Article
Biochemistry & Molecular Biology
Monica S. Schoenenberger, Willi Halfter, Alexia Ferrand, Kathrin Halfter, Alexandar Tzankov, Hendrik P. N. Scholl, Paul Bernhard Henrich, Christophe A. Monnier
Summary: This article examines the compositional and biophysical properties of human basement membranes, revealing them to be stiff yet highly elastic materials. The role of composition, mechanics, and hydration in determining the properties of basement membranes is highlighted.
Article
Oncology
Lorena Carmona-Rodriguez, Diego Martinez-Rey, Paula Martin-Gonzalez, Monica Franch, Lydia Sorokin, Emilia Mira, Santos Manes
Summary: Tumor-infiltrating lymphocytes play a crucial role in cancer prognosis and the response to immunotherapy. This study investigates the effect of SOD3 protein on the expression of laminin-alpha 4 and laminin-alpha 5 in tumor blood vessels. The results show that SOD3 regulates laminin-alpha 4 and laminin-alpha 5 differentially, promoting a balance that allows T cell infiltration into tumors and improves cancer immune surveillance. The study provides insights into the mechanism of immune cell infiltration in tumors and highlights the potential importance of SOD3 in cancer therapy.
Article
Cell Biology
Samarpita Banerjee, Wen-Cheng Lo, Payel Majumder, Debleena Roy, Mimosa Ghorai, Nusrat K. Shaikh, Nishi Kant, Mahipal S. Shekhawat, Vijaykumar Shivaji Gadekar, Suchanda Ghosh, Ercan Bursal, Faris Alrumaihi, Navneet Kumar Dubey, Sanjay Kumar, Danish Iqbal, Wael Alturaiki, Vijay Jagdish Upadhye, Niraj Kumar Jha, Abhijit Dey, Rohit Gundamaraju
Summary: Metastasis is a major challenge in cancer therapy, and the epithelial-mesenchymal transition plays a critical role in this process. Collagen, laminin, and integrin are important components involved in tumor cell metastasis and can also serve as biomarkers for metastatic cells. This review summarizes the current knowledge of therapeutics in preclinical or clinical stages.
EUROPEAN JOURNAL OF CELL BIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Conor J. Sugden, Valentina Iorio, Lee D. Troughton, Ke Liu, Mychel R. P. T. Morais, Rachel Lennon, George Bou-Gharios, Kevin J. Hamill
Summary: Transgenic expression of LaNt alpha 31 in mice resulted in defects in tissue morphogenesis, including extravascular bleeding, kidney epithelial detachment, tubular dilation, disruption of the epidermal basal cell layer and hair follicle outer root sheath, as well as reduced cell numbers in the liver.
Article
Oncology
Hao Han, Hui Li, Yifan Ma, Zhite Zhao, Qingling An, Jumei Zhao, Changhong Shi
Summary: Monoamine oxidase A (MAOA) is an enzyme that plays a crucial role in prostate cancer progression, including various stages such as castration-resistant prostate cancer and metastasis. It is also involved in intercellular interactions between prostate cancer cells and the tumor microenvironment. Targeting MAOA can disrupt these interactions and potentially improve the efficacy of prostate cancer therapy. Furthermore, MAOA targeting can enhance the sensitivity of enzalutamide, block the growth of prostate cancer cells, and potentially improve immune checkpoint inhibition. Overall, MAOA is a promising therapeutic target that requires further investigation in both preclinical and clinical settings.
Article
Clinical Neurology
Hiroyuki Honda, Kosuke Matsuzono, Kota Satoh, Masayoshi Fujisawa, Satoshi O. Suzuki, Chiaki Furuyama, Tetsuyuki Kitamoto, Shigeru Fujimoto, Koji Abe, Toru Iwaki
Summary: Immunohistochemical detection of PrP in cutaneous samples revealed abnormal PrP deposits in patients with GPI-anchorless PrP disease, particularly localized at the basement membrane and colocalized with laminin. This method could be used for definitive diagnosis of the disease.
EUROPEAN JOURNAL OF NEUROLOGY
(2021)
Article
Cell Biology
Peng Li Zhou, Zhengyang Wu, Wenguang Zhang, Miao Xu, Jianzhuang Ren, Qinhui Zhang, Zhanguo Sun, Xinwei Han
Summary: This study identified the oncogenic role of circPDE3B/miR-4766-5p/LAMA1 axis in promoting ESCC cell proliferation, migration, and invasion by acting as a ceRNA to eliminate the inhibitory effect on LAMA1 and inducing epithelial-mesenchymal transition (EMT). This axis may have potential prognostic and therapeutic significance in ESCC.
