Article
Pharmacology & Pharmacy
Boukje C. Eveleens Maarse, Claus Graff, Jorgen K. Kanters, Michiel J. van Esdonk, Michiel J. B. Kemme, Aliede E. In 't Veld, Manon A. A. Jansen, Matthijs Moerland, Pim Gal
Summary: In this study, hydroxychloroquine did not affect ventricular repolarization, including the QTcF-interval and T-wave morphology, at plasma concentrations up to 200 ng/mL. Based on this analysis, hydroxychloroquine does not appear to increase the risk of QTcF-induced arrhythmias.
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY
(2022)
Article
Microbiology
Vipul K. Gupta, Gary Maier, Paul Eckburg, Lisa Morelli, Yang Lei, Akash Jain, Erika Manyak, David Melnick
Summary: Tebipenem pivoxil hydrobromide (TBP-PI-HBr) was found to have no clinically significant adverse effects on heart rate or ECG parameters, supporting the use of QT interval corrected by Fridericia's method as an appropriate correction. The study evaluated the effects of single therapeutic and supratherapeutic doses of TBP-PI-HBr on the heart rate-corrected QT interval using exposure-response modeling.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2021)
Article
Cardiac & Cardiovascular Systems
Sylvie Pilote, Chantale Simard, Benoit Drolet
Summary: This study evaluated the effects of remdesivir on cardiac electrophysiology. The results showed that remdesivir had no significant impact on cardiac electrophysiology in ex vivo experiments. In vivo experiments demonstrated that remdesivir caused bradycardia and mild prolongation of QTc interval, but no ventricular arrhythmias were observed. These findings may have clinical relevance in COVID-19 patients concomitantly treated with multiple drugs.
JOURNAL OF CARDIOVASCULAR PHARMACOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Adjani A. Peralta, Joel Schwartz, Diane R. Gold, Brent Coull, Petros Koutrakis
Summary: This study explores the impact of PM2.5 components and temperature on ventricular repolarization as measured by QT interval. Higher sulfate levels and colder temperatures were associated with longer QTc interval, while other particles had varying effects. Diabetic status did not modify the association between PM2.5 components and QTc interval.
EUROPEAN JOURNAL OF PREVENTIVE CARDIOLOGY
(2021)
Article
Environmental Sciences
Adjani A. Peralta, Joel Schwartz, Diane R. Gold, Brent Coull, Petros Koutrakis
Summary: Exposure to metals in PM2.5 is associated with acute changes in ventricular repolarization, with higher lead concentrations significantly increasing QT intervals. Copper showed a negative association with QT intervals, possibly due to its essential function in the human body.
ENVIRONMENTAL RESEARCH
(2021)
Article
Clinical Neurology
Salma I. Patel, Wojciech Zareba, Bonnie LaFleur, Jean-Phillipe Couderc, Xiaojuan Xia, Raymond Woosley, Imran Y. Patel, Daniel Combs, Saif Mashaqi, Stuart F. Quan, Sairam Parthasarathy
Summary: Sleep-disordered breathing is associated with some measures of ventricular repolarization but does not modify the association between ventricular repolarization and overall mortality.
Article
Environmental Sciences
Adjani A. Peralta, Joel Schwartz, Diane R. Gold, Brent Coull, Petros Koutrakis
Summary: This study investigated the association between PM2.5 metal components and QT interval length, with findings indicating that higher lead levels were associated with significant QT interval lengthening. Copper, on the other hand, showed a smaller impact compared to other metal components.
ENVIRONMENTAL RESEARCH
(2021)
Article
Infectious Diseases
Yutong Jin, David Benkeser, Maia Kipiani, Nicole F. Maranchick, Lali Mikiashvili, Ketevan Barbakadze, Zaza Avaliani, Wael A. Alghamdi, Mohammad H. Alshaer, Charles A. Peloquin, Henry M. Blumberg, Russell R. Kempker
Summary: This study investigated the potential prolongation of the QT interval caused by newer anti-tuberculosis drugs. The findings suggest that while these drugs may cause a modest increase in QTc interval, the impact on clinical outcomes is minimal.
INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS
(2023)
Article
Microbiology
Pere Millat-Martinez, Sam Salman, Brioni R. Moore, Barbara Baro, Madhu Page-Sharp, Kevin T. Batty, Leanne J. Robinson, William Pomat, Harin Karunajeewa, Moses Laman, Laurens Manning, Oriol Mitja, Quique Bassat
Summary: Mass drug administration (MDA) with monthly dihydroartemisinin-piperaquine (DHA-PQP) is effective in malaria control and elimination. A study found that consecutive use of piperaquine phosphate has minimal impact on QT interval prolongation, indicating the safety of the drug at standard doses.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2022)
Article
Cardiac & Cardiovascular Systems
Joanna Fishbein, Kristie M. Coleman, Amarbir Bhullar, Nikhil Sharma, Stefanos Zafeiropoulos, Umair Ansari, Tia Bimal, Yan Liu, Stavros E. Mountantonakis
Summary: This study retrospectively analyzed COVID-19 patients and identified independent factors associated with in-hospital mortality, which were incorporated into a risk score for prediction.
Article
Critical Care Medicine
Roi Bar Cohen, Matthew Dai, Anthony Aizer, Chirag Barbhaiya, Connor Peterson, Scott Bernstein, David S. Park, Michael Spinelli, Larry A. Chinitz, Lior Jankelson
Summary: The QTc/JTc interval is significantly and independently prolonged after sudden cardiac arrest, regardless of known QT prolonging triggers. Normalization of the QTc is expected only after day 6 of hospitalization. Assessment of the QTc for determining the etiology of arrest or monitoring the effect of QT prolonging medications may be unreliable.
Article
Medicine, General & Internal
Avni Thakore, James Nguyen, Simcha Pollack, Stefan Muehlbauer, Benjamin Chi, Derek Knight, Bhoomi Mehrotra, Joshua Stern, J. Jane Cao, Charles Lucore, Joseph Levine
Summary: Prolonged QTc and QRS intervals in COVID-19 patients may serve as early markers for disease progression and mortality. Baseline QTc prolongation is associated with abnormal cardiac biomarkers.
Review
Cardiac & Cardiovascular Systems
Christian Krijger Juarez, Ahmad S. Amin, Joost A. Offerhaus, Connie R. Bezzina, Bastiaan J. Boukens
Summary: Abnormal cardiac repolarization is the underlying cause of life-threatening arrhythmias in various congenital and acquired cardiac diseases. Dysfunction of ion channels involved in repolarization at the cellular level often leads to the repolarization abnormality. Understanding the genetic and electrophysiological basis of repolarization provides insights into cardiac repolarization and may contribute to improved patient-specific management in the future.
JACC-CLINICAL ELECTROPHYSIOLOGY
(2023)
Article
Multidisciplinary Sciences
Dena Esfandyari, Bio Maria Gheo Idrissou, Konstantin Hennis, Petros Avramopoulos, Anne Dueck, Ibrahim El-Battrawy, Laurenz Grueter, Melanie Annemarie Meier, Anna Christina Naeger, Deepak Ramanujam, Tatjana Dorn, Thomas Meitinger, Christian Hagl, Hendrik Milting, Martin Borggrefe, Stefanie Fenske, Martin Biel, Andreas Dendorfer, Yassine Sassi, Alessandra Moretti, Stefan Engelhardt
Summary: MicroRNA-365 regulates human cardiac action potential by modulating key cardiac repolarizing channels.
NATURE COMMUNICATIONS
(2022)
Article
Medicine, Research & Experimental
Britt Drogemoller, Galen E. B. Wright, Jessica Trueman, Kaitlyn Shaw, Michelle Staub, Shahnaz Chaudhry, Fudan Miao, Michelle Higginson, Gabriella S. S. Groeneweg, James Brown, Laura A. Magee, Simon D. Whyte, Nicholas West, Sonia M. Brodie, Geert 't Jong, Sara Israels, Howard Berger, Shinya Ito, Shahrad R. Rassekh, Shubhayan Sanatani, Colin J. D. Ross, Bruce C. Carleton
Summary: This study provides insights into the genomic basis of ondansetron-induced cardiac changes and highlights the importance of genes implicated in serotonin-related traits. These findings are biologically relevant and represent the first step towards improving the safety of this commonly used antiemetic medication.
BIOMEDICINE & PHARMACOTHERAPY
(2022)