Article
Oncology
Jeroen A. A. van de Pol, Lisa George, Piet A. van den Brandt, Marcella M. L. L. Baldewijns, Leo J. Schouten
Summary: The study found that there are different impacts of body mass index (BMI) and smoking on the risk of clear-cell RCC (ccRCC) and papillary RCC (pRCC), while alcohol consumption is negatively associated with the risk of both. Hypertension is positively associated with the risk of both ccRCC and pRCC. The research also indicates significant differences in BMI, BMI change, and smoking duration among current smokers in terms of ccRCC and pRCC risk.
INTERNATIONAL JOURNAL OF CANCER
(2021)
Article
Biochemistry & Molecular Biology
Xin Zhou, Jingwei Yang, Yongqu Lu, Yanpeng Ma, Yan Meng, Qingqing Li, Junpeng Gao, Zhaoyu Jiang, Limei Guo, Wei Wang, Yun Liu, Lu Wen, Miao Kai, Wei Fu, Fuchou Tang
Summary: The study revealed the heterogeneity of gastric cancers and the relationship between differentiation status of cancer cells and tumor immune microenvironments. PDGC showed enrichment of genes related to epithelial-mesenchymal transition (EMT) program. DGC tended to be immune-rich type while PDGC tended to be immune-poor type, and this was associated with the density of tumor-infiltrating CD8(+) T cells. Along the trans-differentiation from DGC to NEC, interferon-related pathways were downregulated, leading to enhanced immune evasion.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2023)
Article
Genetics & Heredity
Joshua T. Lange, John C. Rose, Celine Y. Chen, Yuriy Pichugin, Liangqi Xie, Jun Tang, King L. Hung, Kathryn E. Yost, Quanming Shi, Marcella L. Erb, Utkrisht Rajkumar, Sihan Wu, Sabine Taschner-Mandl, Marie Bernkopf, Charles Swanton, Zhe Liu, Weini Huang, Howard Y. Chang, Vineet Bafna, Anton G. Henssen, Benjamin Werner, Paul S. Mischel
Summary: Random segregation of extrachromosomal DNA contributes to intratumoral heterogeneity and facilitates the rapid adaptation of human tumor cells to anticancer drugs. Oncogene amplification on extrachromosomal DNA (ecDNA) is a common event, driving aggressive tumor growth, drug resistance and shorter survival. Through theoretical models, unbiased image analysis, CRISPR-based ecDNA tagging with live-cell imaging and CRISPR-C, it is shown that random ecDNA inheritance results in extensive intratumoral ecDNA copy number heterogeneity and rapid adaptation to metabolic stress and targeted treatment.
Review
Food Science & Technology
Shen Gu, Mingxuemei Jiang, Bo Zhang
Summary: Cyanobacterial blooms caused by eutrophic water bodies are a serious global environmental issue. After cellular lysing or algaecide treatment, microcystins (MCs), particularly MC-LR, are released into water, posing severe hepatotoxicity. This review summarizes the major achievements and shortcomings observed in understanding the role of MC-LR in primary liver cancers (PLCs) in recent years. It elucidates the mechanisms of how MC-LR induces or promotes PLCs and provides a rational approach for future applications.
Article
Biology
Natalie Andersson, Subhayan Chattopadhyay, Anders Valind, Jenny Karlsson, David Gisselsson
Summary: The study introduces an algorithm and tool called DEVOLUTION that enables researchers to reconstruct tumor clonal lineages from diverse pediatric cancers, demonstrating its potential applications for cancer research.
COMMUNICATIONS BIOLOGY
(2021)
Article
Oncology
Varduhi Petrosyan, Lacey E. Dobrolecki, Emily L. LaPlante, Ramakrishnan Rajaram Srinivasan, Matthew H. Bailey, Alana L. Welm, Bryan E. Welm, Michael T. Lewis, Aleksandar Milosavljevic
Summary: TNBC is a heterogeneous subtype of breast cancer, and only a subset of TNBC can be established as PDXs. Our study suggests that there is a preferential engraftment bias towards TNBC with low levels of immune cell infiltration, and TNBC that failed to engraft exhibits gene expression consistent with a cancer-promoting immunological state, indicating the potential importance of tumor immunological state and host immune system state for engraftment.
Review
Biochemistry & Molecular Biology
Chaoran Chen, Yueming Ding, Huiyang Liu, Mengyao Sun, Honggang Wang, Dongdong Wu
Summary: Flubendazole, a broad-spectrum insect repellent, has been repurposed as a promising anticancer drug. Recent studies have shown its anti-tumor effects in different types of cancers, but the underlying mechanisms are not fully understood. This review summarizes the latest research on the anti-tumor effects of flubendazole in different types of cancers and analyzes the related mechanisms for future studies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Oncology
Zhangguo Chen, Jessy John, Jing H. Wang
Summary: This study explores the possible reasons for the heterogeneity of immune checkpoint inhibitor (ICI) response in head and neck squamous cell carcinoma (HNSCC). The findings suggest that the response to ICI in HNSCC is associated with genetic, transcriptional, and functional variations in tumor cells, as well as the composition of the immune tumor microenvironment (TME) and the relative abundance of immune subsets. These findings have potential implications for designing personalized immunotherapy strategies.
