Article
Oncology
Nikki B. Thuijs, Willemijn A. M. Schonck, Linde L. J. Klaver, Guus Fons, Marc van Beurden, Renske D. M. Steenbergen, Maaike C. G. Bleeker
Summary: In this exploratory study, biomarker profiles in patients with multiple high-risk HPV-associated vulvar precursor lesions were compared. While the biomarkers generally showed similar expression between lesions, marked differences were occasionally observed, indicating heterogeneity within multifocal lesions. This study contributes to a better understanding of the potential diagnostic, prognostic, and predictive value of biomarkers in patients with multifocal HSIL.
Article
Public, Environmental & Occupational Health
Philip E. Castle, Brian Befano, Mark Schiffman, Nicolas Wentzensen, Thomas Lorey, Nancy Poitras, Marianne Hyer, Li C. Cheung
Summary: This study compared the risks of cervical intraepithelial neoplasia grade 2 (CIN2) or more severe diagnoses (CIN2+) between women living with HIV (WLWH) and women not known to have HIV (HIV[-]) following cervical cancer screening. WLWH were more likely to test HPV positive and have abnormal cytology compared to HIV[-] women. The results suggest that both populations could be managed similarly once the screening results are known.
PREVENTIVE MEDICINE
(2022)
Article
Oncology
Huei-Jean Huang, Hsiu-Jung Tung, Lan-Yan Yang, Angel Chao, Yun-Hsin Tang, Hung-Hsueh Chou, Wei-Yang Chang, Ren-Chin Wu, Chu-Chun Huang, Chiao-Yun Lin, Min-Jie Liao, Wei-Chun Chen, Cheng-Tao Lin, Min-Yu Chen, Kuan-Gen Huang, Chin-Jung Wang, Ting-Chang Chang, Chyong-Huey Lai
Summary: This observational study investigated the long-term outcomes and HPV genotype changes after conization for high-grade cervical intraepithelial neoplasia (HG-CIN). Results showed that active surveillance may reduce the severity of progression to cancer, and a majority of patients with recurrent CIN2+ had persistent type-specific HPV infections. Effective therapeutic vaccines for such cases are still needed.
INTERNATIONAL JOURNAL OF CANCER
(2021)
Article
Oncology
Luca Giannella, Paolo Giorgi Rossi, Giovanni Delli Carpini, Jacopo Di Giuseppe, Giorgio Bogani, Barbara Gardella, Ermelinda Monti, Carlo Antonio Liverani, Alessandro Ghelardi, Salvatore Insinga, Francesco Raspagliesi, Arsenio Spinillo, Paolo Vercellini, Elena Roncella, Andrea Ciavattini
Summary: This study evaluated the age-related distribution of HPV genotypes affecting the risk-assessment in cervical cancer screening programs, showing that non-screening-type-HPV and non-HPV-16/18 genotypes have an impact on CIN3 lesions and their prevalence varies with age.
GYNECOLOGIC ONCOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Karen Cortes-Sarabia, Luz del Carmen Alarcon-Romero, Eugenia Flores-Alfaro, Berenice Illades-Aguiar, Amalia Vences-Velazquez, Miguel Angel Mendoza-Catalan, Napoleon Navarro-Tito, Jesus Valdes, Ma Elena Moreno-Godinez, Carlos Ortuno-Pineda
Summary: The study evaluated the expression of REST and RASSF1A in cervical cytological and histological samples, finding a significant decrease in nuclear expression of REST and RASSF1A in patients with high-grade SIL and SCC. These findings may contribute to the diagnosis, prognosis, and post-treatment follow-up of patients with SIL or SCC.
BIOMEDICAL JOURNAL
(2021)
Article
Biochemical Research Methods
Miso Nam, Sang-Soo Seo, Sunhee Jung, Seo Young Jang, Jueun Lee, Minji Kwon, Imran Khan, Do Hyun Ryu, Mi Kyung Kim, Geum-Sook Hwang
Summary: This study compared lipid alterations associated with high-grade CIN and cervical cancer with those associated with a normal status and low-grade CIN. It identified 31 lipids with similar alterations in both high-grade CIN and cervical cancer, and found that lipid metabolites belonging to the same classes were positively correlated with each other. High-grade CIN and cervical cancer induce comparable changes in lipid levels, which are closely related to the development of cervical tumors.
