Article
Microbiology
Barbara Gardella, Mattia Dominoni, Cecilia Sosso, Anna Arrigo, Andrea Gritti, Stefania Cesari, Giacomo Fiandrino, Arsenio Spinillo
Summary: A study analyzed the time trends prevalence of HPV genotypes among 5807 subjects with abnormal pap-smears and/or cervical intraepithelial neoplasia over a 15-year period. Results showed a decrease in HPV16 rates in CIN1 biopsies and an increase of HR-HPV types unrelated to nonavalent vaccine in CIN1 lesions. Additionally, HPV 18, 31, and 52 rates decreased in CIN2+ patients.
Article
Public, Environmental & Occupational Health
Anna-Barbara Moscicki, Charlene Chang, Sitaram Vangala, Xinkai Zhou, David A. Elashoff, Christine Dehlendorf, George F. Sawaya, Miriam Kuppermann, Ysabel Duron, Fred L. Wyand, Sandy K. Navarro, Heike Thiel de Bocanegra
Summary: This study aimed to determine whether using a provider mobile phone application and a patient educational tool could promote adherence to guidelines for cervical cancer screening and management of abnormal cytology in young women. Results showed that the intervention did not have a significant effect on 18-month Pap and colposcopy rates in the regression model, but the sensitivity analysis for the patient educational tool was encouraging.
AMERICAN JOURNAL OF PREVENTIVE MEDICINE
(2021)
Article
Public, Environmental & Occupational Health
Philip E. Castle, Brian Befano, Mark Schiffman, Nicolas Wentzensen, Thomas Lorey, Nancy Poitras, Marianne Hyer, Li C. Cheung
Summary: This study compared the risks of cervical intraepithelial neoplasia grade 2 (CIN2) or more severe diagnoses (CIN2+) between women living with HIV (WLWH) and women not known to have HIV (HIV[-]) following cervical cancer screening. WLWH were more likely to test HPV positive and have abnormal cytology compared to HIV[-] women. The results suggest that both populations could be managed similarly once the screening results are known.
PREVENTIVE MEDICINE
(2022)
Article
Nursing
Kristine N. Siseho, Beauty Etinosa Omoruyi, Benjamin Okeleye, Vincent Okudoh, Hans J. Amukugo, Yapo G. Aboua
Summary: This study examines the limiting factors associated with cervical cancer Pap smear screening among participants of reproductive age in Namibia. The results reveal that participants have limited knowledge of cervical cancer and a significant portion have never undergone the screening test before. Lack of information about the screening and its associated risks, as well as unaffordable screening fees, are identified as barriers to screening. Additionally, participants complain about the long waiting period and missed announcements as obstacles to getting screened.
Article
Multidisciplinary Sciences
Stephanie S. Liu, Karen K. L. Chan, Tina N. Wei, Ka Yu Tse, Siew F. Ngu, Mandy M. Y. Chu, Lesley S. K. Lau, Annie N. Y. Cheung, Hextan Y. S. Ngan
Summary: High-risk human papillomavirus (HR-HPV) testing has become increasingly important in primary cervical cancer screening. This study validated the performance of Roche Cobas 4800 HPV test and compared it with Digene Hybrid Capture 2 (HC2) high-risk HPV DNA test. The overall agreement between Cobas and HC2 was 92.23%, with Cobas test demonstrating significantly higher specificity in identifying high-grade cervical intraepithelial neoplasia (CIN2+)/CIN3+ cases than HC2 test.
Article
Oncology
Frederik A. Stuebs, Anna K. Dietl, Martin C. Koch, Werner Adler, Carol Immanuel Geppert, Arndt Hartmann, Antje Knoell, Grit Mehlhorn, Matthias W. Beckmann, Carla E. Schulmeyer, Felix Heindl, Julius Emons, Anja Seibold, Annika S. Behrens, Paul Gass
Summary: Vaginal intraepithelial neoplasia (VaIN) is a rare premalignant disease with a challenging diagnosis. Cytology and HPV co-testing have moderate accuracy in detecting VaIN.
