Article
Immunology
Xueyan Li, Xiaoqi Luo, Siru Chen, Jiayi Chen, Xue Deng, Jiahui Zhong, Hui Wu, Xuhui Huang, Changjun Wang
Summary: Hepatocellular carcinoma is characterized by high infiltration of myeloid-derived suppressor cells (MDSCs), which are key drivers of maintaining the immunosuppressive tumor microenvironment. All-trans retinoic acid (ATRA) can differentiate MDSCs into mature myeloid cells, but its effect on liver cancer growth inhibition is unknown.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Tao Liu, Fan Yang, Jie Xie, Jiajun Chen, Wei Gao, Xiangjun Bai, Zhanfei Li
Summary: ATRA can reduce the frequency and activity of MDSCs in the spleen of mice by regulating the expression of arginase-1 and iNOS, as well as the secretion of immune-suppressive cytokines. The administration of ATRA ultimately decreased mortality in CLP-surviving mice with secondary infection, potentially due to the restoration of CD4+ T cell function.
MOLECULAR IMMUNOLOGY
(2021)
Article
Cell Biology
Vinzeigh N. Leukes, Anca Dorhoi, Stephanus T. Malherbe, Elizna Maasdorp, Justine Khoury, Shirley McAnda, Gerhard Walzl, Nelita du Plessis
Summary: This study evaluated the impact of all-trans retinoic acid (ATRA) on MDSCs from active TB cases on T-cell responsiveness, showing that ATRA treatment decreases MDSC frequency but does not restore T-cell function or cytokine production. Further development of MDSC-targeting host-directed therapies for TB is needed.
CELLULAR IMMUNOLOGY
(2021)
Review
Immunology
Estefania Prochetto, Eliana Borgna, Carlos Jimenez-Cortegana, Victor Sanchez-Margalet, Gabriel Cabrera
Summary: Myeloid-derived suppressor cells (MDSCs) play a role in both pathological and non-pathological conditions, including cancer, infections, pregnancy, aging, and vaccination. Vaccination is a crucial public health measure, but the presence of MDSCs may impact vaccine efficacy.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Review
Medicine, Research & Experimental
Guoshu Bi, Jiaqi Liang, Yunyi Bian, Guangyao Shan, Valeria Besskaya, Qun Wang, Cheng Zhan
Summary: All-trans retinoic acid (ATRA), an essential nutrient for human beings, plays important roles in multiple biological processes. It regulates the transcription of target genes and has both differentiation-inducing and immunoregulatory effects in cancer immunology and immunotherapy. The combination of ATRA with other therapeutic approaches has been extensively studied for its potential clinical significance in cancer treatment.
CLINICAL AND EXPERIMENTAL MEDICINE
(2023)
Review
Oncology
Zhaonian Hao, Ruyuan Li, Yuanyuan Wang, Shuangying Li, Zhenya Hong, Zhiqiang Han
Summary: MDSC play vital roles in cancer microenvironment, influencing the responses to immunotherapies and prognosis of cancer patients. Therefore, proposing MDSC-inhibiting strategies becomes crucial in the field of cancer immunotherapies.
BIOMARKER RESEARCH
(2021)
Article
Oncology
Mina M. Tayari, Helena G. Dos Santos, Deukwoo Kwon, Terrence J. Bradley, Amber Thomassen, Charles Chen, Yvonne Dinh, Aymee Perez, Arthur Zelent, Lluis Morey, Luisa Cimmino, Ramin Shiekhattar, Ronan T. Swords, Justin M. Watts
Summary: Clinical trial of ATRA plus TCP in patients with relapsed/refractory AML and MDS showed acceptable safety and improved efficacy in subsets of patients. Gene expression analysis revealed that responders had a more quiescent phenotype while nonresponders exhibited a more proliferative one.
