Review
Biochemistry & Molecular Biology
Reza Hosseini, Leila Asef-Kabiri, Hassan Yousefi, Hamzeh Sarvnaz, Majid Salehi, Mohammad Esmaeil Akbari, Nahid Eskandari
Summary: This paper delves into the impact of tumor-derived exosomes on dendritic cells and how they induce subversion of DCs differentiation, maturation, and function, as well as their significance at the therapeutic level. Understanding the exosomal content and pathways responsible for immune evasion could lead to the development of novel therapeutic approaches.
Review
Medicine, General & Internal
Hiroyuki Nakashima, Manabu Kinoshita
Summary: The liver plays a crucial role in systemic immunity and defends against the spread of tumor cells. It contains a higher percentage of innate immune lymphocytes, such as NK and NKT cells, which eliminate malignant cells with their strong cytotoxic ability. These lymphocytes also initiate immune responses by adaptive immune cells, making them important contributors to systemic antitumor immunity. Understanding the mechanisms of these immune cells provides insight for tumor immunity research and potential clinical applications for cancer therapies.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Immunology
Yuhan Sun, Alexander James Sedgwick, Md Abdullah-Al-Kamran Khan, Yaseelan Palarasah, Stefano Mangiola, Alexander David Barrow
Summary: The activation of NK cell function in bladder cancer is regulated by cytokines and secreted factors. IL-2-expanded NK cell phenotype is associated with improved prognosis, while PDGF-DD-activated NK cell phenotype is associated with poor prognosis. High expression of activating NK cell receptors correlates with IL-2-expanded NK cell phenotype and improved prognosis in bladder cancer.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Immunology
Benedikt Jacobs, Veronika Gebel, Lukas Heger, Victoria Greze, Hansjorg Schild, Diana Dudziak, Evelyn Ullrich
Summary: Cellular therapy, including CAR T cell and DCs vaccines, has become a part of daily clinical practice. To ensure sustained therapeutic success, challenges such as strategies to combat tumor escape mechanisms and establish an immunosuppressive tumor microenvironment need to be addressed. The interaction of DCs and NK cells within the TME is crucial for understanding and potentially improving cancer treatment outcomes.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Immunology
Sofie Hedlund Moller, Limei Wang, Ping-Chih Ho
Summary: Immune cells rely on specific metabolic traits to function, while the extracellular environment can influence cell metabolism and vice versa. Dendritic cell subsets modulate their stimulatory abilities based on unique metabolic programming in diverse environments. The metabolic requirements of dendritic cells are intertwined with their functions.
CELLULAR & MOLECULAR IMMUNOLOGY
(2022)
Article
Immunology
Joseph R. Podojil, Andrew C. Cogswell, Ming-Yi Chiang, Valerie Eaton, Igal Ifergan, Tobias Neef, Dan Xu, Khyati A. Meghani, Yanni Yu, Sophia M. Orbach, Tushar Murthy, Michael T. Boyne, Adam Elhofy, Lonnie D. Shea, Joshua J. Meeks, Stephen D. Miller
Summary: This study found that the use of ONP-302 can control tumors by reprogramming myeloid cells through the activation of the STING/IL-15/NK cell mechanism, and enhance the efficacy of anti-PD-1.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Immunology
Lei Zhao, Xi Yang
Summary: The interaction between dendritic cells and NKT cells is crucial for host defense against infections, as they can modulate each other's immune responses.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Immunology
Elena V. Abakushina, Liubov I. Popova, Andrey A. Zamyatnin, Jens Werner, Nikolay V. Mikhailovsky, Alexandr V. Bazhin
Summary: In the past decade, significant progress has been made in adoptive cell therapy, with dendritic cell vaccines and NK cells being potential cell preparations for cancer treatment. While NK cell immunotherapy shows high efficacy and promise against many types of cancer, there are still challenges to be overcome, such as infiltration limitations and low cytotoxic activity in solid tumors.