Article
Oncology
Erika Hurtado-Salgado, Luz Cardenas-Cardenas, Jorge Salmeron, Rufino Luna-Gordillo, Eduardo Ortiz-Panozo, Betania Allen-Leigh, Nenetzen Saavedra-Lara, Eduardo L. Franco, Eduardo Lazcano-Ponce
Summary: This study analyzed screening data from Mexico's public cervical cancer prevention program from 2010 to 2015, and found that hrHPV testing with cytological triage can detect twice as many CIN2+ cases compared to screening using cytology alone in women aged 35 to 64.
INTERNATIONAL JOURNAL OF CANCER
(2022)
Article
Obstetrics & Gynecology
Malene Skorstengaard, Petra Hall Viborg, Ane Birgitte Telen Andersen, Berit Andersen, Mary Holten Bennetsen, Kirsten Marie Jochumsen, Tonje Johansen, Lise Grupe Larsen, Maja Ulrikka Bruun Laustsen, Rouzbeh Salmani, Reza Serizawa, Marianne Waldstrom, Elsebeth Lynge
Summary: This study assessed the outcomes of a one-time HPV screening in Danish women aged 70+. The study found that the prevalence of high-risk HPV in women aged 70-74 was 4.3%, and there were 5 cases of CIN2+ detected per 1000 screened women, with a recommended treatment threshold of CIN2.
ACTA OBSTETRICIA ET GYNECOLOGICA SCANDINAVICA
(2023)
Article
Obstetrics & Gynecology
Diede L. Loopik, Lisanne M. Koenjer, Albert G. Siebers, Willem J. G. Melchers, Ruud L. M. Bekkers
Summary: This study compared the effectiveness of the new high-risk human papillomavirus-based cervical cancer screening program with the previous cytology-based screening program in the Netherlands. The findings showed that high-risk human papillomavirus-based screening can increase the detection of high-grade cervical intraepithelial neoplasia, but also comes with a higher risk of overdiagnosis.
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2021)
Article
Oncology
Huei-Jean Huang, Hsiu-Jung Tung, Lan-Yan Yang, Angel Chao, Yun-Hsin Tang, Hung-Hsueh Chou, Wei-Yang Chang, Ren-Chin Wu, Chu-Chun Huang, Chiao-Yun Lin, Min-Jie Liao, Wei-Chun Chen, Cheng-Tao Lin, Min-Yu Chen, Kuan-Gen Huang, Chin-Jung Wang, Ting-Chang Chang, Chyong-Huey Lai
Summary: This observational study investigated the long-term outcomes and HPV genotype changes after conization for high-grade cervical intraepithelial neoplasia (HG-CIN). Results showed that active surveillance may reduce the severity of progression to cancer, and a majority of patients with recurrent CIN2+ had persistent type-specific HPV infections. Effective therapeutic vaccines for such cases are still needed.
INTERNATIONAL JOURNAL OF CANCER
(2021)
Article
Medicine, General & Internal
Veronique Bouvard, Nicolas Wentzensen, Anne Mackie, Johannes Berkhof, Julia Brotherton, Paolo Giorgi-Rossi, Rachel Kupets, Robert Smith, Silvina Arrossi, Karima Bendahhou, Karen Canfell, Z. Mike Chirenje, Michael H. Chung, Marta del Pino, Silvia de Sanjose, Miriam Elfstrom, Eduardo L. Franco, Chisato Hamashima, Francoise F. Hamers, C. Simon Herrington, Raul Murillo, Suleeporn Sangrajrang, Rengaswamy Sankaranarayanan, Mona Saraiya, Mark Schiffman, Fanghui Zhao, Marc Arbyn, Walter Prendiville, Blanca I. Indave Ruiz, Isabel Mosquera-Metcalfe, Beatrice Lauby-Secretan
Summary: This article reviews the best methods of screening for cervical cancer, with HPV nucleic acid testing being superior whether used alone or in combination with other methods.