CELL DEATH & DISEASE
(2021)
Review
Dermatology
Monique Aumailley
Summary: The basement membrane at the dermal-epidermal junction is composed of four categories of extracellular matrix proteins, which are precisely arranged through specific interactions. Some proteins are provided by both fibroblasts and keratinocytes, while others are exclusively synthesized by one of the cell types. Further research is needed to determine how the components from fibroblasts are targeted to the junction and integrated with keratinocytes' proteins to form the basement membrane.
EXPERIMENTAL DERMATOLOGY
(2021)
Review
Biochemistry & Molecular Biology
William Tyler Turchan, Sean P. Pitroda, Ralph R. Weichselbaum
Summary: Radiotherapy and immunotherapy are most effective in treating cancer in the setting of low-volume disease. Further investigation of radio-immunotherapy in metastatic patients should focus upon patients with oligometastatic disease.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Anna-Liisa Luik, Melanie-Jane Hannocks, Sophie Loismann, Kishan Kapupara, Manuela Cerina, Miesje van der Stoel, Yaroslav Tsytsyura, Nataliya Glyvuk, Caroline Nordenvall, Jurgen Klingauf, Stephan Huveneers, Sven Meuth, Lars Jakobsson, Lydia Sorokin
Summary: Using high-resolution confocal imaging, we identified novel components of myoendo-thelial junctions (MEJs) in blood vessels, including integrins, vinculin, focal adhesion kinase (FAK), and laminins. The electron microscopy revealed multiple layers of endothelial basement membranes (BMs) in MEJs. The TRPV4 calcium channel, which is shear-responsive, was found to be broadly distributed in endothelial cells and was localized at the endothelial-SMC interface in MEJs. Mice lacking endothelial laminin isoform showed increased TRPV4 localization at the endothelial-SMC interface in MEJs.
Review
Chemistry, Multidisciplinary
Yamei Liu, Lu Zhang, Rui Chang, Xuehai Yan
Summary: Peptide-based supramolecular PIT nanoagents have been shown to enhance the effect of photoimmunotherapy by utilizing multiple pathways and collaborative strategies to amplify the immune response.
CHEMICAL COMMUNICATIONS
(2022)
Article
Oncology
Edwin Nieblas-Bedolla, Naema Nayyar, Mohini Singh, Ryan J. Sullivan, Priscilla K. Brastianos
Summary: Brain metastases cause significant morbidity and mortality in cancer patients, with immunotherapies showing potential benefits in treatment but also facing challenges. Checkpoint inhibitors, chimeric antigen receptor T-cell therapy, and oncolytic viruses are considered potential options for treating brain metastases.
Article
Biochemistry & Molecular Biology
Jennifer L. Bailey, David H. Burk, Susan J. Burke, Scott D. Reed, Sujoy Ghosh, Carrie M. Elks
Summary: This study found that adipocyte-specific LAMA4 deletion is protective in an obesogenic environment, even though overall adiposity is increased. Laminin alpha 4 was found to be highly expressed in human and murine adipocytes.
Review
Genetics & Heredity
Liam Shaw, Conor J. Sugden, Kevin J. Hamill
Summary: Laminins play crucial roles in cell adhesion, signaling, and migration, forming functional networks through extracellular interactions. Pathogenic point mutations can lead to clinical syndromes, shedding light on the roles of laminins in tissue function through genotype-phenotype comparisons.