Article
Immunology
Miho Tokumasu, Mikako Nishida, Takamasa Kawaguchi, Ikuru Kudo, Tohru Kotani, Kazuhiko Takeda, Takao Yoshida, Heiichiro Udono
Summary: In this study, it was found that EP4i, an inhibitor of the PGE2 receptor EP4, suppressed tumor metabolism, stimulated IFN gamma production by NK cells, polarized macrophages, and reduced tumor hypoxia through normalization of the tumor vasculature.
INTERNATIONAL IMMUNOLOGY
(2022)
Review
Immunology
Laurent Schmied, Petter Hoglund, Stephan Meinke
Summary: The interactions between platelets and cancer cells play a significant role in supporting tumor metastasis by promoting vascular evasion and establishing solid tumor metastasis, as well as contributing to an immunosuppressive tumor microenvironment. Platelets are a major source of TGF-beta, which is crucial in immunosuppression. While the interactions between platelets and solid tumors are well-studied, their physiological relevance in hematological malignancies requires further research.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Yuhan Sun, Alexander James Sedgwick, Yaseelan Palarasah, Stefano Mangiola, Alexander David Barrow
Summary: The activation of NK cells by PDGF-DD and the expression of KLR family receptors are associated with a more favorable prognosis in low-grade glioma patients, suggesting their important clinical role in immune surveillance.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Immunology
Hongwei Jiang, Jingting Jiang
Summary: NK cells are fundamental components of innate immunity and have regulatory functions in both innate and adaptive immunity. This review integrates multiple studies to illuminate the regulatory function of NK cells in the adaptive immune responses of B cells and T cells, with a focus on viral infections and the tumor microenvironment.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Immunology
Raghad Khaleafi, Jelena Zeleznjak, Sapir Cordela, Shani Drucker, Tihana Lenac Rovis, Stipan Jonjic, Yotam Bar-On
Summary: Reovirus infection can downregulate NKG2D ligands on tumor cells, impairing the recognition and elimination of tumors by natural killer (NK) cells. This finding may lead to the development of new reovirus-based therapeutics to enhance the anti-tumor immune response.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Robbe Naert, Alejandro Lopez-Requena, Karel Talavera
Summary: TRPA1 channel, known for its role in nociceptive neurons, is also expressed in immune cells. While detected in various immune cells, functional measurements remain limited. The channel has been linked to multiple diseases in immune cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Immunology
Hee Young Kang, Soo Yun Lee, Hyun Min Kim, Su Ui Lee, Hyunseung Lee, Mi Young Cho, Se-Chan Oh, Seok-Min Kim, Hye Sun Park, Eun Hee Han, Seong-Eun Kim, Hyori Kim, Suk Ran Yoon, Junsang Doh, Junho Chung, Kwan Soo Hong, Inpyo Choi, Tae-Don Kim
Summary: The Cot-CAR system is a versatile cellular immunotherapy system that enhances cytolytic activity and inhibits tumor relapse.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Oncology
Verena Seifert, Susan Richter, Nicole Bechmann, Michael Bachmann, Christian G. Ziegler, Jens Pietzsch, Martin Ullrich
Summary: Low oxygen levels and genetic defects activating hypoxia signaling pathways contribute to tumorigenesis and therapy resistance. Pseudohypoxia plays a role in tumor formation and metastasis in pheochromocytomas and paragangliomas. Pseudohypoxia may protect against radiation treatments in these tumors, highlighting potential targets for radiosensitizing therapies.
