Review
Oncology
Laura Garcia-Estevez, Javier Cortes, Silvia Perez, Isabel Calvo, Isabel Gallegos, Gema Moreno-Bueno
Summary: Breast cancer is the most common tumor in women globally, and the relationship between obesity and breast cancer risk is closely related to menopausal status. Obesity increases the risk of breast cancer in postmenopausal women but appears to be protective in premenopausal women.
FRONTIERS IN ONCOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Feiyu Shi, Gaixia Liu, Yufeng Lin, Cosmos Liutao Guo, Jing Han, Eagle S. H. Chu, Chengxin Shi, Yaguang Li, Haowei Zhang, Chenhao Hu, Ruihan Liu, Shuixiang He, Gang Guo, Yinnan Chen, Xiang Zhang, Olabisi Oluwabukola Coker, Sunny Hei Wong, Jun Yu, Junjun She
Summary: Appendectomy is associated with an increased risk of colorectal cancer (CRC) due to gut microbial dysbiosis. A longitudinal study (cohort 1, n = 129,155) showed a 73.0% increase in CRC risk among appendectomy cases during a 20-year follow-up period. Fecal samples from another cohort (n = 314) revealed dysbiosis in the gut microbiome of appendectomy subjects, with enrichment of CRC-promoting bacteria and depletion of beneficial commensals. Microbial network analysis indicated stronger correlations and enriched oncogenic pathways among bacteria in appendectomy subjects compared to controls. Appendectomy was also found to promote colorectal tumorigenesis in mice through microbial dysbiosis and impaired intestinal barrier function. This study highlights the importance of the gut microbiome in CRC development following appendectomy.
Correction
Biochemistry & Molecular Biology
Yonghua Bao, Yongchen Guo, Yiqiong Yang, Xiaonan Wei, Shanshan Zhang, Yongmeng Zhang, Kai Li, Ming Yuan, Dongli Guo, Virgilia Macias, Xiangdong Zhu, Wei Zhang, Wancai Yang
Summary: A correction to this paper has been published.
Article
Oncology
Yoshiyuki Suzuki, Koji Okabayashi, Hirotoshi Hasegawa, Masashi Tsuruta, Ryo Seishima, Toshiki Tokuda, Yuko Kitagawa
Summary: Obesity is a major problem worldwide, and this study found that it can disrupt the Eph-ephrin B signaling pathway, promoting the development and progression of colorectal cancer. The expression of Ephrin-B1 and EphB2 was downregulated in obese individuals and KKAy mice, while the number of infiltrated macrophages increased.
Article
Plant Sciences
Bushra Ansari, Michael Aschner, Yaseen Hussain, Thomas Efferth, Haroon Khan
Summary: The research focuses on evaluating the inhibitory effects of naringin in citrus fruits on colorectal cancer, as well as its potential mechanistic pathways, including multiple signaling pathways such as NF-Kappa B/IL-6/STAT3, PI3K/AKT/mTOR, apoptosis, NF-Kappa B-COX-2-iNOS, and beta-catenin pathways.
Article
Gastroenterology & Hepatology
Weixin Liu, Xiang Zhang, Hongzhi Xu, Shengmian Li, Harry Cheuk-Hay Lau, Qiongyun Chen, Bin Zhang, Liuyang Zhao, Huarong Chen, Joseph Jao-Yiu Sung, Jun Yu
Summary: The study revealed that the microbial communities within colorectal neoplasia are heterogeneous, with variations in abundance of CRC-associated pathobionts playing a role in CRC development. Intra-neoplasia changes in microbial abundance were observed along the adenoma-carcinoma sequence. Furthermore, significant differences in intra-neoplasia microbiota were found between biopsies with and without genetic alterations, highlighting the association of intratumoral microbial heterogeneity with genetic changes.
Article
Dentistry, Oral Surgery & Medicine
Vesile Elif Toy, Tamer Ataoglu, Abubekir Eltas, Husniye Gul Otlu, Aysun Bay Karabulut
Summary: This study aims to evaluate the periodontal therapy outcomes and the effects on serum and gingival crevicular fluid (GCF) levels of adipocytokines and oxidative stress (OS) markers in obese patients with periodontitis to understand the association between obesity and periodontitis. The results show that although both groups of patients had significant improvements in clinical periodontal parameters after non-surgical periodontal therapy, the obese group had higher levels of TNF-alpha, leptin, and total oxidant status (TOS) at baseline and remained higher at 3 months. Non-surgical periodontal therapy improved GCF levels of total antioxidant status (TAS) and TOS in both groups, but the differences between the two groups were still significant after therapy.
CLINICAL ORAL INVESTIGATIONS
(2023)
Article
Biology
Noshin Mubtasim, Lauren Gollahon
Summary: The increasing prevalence of obesity has led to extensive research on its pathogenesis and appropriate treatments. Researchers have developed a reliable white adipocyte model in vitro, 3T3-L1 MBX cells, to study obese adipocytes and their effects.