FRONTIERS IN GENETICS
(2021)
Article
Biochemistry & Molecular Biology
Justin D. Middleton, Subhakeertana Sivakumar, Tsonwin Hai
Summary: The study indicates that pre-treatment with cyclophosphamide (CTX) can increase the abundance of cancer cells in the lung by enhancing vascular adhesiveness through mechanisms involving increased vascular permeability and matrix metalloproteinase-2 (MMP-2) levels. This results in higher accessibility of critical protein domains in the basement membrane (BM), facilitating cancer cell adhesion to the vascular wall.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Physiology
Leonor Gouveia, Simone Kraut, Stefan Hadzic, Elisa Vazquez-Liebanas, Baktybek Kojonazarov, Cheng-Yu Wu, Christine Veith, Liqun He, Georgics Mermekkas, Ralph Theo Schermuly, Norbert Weissmann, Christer Betsholtz, Johanna Andrae
AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY
(2020)
Article
Oncology
Qi He, Xiujuan Li, Liqun He, Yousheng Li, Christer Betsholtz, Michael Welsh
INTERNATIONAL JOURNAL OF CANCER
(2020)
Article
Oncology
Chatarina Larsson, Lina Cordeddu, Lee Siggens, Tatjana Pandzic, Snehangshu Kundu, Liqun He, Muhammad Akhtar Ali, Nusa Pristovsek, Karin Hartman, Karl Ekwall, Tobias Sjoblom
CLINICAL EPIGENETICS
(2020)
Article
Multidisciplinary Sciences
Lars Muhl, Guillem Genove, Stefanos Leptidis, Jianping Liu, Liqun He, Giuseppe Mocci, Ying Sun, Sonja Gustafsson, Byambajav Buyandelger, Indira Chivukula, Asa Segerstolpe, Elisabeth Raschperger, Emil M. Hansson, Johan L. M. Bjorkegren, Xiao-Rong Peng, Michael Vanlandewijck, Urban Lendahl, Christer Betsholtz
NATURE COMMUNICATIONS
(2020)
Article
Cell Biology
Ahmed M. Osman, Ying Sun, Terry C. Burns, Liqun He, Nigel Kee, Nuria Oliva-Vilarnau, Androniki Alevyzaki, Kai Zhou, Lauri Louhivuori, Per Uhlen, Eva Hedlund, Christer Betsholtz, Volker M. Lauschke, Julianna Kele, Klas Blomgren
Article
Oncology
Yanyu Zhang, Yuan Xie, Liqun He, Jiefu Tang, Qiyuan He, Qingze Cao, Langjun Cui, Wei Guo, Kai Hua, Anna Dimberg, Liang Wang, Lei Zhang
Summary: This study found that in IDH-mutated LGGs, most TAMs expressed M1 activation markers CD86 and TNF, with some TAMs co-expressing both M1 and M2-related markers. Higher levels of TAMs expressing M2-related markers were observed in 1p/19q non-codeletion IDH-mutated LGGs compared to 1p/19q codeletion LGGs. Inhibition of M-CSF and TGF beta 1 signaling decreased tumor growth and modulated TAM phenotype in a glioma mouse model, indicating a potential role of these proteins in regulating TAM phenotype in glioma.
Letter
Cardiac & Cardiovascular Systems
Ian R. McCracken, Gaye Saginc, Liqun He, Alik Huseynov, Alison Daniels, Sarah Fletcher, Claire Peghaire, Viktoria Kalna, Maarja Andaloussi-Mae, Lars Muhl, Nicky M. Craig, Samantha J. Griffiths, Jurgen G. Haas, Christine Tait-Burkard, Urban Lendahl, Graeme M. Birdsey, Christer Betsholtz, Michela Noseda, Andrew H. Baker, Anna M. Randi
Article
Cardiac & Cardiovascular Systems
Markus Rasanen, Ibrahim Sultan, Jennifer Paech, Karthik Amudhala Hemanthakumar, Wei Yu, Liqun He, Juan Tang, Ying Sun, Ruslan Hlushchuk, Xiuzheng Huan, Emma Armstrong, Oleksiy-Zakhar Khoma, Eero Mervaala, Valentin Djonov, Christer Betsholtz, Bin Zhou, Riikka Kivela, Kari Alitalo
Summary: Recent research has shown that VEGF-B plays a significant role in coronary vessel development in the heart, potentially offering a new therapeutic strategy for cardiac neovascularization.
Article
Cardiac & Cardiovascular Systems
Maarja A. Mae, Liqun He, Sofia Nordling, Elisa Vazquez-Liebanas, Khayrun Nahar, Bongnam Jung, Xidan Li, Bryan C. Tan, Juat Chin Foo, Amaury Cazenave-Gassiot, Markus R. Wenk, Yvette Zarb, Barbara Lavina, Susan E. Quaggin, Marie Jeansson, Chengua Gu, David L. Silver, Michael Vanlandewijck, Eugene C. Butcher, Annika Keller, Christer Betsholtz
Summary: Through single-cell RNA sequencing and other methods, the study revealed the transcriptional, morphological, and functional changes in brain endothelial cells in response to pericyte deficiency. Endothelial cells without pericyte contact maintain a BBB-specific gene expression profile and acquire a venous-shifted molecular pattern.
