期刊
INTERNATIONAL JOURNAL OF CANCER
卷 127, 期 12, 页码 2739-2748出版社
WILEY
DOI: 10.1002/ijc.25615
关键词
prostate cancer; microenvironment; senescence; extracellular matrix; matricellular proteins
类别
资金
- NIH [U54 CA126540, R01 AG015837]
- Department of Defense [W81XWH-09-1-0177]
Age is the greatest risk factor for the development of epithelial cancers. In this minireview, we will examine key extracellular matrix and matricellular components, their changes with aging, and discuss how these alterations might influence the subsequent progression of cancer in the aged host. Because of the tight correlation between advanced age and the prevalence of prostate cancer, we will use prostate cancer as the model throughout this minireview.
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