Article
Veterinary Sciences
Alexandra Guillen, Katerina Stiborova, Lorenzo Ressel, Laura Blackwood, Riccardo Finotello, Isabel Amores-Fuster, Nimo Jama, David Killick
Summary: The study found that MAGE-A proteins were expressed in 88.4% of canine oral malignant melanomas, with a predominantly cytoplasmic expression pattern. The intensity of MAGE-A expression did not show a significant correlation with survival time.
RESEARCH IN VETERINARY SCIENCE
(2021)
Review
Genetics & Heredity
Reihaneh Alsadat Mahmoudian, Maharati Amirhosein, Parvaneh Mahmoudian, Fatemeh Fardi Golyan, Leila Mokhlessi, Mina Maftooh, Majid Khazaei, Mohammadreza Nassiri, Seyed Mahdi Hassanian, Majid Ghayour-Mobarhan, Gordon Ferns, Soodabeh Shahidsales, Amir Avan
Summary: Gastric cancer is a leading cause of mortality globally and presents challenges in diagnosis, prognosis, and therapy. Cancer-testis antigens (CTAs) have been identified as potential biomarkers and targets for cancer immunotherapy. Numerous studies have reported the dysregulation of CTAs in gastric cancer, and clinical trials have been conducted to evaluate their immunotherapeutic potential.
Review
Biochemistry & Molecular Biology
Ping Yang, Mei Meng, Quansheng Zhou
Summary: The study reveals that oncogenic CTAs are overexpressed in various cancers, promoting carcinogenesis, metastasis, and drug resistance. However, challenges in CTA-targeted cancer immunotherapy include deficient MHC-I antigen presentation, immunosuppressive cells in tumor tissues, and the tumor microenvironment reducing therapy efficacy. New strategies are proposed to overcome these barriers and develop potent immune therapeutics against cancer, as oncogenic CTAs show high tumor specificity and immunogenicity. Future breakthroughs in cancer therapy are expected with CTAs-targeted immunotherapy.
BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER
(2021)
Article
Oncology
Philip C. Simister, Ellen C. Border, Joao F. Vieira, Nicholas J. Pumphrey
Summary: Modest changes in engineered TCRs targeting MAGE-A10 produced significantly different properties, which may be desirable for clinically relevant TCR-pHLA systems to reduce the likelihood of structurally similar peptide mimics being tolerated by a TCR.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2022)
Article
Oncology
Zhenghang Wang, Qi Zhang, Changsong Qi, Yuezong Bai, Feilong Zhao, Hui Chen, Zhongwu Li, Xicheng Wang, Mifen Chen, Jifang Gong, Zhi Peng, Xiaotian Zhang, Jinping Cai, Shiqing Chen, Xiaochen Zhao, Lin Shen, Jian Li
Summary: AKT1 and CDH1 mutations were identified as independent predictors of poor progression-free survival (PFS) and primary resistance to ICIs in dMMR/MSI-H GI cancer. The combination of these two genes as an immuno-oncology therapy predictor (IOpred) showed a high positive predictive value (PPV) and good performance in predicting primary resistance.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2022)
Article
Oncology
Chunmei Fan, Hongke Qu, Xu Wang, Navid Sobhani, Leiming Wang, Shuanglin Liu, Wei Xiong, Zhaoyang Zeng, Yong Li
Summary: CTAs are a group of tumor antigens expressed in various cancer tissues, with potential as promising candidates for cancer detection and treatment, especially in lung cancer, bladder cancer, and skin cancer.
SEMINARS IN CANCER BIOLOGY
(2021)
Article
Chemistry, Multidisciplinary
Hongxin Liu, Zhigang Xie, Min Zheng
Summary: Cancer immunotherapy is a popular area of research, and carbon dots have shown potential as nanovectors to enhance its efficacy.
