Review
Endocrinology & Metabolism
Nicolas Chevalier, Charlotte Hinault, Stephan Clavel, Rachel Paul-Bellon, Patrick Fenichel
Summary: GPER/GPR30, a novel estrogen-binding protein structurally distinct from classic estrogen receptors, is involved in male germ cell proliferation in testicular germ cell cancers. Overexpression of GPER/GPR30 in seminomas, potentially linked to genetic variations, suggests it as a therapeutic target.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Environmental Sciences
Ignacio Babiloni-Chust, Reinaldo S. dos Santos, Regla M. Medina-Gali, Atenea A. Perez-Serna, Jose-Antonio Encinar, Juan Martinez-Pinna, Jan-Ake Gustafsson, Laura Marroqui, Angel Nadal
Summary: 17 beta-estradiol protects pancreatic beta-cells from apoptosis via estrogen receptors ER alpha, ER beta, and GPER. Conversely, the endocrine disruptor bisphenol-A (BPA) increases basal apoptosis in the same cell type through the same estrogen receptors. The molecular events that trigger these opposite actions have not been identified yet.
ENVIRONMENT INTERNATIONAL
(2022)
Article
Environmental Sciences
Mingquan Huang, Meizhou Huang, Xingjie Li, Shuang Liu, Li Fu, Xue Jiang, Meng Yang
Summary: The study found that BPA exposure induces apoptosis of KGN cells through the activation of GPER-dependent signaling pathways, leading to increased expression of apoptotic proteins, decreased mitochondrial membrane potential, and elevated generation of ROS and Ca2+. Inhibiting ROS and Ca2+ as well as the corresponding signaling pathways can effectively inhibit BPA-induced cell apoptosis.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2021)
Article
Environmental Sciences
Chen Sang, Yu Song, Tong-wang Jin, Shuo Zhang, Linyan Fu, Yi Zhao, Xinxin Zou, Zhe Wang, Hui Gao, Sijin Liu
Summary: The study found that BPA can stimulate proliferation and metastasis of ovarian cancer cells by upregulating various proteins through the ER alpha signaling pathway. These results provide new insights into the carcinogenic effects of BPA on ovarian cancer.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2021)
Article
Agriculture, Dairy & Animal Science
Dongqin Wei, De Wu, Wenxian Zeng, Lianqiang Che, Shengyu Xu, Zhengfeng Fang, Bin Feng, Jian Li, Yong Zhuo, Caimei Wu, Junjie Zhang, Yan Lin
Summary: Dietary supplementation with arginine in boars can improve testicular development and semen quality by increasing the number of spermatogonia, height of the seminiferous epithelium, sperm density, and levels of nitric oxide and putrescine in testicular tissue.
JOURNAL OF ANIMAL PHYSIOLOGY AND ANIMAL NUTRITION
(2022)
Article
Cell Biology
Francesca Cirillo, Marianna Talia, Maria Francesca Santolla, Michele Pellegrino, Domenica Scordamaglia, Asia Spinelli, Salvatore De Rosis, Francesca Giordano, Lucia Muglia, Azzurra Zicarelli, Marika Di Dio, Damiano Cosimo Rigiracciolo, Anna Maria Miglietta, Gianfranco Filippelli, Ernestina Marianna De Francesco, Antonino Belfiore, Rosamaria Lappano, Marcello Maggiolini
Summary: In this study, the researchers used CRISPR/Cas9 technology to knock out GPER expression in TNBC cells and made new mechanistic and biological discoveries. They found that GPER KO led to anti-proliferative and pro-apoptotic effects in TNBC cells, as well as impairments in migratory effects in cancer-associated fibroblasts. These findings suggest that GPER may be a valuable target for comprehensive therapeutic approaches in halting TNBC progression.
CELL DEATH DISCOVERY
(2023)
Review
Oncology
Jane Belfield, Charlotte Findlay-Line
Summary: This article provides a detailed description of the use of ultrasound in germ cell tumours and offers guidance on performing an ultrasound examination. It also includes the classification of germ cell tumours and describes the key features of different types of tumours. The challenges and pitfalls of ultrasound are discussed, as well as other applications of ultrasound in this patient group.
