Article
Toxicology
Hanting Liu, Jingjing Gu, Yu Jin, Qi Yuan, Gaoxiang Ma, Mulong Du, Yuqiu Ge, Chao Qin, Qiang Lv, Guangbo Fu, Meilin Wang, Haiyan Chu, Lin Yuan, Zhengdong Zhang
Summary: The study investigated the association between genetic variants in m(6)A-switches and bladder cancer risk, identifying a significant effect of a specific SNP in the SOD2 gene on reducing bladder cancer risk. It was also found that SOD2 may regulate its expression through an m(6)A-hnRNP C dependent mechanism, playing a crucial role in suppressing bladder cancer cell growth and invasion.
ARCHIVES OF TOXICOLOGY
(2021)
Article
Toxicology
Kuan Shen, Kanghui Liu, Yuanhang Wang, Peidong Ni, Jian Xiao, Fan Hao, Xinyi Zhou, Zekuan Xu, Li Yang
Summary: This study found that MSLN plays a cancer-promoting role in gastric cancer. Additionally, rs3764247 and rs3764246 were associated with a reduced risk of gastric cancer. It was also observed that rs3764247 was closely related to T stage, vascular infiltration, and HER2 expression. Furthermore, patients with rs3764247 CC genotype had poorer survival compared to patients with AA + AC genotype.
ARCHIVES OF TOXICOLOGY
(2022)
Article
Toxicology
Zhichao Han, Jingjing Gu, Junyi Xin, Hanting Liu, Yanling Wu, Mulong Du, Haiyan Chu, Yadong Liu, Zhengdong Zhang
Summary: This study investigated the association between genetic variants in the choline metabolism pathway and bladder cancer susceptibility. The results showed that the C allele of rs6810830 in ENPP6 was a significant protective allele for bladder cancer. Additionally, the study found that the expression of ENPP6 was decreased in bladder tumors and high expression was associated with worse overall survival in bladder cancer patients.
ARCHIVES OF TOXICOLOGY
(2022)
Article
Genetics & Heredity
Shuyong Yu, Zhuang Chen, Jiajia Cheng, Xingang Shi, Jiaqi Liu, Ping Zhong, Jian Song
Summary: This study found a significant association between the CYP4B1 rs4646491 polymorphism and gastric cancer risk, suggesting it may be a risk factor for gastric cancer.
BMC MEDICAL GENOMICS
(2022)
Article
Oncology
Yuxin He, Yida Wang, Fujuan Luan, Zhuwen Yu, Huang Feng, Bingxin Chen, Weichang Chen
Summary: The study revealed that the incidence and mortality rates of gastric cancer in China are decreasing, and there has been a slight decrease in the global incidence rate of gastric cancer. Different geographical regions show distinct patterns of gastric cancer rates and trends, indicating the need for specific prevention strategies.
Article
Oncology
Qian Xin, Shan Shan, E. Ding, Mingxin Jin, Bei Li, Jiangxia Li, Qiji Liu, Cuihua Yi, Jisheng Li
Summary: This study investigated the association between three common miRNA polymorphisms and the susceptibility of gastric cancer. The results showed that none of the three SNPs were associated with the risk of gastric cancer, but miR-146a rs2910164 SNP was strongly associated with age and gender in gastric cancer patients.
JOURNAL OF CANCER RESEARCH AND THERAPEUTICS
(2022)
Article
Medicine, General & Internal
Ze-Xian Liu, Xiao-Long Zhang, Qi Zhao, Yungchang Chen, Hui Sheng, Cai-Yun He, Yu-Ting Sun, Ming-Yu Lai, Min-Qing Wu, Zhi-Xiang Zuo, Wei Wang, Zhi-Wei Zhou, Feng-Hua Wang, Yu-Hong Li, Rui-Hua Xu, Miao-Zhen Qiu
Summary: This study provides a genetic landscape for HDGC, identifies potential susceptibility genes beyond CDH1, and explores mechanisms for HDGC tumorigenesis.
Article
Oncology
Sadia Ajaz, Sani-e-Zehra Zaidi, Saleema Mehboob Ali, Aisha Siddiqa, Muhammad Ali Memon, Sadaf Firasat, Aiysha Abid, Shagufta Khaliq
Summary: This study identifies a significant genetic association between GSTT1-absent genotype and breast cancer susceptibility in a Pakistani population. Additionally, the study reveals that the GSTT1-absent genotype is associated with shorter overall survival in breast cancer cases. Further validation of GSTT1 variation may lead to better population-specific strategies for screening and treating breast cancers.