JOURNAL OF PROTEOME RESEARCH
(2021)
Article
Obstetrics & Gynecology
Ting Ding, Lin Li, Ruiqi Duan, Yun Chen, Bowen Yang, Mingrong Xi
Summary: This retrospective study evaluated the risk factors for recurrent high-grade cervical intraepithelial neoplasia after loop electrosurgical excision procedure (LEEP). High-risk HPV infection, margin status, baseline diagnosis, smoking, and immunosuppression were identified as significant independent risk factors for recurrence. HPV genotypes were associated with higher risk of recurrence.
INTERNATIONAL JOURNAL OF GYNECOLOGY & OBSTETRICS
(2023)
Article
Medicine, General & Internal
Sarah J. Bowden, Triada Doulgeraki, Emmanouil Bouras, Georgios Markozannes, Antonios Athanasiou, Harriet Grout-Smith, Konstantinos S. Kechagias, Laura Burney Ellis, Verena Zuber, Marc Chadeau-Hyam, James M. Flanagan, Konstantinos K. Tsilidis, Ilkka Kalliala, Maria Kyrgiou
Summary: Persistent HPV infection is necessary but not sufficient for cervical cancer. Behavioral, environmental, or comorbid exposures may affect the development of cervical cancer. However, the validity of the observational studies describing these associations is still unclear.
Article
Cell Biology
Nikki B. Thuijs, Marc van Beurden, Sylvia Duin, Danielle A. M. Heideman, Johannes Berkhof, Renske D. M. Steenbergen, Maaike C. G. Bleeker
Summary: This study comprehensively classified and assessed a large series of vulvar lesions, finding that 88.4% of high-grade VIN were associated with HPV and 10.9% were HPV independent. Immunohistochemistry testing for p16INK4a and p53 is important for distinguishing between the two types, which have different cancer risks.
Article
Microbiology
Hongyu Xie, Mingjing Wei, Lifang Yao, Yi Liu, Xing Xie, Xiao Li
Summary: This study investigates the relationship between single nucleotide polymorphisms (SNPs) in human papillomavirus (HPV) receptor associated genes and HPV susceptibility and clinical outcomes in Chinese women, and explores a new triaging strategy for non-16/18 high-risk HPV infection.
MICROBIOLOGY SPECTRUM
(2023)
Article
Obstetrics & Gynecology
Rikke Kamp Damgaard, David Jenkins, Mark H. Stoler, Miekel M. van de Sandt, Kathrine Dyhr Lycke, Maurits N. C. de Koning, Wim G. V. Quint, Torben Steiniche, Lone Kjeld Petersen, Anne Hammer
Summary: This study aimed to describe the distribution of HPV genotypes, age, and cytology in women undergoing active surveillance for CIN2. The results showed a high prevalence of HPV16 and high-grade cytology, implying that these women may be perceived as a high-risk population and non-eligible for active surveillance in countries outside Denmark.
ACTA OBSTETRICIA ET GYNECOLOGICA SCANDINAVICA
(2023)
Article
Oncology
Fl Sand, Kirsten Frederiksen, Susanne K. Kjaer
Summary: This study investigates the relationship between post-conization HPV status and surgical margins and the absolute risk of cervical intraepithelial neoplasia grade 2 or worse (CIN2+). The results suggest that considering both HPV status and margin in risk assessment provides additional stratification compared to HPV status alone. Combined testing with HPV and margin status has higher sensitivity but lower specificity than HPV testing alone, which is important in high-risk populations.
GYNECOLOGIC ONCOLOGY
(2022)
Article
Infectious Diseases
Luca Giannella, Giovanni Delli Carpini, Jacopo Di Giuseppe, Giorgio Bogani, Barbara Gardella, Ermelinda Monti, Carlo Antonio Liverani, Alessandro Ghelardi, Salvatore Insinga, Michele Montanari, Francesco Raspagliesi, Arsenio Spinillo, Paolo Vercellini, Elena Roncella, Andrea Ciavattini
Summary: The study found a decreasing trend in HPV 16/18 prevalence in women with CIN3 over the years, indicating the herd effect of the HPV vaccine, but the increase in high-risk HPV genotypes must be closely monitored.
