Article
Biochemistry & Molecular Biology
Jiayao Qu, Jia Li, Yaming Zhang, Rongzhang He, Xiangting Liu, Ke Gong, Lili Duan, Weihao Luo, Zheng Hu, Gengsheng Wang, Chenglai Xia, Dixian Luo
Summary: Elevated expression of AKR1B10 in breast cancer tissues was associated with lymph node metastasis, tumor size, Ki67 expression, and p53 expression, while inversely correlated with overall and disease-free survival rates. AKR1B10 promotes proliferation, migration, and invasion of breast cancer cells via the PI3K/AKT/NF-kappa B signaling pathway, indicating its potential as a prognostic indicator and therapeutic target in breast cancer.
CELL AND BIOSCIENCE
(2021)
Article
Food Science & Technology
Haiyan Wen, Siqi Zhou, Jianping Li, Fei Peng, Xiaotao Han, Haohuan Li
Summary: The study highlights the protective effect of Nuciferine (Nuf) against osteoarthritis (OA) by reducing extracellular matrix degradation and inhibiting the production of inflammatory cytokines. Nuf attenuates OA progression by targeting the PI3K/Akt/NF-kappa B signaling pathway.
JOURNAL OF FUNCTIONAL FOODS
(2021)
Article
Immunology
Zhangping He, Jian Xiao, Jianye Wang, Simin Lu, Kang Zheng, Maoying Yu, Jie Liu, Chuan Wang, Nan Ding, Mingxing Liang, Yimou Wu
Summary: CPSIT_0556 inhibits hPMN apoptosis through the PI3K/Akt and NF-kappa B signaling pathways by releasing IL-8, delaying procaspase-3 processing, and regulating the expression of apoptosis-related proteins, providing new insights into the molecular pathogenesis and immune escape mechanisms of C. psittaci.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Integrative & Complementary Medicine
Wen-Ya Su, Ying Li, Xuan Chen, Xin Li, Heng Wei, Zhi Liu, Qiong Shen, Chen Chen, Ying-Ping Wang, Wei Li
Summary: This study evaluates the ameliorative effects of ginsenoside Rh1 on obesity-linked diabetic nephropathy induced by high fat diet and streptozotocin. The results suggest that G-Rh1 shows potential in improving treatment of DN.
AMERICAN JOURNAL OF CHINESE MEDICINE
(2021)
Article
Oncology
Fan Xu, Jiali Wang, Shuman Zhen, Yuqing Duan, Qingshan Li, Lihua Liu
Summary: The stemness characteristic of breast cancer is important for cancer recurrence and metastasis. This study found that C1ql4 is highly expressed in breast cancer tissues and cell lines, and its high expression is significantly correlated with malignancy. Mechanistically, C1ql4 promotes breast cancer cell stemness and EMT through the PI3K/AKT/NF-kB signaling pathway. Therefore, C1ql4 might be a potential target for breast cancer treatment.
FRONTIERS IN ONCOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Peng Han, Jin Shang, Dan-Ling Chen, Si-Yang Li, Rui Fan, Rui-Han Li, Hui-Qi Li, Shi-Yang Zhang, Dong-Yan Shen
Summary: Baicalein, derived from Scutellaria baicalensis Georgi, shows anticancer effects on cholangiocarcinoma cells by inhibiting cell viability and proliferation, inducing apoptosis and cell cycle arrest, suppressing migration and invasion, reducing aerobic glycolysis, and inhibiting tumor growth through regulating protein expression and signaling pathways both in vitro and in vivo.
PROCESS BIOCHEMISTRY
(2021)
Article
Pharmacology & Pharmacy
Yingchun Zhao, Xinglong Liu, Chuanbo Ding, Yan Gu, Wencong Liu
Summary: The study demonstrated that DHM treatment significantly inhibited liver fibrosis in mice induced by TAA, with decreased ALT and AST activities, increased SOD and GSH levels, and reversed MDA levels. DHM also inhibited hepatocyte apoptosis and hepatic stellate cell activation, and regulated the expression of TGF-beta 1, showing its potential hepatoprotective effects in treating liver fibrosis.
FRONTIERS IN PHARMACOLOGY
(2021)
Review
Oncology
Soudeh Ghafouri-Fard, Zahra Bahroudi, Hamed Shoorei, Bashdar Mahmud Hussen, Seyedeh Fahimeh Talebi, Sadia Ghousia Baig, Mohammad Taheri, Seyed Abdulmajid Ayatollahi
Summary: Resveratrol is a natural phenol that is present in various fruits and plants. It has potential beneficial effects in diverse pathological conditions and can modulate the expression of genes and the activity of signaling pathways.