Article
Biochemistry & Molecular Biology
Nicole Berndt, Claudia C. Bippes, Irene Michalk, Dominik Bachmann, Jennifer Bachmann, Edinson Puentes-Cala, Tabea Bartsch, Liliana R. Loureiro, Alexandra Kegler, Ralf Bergmann, Joanne K. Gross, Tim Gross, Biji T. Kurien, R. Hal Scofield, A. Darise Farris, Judith A. James, Marc Schmitz, Karim Fahmy, Anja Feldmann, Claudia Arndt, Michael P. Bachmann
Summary: The autoantigen La is involved in Cap-independent translation, with the possibility of forming dimers, oligomers, and polymers through redox-dependent structural changes. The three cysteine residues in the La protein are crucial for these redox-dependent structural modifications.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Immunology
Karthikeyan Subbarayan, Kamatchi Ulagappan, Claudia Wickenhauser, Michael Bachmann, Barbara Seliger
Summary: The study revealed that immune system process genes are associated with SARS-CoV-2 targets in cancer and diabetes patients, and further analysis using STRING and STITCH identified functional protein associations among these genes and potential druggable targets.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Oncology
Maximilian Kiessler, Ioana Plesca, Ulrich Sommer, Rebekka Wehner, Friederike Wilczkowski, Luise Mueller, Antje Tunger, Xixi Lai, Anke Rentsch, Kenneth Peuker, Sebastian Zeissig, Adrian M. Seifert, Lena Seifert, Juergen Weitz, Michael Bachmann, Martin Bornhaeuser, Daniela Aust, Gustavo Baretton, Marc Schmitz
Summary: The study found that higher densities of tumor-infiltrating pDCs are associated with lower UICC staging, increased progression-free and overall survival in colon cancer patients. A lower number of colon cancer-infiltrating pDCs was independently linked to worse prognosis, while the colocalization of activated pDCs and T cells in tumor stroma and within TLS may contribute to the correlation between higher pDC densities and better prognosis.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2021)
Article
Biology
Sophia B. Strobel, Devayani Machiraju, Ingrid Huelsmeyer, Jurgen C. Becker, Annette Paschen, Dirk Jager, Winfried S. Wels, Michael Bachmann, Jessica C. Hassel
Summary: High expression of gp100, TRP2, and GD2 proteins was observed in melanoma tumor samples, with TRP2 and ABCB5 expression correlated with lower tumor thickness in primary tumors. However, protein expression levels showed no association with survival in advanced melanoma patients. Abundant surface expression of GD2 and HER2 in melanoma cell lines suggests potential targets for CAR- or TCR-cell therapies against melanoma.
Article
Biochemistry & Molecular Biology
Nicola Mitwasi, Claudia Arndt, Liliana R. Loureiro, Alexandra Kegler, Frederick Fasslrinner, Nicole Berndt, Ralf Bergmann, Vaclav Horejsi, Claudia Roessig, Michael Bachmann, Anja Feldmann
Summary: This paper investigates the use of CD10 as a therapeutic target and addresses the challenges in improving CAR T-cell therapy for B-ALL.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Oncology
Ioana Plesca, Iva Benesova, Carolin Beer, Ulrich Sommer, Luise Mueller, Rebekka Wehner, Max Heiduk, Daniela Aust, Gustavo Baretton, Michael P. Bachmann, Anja Feldmann, Juergen Weitz, Lena Seifert, Adrian M. Seifert, Marc Schmitz
Summary: Tumor-infiltrating dendritic cells (DCs) are associated with survival of pancreatic ductal adenocarcinoma (PDAC) patients. Specifically, a higher frequency of cDC1s infiltration in the whole tumor area and tumor stroma, as well as an increased frequency of cDC2s infiltration in the intraepithelial tumor, is associated with improved survival.
Article
Oncology
Claudia Arndt, Ralf Bergmann, Franziska Striese, Keresztely Merkel, Domokos Mathe, Liliana R. Loureiro, Nicola Mitwasi, Alexandra Kegler, Frederick Fasslrinner, Karla Elizabeth Gonzalez Soto, Christin Neuber, Nicole Berndt, Noemi Kovacs, David Szollosi, Nikolett Hegedus, Gyula Toth, Jan-Philipp Emmermann, Kuzhuvelil B. Harikumar, Tibor Kovacs, Michael Bachmann, Anja Feldmann
Summary: This article describes a novel antibody derivative, anti-PSCA IgG4-TM, targeting prostate cancer (PCa) for UniCAR T cell immunotherapy, PET imaging, and targeted alpha therapy. The antibody exhibits favorable pharmacological properties and shows high selectivity and inhibition against tumors in experiments. This study suggests that anti-PSCA IgG4-TM holds promising potential as a multifunctional radio-/immunotheranostic tool.
