期刊
INTERNATIONAL JOURNAL OF CANCER
卷 129, 期 7, 页码 1541-1551出版社
WILEY
DOI: 10.1002/ijc.26102
关键词
beta-catenin; Wnt pathway; cadherin junction; tumorigenesis
类别
资金
- National Natural Science Foundation of China [30700534, 30901774]
- Natural Science Foundation of Shanxi Province [2008021039]
- Medical Science and Technique Foundation of Shanxi Province [200617]
- National High Technology Research and Development Program of China (863 Program)
beta-catenin is a multifunctional protein identified to be pivotal in embryonic patterning, organogenesis and adult homeostasis. It plays a critical structural role in mediating cadherin junctions and is also an essential transcriptional co-activator in the canonical Wnt pathway. Evidence has been documented that both the canonical Wnt pathway and cadherin junctions are deregulated or impaired in a plethora of human malignancies. In the light of this, there has been a recent surge in elucidating the mechanisms underlying the etiology of cancer development from the perspective of beta-catenin. Here, we focus on the emerging roles of beta-catenin in the process of tumorigenesis by discussing novel functions of old players and new proteins, mechanisms identified to mediate or interact with beta-catenin and the most recently unraveled clinical implications of beta-catenin regulatory pathways toward tumor suppression.
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