INFECTION AND DRUG RESISTANCE
(2021)
Letter
Dermatology
Camille Isnard, Johan Chanal, Christine Bergeron, Olivier Aynaud
Summary: We conducted the first study on cervical HPV lesions in female partners of males with PHSILs. In 81% of cases, histologically confirmed cervical SIL was observed, with high-grade SIL in more than two-thirds of cases and low-grade SIL in one-third. Screening of females with male partners who have PHSIL is important to detect and treat clinical HPV lesions early. Our results suggest that HPV testing and reflex cytology should be performed for female partners of males with PHSILs. Colposcopy should be done if there is an abnormal Pap smear.
BRITISH JOURNAL OF DERMATOLOGY
(2023)
Article
Oncology
Stephan Polterauer, Olaf Reich, Andreas Widschwendter, Laudia Hadjari, Gerhard Bogner, Alexander Reinthaller, Elmar Joura, Gerda Trutnovsky, Alexandra Ciresa-Koenig, Julia Ganhoer-Schimboeck, Ina Boehm, Regina Berger, Eva Langthaler, Stephan W. Aberle, Georg Heinze, Andreas Gleiss, Christoph Grimm
Summary: This study investigates the non-inferiority of topical IMQ therapy compared to LLETZ in patients diagnosed with HSIL. The results show that IMQ treatment leads to lower HPV clearance rates compared to LLETZ, suggesting that LLETZ remains the standard treatment for HSIL patients.
GYNECOLOGIC ONCOLOGY
(2022)
Article
Gastroenterology & Hepatology
Reinier G. S. Meester, Hilliene J. van de Schootbrugge-vandermeer, Emilie C. H. Breekveldt, Lucie de Jonge, Esther Toes-Zoutendijk, Arthur Kooyker, Daan Nieboer, Christian R. Ramakers, Manon C. W. Spaander, Anneke J. van Vuuren, Ernst J. Kuipers, Folkert J. van Kemenade, Iris D. Nagtegaal, Evelien Dekker, Monique E. van Leerdam, Iris Lansdorp-Vogelaar
Summary: The prognostic potential of repeated faecal haemoglobin (F-Hb) concentration measurements in faecal immunochemical test (FIT)-based screening for colorectal cancer (CRC) was examined. The study found that F-Hb concentrations in rounds 1 and 2 were the strongest predictors. In external validation, the model retained similar discrimination accuracy. This suggests that individuals can be accurately identified as low or high risk based on age, sex, and prior F-Hb concentrations, and risk stratification should be considered based on this information.
Article
Oncology
Clare A. Aitken, Federica Inturrisi, Sylvia Kaljouw, Daan Nieboer, Albert G. Siebers, Willem J. G. Melchers, Adriaan J. C. van den Brule, Anco Molijn, John W. J. Hinrichs, Hubert G. M. Niesters, Folkert J. van Kemenade, Johannes Berkhof, Inge M. C. M. de Kok
Summary: In the Netherlands, self-collected samples have lower high-risk human papillomavirus (hrHPV) positivity but higher cervical intraepithelial neoplasia (CIN) 2+ detection compared to clinician-collected samples. The differences between the two sampling methods are likely related to sociodemographic factors as well as differences in screening test accuracy and background risk. Self-sampling can be used as a more convenient screening tool for underscreened women.
CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION
(2023)
Article
Gastroenterology & Hepatology
David E. F. W. M. van Toledo, Emilie C. H. Breekveldt, Joep E. G. IJspeert, Anneke J. van Vuuren, Folkert J. van Kemenade, Christian Ramakers, Iris D. Nagtegaal, Monique E. van Leerdam, Manon C. W. Spaander, Iris Lansdorp-Vogelaar, Esther Toes-Zoutendijk, Evelien Dekker
Summary: This study assessed the detection rate and positive predictive value (PPV) of advanced serrated polyps (ASPs) in a FIT-based screening program. The results showed that 5.9% of FIT-positive screenees had ASPs, and including ASPs slightly increased the yield of the screening.