CANCER CELL INTERNATIONAL
(2022)
Article
Pharmacology & Pharmacy
Zhen Ye, Yuzheng Li, Yingqi She, Mingquan Wu, Yu Hu, Kaihua Qin, Linzhen Li, Han Yu, Qian Zhao, Zhao Jin, Fating Lu, Qiaobo Ye
Summary: This study investigated the potential active components and molecular mechanisms of Renshen Baidu powder (RSBDP) for the treatment of ulcerative colitis. Results showed that RSBDP could ameliorate disease activity index, colon weight, colon shortening, and histology in TNBS-induced colitis rats. Furthermore, RSBDP inhibited the PI3K/Akt/NF-kappa B signaling pathway to effectively alleviate colitis in rats.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Xin Chen, Qian Lin Song, Jia Yu Wang, Rui Ji, Ming Liang Cao, Duan Ying Guo, Yan Zhang, Jing Yang
Summary: This study demonstrates the involvement of FK506-binding protein 5 (FKBP5) in recurrent spontaneous abortion (RSA), suggesting its potential as a diagnostic and therapeutic target. FKBP5 upregulation at the placental interface contributes to the pathogenesis of RSA by impairing trophoblast function and promoting M1-type macrophage polarization. FKBP5 inhibits trophoblast IL-6 secretion and suppresses trophoblast function through the PI3K/AKT signaling pathway. Moreover, FKBP5 promotes M1 macrophage polarization in decidual macrophages via the ROS/NF-kappa B signaling pathway. FKBP5 inhibitors improve embryo resorption rate in a mouse model of miscarriage, emphasizing the importance of FKBP5 in maintaining pregnancy and trophoblast-macrophage crosstalk at the maternal-fetal interface.
FREE RADICAL BIOLOGY AND MEDICINE
(2023)
Article
Environmental Sciences
Laura O. Walter, Mariana F. Maioral, Lisandra O. Silva, Douglas B. Speer, Sanjay C. Campbell, Winklet Gallimore, Miriam B. Falkenberg, Maria Claudia Santos-Silva
Summary: This study evaluated the cytotoxicity of the o-quinone stypoldione isolated from brown algae on multiple myeloma cells (MM) and found it to have potential for MM treatment.
ENVIRONMENTAL TOXICOLOGY
(2022)
Article
Chemistry, Medicinal
Yan-Qiu Zhou, Yue Sun, Han-Lin Luo, Zhong-Fei Gao, Hong-Qin Zhang, Qing-Guo Meng, Xian-Yong Bai, Gui-Ge Hou, Yun Hou
Summary: A series of novel compounds were synthesized in this study, among which the 4-CF3-substituted 4k exhibited anti-hepatoma activity and promoted apoptosis of hepatoma cells through various mechanisms. The research findings provide important scientific basis for further studies on hepatoma treatment.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Sang Eun Ha, Seong Min Kim, Preethi Vetrivel, Hun Hwan Kim, Pritam Bhagwan Bhosale, Jeong Doo Heo, Ho Jeong Lee, Gon Sup Kim
Summary: SCU as a potential agent for HCC therapy inhibits cell proliferation and metastasis in HepG2 cells through upregulation of PTEN and inhibition of the PI3K/Akt/NF-kappa B signaling pathway. It is a natural based agent that shows promise in improving therapeutic outcomes for HCC treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Pharmacology & Pharmacy
Ming Sui, Hairong Yang, Mingqi Guo, Wenle Li, Zheng Gong, Jing Jiang, Peiling Li
Summary: The study showed that cajanol significantly restored the sensitivity of A2780/Taxol ovarian cancer cells to paclitaxel by inhibiting P-glycoprotein expression and affecting its transcription and translation through the PI3K/Akt/NF-kappa B pathway. Cajanol may serve as a potential candidate compound for developing paclitaxel sensitizers, presenting a promising approach for overcoming multi-drug resistance in ovarian cancer treatment.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Environmental Sciences
Tingxu Yan, Xiaozhuo Zhang, Qianqian Mao, Bo Wu, Bosai He, Ying Jia, Lei Shang
Summary: Alpinae Oxyphyllae Fructus (AOF) has been shown to improve memory decline in LPS-induced AD mice by protecting neurons through the PI3K/AKT signaling pathway and reducing neuroinflammation levels. Additionally, AOF can decrease cytokine expression and NF-kappa B activity induced by LPS, demonstrating its potential anti-neuroinflammatory effects in AD models.