NEW ENGLAND JOURNAL OF MEDICINE
(2021)
Article
Oncology
Marta del Pino, Isabel Matas, Pilar Carrillo, Cristina Marti, Ariel Glickman, Nuria Carreras-Dieguez, Lorena Marimon, Adela Saco, Natalia Rakislova, Aureli Torne, Jaume Ordi
Summary: Women with anal HPV infection treated for HSIL/CIN2-3 should be re-tested for anal HPV after treatment. Those who have persisting anal HPV infection after treatment are at high risk of developing HSIL/AIN and may benefit from anal exploration. Additionally, women with anal HPV infection treated for HSIL/CIN might have a higher risk of recurrent cervical HPV infection.
Review
Oncology
Matejka Rebolj, Alexandra Sargent, Sisse Helle Njor, Kate Cuschieri
Summary: Self-collection of samples for HPV testing has the potential to increase cervical screening uptake and play a crucial role in eliminating cervical cancer. However, the success of self-collection depends on meeting specific thresholds for uptake and sensitivity for the detection of high-grade cervical intraepithelial neoplasia (CIN2+). The available evidence suggests that low uptake among underscreened women combined with high substitution of clinician sampling with self-collection among well-screened women may pose risks to overall program performance.
INTERNATIONAL JOURNAL OF CANCER
(2023)
Article
Public, Environmental & Occupational Health
Jaime M. Kiff, Madisen Cotter, Elizabeth G. Munro, Molly E. Leonard, Terry K. Morgan, Amanda S. Bruegl
Summary: This study suggests that hrHPV testing may be more accurate than co-testing in postmenopausal women, and cytology does not provide additional clinical value in this population. Women with persistent hrHPV were more likely to develop CIN2+ compared to those who cleared the virus, but no specific risk factors for persistence were identified in the study.
JOURNAL OF WOMENS HEALTH
(2021)
Article
Obstetrics & Gynecology
Afsaneh Tehranian, Akram Ghahghaei-Nezamabadi, Akram Seifollahi, Parisa Mansouri, Arezoo Maleki-Hajiagha, Reyhaneh Aghajani
Summary: This study found no correlation between abnormal cervical cytology, dysplasia, or cervical high-risk HPV with anal abnormal cytology.
INTERNATIONAL JOURNAL OF GYNECOLOGY & OBSTETRICS
(2023)
Article
Gastroenterology & Hepatology
Siew C. Ng, Zhilu Xu, Joyce Wing Yan Mak, Keli Yang, Qin Liu, Tao Zuo, Whitney Tang, Louis Lau, Rashid N. Lui, Sunny H. Wong, Yee Kit Tse, Amy Y. L. Li, Kitty Cheung, Jessica Y. L. Ching, Vincent W. S. Wong, Alice P. S. Kong, Ronald C. W. Ma, Elaine Y. K. Chow, Simon K. H. Wong, Ivan Chak Hang Ho, Paul K. S. Chan, Francis K. L. Chan
Summary: Repeated FMTs enhance microbiota engraftment in obese patients with T2DM, leading to more favorable changes in recipients' microbiota and improvement in lipid profile and liver stiffness when combined with lifestyle intervention.
Letter
Gastroenterology & Hepatology
Siu Lam, Jingwan Zhang, Keli Yang, Lok Cheung Chu, Wenyi Zhu, Whitney Tang, Francis K. L. Chan, Paul K. S. Chan, William K. K. Wu, Siew C. Ng
Article
Infectious Diseases
Shi Zhao, Jingzhi Lou, Lirong Cao, Ka Chun Chong, Benny C. Y. Zee, Paul K. S. Chan, Maggie H. Wang
Summary: The circulation of SARS-CoV-2 Delta variants poses challenges to pandemic control, with reported case fatality ratio decreasing but the trend for Delta variants being weak. The association between vaccine coverage and CFR may differ based on circulating variants. Analysis results should be interpreted with caution due to the limitations of the study design.
INFECTION GENETICS AND EVOLUTION
(2022)
Article
Gastroenterology & Hepatology
Lin Zhang, Zhilu Xu, Joyce W. Y. Mak, Kai Ming Chow, Grace Lui, Timothy C. M. Li, Chun Kwok Wong, Paul K. S. Chan, Jessica Y. L. Ching, Yasuhiro Fujiwara, Francis K. L. Chan, Siew C. Ng
Summary: This study demonstrated that hospitalized COVID-19 patients receiving a novel gut microbiota-derived synbiotic formula (SIM01) as an adjuvant therapy showed accelerated antibody formation against SARS-CoV-2, reduced nasopharyngeal viral load, decreased pro-inflammatory immune markers, and restored gut dysbiosis.