Article
Oncology
Sanne ten Hoorn, Linda Mol, Dirkje W. Sommeijer, Lisanne Nijman, Tom van den Bosch, Tim R. de Back, Bauke Ylstra, Erik van Dijk, Carel J. M. van Noesel, Roy J. Reinten, Iris D. Nagtegaal, Miriam Koopman, Cornelis J. A. Punt, Louis Vermeulen
Summary: We evaluated the potential efficacy of adding anti-EGFR therapy to anti-VEGF therapy in a subgroup of patients with metastatic colorectal cancer. The retrospective study (CAIRO2 trial, n = 736) showed no benefit of anti-EGFR addition within the subgroup, but an overall survival increase of 6.5 months compared to the original trial.
CLINICAL COLORECTAL CANCER
(2023)
Article
Oncology
Emilie C. H. Breekveldt, Esther Toes-Zoutendijk, Hilliene J. van de Schootbrugge-Vandermeer, Lucie de Jonge, Arthur I. Kooyker, Manon C. W. Spaander, Anneke J. van Vuuren, Folkert J. van Kemenade, Christian Ramakers, Evelien Dekker, Iris D. Nagtegaal, Monique E. van Leerdam, Iris Lansdorp-Vogelaar
Summary: The interval colorectal cancer (CRC) rate after negative fecal immunochemical testing (FIT) is an important quality indicator of CRC screening programs. Our study analyzed the outcomes of a FIT-based CRC screening program in the Netherlands, showing low incidence of interval CRC and high FIT-sensitivity. Risk-stratified CRC screening based on prior fecal hemoglobin concentration (f-Hb) may further optimize the screening program.
INTERNATIONAL JOURNAL OF CANCER
(2023)
Article
Endocrinology & Metabolism
Evert F. S. van Velsen, Robin P. Peeters, Merel T. Stegenga, Folkert J. van Kemenade, Tessa M. van Ginhoven, Mathe van Balkum, Frederik A. Verburg, W. Edward Visser
Summary: This study compared the performance of different risk stratification systems in predicting disease-specific survival in patients with differentiated thyroid cancer. The optimized age-adjusted TNM system showed the best predictive value among all the systems.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Article
Immunology
Hilal Varol, Angela Ernst, Iacopo Cristoferi, Wolfgang Arns, Carla C. Baan, Myrthe van Baardwijk, Thierry van den Bosch, Jennifer Eckhoff, Ana Harth, Dennis A. Hesselink, Folkert J. van Kemenade, Willem de Koning, Christine Kurschat, Robert C. Minnee, Dana A. Mustafa, Marlies E. J. Reinders, Shazia P. Shahzad-Arshad, Malou L. H. Snijders, Dirk Stippel, Andrew P. Stubbs, Jan von der Thusen, Katharina Wirths, Jan U. Becker, Marian C. Clahsen-van Groningen
Summary: This study assessed the feasibility and potential of using NanoString nCounter analysis on KTx biopsies to aid in the classification of rejection in clinical practice. The results showed that transcriptome analysis has the potential to differentiate between different types of kidney transplant rejection and could be valuable in assisting with the classification of kidney transplant rejection.
Article
Gastroenterology & Hepatology
Maarten te Groen, Lauranne A. A. P. Derikx, Lisa van Lierop, Bauke Ylstra, Frank Hoentjen, Iris D. Nagtegaal, Femke Simmer
Summary: The presence of previous colorectal neoplasia is the most significant indicator for the development of pouch neoplasia in inflammatory bowel disease. However, the underlying mechanism remains unknown. Our study found evidence of clonality between colorectal and pouch neoplasia in 30% of patients, suggesting that most pouch neoplasia develops independently from prior colorectal lesions.
INFLAMMATORY BOWEL DISEASES
(2023)
Article
Oncology
Feline O. Voss, Nikki B. Thuijs, Sylvia Duin, Mujde Ozer, Marc van Beurden, Johannes Berkhof, Renske D. M. Steenbergen, Maaike C. G. Bleeker
Summary: This study aimed to validate the accuracy of previously identified DNA methylation markers for detection of high-grade vulvar intraepithelial neoplasia (VIN). The best-performing individual marker was found to be SST, detecting 80% of high-grade VIN cases, with excellent detection of HPV-independent VIN, known to have the highest cancer risk. Selection of a marker panel including ZNF582, SST, and miR124-2 also yielded high accuracy for detection of high-grade VIN.
INTERNATIONAL JOURNAL OF CANCER
(2023)
Article
Oncology
Tessa M. Schurink-van 't Klooster, Albert G. Siebers, Joske Hoes, Folkert J. van Kemenade, Johannes Berkhof, Johannes A. Bogaards, Hester E. de Melker
Summary: By linking national registries on vaccination and pathology, this study found significant beneficial early effects of HPV-vaccination on cytological abnormalities and high-risk HPV positivity in cervical samples of young women who have not yet entered the regular screening program.
Article
Oncology
Anna Lena van Gulik, Ellen Sluydts, Liesbet Vervoort, Mark Kockx, Pim Kortman, Bauke Ylstra, Stephen P. Finn, Lukas Bubendorf, Idris Bahce, Daoud Sie, Teodora Radonic, Birgit Lissenberg-Witte, Erik Thunnissen
Summary: This study investigates the impact of cell size and ploidy on FISH results. The results show that in liver cell nuclei, the number of FISH signals increases with nuclear size and section thickness. In non-small cell lung cancer cases, tumor cells with higher ploidy levels and nuclear size have an increased chance of single signals. In addition, no rearrangements were found in lung cancer samples with borderline ALK FISH results, proving a false positive result.
TRANSLATIONAL LUNG CANCER RESEARCH
(2023)
Article
Oncology
Elisabeth M. Jongbloed, Hedwig M. Blommestein, Hannah M. van Schoubroeck, John W. M. Martens, Saskia M. Wilting, Carin A. Uyl-de Groot, Agnes Jager
Summary: The addition of two years of abemaciclib treatment to high-risk ER+, HER2-early breast cancer patients has been approved by the FDA. Using detection of minimal residual disease (MRD) through patient-informed circulating tumor DNA assays, the addition of abemaciclib treatment shows cost-effectiveness for high-risk patients. However, adding abemaciclib to all high-risk patients is not cost-effective, while MRD-guided treatment is more cost-effective compared to standard treatment.
BREAST CANCER-TARGETS AND THERAPY
(2023)
Article
Public, Environmental & Occupational Health
Maarten D. Vink, Geeske Hofstra, Xander Koolman, Ruud L. Bekkers, Albert G. Siebers, Folkert J. van Kemenade, Koen B. Bocker, Michiel ten Hove, Eric J. van der Hijden
Summary: Research showed evidence of both overtreatment and undertreatment of cervical intraepithelial neoplasia (CIN) in Dutch hospitals, highlighting the need for better adherence to guidelines. The study used nationwide insurance and pathology data to identify deviations from the screening program and constructed quality indicators for compliance assessment. The findings emphasize the importance of implementing feedback mechanisms to improve guideline adherence in routine clinical practice.
PREVENTIVE MEDICINE REPORTS
(2023)
Article
Cell Biology
Nikki B. Thuijs, Marc van Beurden, Sylvia Duin, Danielle A. M. Heideman, Johannes Berkhof, Renske D. M. Steenbergen, Maaike C. G. Bleeker
Summary: This study comprehensively classified and assessed a large series of vulvar lesions, finding that 88.4% of high-grade VIN were associated with HPV and 10.9% were HPV independent. Immunohistochemistry testing for p16INK4a and p53 is important for distinguishing between the two types, which have different cancer risks.
Article
Pathology
Tanya T. D. Soeratram, Hedde D. Biesma, Jacqueline M. P. Egthuijsen, Elma Meershoek-Klein Kranenbarg, Henk H. Hartgrink, Cornelis J. H. van de Velde, Aart Mookhoek, Erik van Dijk, Yongsoo Kim, Bauke Ylstra, Hanneke W. M. van Laarhoven, Nicole C. T. van Grieken
Summary: Tumor-infiltrating lymphocytes are important for the survival of gastric cancer patients, and T-cell densities in different regions of the tumor can serve as prognostic markers. CD8OIM and FOXP3TC are identified as key factors for survival, and the combination of their densities can stratify patients into distinct subgroups with different prognosis. These immune subgroups are independent predictors for cancer-specific survival in resectable gastric cancer.
