De novo constitutional MLH1 epimutations confer early-onset colorectal cancer in two new sporadic Lynch syndrome cases, with derivation of the epimutation on the paternal allele in one

Comprehensive Molecular Analysis of Mismatch Repair Gene Defects in Suspected Lynch Syndrome (Hereditary Nonpolyposis Colorectal Cancer) Cases

(2009) J. Mueller et al.   CANCER RESEARCH

Implementation of Novel Pyrosequencing Assays to Screen for Common Mutations of BRAF and KRAS in a Cohort of Sporadic Colorectal Cancers

(2009) Deborah Packham et al.   DIAGNOSTIC MOLECULAR PATHOLOGY

Germline hypermethylation ofMLH1andEPCAMdeletions are a frequent cause of Lynch syndrome

(2009) Renée C. Niessen et al.   GENES CHROMOSOMES & CANCER

Constitutional (germline) MLH1 epimutation as an aetiological mechanism for hereditary non-polyposis colorectal cancer

(2009) M P Hitchins et al.   JOURNAL OF MEDICAL GENETICS

Further evidence for heritability of an epimutation in one of 12 cases with MLH1 promoter methylation in blood cells clinically displaying HNPCC

(2008) Monika Morak et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

Large genomic rearrangements and germline epimutations in Lynch syndrome

(2008) Annette Gylling et al.   INTERNATIONAL JOURNAL OF CANCER

Population-based detection of Lynch syndrome in young colorectal cancer patients using microsatellite instability as the initial test

(2008) Lyn Schofield et al.   INTERNATIONAL JOURNAL OF CANCER

Heritable somatic methylation and inactivation of MSH2 in families with Lynch syndrome due to deletion of the 3′ exons of TACSTD1

(2008) Marjolijn J L Ligtenberg et al.   NATURE GENETICS

MLH1 promoter germline-methylation in selected probands of Chinese hereditary non-polyposis colorectal cancer families

(2008) Heng-Hua Zhou et al.   WORLD JOURNAL OF GASTROENTEROLOGY