Review
Oncology
Saeideh Nakhaei-Rad, Zahra Soleimani, Saeedeh Vahedi, Zahra Gorjinia
Summary: This article summarizes the genetic risk factors for testicular germ cell tumors (TGCTs) and their association with chemotherapy resistance, as well as the impact of epigenetic changes on TGCT progression. It also proposes a model for RAS-dependent signaling networks in TGCTs.
CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY
(2023)
Article
Oncology
Qiang Feng, Dongkui Xu, Mingyao Zhou, Zijian Wu, Zhiyuan Wu, Zheng Wang, Jianjun Bi, Wei Pei
Summary: In this study, the role of CDC42EP3 in colorectal cancer (CRC) was investigated. The results showed that CDC42EP3 was significantly upregulated in CRC and its knockdown inhibited proliferation, colony formation, and migration, while promoting apoptosis of CRC cells. Furthermore, in vivo results confirmed that knockdown of CDC42EP3 attenuated tumor growth in CRC, indicating its potential as a target for innovative therapeutic approaches.
CANCER CELL INTERNATIONAL
(2021)
Article
Multidisciplinary Sciences
Ruiling Liu, Cuilian Liu, Xiaozhen He, Peng Sun, Bin Zhang, Haoran Yang, Weiyun Shi, Qingguo Ruan
Summary: In this study, researchers investigate the role of miR-21 in the regulation of pancreatic beta cell function. They find that miR-21 promotes glucose-stimulated insulin secretion by enhancing glucose uptake and up-regulating Glut2 expression. They also demonstrate that delivering miR-21 into the pancreas can decrease blood glucose levels in diabetic mice.
NATURE COMMUNICATIONS
(2022)
Article
Cell Biology
Dawei Zhu, Jie Huang, Ning Liu, Wei Li, Limei Yan
Summary: PSMC2 is an essential component in ovarian cancer, its upregulation associated with tumor grade and poor prognosis. Knocking down PSMC2 expression in ovarian cancer cells reduces colony formation, cell motility, proliferation, and increases apoptosis. PSMC2 may promote ovarian cancer development through CCND1.
CELL DEATH & DISEASE
(2021)
Review
Oncology
Aitziber Velado-Eguskiza, Laura Gomez-Santos, Iker Badiola, Francisco Jose Saez, Edurne Alonso
Summary: Despite the high survival rate of testicular germ cell tumors, the treatment's long-term side effects significantly impact patients' quality of life, highlighting the need for research on proprotein convertases as diagnostic biomarkers and therapeutic targets.
Article
Biotechnology & Applied Microbiology
Yang Luo, Qianyin Zhou, Fang Zhu, Liqing Fan, Hao Bo, Xingming Wang
Summary: AKT3 is upregulated and frequently amplified in TGCT, leading to poor survival outcomes, while loss-of-function mutations in AKT3 are associated with better prognosis. Silencing AKT3 inhibits proliferation and colony formation in TGCT cells. AKT3 may be involved in TGCT progression through multiple signaling pathways and its upregulation may be driven by promoter hypomethylation.
Article
Cell Biology
Karthika Radhakrishnan, Michael Luu, Josie Iaria, Jessie M. Sutherland, Eileen A. McLaughlin, Hong-Jian Zhu, Kate L. Loveland
Summary: Testicular germ cell tumours (TGCTs) are the most common malignancy in young men. The balance between activin and BMP signalling may influence TGCT emergence and progression. The study investigated the effects of activin A and BMP4 on gene expression in human cell line models of seminoma (TCam-2) and non-seminoma (NT2/D1), revealing their differential roles in regulating pluripotency, cancer, and various signaling pathways. The nuclear transport protein IPO5 was found to be highly regulated and potentially involved in determining TGF-beta signaling outcomes in TGCTs.
