Article
Pharmacology & Pharmacy
Gustavo Lopez-Cordoba, Guadalupe Martinez-Lorenzana, Jair Lozano-Cuenca, Miguel Condes-Lara, Abimael Gonzalez-Hernandez
Summary: Spinal alpha(2)-adrenoceptors induce analgesia by inhibiting primary afferent fibers. The alpha(2A) subtype is involved in acute or tonic nociception, while the alpha(2C) subtype has an opposing effect under tonic nociceptive input.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Critical Care Medicine
Tim Lahm, Edward Hess, Anna E. Baron, Thomas M. Maddox, Mary E. Plomondon, Gaurav Choudhary, Bradley A. Maron, Roham T. Zamanian, Peter J. Leary
Summary: ACEIs and ARBs are associated with lower mortality in patients with pulmonary hypertension, while AA use is a marker of disease severity and may be used preferentially in sicker patients. ACEIs and ARBs may represent a novel treatment strategy for different PH phenotypes.
Review
Medicine, General & Internal
Jean-Baptiste de Freminville, Laurence Amar
Summary: Hypertension is the most common modifiable risk factor globally, affecting approximately 30% to 40% of adults. Secondary hypertension, resulting from identified causes, accounts for 10% to 15% of hypertensive patients. Renal arteries abnormalities, kidney disease, and endocrine hypertension, primarily due to adrenal causes, are the most frequent secondary causes. Detecting and exploring endocrine causes of hypertension is particularly important as some causes can be cured or have specific treatments available. Screening and exploration for secondary hypertension should be a serious concern for physicians treating hypertensive patients.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Pharmacology & Pharmacy
Joseph C. Galley, Scott A. Hahn, Megan P. Miller, Brittany G. Durgin, Edwin K. Jackson, Sean D. Stocker, Adam C. Straub
Summary: In the study, it was found that reduced renal blood flow activates the RAAS system, leading to renovascular hypertension. Ang II was shown to affect sGC expression through an AT(1) receptor-FoxO transcription factor mechanism, both in vivo and in vitro. This up-regulation of sGC led to increased downstream cGMP signaling, suggesting a protective mechanism to improve renal blood flow in the uninjured contralateral renal artery.
BRITISH JOURNAL OF PHARMACOLOGY
(2022)
Article
Peripheral Vascular Disease
Hanna Remde, Christina Pamporaki, Marcus Quinkler, Svenja Nolting, Aleksander Prejbisz, Henri J. L. M. Timmers, Jimmy Masjkur, Carmina T. Fuss, Martin Fassnacht, Graeme Eisenhofer, Timo Deutschbein
Summary: This study aimed to evaluate the diagnostic outcome of CST in patients with moderate NMN elevations, showing high sensitivity and specificity in diagnosing PPGL.
Review
Peripheral Vascular Disease
Jean-Baptiste de Freminville, Laurence Amar, Michel Azizi, Julien Mallart-Riancho
Summary: Hypertension affects a large percentage of adults worldwide, and distinguishing between secondary and primary hypertension is important in order to provide appropriate treatment. Identifying secondary hypertension can lead to specific therapies and better control of blood pressure. Endocrine and renal vascular abnormalities are the main causes of secondary hypertension.
HYPERTENSION RESEARCH
(2023)
Article
Pharmacology & Pharmacy
Sean A. Cullum, Dmitry B. Veprintsev, Stephen J. Hill
Summary: This study analysed the kinetic phases of cAMP responses to beta(2)-adrenoceptor agonists in HEK293 cells expressing low levels of endogenous beta(2)-adrenoceptor. It was found that partial agonists had reduced relative IRmax values compared to isoprenaline. Preincubation with beta(2)-adrenoceptor antagonists led to a decrease in the peak response and exacerbated the effect on IRmax values. These findings provide insights into the hemi-equilibria in low receptor reserve systems with agonist-antagonist interactions.
BRITISH JOURNAL OF PHARMACOLOGY
(2023)
Article
Endocrinology & Metabolism
Spyridoula Tsiomidou, Christina Pamporaki, Aikaterini Geroula, Lukas Van Baal, Frank Weber, Henning Dralle, Kurt W. Schmid, Dagmar Fuehrer, Nicole Unger
Summary: This study evaluated the role of the clonidine suppression test (CST) in the diagnosis or exclusion of pheochromocytoma/paraganglioma (PPGL) and found that CST can accurately identify all false-positive plasma normetanephrine (NMN) screening results in patients with suspected PPGL.
