Targeting the hedgehog signal transduction pathway at the level of GLI inhibits neuroblastoma cell growthin vitroandin vivo

Hedgehog Pathway Inhibitor HhAntag691 Is a Potent Inhibitor of ABCG2/BCRP and ABCB1/Pgp

(2015) Yimao Zhang et al.   NEOPLASIA

Inhibition of the sonic hedgehog pathway by cyplopamine reduces the CD133+/CD15+ cell compartment and the in vitro tumorigenic capability of neuroblastoma cells

(2011) Paula Schiapparelli et al.   CANCER LETTERS

Blocking Hedgehog Survival Signaling at the Level of the GLI Genes Induces DNA Damage and Extensive Cell Death in Human Colon Carcinoma Cells

(2011) T. Mazumdar et al.   CANCER RESEARCH

Hedgehog Signaling Drives Cellular Survival in Human Colon Carcinoma Cells

(2010) T. Mazumdar et al.   CANCER RESEARCH

Antipsychotic Drugs Regulate Hedgehog Signaling by Modulation of 7-Dehydrocholesterol Reductase Levels

(2010) M. Lauth et al.   MOLECULAR PHARMACOLOGY

Recent Advances in Neuroblastoma

(2010) John M. Maris   NEW ENGLAND JOURNAL OF MEDICINE

High-risk neuroblastoma tumors with 11q-deletion display a poor prognostic, chromosome instability phenotype with later onset

(2010) H. Caren et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A critical role of Sonic Hedgehog signaling in maintaining the tumorigenicity of neuroblastoma cells

(2009) Ling Mao et al.   CANCER SCIENCE

N-myc alters the fate of preneoplastic cells in a mouse model of medulloblastoma

(2009) J. D. Kessler et al.   GENES & DEVELOPMENT

Mechanisms of Hedgehog pathway activation in cancer and implications for therapy

(2009) Suzie J. Scales et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Hedgehog: functions and mechanisms

(2008) M. Varjosalo et al.   GENES & DEVELOPMENT

Novel Human Glioma-associated Oncogene 1 (GLI1) Splice Variants Reveal Distinct Mechanisms in the Terminal Transduction of the Hedgehog Signal

(2008) Takashi Shimokawa et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The fluorometric microculture cytotoxicity assay

(2008) Elin Lindhagen et al.   Nature Protocols

Tumor-growth–promoting cyclooxygenase-2 prostaglandin E2 pathway provides medulloblastoma therapeutic targets

(2008) Ninib Baryawno et al.   NEURO-ONCOLOGY