ENVIRONMENTAL TOXICOLOGY
(2022)
Article
Surgery
Sprague W. Hazard, Charles F. Zwemer, Donald R. Mackay, Srinivas V. Koduru, Dino J. Ravnic, H. Paul Ehrlich
JOURNAL OF SURGICAL RESEARCH
(2017)
Meeting Abstract
Surgery
Ashley N. Leberfinger, Srinivas V. Koduru, Dino J. Ravnic
JOURNAL OF THE AMERICAN COLLEGE OF SURGEONS
(2017)
Article
Oncology
Srinivas V. Koduru, Amit K. Tiwari, Ashley Leberfinger, Sprague W. Hazard, Yuka Imamura Kawasawa, Milind Mahajan, Dino J. Ravnic
Article
Multidisciplinary Sciences
Srinivas V. Koduru, Ashley N. Leberfinger, Yuka I. Kawasawa, Milind Mahajan, Niraj J. Gusani, Arun J. Sanyal, Dino J. Ravnic
SCIENTIFIC REPORTS
(2018)
Article
Biochemistry & Molecular Biology
Srinivas V. Koduru, Ben-hua Sun, Joanne M. Walker, Meiling Zhu, Christine Simpson, Madhav Dhodapkar, Karl L. Insogna
JOURNAL OF BIOLOGICAL CHEMISTRY
(2018)
Meeting Abstract
Gastroenterology & Hepatology
Rebecca Caffrey, Srinivas V. Koduru, Amon Asgharpour, Jonathon Marioneaux, Pierre Bedossa, Arun J. Sanyal
Meeting Abstract
Gastroenterology & Hepatology
Rebecca Caffrey, Jonathon Marioneaux, Binu Phillip, Suresh Giri, Mukul R. Jain, Deven V. Parmar, Srinivas V. Koduru, Andrea Vadillo, Marta Iruarrizaga-Lejarretae, Cristina Alonso, Arun J. Sanyal
Meeting Abstract
Gastroenterology & Hepatology
Rebecca Caffrey, Amon Asgharpour, Srinivas V. Koduru, Pierre Bedossa, Jonathon Marioneaux, Arun J. Sanyal
Meeting Abstract
Gastroenterology & Hepatology
Rebecca Caffrey, Srinivas V. Koduru, Jonathon Marioneaux, Binu Phillip, Suresh Giri, Mukul R. Jain, Deven V. Parmar, Arun J. Sanyal
Meeting Abstract
Gastroenterology & Hepatology
Anca Dobrian, Ryan Huyck, Jonathon Marioneaux, Srinivas V. Koduru, Arun J. Sanyal, Jerry Nadler, Rebecca Caffrey
Article
Surgery
Ashley N. Leberfinger, Monika Hospodiuk, Abdon Pena-Francesch, Bugra Ayan, Veli Ozbolat, Srinivas V. Koduru, Ibrahim T. Ozbolat, Melik C. Demirel, Dino J. Ravnic
PLASTIC AND RECONSTRUCTIVE SURGERY-GLOBAL OPEN
(2018)
Meeting Abstract
Gastroenterology & Hepatology
Abdul Oseini, Stefano Toldo, Mulugeta Seneshaw, Divya P. Kumar, Prasanna K. Santhekadur, Hae-Ki Min, Eleonora Mezzaroma, Pierre Bedossa, A. Gabriele Mauro, Federico Quaini, Caterina Frati, Angela Falco, Srinivas Koduru, Bubu A. Banini, Faridoddin Mirshahi, Antonio Abbate, Oliver Rider, Mohammad Siddiqui, Arun J. Sanyal
Article
Surgery
Ashley N. Leberfinger, Dino J. Ravnic, Russell Payne, Elias Rizk, Srinivas V. Koduru, Sprague W. Hazard
CURRENT SURGERY REPORTS
(2017)
Review
Surgery
Dino J. Ravnic, Ashley N. Leberfinger, Srinivas V. Koduru, Monika Hospodiuk, Kazim K. Moncal, Pallab Datta, Madhuri Dey, Elias Rizk, Ibrahim T. Ozbolat
Meeting Abstract
Gastroenterology & Hepatology
Rebecca Caffrey, Jonathon Marioneaux, Pierre Bedossa, Binu Phillip, Suresh Giri, Mukul R. Jain, Deven V. Parmar, Srinivas V. Koduru, Madhavi M. Bhat, Andrea Vadillo, Marta Iruarrizaga-Lejarreta, Cristina Alonso, Arun J. Sanyal
Article
Oncology
Yuxin Liu, Swati Bhardwaj, Keith Sigel, John Winters, Joseph Terlizzi, Michael M. Gaisa
Summary: This study investigated the prevalence and severity of anal HPV disease among MSM LWH under the age of 35, finding a high prevalence of HPV infection and precancer but no cases of invasive anal cancer. This supports the adoption of age-based anal cancer screening for this population.
INTERNATIONAL JOURNAL OF CANCER
(2024)
Correction
Oncology
J. Gu, S. Xie, S. Wang
INTERNATIONAL JOURNAL OF CANCER
(2024)