Article
Oncology
Sandra N. Freiberger, David Holzmann, Gregoire B. Morand, Martin Huellner, Mitchell P. Levesque, Reinhard Dummer, Viktor H. Koelzer, Niels J. Rupp
Summary: This study investigates novel biomarkers in mucosal melanoma that predict response to combined ipilimumab and nivolumab immunotherapy. The results suggest that the testis antigens CTAG1B (NY-ESO-1), MAGE-A3, and MAGE-A4 are predominantly expressed in responding tumors, and could potentially be used for future routine diagnostics to predict treatment outcomes.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2023)
Review
Immunology
Xiaoyan Meng, Xueqing Sun, Zhonglong Liu, Yue He
Summary: Immunotherapy is a treatment used for advanced cancers, focusing on tumor antigens like cancer/testis antigens (CTAs) and their use in cancer vaccines and T cell transfer therapy. CTAs are promising targets for vaccine or T cell therapy, enhancing the immune system's response.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Oncology
Jie Xiao, Fengli Huang, Lin Li, Lianru Zhang, Li Xie, Baorui Liu
Summary: The expression of CTAs, including MAGE-A4, NY-ESO-1, PRAME, and KK-LC-1, is significantly higher in breast cancer, especially in triple-negative breast cancer. Positive expression of MAGE-A4 or PRAME may be associated with prolonged disease-free survival. These CTAs could be potential targets for immunotherapy.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2023)
Review
Oncology
Jian Liu, Minyang Fu, Manni Wang, Dandan Wan, Yuquan Wei, Xiawei Wei
Summary: Research on tumor immunotherapy has made significant progress, and cancer vaccines have emerged as a promising therapeutic strategy. Cancer vaccines stimulate anti-tumor immunity with tumor antigens, potentially overcoming immune suppression and inducing both humoral and cellular immunity. This review introduces the working mechanism of cancer vaccines, summarizes different development platforms, and highlights their clinical research progress, with a focus on clinical application and therapeutic efficacy.
JOURNAL OF HEMATOLOGY & ONCOLOGY
(2022)
Article
Multidisciplinary Sciences
Chen Chen, Dan Gao, Jinlong Huo, Rui Qu, Youming Guo, Xiaochi Hu, Libo Luo
Summary: CT83 is identified as the most TNBC-specific gene and is frequently activated in TNBC and other cancers, while silenced in non-TNBC and many normal tissues. The abnormal activation of CT83 may have an oncogenic role by triggering the activation of cell cycle signaling.
SCIENTIFIC REPORTS
(2021)
Article
Oncology
Lisanne Noordam, Zhouhong Ge, Hadiye Ozturk, Michail Doukas, Shanta Mancham, Patrick P. C. Boor, Lucia Campos Carrascosa, Guoying Zhou, Thierry P. P. van den Bosch, Qiuwei Pan, Jan N. M. IJzermans, Marco J. Bruno, Dave Sprengers, Jaap Kwekkeboom
Summary: High recurrence rates after resection of liver cancer with curative intent impair clinical outcomes of patients diagnosed with liver cancer. Cancer/testis antigens (CTAs) were found to be expressed in a majority of liver cancer patients, with expression in tumor-free liver tissue associated with increased risk of tumor recurrence and poor survival. Targeting these CTA-expressing cells may be beneficial in preventing liver cancer recurrence.
Article
Oncology
Qing Kay Li, Tung-Shing Mamie Lih, Yuefan Wang, Yingwei Hu, Naseruddin Hoti, Daniel W. Chan, Hui Zhang
Summary: This study evaluated the diagnostic utility of 12 protein markers for assessing the aggressiveness of prostate cancer (PCa). Four proteins were found to be over-expressed in aggressive tumors, while three proteins showed stronger staining patterns in non-aggressive tumors. Combining different protein markers improved the accuracy of diagnosing the aggressiveness of PCa.
AMERICAN JOURNAL OF CANCER RESEARCH
(2022)
Article
Chemistry, Medicinal
Matthew C. Fleming, Lilly F. Chiou, Percy P. Tumbale, Gaith N. Droby, Jiwoong Lim, Jacqueline L. Norris-Drouin, Jason G. Williams, Kenneth H. Pearce, R. Scott Williams, Cyrus Vaziri, Albert A. Bowers
Summary: MAGE-A4 proteins play a crucial role in promoting aggressive cancers by increasing tolerance to DNA damage and resistance to chemotherapy. This study identifies a series of highly selective inhibitors of the MAGE-A4:RAD18 interaction and provides valuable tools and structural insights for the development of cellular probes targeting MAGE-A4.
JOURNAL OF MEDICINAL CHEMISTRY
(2022)
Article
Oncology
John Gallon, Mairene Coto-Llerena, Caner Ercan, Gaia Bianco, Viola Paradiso, Sandro Nuciforo, Stephanie Taha-Melitz, Marie-Anne Meier, Tujana Boldanova, Sofia Perez-Del-Pulgar, Sergio Rodriguez-Tajes, Markus von Flue, Savas D. Soysal, Otto Kollmar, Josep M. Llovet, Augusto Villanueva, Luigi M. Terracciano, Markus H. Heim, Charlotte K. Y. Ng, Salvatore Piscuoglio
Summary: The study reveals that epigenetic priming in chronic liver disease affects the outcomes of hepatocellular carcinomas by influencing their genomic and transcriptomic landscapes. Oncogenic transcriptional and methylation dysregulation is evident in chronic liver disease and compounded in hepatocellular carcinomas, suggesting that the extent of epigenetic priming in chronic liver disease could influence disease outcomes.
