Article
Biochemistry & Molecular Biology
Saad S. Al-Shehri
Summary: The innate immune system plays a crucial role in fighting pathogens, with reactive oxygen and nitrogen species serving as key components. However, high concentrations of these reactive species may damage microbial biomolecules. The system can generate more biocidal agents through interactions between its components, and deficiencies in these antimicrobial agents can lead to severe infections and immunocompromised diseases.
Article
Mathematics, Interdisciplinary Applications
Qi Deng, Ting Guo, Zhipeng Qiu, Libin Rong
Summary: This study investigates the oxidative stress in individuals infected with HIV and the role of CTL immune response in infection dynamics, finding that incorporating ROS and CTL immune response leads to rich dynamics in the model, including bistable phenomena and periodic solutions. High levels of ROS may contribute to HIV persistence in patients.
INTERNATIONAL JOURNAL OF BIFURCATION AND CHAOS
(2021)
Review
Agronomy
Rupal Singh Tomar, Sunita Kataria, Anjana Jajoo
Summary: This article explores the recent research on signaling and mechanisms for salt tolerance in plants, focusing on the role of the salt overly sensitive system (SOS) and related antiporters proteins and mitogen-activated protein kinase cascades under salt stress. It also highlights the differential expression of various antioxidative enzymes in C3, C4 and CAM plants.
JOURNAL OF AGRONOMY AND CROP SCIENCE
(2021)
Article
Biochemistry & Molecular Biology
Anne Abot, Steven Fried, Patrice D. Cani, Claude Knauf
Summary: The role of reactive oxygen/nitrogen species as friend or foe messengers in the body is well studied, with their effects depending on concentration in tissues. The intestine, affected by oxidation and inflammation, plays a crucial role in diabetic symptoms. Controlling levels of intestinal reactive oxygen/nitrogen species is a complex balance with potential therapeutic implications.
ANTIOXIDANTS & REDOX SIGNALING
(2022)
Review
Pharmacology & Pharmacy
Caiyan Zhao, Hongzhang Deng, Xiaoyuan Chen
Summary: This review provides an overview of the latest progress in ROS-nanotechnology mediated immunomodulation. Inorganic biomaterials can modulate immune responses by generating or eliminating ROS, with potential applications in combating inflammation, autoimmune diseases, and cancers.
ADVANCED DRUG DELIVERY REVIEWS
(2022)
Review
Engineering, Biomedical
Xiaohua Zheng, Yilan Jin, Xiao Liu, Tianqing Liu, Weiqi Wang, Haijun Yu
Summary: Reactive species-based cancer therapies have gained significant attention for their simplicity, controllability, and efficacy. Utilizing nanomaterials for photo-controlled generation of highly reactive radical species is a promising approach for cancer treatment, showing potential synergistic effects with other therapeutic modalities.
BIOACTIVE MATERIALS
(2021)
Review
Biology
Urszula Krasuska, Agnieszka Wal, Pawel Staszek, Katarzyna Ciacka, Agnieszka Gniazdowska
Summary: Carnivorous plants attract and digest animals using specialised traps, with the involvement of reactive oxygen and nitrogen species (RONS) that play various roles in digestion, including antimicrobial activities and signal transduction.
Review
Biochemistry & Molecular Biology
Kave Moloudi, Paromita Sarbadhikary, Heidi Abrahamse, Blassan P. George
Summary: Photodynamic therapy (PDT) is a clinically approved treatment modality used for various conditions, including cancer. The bystander and abscopal effects, which involve reactive oxygen and nitrogen species and immune responses, play significant roles in imparting long-term systemic effects. However, the results in this regard are unsatisfactory and unpredictable due to poorly elucidated underlying mechanisms and other factors. This review highlights the challenges and prospects of non-targeted effects of PDT, aiming to improve the effectiveness and outcomes of targeted and untargeted PDT responses in clinics through further research in this area.
Article
Chemistry, Multidisciplinary
Jia Liu, Lin Shi, Yang Wang, Mingyi Li, Cheng Zhou, Lifang Zhang, Chundong Yao, Ye Yuan, Daan Fu, Yan Deng, Miaodeng Liu, Guobin Wang, Lin Wang, Zheng Wang
Summary: A nanosized ruthenium-based metal-organic framework (Ru-MOF) with high porosity and versatile reactive oxygen and nitrogen species (RONS) scavenging activities has been developed for treating inflammatory diseases.