Review
Medicine, Research & Experimental
John M. Macharia, Ruth W. Mwangi, Nora Rozmann, Kaposztas Zsolt, Timea Varjas, Paschal O. Uchechukwu, Isabel N. Wagara, Bence L. Raposa
Summary: The development and identification of molecular compounds that can kill or inhibit transformed cells promoting carcinogenesis without toxic effects on normal cells are extremely important. This study conducted a systematic review and evaluated pharmacotherapeutic biomolecules active against colon cancer carcinogenesis. The research found that natural antioxidants in certain plants have inhibitory effects on the occurrence and progression of colon cancer.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Gastroenterology & Hepatology
Yi Bao, Jianning Zhai, Huarong Chen, Chi Chun Wong, Cong Liang, Yanqiang Ding, Dan Huang, Hongyan Gou, Danyu Chen, Yasi Pan, Wei Kang, Ka Fai To, Jun Yu
Summary: YTHDF1 plays a crucial role in the tumour immune microenvironment of colorectal cancer by regulating the m(6)A-p65-CXCL1/CXCR2 pathway, affecting anti-tumour immune response, and serving as a potential target for immune checkpoint blockade therapy.
Review
Oncology
Jin Cheon Kim, Walter F. Bodmer
Summary: This study assessed the molecular pathogenesis of solid tumors, focusing specifically on colorectal cancer. Through a review of relevant literature, it was found that colorectal carcinogenesis mainly occurs through chromosomal instability, microsatellite instability, and serrated pathway. Familial colorectal cancers and genotype-phenotype correlations also play a role in colorectal carcinogenesis. The use of multi-gene panels has facilitated the detection of previously unidentified genes involved in colorectal carcinogenesis.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2022)
Article
Multidisciplinary Sciences
Tsuneyuki Miyazaki, Yohei Shirakami, Taku Mizutani, Akinori Maruta, Takayasu Ideta, Masaya Kubota, Hiroyasu Sakai, Takashi Ibuka, Salvatore Genovese, Serena Fiorito, Vito Alessandro Taddeo, Francesco Epifano, Takuji Tanaka, Masahito Shimizu
Summary: The study showed that the novel FXR agonist nelumal A can effectively attenuate colonic inflammation and suppress colitis-related carcinogenesis by reducing bile acid synthesis and oxidative damage. This agent may have potential for treating inflammatory bowel diseases and related colorectal cancer chemoprevention.
SCIENTIFIC REPORTS
(2021)
Article
Multidisciplinary Sciences
Amal Idrissi Janati, Igor Karp, Daniel Von Renteln, Mickael Bouin, Younan Liu, Simon D. Tran, Elham Emami
Summary: This study aimed to investigate the expression of Fusobacterium nucleatum (F. nucleatum) in both oral and colorectal sites in colorectal neoplasms (CRN) cases and controls. The detection rate of F. nucleatum was 95% in saliva samples and 18% in colorectal mucosa specimens. The results support further studies to explore the association between oral and colorectal levels of F. nucleatum in CRN cases and controls.
SCIENTIFIC REPORTS
(2022)
Review
Biochemistry & Molecular Biology
Jedrzej Borowczak, Krzysztof Szczerbowski, Mateusz Maniewski, Adam Kowalewski, Marlena Janiczek-Polewska, Anna Szylberg, Andrzej Marszalek, Lukasz Szylberg
Summary: Inflammation plays a significant role in colon cancer development, with cytokine networks in the intestines being critical for tissue homeostasis and inflammation regulation. Recent studies suggest that inflammation is more important in the serrated pathway than in the adenoma-carcinoma pathway. Interleukins have received attention for their potential role in CRC pathogenesis and promising results in clinical trials. The balance between proinflammatory and anti-inflammatory factors is crucial for maintaining homeostasis, and immune cells in the tumor microenvironment modulate immune sensitivity and aid cancer immune evasion.
Article
Nutrition & Dietetics
Ana Claudia Pelissari Kravchychyn, Raquel Munhoz da Silveira Campos, Luciana Oliveira e Silva, Yasmin Alaby Martins Ferreira, Flavia Campos Corgosinho, Deborah Cristina Landi Masquio, Sofia Emanuelle de Castro Ferreira Vicente, Lila Missae Oyama, Lian Tock, Marco Tulio de Mello, Sergio Tufik, David Thivel, Ana Raimunda Damaso
Summary: The study investigated the relationship between weight loss magnitude and serum levels of adipocytokines and appetite-regulating hormones in obese adolescents. Weight loss >10% appeared to reverse obesity-induced hyperleptinemia while stabilizing appetite-controlling neuropeptides. A mathematical model using weight, leptin, and alpha-MSH variations was developed to predict body fat loss.