FRONTIERS IN ONCOLOGY
(2022)
Article
Multidisciplinary Sciences
Rui Wu, Wenbo Guo, Xinyao Qiu, Shicheng Wang, Chengjun Sui, Qiuyu Lian, Jianmin Wu, Yiran Shan, Zhao Yang, Shuai Yang, Tong Wu, Kaiting Wang, Yanjing Zhu, Shan Wang, Changyi Liu, Yangqianwen Zhang, Bo Zheng, Zhixuan Li, Yani Zhang, Siyun Shen, Yan Zhao, Wenwen Wang, Jinxia Bao, Ji Hu, Xuan Wu, Xiaoqing Jiang, Hongyang Wang, Jin Gu, Lei Chen
Summary: The study constructed a high-resolution spatial transcriptome map of primary liver cancers and revealed the evolution of tumor microenvironment characteristics from nontumor to tumor regions. It proposed a signature for accurately locating tertiary lymphoid structures spatially and identified interactions related to TME remodeling and tumor metastasis.
Article
Oncology
I. Hernandez-Verdin, E. Kirasic, K. Wienand, K. Mokhtari, S. Eimer, H. Loiseau, A. Rousseau, J. Paillassa, G. Ahle, F. Lerintiu, E. Uro-Coste, L. Oberic, D. Figarella-Branger, O. Chinot, G. Gauchotte, L. Taillandier, J. -P. Marolleau, M. Polivka, C. Adam, R. Ursu, A. Schmitt, N. Barillot, L. Nichelli, F. Lozano-Sanchez, M. -J. Ibanez-Julia, M. Peyre, B. Mathon, Y. Abada, F. Charlotte, F. Davi, C. Stewart, A. de Reynies, S. Choquet, C. Soussain, C. Houillier, B. Chapuy, K. Hoang-Xuan, A. Alenorn
Summary: Through comprehensive multi-omic analysis, we identified and characterized four molecular patterns in PCNSL, which have a distinct prognostic impact and can guide future clinical stratification and targeted interventions.
ANNALS OF ONCOLOGY
(2023)
Review
Pharmacology & Pharmacy
Libo Xu, Jinghua Zhang, Jicheng Sun, Kunlin Hou, Chenxin Yang, Ying Guo, Xiaorui Liu, Dhan V. Kalvakolanu, Ling Zhang, Baofeng Guo
Summary: Cancer stem cells (CSCs) play a crucial role in tumor progression, metastasis, and recurrence. The epigenetic modification machinery is essential for the viability and aggressive evolution of CSCs. Targeting these mechanisms with specific drugs offers a promising approach to block CSCs and reduce drug resistance, quiescence, and tumor heterogeneity.
BIOCHEMICAL PHARMACOLOGY
(2022)
Review
Cell Biology
Kailash Ganesh, Manjunath B. Joshi
Summary: This review summarizes various studies on the heterogeneous nature of neutrophils and their associated functions in steady state and pathological conditions. Recent advances in high throughput technologies have revealed the existence of functionally diverse subsets of neutrophils in bone marrow, blood, and tissues. The proportions of these subsets significantly vary in pathological conditions, and specific signaling pathways in neutrophils have been identified.
INFLAMMATION RESEARCH
(2023)
Article
Oncology
Yanming Chen, Xiaoxiao Dai, Ji Wang, Chuming Tao, Ye Wang, Qing Zhu, Zhongyong Wang, Tan Zhang, Qing Lan, Jizong Zhao
Summary: This study reveals the genetic and immune heterogeneity between primary lung cancers and brain metastases by analyzing 26 tumor samples from 10 patients. In addition to inheriting characteristics from the primary lung cancers, brain metastases also exhibit unique genetic and molecular features, indicating the complex evolution and heterogeneity of tumors at a single-patient level. The findings provide novel insights for formulating individualized treatment strategies for brain metastases.
FRONTIERS IN ONCOLOGY
(2023)
Article
Oncology
Marcia A. Inda, Paul van Swinderen, Anne van Brussel, Cathy B. Moelans, Wim Verhaegh, Hans van Zon, Eveline den Biezen, Jan Willem Bikker, Paul J. van Diest, Anja van de Stolpe
Summary: Personalized breast cancer treatment with targeted therapy requires identification of responder patients. Phenotypical heterogeneity within the primary tumor and between primary tumor and metastases may affect therapy response, suggesting analysis of metastatic samples for late stage patients is important. Targeted therapy based on analysis of one primary tumor biopsy may not fully represent the heterogeneity within and between tumors, highlighting the need for further analysis of metastatic biopsies.
Review
Oncology
Mina Komuta
Summary: Primary liver cancers (PLCs) mainly consist of hepatocellular carcinoma (HCC), intrahepatic cholangiocarcinoma (iCCA), and combined (c)HCC-CCA. Understanding the pathological features, diagnostic pitfalls, and treatment choices related to HCC, iCCA, and cHCC-CCA is crucial for clinicians dealing with these tumors.