MOLECULAR ONCOLOGY
(2022)
Article
Oncology
Mattia Marinucci, Caner Ercan, Stephanie Taha-Mehlitz, Lana Fourie, Federica Panebianco, Gaia Bianco, John Gallon, Sebastian Staubli, Savas D. Soysal, Andreas Zettl, Stephan Rauthe, Juerg Vosbeck, Raoul A. Droeser, Martin Bolli, Ralph Peterli, Markus von Fluee, Charlotte K. Y. Ng, Otto Kollmar, Mairene Coto-Llerena, Salvatore Piscuoglio
Summary: The use of patient-derived organoids (PDO) has become increasingly important in cancer research. In this study, we tested different washing solutions to prevent contamination in organoid cultures and found that phosphate-buffered saline (PBS) and PBS with penicillin/streptomycin reduced the contamination rate, while PBS with Primocin completely eliminated contamination. Interestingly, the addition of penicillin/streptomycin negatively impacted organoid growth.
FRONTIERS IN ONCOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Jeanne du Fay de Lavallaz, Alexandra Prepoudis, Maria Janina Wendebourg, Eva Kesenheimer, Diego Kyburz, Thomas Daikeler, Philip Haaf, Julia Wanschitz, Wolfgang N. Loescher, Bettina Schreiner, Mira Katan, Hans H. Jung, Britta Maurer, Angelika Hammerer-Lercher, Agnes Mayr, Danielle M. Gualandro, Annemarie Acket, Christian Puelacher, Jasper Boeddinghaus, Thomas Nestelberger, Pedro Lopez-Ayala, Noemi Glarner, Samyut Shrestha, Robert Manka, Joanna Gawinecka, Salvatore Piscuoglio, John Gallon, Sophia Wiedemann, Michael Sinnreich, Christian Mueller
Summary: This study aimed to confirm the cardiac specificity of cTnT in patients with various skeletal muscle disorders (SMDs). The results showed that elevations in cTnT concentrations in patients with active chronic SMDs are common and not attributable to cardiac disease, while this phenomenon was not observed for cTnI. The re-expression of cTnT in skeletal muscle may partially explain this.
Article
Multidisciplinary Sciences
Charlotte K. Y. Ng, Eva Dazert, Tuyana Boldanova, Mairene Coto-Llerena, Sandro Nuciforo, Caner Ercan, Aleksei Suslov, Marie-Anne Meier, Thomas Bock, Alexander Schmidt, Sylvia Ketterer, Xueya Wang, Stefan Wieland, Matthias S. Matter, Marco Colombi, Salvatore Piscuoglio, Luigi M. Terracciano, Michael N. Hall, Markus H. Heim
Summary: This study presents a comprehensive proteogenomic and phosphoproteomic analysis of HCCs from patients with multiple etiologies and stages, revealing the major pathways altered in the (phospho)proteome.
NATURE COMMUNICATIONS
(2022)
Article
Urology & Nephrology
Mitchell G. Lawrence, Renea A. Taylor, Georgia B. Cuffe, Lisa S. Ang, Ashlee K. Clark, David L. Goode, Laura H. Porter, Clementine Le Magnen, Nora M. Navone, Jack A. Schalken, Yuzhuo Wang, Wytske M. van Weerden, Eva Corey, John T. Isaacs, Peter S. Nelson, Gail P. Risbridger
Summary: This Perspective article discusses patient-derived xenografts (PDXs) of prostate cancer and their utility in basic and preclinical research. The authors emphasize the need for more diverse and accessible PDX models to reflect patient diversity and study emerging treatment strategies and mechanisms of resistance. Collaboration and data sharing can greatly enhance the use of PDXs in prostate cancer research.
NATURE REVIEWS UROLOGY
(2023)
Article
Multidisciplinary Sciences
Joanna Triscott, Matthias Reist, Lukas King, Francielle C. Moselle, Marika Lehner, John Gallon, Archna Ravi, Gurpreet K. Arora, Simone de Brot, Mark Lundquist, Hector Gallart-Ayala, Julijana Ivanisevic, Salvatore Piscuoglio, Lewis C. Cantley, Brooke M. Emerling, Mark A. Rubin
Summary: Phosphatidylinositol (PI)regulating enzymes, especially PI5P4K alpha isoform, play a crucial role in androgen receptor (AR) signaling and prostate cancer (PCa) cell survival. Metabolic stress adaptation of PCa during androgen deprivation (AD) influences PI abundance and activates intracellular pools of PI-4,5-P2. Dysregulation of the mTORC1 pathway and colocalization of PI5P4K alpha to the lysosome are involved in the PI5P4K alpha-AR relationship. Inhibition of PI5P4K alpha shows potential in disrupting PCa metabolic adaptation and castrate resistance.
