Involvement of p53 in the cytotoxic activity of the NAMPT inhibitor FK866 in myeloid leukemic cells

Inhibition of NAMPT pathway by FK866 activates the function of p53 in HEK293T cells

(2012) Basant Kumar Thakur et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Activation of p53 by SIRT1 Inhibition Enhances Elimination of CML Leukemia Stem Cells in Combination with Imatinib

(2012) Ling Li et al.   CANCER CELL

Nicotinamide Blocks Proliferation and Induces Apoptosis of Chronic Lymphocytic Leukemia Cells through Activation of the p53/miR-34a/SIRT1 Tumor Suppressor Network

(2011) V. Audrito et al.   CANCER RESEARCH

SIRT1 RNAi knockdown induces apoptosis and senescence, inhibits invasion and enhances chemosensitivity in pancreatic cancer cells

(2011) G Zhao et al.   GENE THERAPY

The role of sirtuin 2 activation by nicotinamide phosphoribosyltransferase in the aberrant proliferation and survival of myeloid leukemia cells

(2011) L. Dan et al.   HAEMATOLOGICA

Nicotinamide inhibits the early stage of carcinogen-induced hepatocarcinogenesis in mice and suppresses human hepatocellular carcinoma cell growth

(2011) Soo Young Park et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Histone onco-modifications

(2011) J Füllgrabe et al.   ONCOGENE

Synergistic Interactions between HDAC and Sirtuin Inhibitors in Human Leukemia Cells

(2011) Michele Cea et al.   PLoS One

The impact of acetylation and deacetylation on the p53 pathway

(2011) Christopher L. Brooks et al.   Protein & Cell

Potent synergistic interaction between the Nampt inhibitor APO866 and the apoptosis activator TRAIL in human leukemia cells

(2010) Gabriele Zoppoli et al.   EXPERIMENTAL HEMATOLOGY

Histone deacetylase inhibitors for the treatment of myelodysplastic syndrome and acute myeloid leukemia

(2010) A Quintás-Cardama et al.   LEUKEMIA

NAMPT overexpression in prostate cancer and its contribution to tumor cell survival and stress response

(2010) B Wang et al.   ONCOGENE

p53 post-translational modification: deregulated in tumorigenesis

(2010) Chao Dai et al.   TRENDS IN MOLECULAR MEDICINE

The NAD biosynthesis inhibitor APO866 has potent antitumor activity against hematologic malignancies

(2009) A. Nahimana et al.   BLOOD

The Nicotinamide Phosphoribosyltransferase: A Molecular Link between Metabolism, Inflammation, and Cancer

(2009) M. Galli et al.   CANCER RESEARCH

Epigenetic changes in therapy-related MDS/AML

(2009) Maria Teresa Voso et al.   CHEMICO-BIOLOGICAL INTERACTIONS

p53 Acetylation Is Crucial for Its Transcription-independent Proapoptotic Functions

(2009) Hirohito Yamaguchi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

NAMPT is essential for the G-CSF–induced myeloid differentiation via a NAD+–sirtuin-1–dependent pathway

(2009) Julia Skokowa et al.   NATURE MEDICINE

Expression and prognostic significance of SIRT1 in ovarian epithelial tumours

(2009) Kyu Yun Jang et al.   PATHOLOGY

Lysine Acetylation Targets Protein Complexes and Co-Regulates Major Cellular Functions

(2009) C. Choudhary et al.   SCIENCE

Acetylation Is Indispensable for p53 Activation

(2008) Yi Tang et al.   CELL

Acetylation of non-histone proteins modulates cellular signalling at multiple levels

(2008) Stephanie Spange et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Transcriptional control of human p53-regulated genes

(2008) Todd Riley et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY