Letter
Oncology
Anushka Walia, Vinay Prasad
Summary: The use of immune checkpoint inhibitors (ICIs) in early stage non-small cell lung cancer (NSCLC) is increasing, with pembrolizumab approved as adjuvant therapy. However, clinical trials of these agents have limitations such as surrogate endpoints and lack of demonstrated survival benefit. Further data is needed to justify their use.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2023)
Article
Oncology
Mohammed Safi, Chenxing Jin, Abdullah Aldanakh, Ping Feng, Henan Qin, Mohammed Alradhi, Lizhi Zhang, Junying Zhang, Salah Adlat, Yi Zhao, Jiwei Liu
Summary: This study investigates the association between immune checkpoint inhibitor genes and survival rates in elderly melanoma patients, and identifies TNFRSF4 gene as being correlated with lower survival rates in the older age group and higher gene expression in the younger age group. The study provides a foundation for further exploration of aging responses in melanoma patients and potential therapeutic targets.
Article
Multidisciplinary Sciences
Hanlin Liang, Jiewen Peng
Summary: This study reveals the role of HOTAIR in the proliferation, migration, and invasion of NSCLC cells by regulating CCL22 expression.
Review
Immunology
Shuai Jiang, Shuai Geng, Xinyu Luo, Can Zhang, Yang Yu, Mengfei Cheng, Shuo Zhang, Ning Shi, Mei Dong
Summary: Cancer is a highly prevalent and deadly disease worldwide. Immunotherapy, specifically immune checkpoint inhibitors, has made significant progress in the treatment of solid tumors, surpassing the clinical benefits of traditional anti-tumor drugs and offering hope to patients who have failed multiple lines of therapy. Studies have shown a correlation between cancer driving genes and the efficacy of immune checkpoint inhibitors, allowing prediction of treatment effects and adverse reactions based on the status of driving genes. Therefore, screening potential biomarkers for individuals who may benefit from immunotherapy is of utmost importance.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Alexandru Filippi, Maria-Magdalena Mocanu
Summary: The study aimed to identify genes associated with advanced/aggressive breast cancer and their effect on survival outcomes using transcriptomics data. The publicly available The Cancer Genome Atlas (TCGA) database was used to analyze RNA sequence data from patients with different survival periods, as well as normal tissue data. The results showed reduced enrichment in gene sets related to tumor immune microenvironment in the group with poor prognosis, indicating potential targets for further research and therapeutic interventions.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Oncology
Alexia Monastirioti, Chara Papadaki, Despoina Kalapanida, Konstantinos Rounis, Kleita Michaelidou, Maria A. Papadaki, Dimitrios Mavroudis, Sofia Agelaki
Summary: The expression levels of circulating microRNAs miR-200c and miR-34a are associated with treatment response and prognosis in patients with advanced NSCLC receiving anti-PD-1 immunotherapy.
Article
Endocrinology & Metabolism
Yi Huang, Qiong Li, Rui Hu, Ruiyun Li, Yuan Yang
Summary: In this study, the differential expression, immune infiltration, and interactions of genes related to endometriosis were comprehensively analyzed. The results identified 332 differentially expressed genes associated with endometriosis and revealed the signaling pathways involved. Five genes with diagnostic value were also screened.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Multidisciplinary Sciences
Pu Cheng, Jiong Ma, Xia Zheng, Chunxia Zhou, Xuejun Chen
Summary: This study investigated immune-related prognostic markers for endometrial carcinoma (EC) and identified gene modules and pathways associated with the immune microenvironment in EC. A total of 14 novel immune-related prognostic biomarkers were identified, providing insights into the tumor microenvironment and potential novel therapeutic targets for EC.
SCIENTIFIC REPORTS
(2021)
Article
Genetics & Heredity
Ann Ying-An Chen, Chao-Wei Huang, Shyh-Hwa Liu, An-Chi Liu, Hso-Chi Chaung
Summary: This study investigated the distribution of SNP sites in immune-related genes and their correlations with cell surface markers in different breeds of pigs. The findings revealed significant SNP differences among breeds, particularly between Taiwan black and Landrace pigs, as well as correlations between certain SNPs and the expression of cell surface markers. Understanding the genetic uniqueness of each breed could help identify functionally important SNPs in immunoregulation.
Article
Cell Biology
Xiaoyan Shen, Xiao Gu, Ruiqiong Ma, Xiaoping Li, Jianliu Wang
Summary: In this study, the tumor immune microenvironment (TIME) in ovarian cancer was investigated using gene expression data and clinical information. Through molecular clustering and functional analysis, immune-related genes were identified, and different immune subtypes were further studied. The findings provide potential clues for immunotherapy strategies in ovarian cancer.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Biochemical Research Methods
XiuLiang Cui, Lu Han, Yang Liu, Ying Li, Wen Sun, Bin Song, Wenxia Zhou, Yongxiang Zhang, Hongyang Wang
Summary: siGCD is a web-based tool for analyzing and visualizing the survival interaction of Genes, Cells and Drugs in human cancers. It utilizes cancer heterogeneity to simulate the manipulated gene expression, cell infiltration, and drug treatment.
BRIEFINGS IN BIOINFORMATICS
(2021)
Article
Oncology
Jian Zhou, Ziyuan Chen, Ming Zou, Rongjun Wan, Tong Wu, Yingquan Luo, Gen Wu, Wanchun Wang, Tang Liu
Summary: This study identified that CBXs are significantly overexpressed in human sarcomas and are associated with survival rate and immune cell infiltration in sarcoma patients. These findings suggest that CBXs could serve as potential biomarkers for prognosis and immune infiltration in sarcoma.
FRONTIERS IN ONCOLOGY
(2021)
Article
Biochemical Research Methods
Fei-Fei Hu, Chun-Jie Liu, Lan-Lan Liu, Qiong Zhang, An-Yuan Guo
Summary: The study identified expression patterns of ICGs and their correlations with patient response to immune checkpoint blockade therapy, providing insights into the mechanisms of ICGs in anticancer treatments. A model using ICG expression features showed robust performance in predicting patient responses and outperformed other mRNA-based predictors.
BRIEFINGS IN BIOINFORMATICS
(2021)
Article
Genetics & Heredity
Anna Balcerzyk-Matic, Tomasz Nowak, Katarzyna Mizia-Stec, Joanna Iwanicka, Tomasz Iwanicki, Pawel Banka, Alicja Jarosz, Artur Filipecki, Iwona Zak, Jolanta Krauze, Pawel Niemiec
Summary: Genetic factors play a role in the risk of coronary artery disease and survival of patients. This study identifies AGT, ABCA1, and CYBA gene polymorphisms that influence the risk of death in patients with CAD.
Review
Biochemistry & Molecular Biology
Piotr Minias, Michal Vinkler
Summary: This review examines the role of balancing selection in Toll-like receptors (TLRs), innate immune genes involved in pathogen recognition and immune response activation. The analysis of infection and fitness-based evidence, as well as population allelic frequencies and heterozygosity levels, reveals that balancing selection maintains variation in TLRs under specific conditions and in certain evolutionary lineages. However, the understanding of balancing selection in non-MHC immune genes remains incomplete.
MOLECULAR BIOLOGY AND EVOLUTION
(2022)
Article
Biochemistry & Molecular Biology
Shuanglin Gu, Li Lv, Xue Lin, Xingyu Li, Juncheng Dai, Jianqiong Zhang, Ren Kong, Wei Xie, Jian Li
Summary: This study identified important mutation sites in HBV and evaluated their impact using molecular dynamics simulation. The findings provide insights for immunotherapy.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2022)
Article
Clinical Neurology
Muhammed Lamin Sambou, Xiaoyu Zhao, Tongtong Hong, Muhammad Naveed, Alima Sambou, Fadoua El Hafa, TIl B. Basnet, Juncheng Dai
Summary: The study found that unhealthy sleep behaviors like insomnia, napping, daytime sleepiness, and difficulty getting up from bed are associated with an increased risk of shortened healthspan. Adherence to healthy sleep behavior is significant for extending healthspan.
SLEEP AND BREATHING
(2022)
Article
Oncology
Mengmeng Ji, Lingbin Du, Zhimin Ma, Junxing Xie, Yanqian Huang, Xiaoxia Wei, Xiangxiang Jiang, Jing Xu, Rong Yin, Yuzhuo Wang, Juncheng Dai, Guangfu Jin, Lin Xu, Chen Zhu, Zhibin Hu, Hongxia Ma, Meng Zhu, Hongbing Shen
Summary: Elevated CRP levels are associated with a 22% increased risk of lung cancer, with positive associations observed in small cell lung cancer, lung adenocarcinoma, and lung squamous cell carcinoma. However, no genetical association between circulating CRP levels and lung cancer risk was found. Adding CRP to the risk model of lung cancer can improve the model's performance in current smokers.
INTERNATIONAL JOURNAL OF CANCER
(2022)
Article
Biology
Cheng Wang, Mingtao Huang, Congcong Chen, Yuancheng Li, Na Qin, Zijian Ma, Jingyi Fan, Linnan Gong, Hui Zeng, Liu Yang, Xianfeng Xu, Jun Zhou, Juncheng Dai, Guangfu Jin, Zhibin Hu, Hongxia Ma, Fengwei Tan, Hongbing Shen
Summary: The study demonstrated the significant role of adenosine-to-inosine (A-to-I) RNA editing in tumorigenesis of lung adenocarcinoma (LUAD) through evaluating RNA editing sites, consensus clustering, and establishing a model for accurate distinction of a new subtype. The new subtype EC3 was associated with poor prognosis, independent of classic molecular subtype classification based on gene expression or DNA methylation, highlighting the potential application of RNA editing in cancer molecular subtyping and clinical treatment.
SCIENCE CHINA-LIFE SCIENCES
(2022)
Article
Oncology
Jing Dong, Zhuping Garacci, Christopher Staffi Buradagunta, Anita D'Souza, Meera Mohan, Ashley Cunningham, Siegfried Janz, Binod Dhakal, Aaron P. Thrift, Parameswaran Hari
Summary: This study assessed the survival differences between non-Hispanic black (NHB) and non-Hispanic white (NHW) patients with multiple myeloma (MM), and found that equitable access to effective treatment modalities is crucial in improving the survival of NHB patients.
BLOOD CANCER JOURNAL
(2022)
Article
Gastroenterology & Hepatology
Hyun-seok Kim, Priya B. Shetty, Spiridon Tsavachidis, Jing Dong, Christopher I. Amos, Hashem B. El-Serag, Aaron P. Thrift
Summary: Admixture mapping identified novel genomic regions on 2q21.1 and 6p21.2 that may be associated with HCV-related cirrhosis risk in African Americans.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2023)
Article
Oncology
Chang Zhang, Qi Sun, Xu Zhang, Na Qin, Zhening Pu, Yayun Gu, Caiwang Yan, Meng Zhu, Juncheng Dai, Cheng Wang, Ni Li, Guangfu Jin, Hongxia Ma, Zhibin Hu, Erbao Zhang, Fengwei Tan, Hongbing Shen
Summary: Epigenetic alterations play a significant role in human carcinogenesis. The activation mechanism and oncogenic role of KIAA1429 in lung adenocarcinoma (LUAD) were explored in this study. Copy number amplification of KIAA1429 in LUAD led to poor overall survival and its regulation was found to affect LUAD proliferation and metastasis.
CANCER COMMUNICATIONS
(2022)
Article
Oncology
Cheng Wang, Juncheng Dai, Na Qin, Jingyi Fan, Hongxia Ma, Congcong Chen, Mingxing An, Jing Zhang, Caiwang Yan, Yayun Gu, Yuan Xie, Yuanlin He, Yue Jiang, Meng Zhu, Ci Song, Tao Jiang, Jia Liu, Jun Zhou, Nanxi Wang, Tingting Hua, Shuang Liang, Lu Wang, Jing Xu, Rong Yin, Liang Chen, Lin Xu, Guangfu Jin, Dongxin Lin, Zhibin Hu, Hongbing Shen
Summary: This study presents the largest whole-genome sequencing study of NSCLC in individuals of Chinese ancestry, identifying common and low-frequency loci and cancer predisposition genes associated with NSCLC risk. The study also highlights the significant effect of promoter variants on NSCLC risk. These findings have been validated in independent case-control and prospective cohort studies.
Article
Oncology
Siwei Wang, Ming Li, Jingyuan Zhang, Peng Xing, Min Wu, Fancheng Meng, Feng Jiang, Jie Wang, Hua Bao, Jianfeng Huang, Binhui Ren, Mingfeng Yu, Ninglei Qiu, Houhuai Li, Fangliang Yuan, Zhi Zhang, Hui Jia, Xinxin Lu, Shuai Zhang, Xiaojun Wang, Youtao Xu, Wenjia Xia, Tongyan Liu, Weizhang Xu, Xinyu Xu, Mengting Sun, Xue Wu, Yang Shao, Qianghu Wang, Juncheng Dai, Mantang Qiu, Jinke Wang, Qin Zhang, Lin Xu, Hongbing Shen, Rong Yin
Summary: This study demonstrates that circulating tumor DNA can be used as a marker for monitoring minimal residual disease in early-to-mid-stage non-small cell lung cancer patients, and can predict the recurrence of high-risk patients.
JOURNAL OF HEMATOLOGY & ONCOLOGY
(2022)
Article
Oncology
Na Qin, Cheng Wang, Congcong Chen, Liu Yang, Su Liu, Jun Xiang, Yuan Xie, Shuang Liang, Jun Zhou, Xianfeng Xu, Xiaoyu Zhao, Meng Zhu, Guangfu Jin, Hongxia Ma, Juncheng Dai, Zhibin Hu, Hongbing Shen
Summary: Detection of mCAs can serve as a new indicator for lung cancer risk, and it may be combined with PRS for personalized risk stratification of lung cancer.
Article
Oncology
Xu Zhang, Na Qin, Jingyi Fan, Chang Zhang, Qi Sun, Yayun Gu, Meng Zhu, Erbao Zhang, Juncheng Dai, Guangfu Jin, Hongxia Ma, Zhibin Hu, Hongbing Shen
Summary: This study identified the causal variant rs3769823 in chromosome 2q33.1 and explored its biological functions in non-small cell lung cancer (NSCLC). The variant was found to inhibit the proliferation and metastasis of lung cancer cells and was involved in the apoptosis pathway.
CANCER BIOLOGY & MEDICINE
(2022)
Letter
Biophysics
Anita D'Souza, Ruta Brazauskas, Bi Qing Teng, Grant Yun, Hannah Uttley, Jing Dong, Michael B. Dwinell, Marcelo C. Pasquini, Sergio Giralt, Heather Landau, Edward Stadtmauer, Amrita Krishnan, Siegfried Janz
BONE MARROW TRANSPLANTATION
(2023)
Article
Biochemistry & Molecular Biology
Cheng Wang, Yayun Gu, Jun Zhou, Jie Zang, Xiufeng Ling, Hong Li, Lingmin Hu, Bei Xu, Bo Zhang, Na Qin, Hong Lv, Weiwei Duan, Yue Jiang, Yuanlin He, Tao Jiang, Congcong Chen, Xiumei Han, Kun Zhou, Bo Xu, Xiaoyu Liu, Shiyao Tao, Yangqian Jiang, Jiangbo Du, Juncheng Dai, Feiyang Diao, Chuncheng Lu, Xuejiang Guo, Ran Huo, Jiayin Liu, Yuan Lin, Yankai Xia, Guangfu Jin, Hongxia Ma, Hongbing Shen, Zhibin Hu
Summary: This study investigates the association between assisted reproductive technology (ART) and initial leukocyte telomere length (LTL) using whole-genome sequencing (WGS) data. The study finds that one-year-old children conceived by ART have shorter LTLs, especially in those conceived through blastocyst-stage embryo transfer. Mouse experiments also confirm that blastocyst-stage embryo transfer results in shorter telomere lengths.
Letter
Biophysics
Meera Mohan, Siegfried Janz, Ruta Brazauskas, Michael B. Dwinell, Bi Qing Teng, Grant Yun, Jing Dong, Marcelo C. Pasquini, Sergio Giralt, Heather Landau, Edward Stadtmauer, Amrita Krishnan, Anita D'Souza
BONE MARROW TRANSPLANTATION
(2023)
Review
Public, Environmental & Occupational Health
Muhammed Lamin Sambou, Juncheng Dai, Xiaoyu Zhao, Tongtong Hong, Til Bahadur Basnet, Gifty Marley, Alima Sambou, El Hafa Fadoua, Muhammad Naveed
Summary: The study identified 8 significant determinants of VCT service uptake among adults in sub-Saharan Africa (SSA), including lower physical access, older age, higher education level, high knowledge of HIV and VCT awareness, unprotected sexual practices, discussion on HIV among partners and others, other STIs, and divorced/separated status. The findings suggest that HIV interventions and policy initiatives should be tailored to these determinants in order to increase VCT service uptake in SSA.
PUBLIC HEALTH REVIEWS
(2022)