Article
Oncology
John Gallon, Antonio Rodriguez-Calero, Andrej Benjak, Dilara Akhoundova, Sina Maletti, Ursula Amstutz, Ekkehard Hewer, Vera Genitsch, Achim Fleischmann, Elisabeth J. Rushing, Rainer Grobholz, Ingeborg Fischer, Wolfram Jochum, Gieri Cathomas, Adeboye O. Osunkoya, Lukas Bubendorf, Holger Moch, George Thalmann, Felix Y. Feng, Silke Gillessen, Charlotte K. Y. Ng, Mark A. Rubin, Salvatore Piscuoglio
Summary: Metastases from primary prostate cancers to rare locations, such as the brain, are becoming more common due to longer life expectancy. Epigenetic dysregulation and distinct DNA methylation profiles are associated with primary prostate cancer and prostate cancer brain metastases (PCBM). This study analyzed the DNA methylation landscapes of PCBM, identified associations with mutational background and PRC2 complex activity, and discovered specific epigenetic alterations potentially involved in PCBM formation.
Article
Biotechnology & Applied Microbiology
Desiree Schnidrig, Andrea Garofoli, Andrej Benjak, Gunnar Ratsch, Mark A. Rubin, Salvatore Piscuoglio, Charlotte K. Y. Ng
Summary: Precision oncology relies on accurately identifying somatic mutations in cancer patients. PipeIT2, a variant calling workflow, addresses the clinical need to define somatic mutations in the absence of germline control and achieves high recall and reliability in mutation identification.
Article
Oncology
Caterina Foppa, Annalisa Maroli, Antonio Luberto, Carlotta La Raja, Paola Spaggiari, Cristiana Bonifacio, Stefano De Zanet, Marco Montorsi, Salvatore Piscuoglio, Luigi Maria Terracciano, Armando Santoro, Antonino Spinelli
Summary: Early-onset rectal cancer (EORC) patients with advanced cancer at diagnosis are more likely to undergo neoadjuvant therapies. This study explores the effect of age of onset on the pathological response to neoadjuvant therapies in locally advanced RC patients. The results indicate a higher rate of incomplete response in EORC patients, with early age of onset being a risk factor for a worse response. Different multimodal strategies are needed for EORC patients.
Article
Biochemistry & Molecular Biology
Markus Linder, Dritan Liko, Venkatesh Kancherla, Salvatore Piscuoglio, Michael N. Hall
Summary: Protein histidine phosphorylation is involved in cell cycle regulation and inflammatory response. Loss of LHPP leads to elevated levels of histidine phosphorylation and intestinal inflammation, but it is not sufficient to cause inflammation on its own.
Meeting Abstract
Medicine, Research & Experimental
Antonio Rodriguez, John Gallon, Mark Rubin, Salvatore Piscuoglio
LABORATORY INVESTIGATION
(2023)
Meeting Abstract
Oncology
Gabriel Fridolin Hess, Manuele Giuseppe Muraro, Mairene Coto-Llerena, Silvio Daster, Caner Ercan, Simone Muenst, Otto Kollmar, Salvatore Piscuoglio, Savas Deniz Soysal
Meeting Abstract
Oncology
Raphaelle Servant, Zoi Diamantopoulou, Michele Garioni, Luca Roma, Tatjana Vlajnic, Arnoud J. Templeton, Heike Pueschel, Salvatore Piscuoglio, Nicola Aceto, Helge Seifert, Cyrill A. Rentsch, Bubendorf Lukas, Clementine Le Magnen
Meeting Abstract
Oncology
Authorsmattia Marinucci, Gaia Bianco, Mairene Coto-Llierena, John Gallon, Venkatesh Kancherla, Federica Panebianco, Stephanie Taha-Mehlitz, Sumana Srivatsa, Niko Beerenwinkel, Hesam Montazeri, Vijaya Tirunagaru, Marta De Menna, Caner Ercan, Ahmed Dahmani, Elodie Montaudon, Marianna Kruithof-de Julio, Luigi M. Terracciano, Rinath M. Jeselsohn, Robert C. Doebele, Francois-Clement Bidard, Elisabetta Marangoni, Charlotte K. Y. Ng, Salvatore Piscuoglio
Meeting Abstract
Oncology
Caner Ercan, Mairene Coto-Llerena, Salvatore Piscuoglio, Luigi M. Terracciano