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
(2022)
Article
Genetics & Heredity
Jingzhi Lou, Shi Zhao, Lirong Cao, Hong Zheng, Zigui Chen, Renee W. Y. Chan, Marc K. C. Chong, Benny C. Y. Zee, Paul K. S. Chan, Maggie H. H. Wang
Summary: During the COVID-19 pandemic, genetic mutations of SARS-CoV-2 have been frequent. This study investigates the patterns of genetic distance in different viral proteins, revealing increasing trends in spike protein, RNA-dependent RNA polymerase region, nonstructural protein 3 of ORF1, and nucleocapsid protein. Mutations in other proteins appeared transiently, with no evident increasing trend in genetic distance to the original variants.
PUBLIC HEALTH GENOMICS
(2022)
Review
Engineering, Biomedical
Zifeng Zhang, Lu Wang, Tony K. F. Chan, Zigui Chen, Margaret Ip, Paul K. S. Chan, Joseph J. Y. Sung, Li Zhang
Summary: The evolution of drug-resistant pathogenic bacteria poses a major threat to public health, exacerbated by the formation of biofilms that resist antibiotics and grow in hard-to-reach regions. Micro/nanorobots show promise in delivering antibacterial agents into targeted sites, offering an attractive alternative to conventional therapies for addressing infections. Insights into the future development of MNRs with good functionality and biosafety promise better approaches for combating bacterial infections in clinical settings.
ADVANCED HEALTHCARE MATERIALS
(2022)
Article
Microbiology
Renee W. Y. Chan, Kin P. Tao, Jiqing Ye, Kevin K. Y. Lui, Xiao Yang, Cong Ma, Paul K. S. Chan
Summary: Influenza virus is a major public health challenge characterized by high morbidity and mortality. Oseltamivir is commonly used as an antiviral, but resistant strains have been detected. This study designed and synthesized two new compounds that showed significant antiviral activity against both seasonal and oseltamivir-resistant strains. These compounds have the potential to be an important addition to the arsenal of antiviral drugs.
Article
Microbiology
Renee W. Y. Chan, Kate C. C. Chan, Grace C. Y. Lui, Joseph G. S. Tsun, Kathy Y. Y. Chan, Jasmine S. K. Yip, Shaojun Liu, Michelle W. L. Yu, Rita W. Y. Ng, Kelvin K. L. Chong, Maggie H. Wang, Paul K. S. Chan, Albert M. Li, Hugh Simon Lam
Summary: The study found that early and intense nasal S1-specific IgA levels are associated with a rapid decrease in viral load in SARS-CoV-2 infected patients. These findings provide insights into the importance of mucosal immunity in SARS-CoV-2 exposure and protection, and suggest a potential role of NELF IgA in screening and diagnosing SARS-CoV-2 infection.
Article
Virology
Sile Li, Ho Yin Luk, Chichao Xia, Zigui Chen, Paul Kay Sheung Chan, Siaw Shi Boon
Summary: Esophageal carcinoma is the sixth leading cause of cancer death, with low survival rates. Infection with oncogenic viruses, notably human papillomavirus (HPV), is suspected to play a significant role in the development of esophageal carcinoma. This review explores the association between oncogenic viruses and esophageal carcinoma, with a focus on HPV. The efficacy of various treatment regimens, including immunotherapy, chemotherapy, and chemoradiotherapy, is also discussed.