Article
Radiology, Nuclear Medicine & Medical Imaging
Mika Hori, Hiroaki Onaya, Nobuyoshi Hiraoka, Taiki Yamaji, Hideaki Kobayashi, Mami Takahashi, Michihiro Mutoh, Kazuaki Shimada, Hitoshi Nakagama
JAPANESE JOURNAL OF RADIOLOGY
(2016)
Article
Cell Biology
Marimu Sakumoto, Rieko Oyama, Mami Takahashi, Yoko Takai, Fusako Kito, Kumiko Shiozawa, Zhiwei Qiao, Makoto Endo, Akihiko Yoshida, Akira Kawai, Tadashi Kondo
IN VITRO CELLULAR & DEVELOPMENTAL BIOLOGY-ANIMAL
(2018)
Article
Biochemistry & Molecular Biology
Rikako Ishigamori, Masami Komiya, Shinji Takasu, Michihiro Mutoh, Toshio Imai, Mami Takahashi
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2017)
Article
Oncology
Marimu Sakumoto, Mami Takahashi, Rieko Oyama, Yoko Takai, Fusako Kito, Kumiko Shiozawa, Zhiwei Qiao, Akihiko Yoshida, Makoto Endo, Akira Kawai, Tadashi Kondo
JAPANESE JOURNAL OF CLINICAL ONCOLOGY
(2017)
Article
Cell Biology
Fusako Kito, Rieko Oyama, Marimu Sakumoto, Mami Takahashi, Kumiko Shiozawa, Zhiwei Qiao, Hiromi Sakamoto, Takeshi Hirose, Nokitaka Setsu, Akihiko Yoshida, Akira Kawai, Tadashi Kondo
IN VITRO CELLULAR & DEVELOPMENTAL BIOLOGY-ANIMAL
(2018)
Article
Cell Biology
Rieko Oyama, Mami Takahashi, Fusako Kito, Marimu Sakumoto, Kumiko Shiozawa, Zhiwei Qiao, Akihiko Yoshida, Makoto Endo, Akira Kawai, Tadashi Kondo
IN VITRO CELLULAR & DEVELOPMENTAL BIOLOGY-ANIMAL
(2018)
Review
Oncology
Mami Takahashi, Mika Hori, Rikako Ishigamori, Michihiro Mutoh, Toshio Imai, Hitoshi Nakagama
Article
Multidisciplinary Sciences
Rieko Oyama, Mami Takahashi, Akihiko Yoshida, Marimu Sakumoto, Yoko Takai, Fusako Kito, Kumiko Shiozawa, Zhiwei Qiao, Yasuhito Arai, Tatsuhiro Shibata, Yoshihiro Araki, Makoto Endo, Akira Kawai, Tadashi Kondo
SCIENTIFIC REPORTS
(2017)
Article
Cell Biology
Rieko Oyama, Fusako Kito, Zhiwei Qiao, Marimu Sakumoto, Rei Noguchi, Mami Takahashi, Shunichi Toki, Yoshikazu Tanzawa, Akihiko Yoshida, Akira Kawai, Tadashi Kondo
IN VITRO CELLULAR & DEVELOPMENTAL BIOLOGY-ANIMAL
(2018)
Article
Cell Biology
Rieko Oyama, Fusako Kito, Mami Takahashi, Marimu Sakumoto, Kumiko Shiozawa, Zhiwei Qiao, Rei Noguchi, Takashi Kubo, Shunichi Toki, Fumihiko Nakatani, Akihiko Yoshida, Akira Kawai, Tadashi Kondo
Article
Biochemical Research Methods
Kumiko Shiozawa, Rieko Oyama, Mami Takahashi, Fusako Kito, Emi Hattori, Akihiko Yoshida, Akira Kawai, Masaya Ono, Tadashi Kondo
PROTEOMICS CLINICAL APPLICATIONS
(2019)
Article
Oncology
Shigehiro Yagishita, Ken Kato, Mami Takahashi, Toshio Imai, Yasushi Yatabe, Takeshi Kuwata, Mikiko Suzuki, Atsushi Ochiai, Atsushi Ohtsu, Kazuaki Shimada, Toshirou Nishida, Akinobu Hamada, Hiroyuki Mano
Summary: The establishment of a Japanese PDX library from cancer specimens of Japanese patients has been successful in providing a platform for drug discovery and development. When conducting coclinical trials, it is important to consider the target cancer type, stage, and engraftment rate based on the findings of this report.
Article
Biochemistry & Molecular Biology
Wataru Murase, Yukino Kamakura, Serina Kawakami, Ayaka Yasuda, Momoka Wagatsuma, Atsuhito Kubota, Hiroyuki Kojima, Tohru Ohta, Mami Takahashi, Michihiro Mutoh, Takuji Tanaka, Hayato Maeda, Kazuo Miyashita, Masaru Terasaki
Summary: Fucoxanthin shows chemopreventive effects in a pancreatic cancer mouse model, suppressing key cancer-related genes and protein expressions to slow down tumor growth.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Medicine, Research & Experimental
Mika Hori, Michihiro Mutoh, Rikako Ishigamori, Toshio Imai, Mami Takahashi
Review
Genetics & Heredity
Takahiro Hamoya, Gen Fujii, Shingo Miyamoto, Mami Takahashi, Yukari Totsuka, Keiji Wakabayashi, Jiro Toshima, Michihiro Mutoh
GENES AND ENVIRONMENT
(2016)