CLINICAL CANCER RESEARCH
(2021)
Article
Immunology
Juan Cruz Gamba, Carolina Roldan, Estefania Prochetto, Giuliana Lupi, Ivan Bontempi, Carolina Veronica Poncini, Monica Vermeulen, Ana Rosa Perez, Ivan Marcipar, Gabriel Cabrera
Summary: The study demonstrates the significant influence of MDSCs on the immune response during T. cruzi infection, even in vaccinated mice, impacting various immune cell populations. Targeting MDSCs may be an effective tool in vaccine design against T. cruzi and potentially other conditions characterized by immune system subversion.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2021)
Article
Immunology
Tianju Liu, Francina Gonzalez De Los Santos, Andrew E. Rinke, Chuling Fang, Kevin R. Flaherty, Sem H. Phan
Summary: Idiopathic pulmonary fibrosis (IPF) is a progressive lung disease without effective therapy. This study investigated the role of myeloid-derived suppressor cells (MDSCs) expressing B7H3 in IPF. The expansion of MDSCs correlated with disease severity in IPF patients. B7H3-mediated MDSCs activated lung fibroblasts and myofibroblast differentiation, and also suppressed T-cell proliferation. Inhibition of MDSC recruitment with anti-B7H3 antibodies reduced inflammation and fibrosis in a mouse model of pulmonary fibrosis. These findings suggest that MDSCs and B7H3 may play a significant role in the progression of IPF and could be potential therapeutic targets.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Dongbei Li, Haijun Li, Cheng Cheng, Gangping Li, Fangfang Yuan, Ruihua Mi, Xiaojiao Wang, Ding Li, Ruihua Fan, Xudong Wei
Summary: The combination therapy of all-trans retinoic acid (ATRA) and ABT-199 shows a synergistic antileukemic effect by inducing apoptosis and cell cycle arrest in acute myeloid leukemia (AML) cells. In vivo, this combination therapy prolongs the survival of AML xenograft mice. The study provides a potential treatment strategy and theoretical support for overcoming the clinical ABT-199 resistance problem in AML patients.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Review
Immunology
Dandan Xu, Cheng Li, Yushan Xu, Mingyue Huang, Dawei Cui, Jue Xie
Summary: Myeloid-derived suppressor cells (MDSCs) are a group of immature cells derived from bone marrow that play critical immunosuppressive functions in autoimmune diseases. Epigenetic modifications, including DNA methylation, histone modifications, and non-coding RNA regulation, have been shown to regulate the differentiation and development of MDSCs and their suppressive functions. Further research is needed to better understand the biological and epigenetic regulation of MDSCs in autoimmune diseases.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Chemistry, Medicinal
Chenyuan Song, Yufei Ji, Wenzhi Wang, Ning Tao
Summary: This study investigates the biological effect of ginger polysaccharide on myeloid-derived suppressor cells (MDSCs) in tumor microenvironment. Ginger polysaccharide promotes apoptosis of MDSCs by regulating lipid metabolism, inhibiting fatty acid synthesis and lipid droplet accumulation.
PHYTOTHERAPY RESEARCH
(2023)
Review
Immunology
Filippo Veglia, Emilio Sanseviero, Dmitry I. Gabrilovich
Summary: MDSCs are pathologically activated cells with potent immunosuppressive activity, closely associated with poor clinical outcomes in diseases like cancer. Recent studies have identified key distinctions between MDSCs and classical neutrophils and monocytes, providing new insights into therapeutic targeting for cancer and autoimmune diseases through understanding their genomic and metabolic characteristics. Emerging data also suggest potential involvement of MDSCs in pregnancy, neonatal biology, and COVID-19.
NATURE REVIEWS IMMUNOLOGY
(2021)
Article
Oncology
Maria Hernandez-Valladares, Rebecca Wangen, Elise Aasebo, Hakon Reikvam, Frode S. Berven, Frode Selheim, Oystein Bruserud
Summary: ATRA/VP combination therapy has shown effectiveness in stabilizing AML in some patients, including those with chemoresistant relapse. Furthermore, combining new and less intensive antileukemic therapies with ATRA/VP may represent a new therapeutic strategy in AML. Proteomic/phosphoproteomic profiling can be used for the early identification of responders to ATRA/VP-based treatment.
Review
Immunology
Norman Fultang, Xinyuan Li, Ting Li, Youhai H. Chen
Summary: MDSCs are a crucial sub-population of leukocytes in carcinogenesis and cancer immunotherapy. Despite the involvement of various transcription factors in regulating MDSC differentiation, none of them are specifically expressed in MDSCs. The recent discovery of the c-Rel-C/EBP beta enhanceosome in MDSCs may provide insights into how transcription factors regulate MDSC differentiation in a lineage-specific manner.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Oncology
Yuxin Liu, Swati Bhardwaj, Keith Sigel, John Winters, Joseph Terlizzi, Michael M. Gaisa
Summary: This study investigated the prevalence and severity of anal HPV disease among MSM LWH under the age of 35, finding a high prevalence of HPV infection and precancer but no cases of invasive anal cancer. This supports the adoption of age-based anal cancer screening for this population.
INTERNATIONAL JOURNAL OF CANCER
(2024)
Correction
Oncology
J. Gu, S. Xie, S. Wang
INTERNATIONAL JOURNAL OF CANCER
(2024)