CLINICAL ENDOCRINOLOGY
(2022)
Article
Pharmacology & Pharmacy
John Sedin, David Dahlgren, Markus Sjoblom, Olof Nylander
Summary: Recent experiments have shown that the sympathetic nervous system can regulate the increase in duodenal mucosal permeability induced by hypotonicity through actions on alpha-adrenoceptors. Specifically, stimulation of the adrenergic alpha(2)-adrenoceptor with the agonist clonidine can prevent the hypotonicity-induced increase in mucosal permeability, while not affecting fluid absorption.
Article
Oncology
Ling Lan, Qian Shu, Chunhua Yu, Lijian Pei, Yuelun Zhang, Li Xu, Yuguang Huang
Summary: Myocardial injury is common after laparoscopic adrenalectomy for pheochromocytoma, and risk factors include ischemic heart disease or stroke, elevated heart rate and blood pressure during surgery, and decreased hemoglobin levels. Prolonged duration of increased heart rate and blood pressure during surgery is associated with an increased risk of myocardial injury.
FRONTIERS IN ONCOLOGY
(2022)
Review
Cardiac & Cardiovascular Systems
James Jiqi Wang, Zuowen He, Yan Yang, Bo Yu, Hong Wang, Hu Ding, Guanglin Cui, Luyun Wang, Dao Wen Wang, Jiangang Jiang
Summary: This study investigated the efficacy and safety of using chlorpromazine in PMC patients, showing that chlorpromazine effectively controlled hypertension in PMC patients and reduced the risk of surgical tumor resection two weeks later.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Article
Chemistry, Analytical
Wenhua Li, Zhao Ma, Lupei Du, Minyong Li
Summary: By conjugating the Py-5 fluorophore with mirabegron using a polyethylene glycol (PEG) chain, we have developed a highly selective fluorescent ligand, H2, for fl3-AR. H2 rapidly releases turn-on fluorescent signals when incubated with fl3-AR, enabling quick and accurate identification at different levels.
ANALYTICAL CHEMISTRY
(2023)
Article
Endocrinology & Metabolism
Hyojung Park, Min-Sun Kim, Jiwon Lee, Jung-Han Kim, Byong Chang Jeong, Sanghoon Lee, Suk-Koo Lee, Sung Yoon Cho, Dong-Kyu Jin
Summary: This study demonstrates that pediatric PPGL tends to be extra-adrenal and bilateral, with a higher potential for genetic mutations. Genetic screening tests are strongly recommended for pediatric PPGL due to their hereditary predisposition, and lifelong follow-up is necessary to detect recurrence and metastasis. Further research with a larger sample size and routine genetic screening is needed to better understand the genetic conditions and long-term prognosis of PPGL.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Endocrinology & Metabolism
Seda Grigoryan, Winnie Nhan, Lei Zhang, Caitlin Urban, Lili Zhao, Adina F. Turcu
Summary: This study aimed to assess the rates and patterns of PPGL screening among eligible patients. The study found that roughly half of patients with adrenal nodules and hypertension were screened for PPGL, but patients with treatment-resistant or early-onset hypertension were rarely screened.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Review
Medicine, General & Internal
Fumihiko Urabe, Shoji Kimura, Kosuke Iwatani, Kazuhiro Takahashi, Kagenori Ito, Kojiro Tashiro, Shunsuke Tsuzuki, Jun Miki, Takahiro Kimura, Nozomu Furuta, Shin Egawa
Summary: Through systematic search and meta-analysis, this study identified tumor size and urinary norepinephrine as important predictors and risk factors for perioperative hemodynamic instability in pheochromocytoma patients undergoing adrenalectomy.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Oncology
Yuxin Liu, Swati Bhardwaj, Keith Sigel, John Winters, Joseph Terlizzi, Michael M. Gaisa
Summary: This study investigated the prevalence and severity of anal HPV disease among MSM LWH under the age of 35, finding a high prevalence of HPV infection and precancer but no cases of invasive anal cancer. This supports the adoption of age-based anal cancer screening for this population.
INTERNATIONAL JOURNAL OF CANCER
(2024)
Correction
Oncology
J. Gu, S. Xie, S. Wang
INTERNATIONAL JOURNAL OF CANCER
(2024)