Article
Biochemistry & Molecular Biology
Surendra Kumar, Rashmi Rana, Dharmendra K. Yadav
Summary: The study revealed that lipid peroxidation causes lateral expansion and increased area of membrane systems, affecting membrane permeability. Nitrogen species have higher permeability through cell membranes compared to oxygen species, suggesting their importance in plasma-based treatments.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2021)
Article
Biology
Yao Zheng, Tracy Naa Adoley Addotey, Jiazhang Chen, Gangchun Xu
Summary: Recent studies have shown the presence of microplastics in freshwater ecosystems and raised concerns about their negative impacts on freshwater organisms. This study examined the effects of chronic sub-lethal doses of polystyrene microspheres on the oxidative status and immune response of genetically improved farmed tilapia (GIFT). The results revealed that microplastics can affect the immune response and antioxidant system of GIFT.
Article
Chemistry, Analytical
Marita A. Cardoso, Abel J. Duarte, Helena M. R. Goncalves
Summary: Three sets of functionalized carbon dots were synthesized and tested as nitric oxide sensors, showing high sensitivity and affinity towards the analyte.
ANALYTICA CHIMICA ACTA
(2022)
Review
Immunology
Si-yue Zhai, Michael G. Kong, Yu-min Xia
Summary: Skin diseases can be categorized into infectious diseases, non-infectious inflammatory diseases, cancers, and wounds. The underlying causes include microbial infections, autoimmune responses, abnormal cellular proliferation or differentiation, and excessive production of inflammatory factors. Cold atmospheric plasma (CAP), as an innovative and non-invasive therapeutic approach, has shown promising efficacy in dermatology by inhibiting infections, promoting wound healing, suppressing cancer growth, and improving psoriasis or vitiligo lesions. This review summarizes recent advances in CAP therapies for various skin diseases and proposes future strategies for increasing effectiveness and expanding clinical indications.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Luisa M. Sandalio, Aurelio M. Collado-Arenal, Maria C. Romero-Puertas
Summary: Plant peroxisomes are dynamic organelles participating in a variety of metabolic processes and cell responses to the environment. This review focuses on the interactions and effects of reactive species such as ROS, RNS, CRS, and SRS in peroxisomes, as well as their role in regulating the redox/ROS homeostasis and plasticity of peroxisomes. The review also highlights the important role of H2O2-dependent peroxisomal retrograde signaling and discusses the specific peroxisomal footprint.
FREE RADICAL BIOLOGY AND MEDICINE
(2023)
Review
Cell Biology
Hamid Aria, Farhoodeh Ghaedrahmati, Mazdak Ganjalikhani-Hakemi
Summary: The term immunometabolism refers to intracellular metabolic changes within immune cells, influencing immune responses and being a key feature in immune cell activation and cancer cell progression. Due to its significance in immunotherapy, studying the immunometabolic situation of cells and understanding cancer cell metabolism can lead to innovative cancer treatment strategies.
JOURNAL OF CELLULAR PHYSIOLOGY
(2021)
Article
Gastroenterology & Hepatology
Sarra Oumrani, Maximilien Barret, Frederic Beuvon, Carole Nicco, Charlotte Chene, Frederic Batteux, Frederic Prat
Summary: This study in a swine model demonstrated that the use of a self-assembling peptide matrix significantly reduced the incidence of esophageal stricture after circumferential endoscopic resection. Adding triamcinolone did not show significant improvement in preventing stricture formation.
DISEASES OF THE ESOPHAGUS
(2021)
Article
Immunology
Gaetane Nocturne, Bineta Ly, Audrey Paoletti, Juliette Pascaud, Raphaele Seror, Carole Nicco, Fabienne Mackay, F. B. Vincent, Thierry Lazure, Sophie Ferlicot, Lev Stimmer, Quentin Pascal, Sandrine Roulland, Roman Krzysiek, Salima Hacein-Bey, Frederic Batteux, Xavier Mariette
Summary: This study found that prolonged treatment with monoclonal anti-TNF antibodies increases the risk of lymphoma in patients with B cell-driven autoimmune diseases, suggesting closer monitoring for lymphoma development in these patients with long-term exposure to monoclonal anti-TNF antibodies.
