called CABANA that allows users to intuitively identify CNVs in NGS data. Through its application in patients with neuromuscular disorders, CABANA's diagnostic yield was deemed acceptable, making it expected to help researchers accurately identify CNVs and reduce the need for subsequent confirmation testing.
Article
Polymer Science
Zejian He, Haifeng Shao, Nannan Zhang, Jie Li, Hai Xiao, Tianhang Weng, Mi Zhou, Bianying Wen, Yulong Chen
Summary: This study designed and synthesized three amide nucleating agents with different symmetries to investigate the effect of symmetry on PLLA crystallization. It was found that the C3 symmetric amide structure exhibited the best performance as an efficient nucleation site.
JOURNAL OF POLYMER SCIENCE
(2023)
Review
Engineering, Environmental
Huijuan Wu, Weiqiong Zheng, Ran Zhu, Mi Zhou, Xiancheng Ren, Yinghan Wang, Chong Cheng, Hongju Zhou, Sujiao Cao
Summary: This article comprehensively summarizes and discusses the most important advances in engineering MOF nanoarchitectures for efficient water electrolysis. First, the methods of modulating the coordination structures and metal atom environments of MOF and MOF-derived catalysts are reviewed, and then their applications in water splitting are discussed based on the coordination structure and local atomic environment.
CHEMICAL ENGINEERING JOURNAL
(2023)
Article
Environmental Sciences
Bing Yang, Mi Zhou, Yuan Meng, Keming Chen, Jie Xu, Xiangfu Huang, Yucheng Liu, Lingli Li, Lili Ma, Mingyan Chen
Summary: Chemical oxidation as a pretreatment for petroleum-contaminated soil, coupled with bioremediation, can have serious impacts on indigenous microorganisms and available nutrients. This study found that hydrogen peroxide treatments significantly promoted the removal of total petroleum hydrocarbons (TPH), especially in the initial days, and also affected the levels of dissolved nutrients. Both chemical oxidation and nutrients contribute to changes in microbial community structure and diversity. However, the long-term effects of H2O2 as a pretreatment had little impact on the soil indigenous microbial community structure and actually facilitated the continuous removal of TPH by indigenous microorganisms.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Article
Oncology
Hyeonah Lee, Jieun Seo, Saeam Shin, Seung-Tae Lee, Jong Rak Choi
Summary: To overcome the limitations of traditional real-time quantitative PCR, a next-generation sequencing assay was designed and validated for quantifying BCR::ABL1 transcripts in CML patients. This assay demonstrated high sensitivity and reliability, making it an effective tool for disease monitoring.
CANCER CELL INTERNATIONAL
(2023)
Article
Engineering, Environmental
Mei Zhang, Yuting Wen, Zhangheng Huang, Xin Qin, Mi Zhou, Dexuan Xiao, Weitong Cui, Zhiqiang Liu, Yunfeng Lin
Summary: A novel nanomedicine was developed for the treatment of rheumatoid arthritis, which carries methotrexate and uses aptamer targeting tumor necrosis factor-alpha. This targeted nanomedicine accumulates in the inflammatory joints, reducing systemic toxicity and decreasing joint damage.
CHEMICAL ENGINEERING JOURNAL
(2023)
Article
Biochemistry & Molecular Biology
Jieun Seo, Saeam Shin, Sang-woon Kim, Su Jin Kim, Myeongseob Lee, Kyungchul Song, Junghwan Suh, Seung-Tae Lee, Yong Seung Lee, Hyun Wook Chae, Ho-Seong Kim, Jong Rak Choi, Sangwon Han, Ahreum Kwon
Summary: This study retrospectively evaluated the genotype-phenotype correlation of 19 Korean patients with 5 alpha-reductase type 2 deficiency (5 alpha RD2) from a structural perspective. The categorization of variants according to the SRD5A2 structure showed that certain mutations were associated with more severe phenotypes, while others were associated with milder phenotypes. The findings suggest that a genotype-phenotype correlation exists in 5 alpha RD2, and the structural approach can aid in predicting disease severity and guiding patient management and genetic counseling.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Medical Laboratory Technology
Jin Ju Kim, Ji Eun Jang, Hyeon Ah Lee, Mi Ri Park, Hye Won Kook, Seung-Tae Lee, Jong Rak Choi, Yoo Hong Min, Saeam Shin, June -Won Cheong
Summary: A targeted next-generation sequencing (NGS) panel was developed to detect residual disease in acute myeloid leukemia (AML) patients. The panel demonstrated high sensitivity and accuracy and can be used to monitor AML patients after treatment and predict the risk of disease relapse.