CIRCULATION RESEARCH
(2021)
Article
Genetics & Heredity
Jianhao Wang, Xiangyi Deng, Yuan Xie, Jiefu Tang, Ziwei Zhou, Fan Yang, Qiyuan He, Qingze Cao, Lei Zhang, Liqun He
Summary: The study reveals key molecular alterations in endothelial cells in response to TBI, including increased Myc targets and Epithelial-Mesenchymal Transition signatures; IGFBP7 is identified as a potential biomarker for vascular response to TBI; TGF beta signaling may contribute to the upregulation of IGFBP7 in the vasculature.
FRONTIERS IN GENETICS
(2021)
Article
Genetics & Heredity
Takahiro Ishikawa, Minoru Takemoto, Yoshihiro Akimoto, Aki Takada-Watanabe, Kunimasa Yan, Kenichi Sakamoto, Yoshiro Maezawa, Miyuki Suguro, Liqun He, Karl Tryggvason, Christer Betsholtz, Koutaro Yokote
Summary: A novel podocyte-expressed protein R3h domain containing-like (R3hdml) was identified, which inhibits podocyte apoptosis by suppressing TGF-beta-mediated p38 MAPK signaling. Overexpression of R3hdml ameliorated albuminuria in STZ-induced diabetes mice, suggesting it may be a potential therapeutic strategy for diabetic nephropathy.
JOURNAL OF MOLECULAR MEDICINE-JMM
(2021)
Article
Oncology
Johanna Schaffenrath, Tania Wyss, Liqun He, Elisabeth Jane Rushing, Mauro Delorenzi, Flavio Vasella, Luca Regli, Marian Christoph Neidert, Annika Keller
Summary: The study characterized transcriptional alterations in endothelial cells of brain tumors, revealing deregulation of genes related to cell proliferation, angiogenesis, and extracellular matrix in GBM and BM vasculature. Dysfunction of genes defining the BBB and deregulated expression of genes in vessel-associated fibroblasts in GBM were also identified. These findings contribute to the development of drug delivery platforms and warrant further investigation into the cellular composition of brain tumor stroma.
Article
Oncology
Jianping Liu, Liqun He, Lars Muhl, Giuseppe Mocci, Sonja Gustavsson, Byambajav Buyandelger, Michael Vanlandewijck, Christer Betsholtz, Bengt Westermark, Johanna Andrae
Summary: The brain vasculature features a blood-brain barrier (BBB) that protects the brain from pathogens and toxins. Recent identification of human cells that may be equivalent to murine brain perivascular fibroblasts, with a similar transcriptomic profile, opens up new possibilities for studying human CNS diseases.
EXPERIMENTAL CELL RESEARCH
(2021)
Article
Medicine, Research & Experimental
Yuan Xie, Liqun He, Roberta Lugano, Yanyu Zhang, Haiyan Cao, Qiyuan He, Min Chao, Boxuan Liu, Qingze Cao, Jianhao Wang, Yang Jiao, Yaqin Hu, Liying Han, Yong Zhang, Hua Huang, Lene Uhrbom, Christer Betsholtz, Liang Wang, Anna Dimberg, Lei Zhang
Summary: By analyzing single-cell RNA sequencing data, researchers discovered different endothelial cell phenotypes in tumor vessels of human glioblastoma, which exhibit varying levels of activation and blood-brain barrier impairment. These findings are associated with different anatomical locations within and around the tumor.
Article
Biochemistry & Molecular Biology
Heon-Woo Lee, Yanying Xu, Xiaolong Zhu, Cholsoon Jang, Woosung Choi, Hosung Bae, Weiwei Wang, Liqun He, Suk-Won Jin, Zoltan Arany, Michael Simons
Summary: Endothelial cells rely on glycolysis for energy production, resulting in lactate production. Pericytes uptake endothelium-derived lactate and use it for energy generation and amino acid biosynthesis. The proximity between endothelial cells and pericytes is crucial for the transport of lactate. Inhibition of endothelial lactate production leads to blood-brain barrier breakdown, while lactate administration can restore these abnormalities to some extent.