CLINICAL AND EXPERIMENTAL IMMUNOLOGY
(2021)
Article
Cell Biology
Yipu Dang, Camille Souchet, Fabiana Moresi, Mohamed Jeljeli, Bruno Raquillet, Carole Nicco, Sandrine Chouzenoux, Isabelle Lagoutte, Louis Marcellin, Frederic Batteux, Ludivine Doridot
Summary: Trained immunity, a concept where innate immune cells undergo long-term metabolic and epigenetic reprogramming, can impact pregnancy outcomes by altering the leukocyte population profile at the maternal-fetal interface and influencing fetal growth and development. In this study, preconceptional infections-induced trained immunity led to fetal growth restriction, thereby suggesting a potential link between immune training and pregnancy outcomes.
JOURNAL OF LEUKOCYTE BIOLOGY
(2022)
Article
Pharmacology & Pharmacy
Justine Clarenne, Julien Gravoulet, Virginie Chopard, Julia Rouge, Amelie Lestrille, Francois Dupuis, Lea Aubert, Sophie Malblanc, Coralie Barbe, Florian Slimano, Celine Mongaret
Summary: During the dispensing process, pharmacists can intervene to manage drug-related problems. This study compares the intervention rates in hospital and ambulatory settings and explores their impact on patients and community pharmacies.
Review
Medicine, Research & Experimental
Prisca Gebrayel, Carole Nicco, Souhaila Al Khodor, Jaroslaw Bilinski, Elisabetta Caselli, Elena M. Comelli, Markus Egert, Cristina Giaroni, Tomasz M. Karpinski, Igor Loniewski, Agata Mulak, Julie Reygner, Paulina Samczuk, Matteo Serino, Mariusz Sikora, Annalisa Terranegra, Marcin Ufnal, Romain Villeger, Chantal Pichon, Peter Konturek, Marvin Edeas
Summary: The human gastrointestinal tract is home to a large microbial community called gut microbiota, which plays important roles in immune function, nutrient absorption, and protection against pathogens. The interaction between gut microbiota and various organs within the human body is bidirectional, and microbial alteration has been shown to be a key factor in the pathogenesis of many diseases. Understanding the mechanisms behind gut microbial symbiosis/dysbiosis is crucial for clinical and health fields.
JOURNAL OF TRANSLATIONAL MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Philippe A. Grange, Guillaume Ollagnier, Laurianne Beauvais Remigereau, Carole Nicco, Constance Mayslich, Anne-Genevieve Marcelin, Vincent Calvez, Nicolas Dupin
Summary: Acne is a chronic inflammatory disease caused by Cutibacterium acnes (C. acnes) bacteria. The current treatments for acne often have adverse effects. However, the study found that meclozine, an anti-histaminic H1 compound, has anti-inflammatory properties. In vitro and in vivo experiments showed that meclozine can reduce inflammation caused by C. acnes and decrease the production of inflammatory cytokines. Clinical trials also demonstrated that meclozine gel can effectively reduce acne severity without any adverse events.
Article
Immunology
Charlotte Chene, Mohamed Maxime Jeljeli, Dominique Rongvaux-Gaida, Marine Thomas, Francois Rieger, Frederic Batteux, Carole Nicco
Summary: This study aimed to enhance the clearance of activated immune cells by combining arsenic trioxide (ATO) with a divalent cation to generate a Fenton reaction. In vitro experiments showed that the combination of ATO and copper chloride induced high levels of oxidative stress. In vivo experiments using a mouse model of GvHD demonstrated that the co-treatment effectively reduced lymphocyte activation and fibrosis, suggesting a potential treatment for GvHD.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Cell Biology
Carole Nicco, Marine Thomas, Julie Guillermet, Maryline Havard, Fanny Laurent-Tchenio, Ludivine Doridot, Francois Dautry, Frederic Batteux, Thierry Tchenio
Summary: Self-sustained quiescence (SSQ) is a stable but reversible non-proliferative cellular state that limits the cloning of cultured cancer cells. It has been found that low cell density and the use of drugs can induce cells into SSQ state. In SSQ state, the tumor growth rate of pancreatic adenocarcinoma cells slows down, but eventually transitions to a rapid growth phase. Identifying new agents targeting cancer cells in SSQ may improve patient survival.