Article
Oncology
Ayse Sedef Koeseer, Liliana R. Loureiro, Justyna Jureczek, Nicola Mitwasi, Karla Elizabeth Gonzalez Soto, Julia Aepler, Tabea Bartsch, Anja Feldmann, Leoni A. Kunz-Schughart, Annett Linge, Mechthild Krause, Michael Bachmann, Claudia Arndt, Anna Dubrovska
Summary: The study identified CD98hc as a potential biomarker for radioresistance in HNSCC and demonstrated the synergistic effect of combining fractionated irradiation with CD98hc-targeted immunotherapy using UniCAR T cells. The combination treatment showed improved antitumor effect and presents a promising approach for the treatment of high-risk HNSCC patients.
Review
Chemistry, Medicinal
Manja Kubeil, Irma Ivette Santana Martinez, Michael Bachmann, Klaus Kopka, Kellie L. Tuck, Holger Stephan
Summary: Molecular imaging allows non-invasive investigation of biological and biochemical processes, providing important information for understanding disease processes and planning treatment strategies. Combining nuclear and optical probes offers increased sensitivity and complementary information. This review article discusses dual-labelled systems for bimodal nuclear and optical imaging, with a focus on radiometal-labelled molecules and metal complexes combined with fluorescent dyes. The clinical potential, especially for fluorescence-guided surgery, is assessed.
Article
Biochemistry & Molecular Biology
Diana Lindner, Claudia Arndt, Liliana Rodrigues Loureiro, Anja Feldmann, Alexandra Kegler, Stefanie Koristka, Nicole Berndt, Nicola Mitwasi, Ralf Bergmann, Marcus Frenz, Michael P. Bachmann
Summary: Radiation of tumor cells can lead to the selection and outgrowth of tumor escape variants. Low dose radiation of T cells can enhance cytokine release and killing capability, while high dose radiation significantly reduces T cell function but does not completely eliminate it.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Oncology
Ayse Sedef Koeseer, Simona Di Gaetano, Claudia Arndt, Michael Bachmann, Anna Dubrovska
Summary: Tumor cells exhibit functional heterogeneity, and cancer stem cells (CSCs) are a population of tumor cells with self-renewal and differentiation properties. CSCs are found in most solid and hematological tumors and are characterized by various markers. These markers can be used to develop tumor-specific antibodies, immune cells, vaccines, and immune responses to tumor cells, including CSCs. This review discusses CSC-directed immunotherapies, their clinical development, safety and efficacy improvements, and future strategies for enhancing anti-CSC immunotherapy.
Review
Engineering, Biomedical
Manja Kubeil, Yota Suzuki, Maria Antonietta Casulli, Rozy Kamal, Takeshi Hashimoto, Michael Bachmann, Takashi Hayashita, Holger Stephan
Summary: Nanogels have a wide range of applications in the field of biomedicine, particularly in drug delivery, therapeutic applications, tissue engineering, and sensor systems. Cyclodextrin-based nanogels are highly biocompatible and customizable, making them especially important. While most biological investigations are currently carried out in vitro, in vivo applications are becoming more important. Radiolabeled nanogels have potential for imaging and therapy.
ADVANCED HEALTHCARE MATERIALS
(2023)
Meeting Abstract
Immunology
Ioana Plesca, Maximilian Kiessler, Ulrich Sommer, Rebekka Wehner, Friederike Wilczkowski, Luise Mueller, Antje Tunger, Xixi Lai, Anke Rentsch, Kenneth Peuker, Sebastian Zeissig, Adrian M. Seifert, Lena Seifert, Juergen Weitz, Michael Bachmann, Martin Bornhaeuser, Daniela Aust, Gustavo Baretton, Marc Schmitz
EUROPEAN JOURNAL OF IMMUNOLOGY
(2021)
Meeting Abstract
Biochemistry & Molecular Biology
Zirui Wang, Theodore Belecciu, Daniel Woldring, Michael Bachmann