Article
Oncology
Kai Funke, Ulf Einsfelder, Aylin Hansen, Lena Arevalo, Simon Schneider, Daniel Nettersheim, Valentin Stein, Hubert Schorle
Summary: The overactivation of neddylation is associated with cisplatin resistance in testicular germ cell tumours (TGCTs). Inhibition of neddylation using MLN4924 in combination with cisplatin enhances cytotoxicity and induces apoptosis, cell cycle arrest, and differentiation in TGCT cells. This study provides a novel treatment option for TGCTs.
BRITISH JOURNAL OF CANCER
(2023)
Review
Endocrinology & Metabolism
Nicolas Chevalier, Charlotte Hinault, Stephan Clavel, Rachel Paul-Bellon, Patrick Fenichel
Summary: GPER/GPR30, a novel estrogen-binding protein structurally distinct from classic estrogen receptors, is involved in male germ cell proliferation in testicular germ cell cancers. Overexpression of GPER/GPR30 in seminomas, potentially linked to genetic variations, suggests it as a therapeutic target.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Endocrinology & Metabolism
Blandine Tramunt, Sarra Smati, Sandrine Coudol, Matthieu Wargny, Matthieu Pichelin, Beatrice Guyomarch, Abdallah Al-Salameh, Coralie Amadou, Sara Barraud, Edith Bigot, Lyse Bordier, Sophie Borot, Muriel Bourgeon, Olivier Bourron, Sybil Charriere, Nicolas Chevalier, Emmanuel Cosson, Bruno Feve, Anna Flaus-Furmaniuk, Pierre Fontaine, Amandine Galioot, Celine Gonfroy-Leymarie, Bruno Guerci, Sandrine Lablanche, Jean-Daniel Lalau, Etienne Larger, Adele Lasbleiz, Bruno Laviolle, Michel Marre, Marion Munch, Louis Potier, Gaetan Prevost, Eric Renard, Yves Reznik, Dominique Seret-Begue, Paul Sibilia, Philippe Thuillier, Bruno Verges, Jean-Francois Gautier, Samy Hadjadj, Bertrand Cariou, Franck Mauvais-Jarvis, Pierre Gourdy
Summary: The paragraph lists the names of a group of researchers of different ages, who may be authors of a study.
EUROPEAN JOURNAL OF ENDOCRINOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Claudine Moratal, Audrey Laurain, Mourad Naimi, Thibault Florin, Vincent Esnault, Jaap G. Neels, Nicolas Chevalier, Giulia Chinetti, Guillaume Favre
Summary: Diabetic nephropathy is characterized by proteinuria, renal dysfunction, renal fibrosis, and infiltration of macrophages derived from peripheral monocytes. Research focuses on the control of monocyte recruitment and modulation of macrophage polarization in the context of diabetic nephropathy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Medicine, General & Internal
Meggy Hayotte, Antonio Iannelli, Veronique Negre, Christian Pradier, Pierre Therouanne, Alain Fuch, Odile Diagana, Jean-Marie Garbarino, Anne Vuillemin, Serge S. Colson, Nicolas Chevalier, Fabienne d'Arripe-Longueville
Summary: This study aims to determine the effects of two technology-based physical activity programmes after bariatric surgery compared to standard care, and to assess the contribution of acceptability and motivational mechanisms in explaining these effects on physical activity, physiological measures, and health indicators.
Review
Endocrinology & Metabolism
Emma Bokobza, Charlotte Hinault, Victor Tiroille, Stephan Clavel, Frederic Bost, Nicolas Chevalier
Summary: Obesity is a significant public health concern associated with increased risk of various cancers, including gastrointestinal tract cancers and hormone-dependent cancers. Adipose tissue plays a crucial role in this process, as it is considered a major internal source of endocrine disrupting chemicals that can impact hormonal balance and cell proliferation.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Endocrinology & Metabolism
Nicolas Chevalier, Alfred Penfornis, Jean-Pierre Riveline, Florence Chartier, Beth Mitchell, Beatrice Osumili, Erik Spaepen, Frank Snoek, Mark Peyrot, Imane Benabbad
Summary: The CRASH survey data from France highlights the need for more discussion about severe hypoglycemic events (SHEs) between healthcare professionals and people with diabetes, as well as their caregivers. It also reveals gaps in diabetes education for both patients and caregivers.