Article
Biochemistry & Molecular Biology
Caroline Prieux-Klotz, Henri Chedotal, Martha Zoumpoulaki, Sandrine Chouzenoux, Charlotte Chene, Alvaro Lopez-Sanchez, Marine Thomas, Priya Ranjan Sahoo, Clotilde Policar, Frederic Batteux, Helene C. Bertrand, Carole Nicco, Romain Coriat
Summary: A new prodrug combining a Mn SOD mimic with oxaliplatin was designed and studied for its antitumoral effects. In vitro and in vivo experiments showed that this combination treatment increased ROS production, improved antitumoral efficacy, and decreased oxaliplatin-induced peripheral neuropathy without impairing the overall clinical tolerance to oxaliplatin.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Gastroenterology & Hepatology
Maximilien Barret, Ludivine Doridot, Morgane Le Gall, Frederic Beuvon, Sebastien Jacques, Anna Pellat, Arthur Belle, Einas Abou Ali, Marion Dhooge, Sarah Leblanc, Marine Camus, Carole Nicco, Romain Coriat, Stanislas Chaussade, Frederic Batteux, Frederic Prat
Summary: Our study aimed to identify transcripts specifically overexpressed or repressed in patients who developed post-endoscopic esophageal stricture, as potential targets for stricture prevention. Transcriptomic analysis revealed activation of the interleukin (IL)-1 group and inhibition of interferon-gamma (INF gamma) and NUPR1 in the stricture group on Day 14, but these differences were no longer significant on Day 90.
ENDOSCOPY INTERNATIONAL OPEN
(2023)
Article
Immunology
Charlotte Chene, Dominique Rongvaux-Gaida, Marine Thomas, Francois Rieger, Carole Nicco, Frederic Batteux
Summary: In this study, the combination of arsenic trioxide (ATO) and copper chloride (CuCl2) was used to treat a mouse model of systemic sclerosis (SSc). The results showed that the combination treatment could achieve the same therapeutic effect as a high dose of ATO alone, while reducing the dosage of ATO and improving the health status of the mice.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Biology
Deepika Raman, Charlotte Chene, Carole Nicco, Mohamed Jeljeli, Jie Qing Eu, Marie-Veronique Clement, Frederic Batteux, Shazib Pervaiz
Summary: Graft-versus-host disease (GVHD) is a serious complication of allogeneic hematopoietic stem cell transplantation (HSCT). A pilot study on a murine model of sclerodermatous cGVHD showed that treatment with the senolytic combination of dasatinib and quercetin (DQ) significantly improved physical and tissue-specific features associated with cGVHD pathogenesis. The study suggests the involvement of senescent cells in cGVHD and highlights the potential therapeutic strategy of using DQ.
Article
Immunology
Anderson Rodrigues de Almeida, Andrea Tavares Dantas, Maria Eduarda de Oliveira Goncalves, Charlotte Chene, Mohamed Jeljeli, Sandrine Chouzenoux, Marine Thomas, Eudes Gustavo Constantino Cunha, Lilian David de Azevedo Valadares, Joao Victor de Melo Gomes, Simao Kalebe Silva de Paula, Marina Galdino da Rocha Pitta, Ivan da Rocha Pitta, Moacyr Jesus Barreto de Melo Rego, Michelly Cristiny Pereira, Angela Luzia Branco Pinto Duarte, Dulcineia Saes Parra Abdalla, Carole Nicco, Frederic Batteux, Maira Galdino da Rocha Pitta
Summary: This study aimed to investigate the immunomodulatory and antifibrotic properties of a TZD derivative called LPSF/GQ-16 in peripheral blood mononuclear cells (PBMC) from SSc patients and in a murine model of SSc. The results showed that LPSF/GQ-16 modulated the secretion of cytokines and significantly reduced dermal fibrosis in the mouse model. This study suggests the therapeutic potential of LPSF/GQ-16 for SSc.
INFLAMMOPHARMACOLOGY
(2023)
Article
Rheumatology
Cindy Orvain, Anne Cauvet, Alexis Prudent, Christophe Guignabert, Raphael Thuillet, Mina Ottaviani, Ly Tu, Fanny Duhalde, Carole Nicco, Frederic Batteux, Jerome Avouac, NingXin Wang, Michelle A. Seaberg, Stacey R. Dillon, Yannick Allanore
Summary: This study investigates the efficacy of acazicolcept in mouse models of systemic sclerosis (SSc) and finds that it can reduce fibrosis and alleviate pulmonary hypertension.
ARTHRITIS RESEARCH & THERAPY
(2022)
Meeting Abstract
Dermatology
Philippe Alain Grange, Guillaume Ollagnier, Carole Nicco, Philippe Morand, Anne-Genevieve Marcelin, Vincent Calvez, Nicolas Dupin
JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY
(2021)