FRONTIERS IN ONCOLOGY
(2021)
Article
Pathology
Lina Yu, Yunlong Li, Hui Wang, Dong Wang, Huiting Hao, DongWei Zhang, Xiao Liang, Mengdi Cai, Rongwei Guan, Jing Bai, Jingcui Yu
Summary: In this study, the association between six single nucleotide polymorphisms (SNPs) of the OVCA1 gene and the risk of gastric cancer in the Han population of northeast China was evaluated. The study found that the AA + AG genotype of rs2273981 was significantly associated with an increased risk of gastric cancer in smokers, while the AG + GG genotype of rs1131600 and the CT + TT genotype of rs2236375 were significantly associated with increased gastric tumor volume. Furthermore, the rs2273981 GG genotype increased the transcription activity of OVCA1, potentially contributing to gastric cancer development.
PATHOLOGY RESEARCH AND PRACTICE
(2022)
Article
Biochemistry & Molecular Biology
Natalia Landeros, Alejandro H. Corvalan, Maher Musleh, Luis A. Quinones, Nelson M. Varela, Patricio Gonzalez-Hormazabal
Summary: This study identified seven novel associations and replicated one previously described in Caucasian population, providing insights into the understanding of miRNA genetic polymorphisms in gastric cancer pathogenesis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Oncology
Xiang Ma, Younan Wang, Hao Fan, Chuming Zhu, Wangwang Chen, Zengliang Li, Jian Xiao, Peidong Ni, Zekuan Xu, Li Yang
Summary: This study investigated the correlation of CTSB-related polymorphisms with gastric cancer (GC) risk and prognosis, finding that certain variants were associated with decreased risks of GC, earlier T stage, and better overall prognosis. The results suggest the importance of CTSB-related polymorphisms in predicting GC risk and prognosis.
Article
Gastroenterology & Hepatology
Mengmeng Li, Jin Young Park, Mahdi Sheikh, Violet Kayamba, Harriet Rumgay, Mazda Jenab, Clement Tetteh Narh, Behnoush Abedi-Ardekani, Eileen Morgan, Catherine de Martel, Valerie McCormack, Melina Arnold
Summary: The incidence rates of gastric cancer (GC) and oesophageal cancer (EC) show correlations across populations, which vary depending on the subsite of GC and subtype of EC. Multisite studies that include populations with different patterns of incidence rates may provide valuable information on etiology.
Article
Multidisciplinary Sciences
Yingyan Yu, Zhen Zhang, Xiaorui Dong, Ruixin Yang, Zhongqu Duan, Zhen Xiang, Jun Li, Guichao Li, Fazhe Yan, Hongzhang Xue, Du Jiao, Jinyuan Lu, Huimin Lu, Wenmin Zhang, Yangzhen Wei, Shiyu Fan, Jing Li, Jingya Jia, Jun Zhang, Jun Ji, Pixu Liu, Hui Lu, Hongyu Zhao, Saijuan Chen, Chaochun Wei, Hongzhuan Chen, Zhenggang Zhu
Summary: Pangenomic study can improve the completeness of the human reference genome and advance precision medicine. In gastric cancer research, highly absent genes were identified and new genes associated with gastric cancer were predicted.
NATURE COMMUNICATIONS
(2022)
Article
Genetics & Heredity
Shanshan Xu, Zhipeng Pan, Li Huang, Yuting Chen, Huimin Xie, Feier Wang, Tingting Zhou, Lingxiang Yu, Jiangpiang Kong, Shengqian Xu, Faming Pan
Summary: The study found that FOXO3a polymorphisms rs12212067 and rs3800232 are associated with an increased risk of ankylosing spondylitis (AS) in Eastern Chinese Han population, especially in males. Furthermore, specific genotypes were also found to be related to disease activity in patients.
Article
Genetics & Heredity
Huiwen Pan, Xuyu Gu, Xiaoyan Wang, Zhenjun Gao, Guowen Ding, Chen Zou, Yu Fan
Summary: This study found that TP73 gene rs1801173 polymorphism is not significantly correlated with the risk of gastric cancer. Smoking is associated with the risk of gastric cancer.
BMC MEDICAL GENOMICS
(2022)