ANNALS OF LABORATORY MEDICINE
(2023)
Article
Immunology
Soon Sung Kwon, Youn Keong Cho, Seungmin Hahn, Jiyoung Oh, Dongju Won, Saeam Shin, Ji-Man Kang, Jong Gyun Ahn, Seung-Tae Lee, Jong Rak Choi
Summary: Inborn errors of immunity (IEI) refer to a group of genetic disorders characterized by defects in the immune system, leading to increased susceptibility to infections and complications. This study evaluated the clinical utility of clinical exome sequencing (CES) for diagnosing IEI. CES was performed on 37 Korean patients with suspected IEI symptoms, signs, or laboratory abnormalities. CES successfully diagnosed IEI in 15 out of 37 patients (40.5%), detecting several previously unreported variants. The findings highlight the diagnostic value of CES in accurate diagnosis and appropriate treatment of IEI.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Medical Laboratory Technology
Kwang Seob Lee, Choong-Kun Lee, Soon Sung Kwon, Woo Sun Kwon, Sejung Park, Seung-Tae Lee, Jong Rak Choi, Sun Young Rha, Saeam Shin
Summary: This study found that clonal hematopoiesis is associated with age and sex in Korean patients and may interfere with cell-free DNA testing.
CLINICAL CHEMISTRY AND LABORATORY MEDICINE
(2023)
Article
Oncology
Kyeongmin Kim, Se Hoon Kim, Jung-Yun Lee, Yoo-Na Kim, Seung-Tae Lee, Eunhyang Park
Summary: The expression of RAD51 is closely associated with prognosis in patients with ovarian high-grade serous carcinoma (HGSC), and the changes in RAD51 expression status before and after chemotherapy have a greater impact on prognosis. Therefore, RAD51 expression status can serve as a predictive marker for the treatment of ovarian HGSC, and sequential monitoring of RAD51 status before and after treatment can reflect the biological behavior of the tumor.
JOURNAL OF GYNECOLOGIC ONCOLOGY
(2023)
Article
Oncology
Jin Ju Kim, Hyun-Young Kim, Zisun Choi, So Yoon Hwang, Hansol Jeong, Jong Rak Choi, Sang Eun Yoon, Won Seog Kim, Sun-Hee Kim, Hee-Jin Kim, Sang-Yong Shin, Seung-Tae Lee, Seok Jin Kim
Summary: This study explored the utility of circulating tumor DNA (ctDNA) as a diagnostic biomarker in Extranodal NK/T cell lymphoma (ENKTL). The concentration of ctDNA was found to be correlated with treatment response, disease stage, and EBV DNA quantitation. Additionally, ctDNA analysis can be used to predict therapeutic efficacy and estimate the tumor burden in ENKTL patients.
FRONTIERS IN ONCOLOGY
(2023)
Article
Oncology
Yoo-Na Kim, Yun Soo Chung, Ji Hyun Lee, Eunhyang Park, Seung-Tae Lee, Sunghoon Kim, Jung-Yun Lee
Summary: A comprehensive evaluation of gene alterations and immunohistochemistry profiles in patients with ovarian cancer helps identify candidates for precision therapy and provides matched treatment options.
JOURNAL OF GYNECOLOGIC ONCOLOGY
(2023)
Review
Chemistry, Multidisciplinary
Tiantian Li, Yuting Deng, Xiao Rong, Chao He, Mi Zhou, Yuanjiao Tang, Hongju Zhou, Chong Cheng, Changsheng Zhao
Summary: This review comprehensively summarizes the main advances and applications of tellurium-based nanomaterials (Te NMs) in electrocatalysis. The engineering strategies and principles to enhance the electrocatalytic activity and stability of Te NMs are discussed, including chemical/physical/multiplex templating strategies, heteroatom doping, and phase engineering. The typical applications of Te NMs in electrocatalysis are also presented. Finally, the key issues, challenges, and development trends of Te NMs as electrocatalysts are highlighted.