ANNALES D ENDOCRINOLOGIE
(2022)
Article
Oncology
S. Sumodhee, V. Atallah, R. Kinj, J. Doyen, B. L'Homel, P. Gillon, P. Paquis, F. Almairac, S. Hieronimus, R. Schiappa, J. -l. Sadoul, D. Sumodhee, N. Pontikos, Q. Richier, J. -m. Hannoun-Levi, C. Scouarnec, N. Chevalier, P. -Y. Bondiau
Summary: This study evaluated the efficacy and toxicity of hypofractionated stereotactic radiotherapy (HSRT) for pituitary adenoma (PA) and found that delivering 35 Gy in 5 fractions is a feasible treatment option that can reduce hormonal overproduction and improve local control.
CANCER RADIOTHERAPIE
(2022)
Article
Endocrinology & Metabolism
Elisa Deflorenne, Michel Peuchmaur, Delphine Vezzosi, Christiane Ajzenberg, Laurent Brunaud, Nicolas Chevalier, Sophie Christin-Maitre, Benedicte Decoudier, Natacha Driessens, Delphine D. Drui, Olivier Gilly, Pierre Goudet, Frederic Illouz, Christel Jublanc, Herve Lefebvre, Antoine-Guy Lopez, Charlotte Lussey, Aurelien Morini, Marie-Laure Raffin-Sanson, Isabelle Raingeard, Peggy Renoult-Pierre, Caroline Storey, Antoine Tabarin, Marie Christine Vantyghem, Emmanuelle Vidal-Petiot, Eric Baudin, Jerome Bertherat, Laurence Amar
Summary: Adrenal ganglioneuromas are rare differentiated neuroblastic tumors that are mostly non-secreting and can be incidentally discovered. Surgery is the main treatment option, with a low risk of recurrence postoperatively.
EUROPEAN JOURNAL OF ENDOCRINOLOGY
(2021)
Review
Pharmacology & Pharmacy
Jerrold J. Heindel, Sarah Howard, Keren Agay-Shay, Juan P. Arrebola, Karine Audouze, Patrick J. Babin, Robert Barouki, Amita Bansal, Etienne Blanc, Matthew C. Cave, Saurabh Chatterjee, Nicolas Chevalier, Mahua Choudhury, David Collier, Lisa Connolly, Xavier Coumoul, Gabriella Garruti, Michael Gilbertson, Lori A. Hoepner, Alison C. Holloway, George Howell, Christopher D. Kassotis, Mathew K. Kay, Min Ji Kim, Dominique Lagadic-Gossmann, Sophie Langouet, Antoine Legrand, Zhuorui Li, Helene Le Mentec, Lars Lind, P. Monica Lind, Robert H. Lustig, Corinne Martin-Chouly, Vesna Munic Kos, Normand Podechard, Troy A. Roepke, RobertM. Sargis, Anne Starling, Craig R. Tomlinson, Charbel Touma, Jan Vondracek, Frederick vom Saal, Bruce Blumberg
Summary: Obesity is a multifactorial disease caused by genetic and environmental factors. Overeating and lack of exercise are common causes, but environmental substances known as obesogens can also disrupt the balance of energy intake and expenditure, increasing the risk of obesity. Obesogens primarily affect the development and function of adipose tissue, liver, pancreas, gastrointestinal tract, and brain, altering the control of metabolism. The most sensitive period for obesogen exposure is in utero and early childhood, which may lead to changes in gene expression that can be transmitted to future generations.
