期刊
INTERNATIONAL JOURNAL OF CANCER
卷 131, 期 9, 页码 2126-2133出版社
WILEY
DOI: 10.1002/ijc.27470
关键词
breast cancer risk; thyroxin; thyroid peroxidase antibodies
类别
资金
- Swedish Cancer Society
- Ernhold Lundstrom Foundation
- Einar and Inga Nilsson Foundation
- Malmo University Hospital
- Crafoord Foundation
- Anna Lisa and Sven-Eric Lundgren Foundation
- Mossfelt Foundation
Thyroid hormones influence both normal breast cell differentiation and breast cancer cell proliferation and stimulate the angiogenesis of certain cancer forms. Several cross-sectional studies have measured thyroid hormones/autoantibodies in breast cancer ceases vs. controls, but it is difficult to determine the causeeffect direction in these studies. Only three prospective studies have reported on the subject so far. The aim of our study was to investigate prediagnostically measured levels of thyroid hormones, thyrotropin (TSH) and thyroid autoantibodies in relation to subsequent risk of breast cancer. The Malmoe Diet and Cancer study examined 17,035 women between 1991 and 1996. Blood samples were collected at baseline and free triiodothyronine (T3), free thyroxin (T4), TSH and thyroid peroxidase autoantibodies (TPO-Ab) levels were measured in 676 cases and 680 controls. Relative risks with 95% confidence intervals were assessed using a logistic regression analysis adjusted for potential confounders. Free T4 levels were positively associated with a high risk of breast cancer, and the OR for women with free T4 levels above vs. below the median was 1.40 (1.101.77). This association was most pronounced in overweight women (1.51:1.072.12). Women with high levels of TPO-Ab had a lower risk of breast cancer, but only the analysis of TPO-Ab as a continuous variable reached statistical significance. Free T4 was in our study positively associated with a high risk of breast cancer. This association was most pronounced in overweight/obese women. Women with a high level of TPO-Ab had a relatively low risk of breast cancer.
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