TUMOUR VIRUS RESEARCH
(2022)
Article
Multidisciplinary Sciences
Bei Huang, Steven W. H. Chau, Yaping Liu, Joey W. Y. Chan, Jing Wang, Suk Ling Ma, Jihui Zhang, Paul K. S. Chan, Yun Kit Yeoh, Zigui Chen, Li Zhou, Sunny Hei Wong, Vincent C. T. Mok, Ka Fai To, Hei Ming Lai, Simon Ng, Claudia Trenkwalder, Francis K. L. Chan, Yun Kwok Wing
Summary: The study reveals that the gut microbiota compositions are significantly altered in early PD and RBD compared with control and RBD-FDR. The depletion of butyrate-producing bacteria and the enrichment of pro-inflammatory Collinsella have emerged in RBD and RBD-FDR after controlling potential confounders. The study also identifies 12 microbial markers that can effectively distinguish RBD from control.
NATURE COMMUNICATIONS
(2023)
Article
Biotechnology & Applied Microbiology
Paul K. S. Chan, Martin C. S. Wong, Macy Chan, Karen Ching, Nikolaos Giannelos, Cheryl Ng
Summary: In Hong Kong, the burden of shingles is increasing due to an aging population with increasing life expectancy. Vaccination with zoster vaccine live (ZVL) or recombinant zoster vaccine (RZV) can reduce the public health burden of shingles in Hong Kong adults aged >= 50 years. RZV is more effective than ZVL, with a higher reduction in cases. Earlier RZV vaccination, from age 50 years, has a greater public health impact compared to vaccination at a later age.
HUMAN VACCINES & IMMUNOTHERAPEUTICS
(2023)
Article
Oncology
Siaw Shi Boon, Yin Ching Lee, Ka Lai Yip, Ho Yin Luk, Chuanyun Xiao, Man Kin Yim, Zigui Chen, Paul Kay Sheung Chan
Summary: This study identified Aurora kinase B (AurB) as a novel interacting partner of human papillomavirus E6, and investigated the molecular mechanism of how E6 recruits AurB to induce cell immortalization and proliferation, leading to eventual cancer development. The study also evaluated the efficacy of Aurora kinase inhibitors in halting HPV-mediated carcinogenesis. The findings revealed the potential for specific and selective inhibitors to be developed for the treatment of HPV-related cancers.
Article
Microbiology
Yehao Chen, Yuping Song, Zigui Chen, Jennifer Wing Ki Yau, Kate Ching Ching Chan, Agnes Sze Yin Leung, Oi Man Chan, Apple Chung Man Yeung, Connie Lai Yuk Yuen, Paul Kay Sheung Chan, Wing Hung Tam, Ting Fan Leung
Summary: This study investigated the early-life evolution of the skin microbiome in Chinese children and its association with eczema phenotypes. The results showed that atopic sensitization at 12 months was strongly associated with persistent eczema at 24 months. Children with atopic eczema had reduced alpha diversity at 12 months and transiently higher abundance of the genus Janibacter at 6 months compared to those with non-atopic eczema. These findings suggest that atopic sensitization at 12 months may predict persistent eczema, and atopic eczema is associated with unique skin microbiome profiles at different time points. Non-invasive skin-microbiome profiling may have predictive value for atopic eczema.
Article
Microbiology
Yu P. Song, Man F. Tang, Agnes S. Y. Leung, Kin P. Tao, Oi M. Chan, Gary W. K. Wong, Paul K. S. Chan, Renee W. Y. Chan, Ting F. Leung
Summary: This case-control study investigated the interaction between CDHR3 genotypes and rhinovirus (RV) species on disease severity in Hong Kong children hospitalized for respiratory tract infection (RTI). There were synergistic effects between RV-C and CDHR3 SNPs for RTI severity, which was mainly driven by RV-C.
MICROBIOLOGY SPECTRUM
(2023)
Article
Microbiology
Man Kit Cheung, Jason Y. K. Chan, Martin C. S. Wong, Po Yee Wong, Pu Lei, Liuyang Cai, Linlin Lan, Wendy C. S. Ho, Apple C. M. Yeung, Paul K. S. Chan, Zigui Chen
Summary: This study characterized the oral bacterial and fungal microbiomes in a large cohort of healthy Chinese adults. The results showed that different factors shaped the diversity and structure of the oral bacterial and fungal microbiomes in healthy adults. Bacterial-fungal interactions were limited in the healthy oral microbiota.
MICROBIOLOGY SPECTRUM
(2022)