BIOCHEMICAL PHARMACOLOGY
(2022)
Article
Environmental Sciences
Claire Beausoleil, Brigitte Le Magueresse-Battistoni, Catherine Viguie, Sylvie Babajko, Marie-Chantal Canivenc-Lavier, Nicolas Chevalier, Claude Emond, Rene Habert, Nicole Picard-Hagen, Sakina Mhaouty-Kodja
Summary: The study compared the similarities between BPS and BPA, revealing potential adverse effects of BPS on human health at lower doses. Inconsistencies in toxicity were found between academic and regulatory studies for BPS, suggesting the need to establish human reference values for exposure to BPS based on academic findings.
ENVIRONMENTAL RESEARCH
(2022)
Correction
Pharmacology & Pharmacy
Jerrold J. Heindel, Sarah Howard, Keren Agay-Shay, Juan P. Arrebola, Karine Audouze, Patrick J. Babin, Robert Barouki, Amita Bansal, Etienne Blanc, Matthew C. Cave, Saurabh Chatterjee, Nicolas Chevalier, Mahua Choudhury, David Collier, Lisa Connolly, Xavier Coumoul, Gabriella Garruti, Michael Gilbertson, Lori A. Hoepner, Alison C. Holloway, George Howell, Christopher D. Kassotis, Mathew K. Kay, Min Ji Kim, Dominique Lagadic-Gossmann, Sophie Langouet, Antoine Legrand, Zhuorui Li, Helene Le Mentec, Lars Lind, P. Monica Lind, Robert H. Lustig, Corinne Martin-Chouly, Vesna Munic Kos, Normand Podechard, Troy A. Roepke, Robert M. Sargis, Anne Starling, Craig R. Tomlinson, Charbel Touma, Jan Vondracek, Frederick vom Saal, Bruce Blumberg
BIOCHEMICAL PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Aurelie Charazac, Charlotte Hinault, Bastien Dolfi, Solene Hautier, Celia Deconde Le Butor, Frederic Bost, Nicolas Chevalier
Summary: Endocrine Disrupting Compounds (EDCs) are compounds found in everyday products that can disrupt hormonal effects and have adverse health effects. This study found that four specific EDCs promoted the proliferation of cancer cell lines from hormone-sensitive organs (prostate and breast), with PFOA and PCB153 showing this effect at very low concentrations (10(-12) M).
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Endocrinology & Metabolism
Blandine Tramunt, Emmanuel Disse, Nicolas Chevalier, Lyse Bordier, Laurent Cazals, Olivier Dupuy, Michel Marre, Odette Matar, Laurent Meyer, Chloe Noilhan, Caroline Sanz, Paul Valensi, Fritz-Line Velayoudom, Jean-Francois Gautier, Pierre Gourdy
Summary: This study aimed to evaluate the use and effectiveness of the insulin Degludec plus Liraglutide (IDegLira) fixed-ratio combination in the French healthcare system. The results showed that IDegLira effectively reduced HbA(1c) levels in T2D patients, but also potentially led to weight gain.
Article
Business
Julien Francois, Anne-Francoise Audrain-Pontevia, Loick Menvielle, Nicolas Chevalier
Summary: The Internet of Things (IoT) is an important development in information technology that aims to improve human life by connecting the digital world with the real world. This study fills the research gap regarding the empowerment of chronic illness patients by healthcare IoT (HIoT) devices and explores how empowerment is defined for HIoT users.
INTERNATIONAL JOURNAL OF CONSUMER STUDIES
(2023)
Review
Biochemistry & Molecular Biology
Charlotte Hinault, Philippe Caroli-Bosc, Frederic Bost, Nicolas Chevalier
Summary: Diabetes mellitus is a significant global health problem, impacting individuals and economies. The chronic hyperglycemia associated with diabetes leads to severe complications, including retinopathy, kidney failure, and cardiovascular diseases. While genetic factors and environmental factors like sedentary lifestyles, overweight, and obesity contribute to the development of diabetes, there is growing evidence suggesting the role of endocrine-disrupting chemicals (EDCs) in the pathophysiology of diabetes and metabolic disorders. This narrative review critically examines the impact of EDCs on our endocrine system and their link to diabetes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
