Review
Oncology
Diana C. Simao, Kevin K. Zarrabi, Jose L. Mendes, Ricardo Luz, Jorge A. Garcia, William K. Kelly, Pedro C. Barata
Summary: Cancer treatments have changed with the introduction of immunotherapy, and new agents that redirect T-cells against cancer are rapidly emerging in multiple tumor types. However, the development of immunotherapy strategies remains a challenge in prostate cancer due to its heterogeneous and immune-suppressive tumor microenvironment.
Review
Oncology
Tanya B. Dorff, Vivek Narayan, Stephen J. Forman, Peter D. Zang, Joseph A. Fraietta, Carl H. June, Naomi B. Haas, Saul J. Priceman
Summary: Immunotherapy has not achieved long-lasting remissions in advanced prostate cancer patients. More potent T-cell redirecting strategies are needed to overcome the immunologically exclusive and suppressive tumor microenvironment. This review provides an in-depth perspective on the various immunotherapy strategies currently under clinical investigation for men with advanced prostate cancer.
CLINICAL CANCER RESEARCH
(2022)
Article
Parasitology
Nora E. Saleh, Samar M. Alhusseiny, Wafaa M. El-Zayady, Engy M. Aboelnaga, Wafaa N. El-beshbishi, Yasser M. Saleh, Hala S. Abou-ElWafa, Samar N. El-Beshbishi
Summary: Trichomonas vaginalis infection may be associated with prostate cancer, but the study did not find evidence to show that this sexually transmitted infection worsens the cancer condition. Only 8.3% of healthy controls were seropositive for trichomoniasis, compared with 19% of prostate cancer patients. Positive associations were found between PSA levels and tumor stage with T. vaginalis IgG optical density scores among the seropositive cases.
PARASITOLOGY RESEARCH
(2021)
Article
Biochemical Research Methods
Mengqi Zhang, F. Richard Guo
Summary: Single-cell sequencing has revolutionized the identification of differentially expressed genes (DEGs) by providing high resolution for heterogeneous cell tissues. However, current analysis mainly focuses on comparing different cell types within the same individual. This study proposes a nonparametric method called barycenter single-cell differential expression (BSDE) to identify DEGs in case-control studies. The method overcomes the limitations of parametric approaches and accurately detects differential expressions. It is demonstrated through simulations and real data analysis that BSDE can effectively identify cell type-specific DEGs. The availability of the R package and datasets further facilitate its application in research.
Article
Oncology
Robert J. Klein, Emily Vertosick, Dan Sjoberg, David Ulmert, Ann-Charlotte Ronn, Christel Haggstrom, Elin Thysell, Goran Hallmans, Anders Dahlin, Par Stattin, Olle Melander, Andrew Vickers, Hans Lilja
Summary: Polygenic risk scores (PRS) for prostate cancer incidence were evaluated and compared to PSA and a commercialized model in predicting lethal prostate cancer. The study found that PRS was associated with incident prostate cancer, but was not a stronger predictor of lethal disease compared to PSA. The combination of PRS and PSA did not contribute additional risk stratification for lethal prostate cancer.
NPJ PRECISION ONCOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Chen Xie, Pen-Jen Lin, Jijun Hao
Summary: PDE4D is highly expressed in chemo-resistant prostate cancer cells, and inhibiting PDE4D with Eggmanone effectively reduces invasion, proliferation, and induces cell death in these cells. Eggmanone also enhances docetaxel cytotoxicity and down-regulates CSC marker gene expression, attenuating sphere formation in chemo-resistant prostate cancer cells.
Review
Oncology
Samantha Gogola, Michael Rejzer, Hisham F. F. Bahmad, Ferial Alloush, Yumna Omarzai, Robert Poppiti
Summary: The standard of care therapy for early prostate cancer includes external beam radiation therapy, brachytherapy, radical prostatectomy, active surveillance, or a combination approach. Androgen deprivation therapy is considered for advanced disease. However, many patients eventually develop castration-resistant prostate cancer, leading to the development of targeted therapies, including prostate cancer stem cell-targeted therapies. In this review, the mechanisms of action of PCSC-targeted therapies are summarized and future development is discussed.
Review
Cell Biology
Chia-Chen Ku, Kenly Wuputra, Jia-Bin Pan, Chia-Pei Li, Chung-Jung Liu, Yi-Chang Liu, Shigeo Saito, Te-Fu Chan, Chang-Shen Lin, Deng-Chyang Wu, Kazunari K. Yokoyama
Summary: There is significant cellular diversity in the human stomach, providing valuable insights into cell plasticity in normal development and tumorigenesis. This article focuses on cancer stem cells and their derived 3D organoids in culture, emphasizing the formation of stem cell niches. The role of H. p. infection and the specific markers of stomach-cancer-derived organoids induced by H. p. are also discussed.
Article
Gastroenterology & Hepatology
Jung Hyun Kwak, Chang Soo Eun, Dong Soo Han, Yong Sung Kim, Kyu Sang Song, Bo Youl Choi, Hyun Ja Kim
Summary: This study found that there is a sex-specific association between MAP3K1 gene polymorphisms and gastric cancer risk. Men carrying the risk allele of MAP3K1 have a significantly increased risk of gastric cancer. Additionally, the association between MAP3K1 gene polymorphisms and gastric cancer risk is modified by soy product intake.
BMC GASTROENTEROLOGY
(2022)
Article
Biochemistry & Molecular Biology
Jian Xiao, Kuan Shen, Kanghui Liu, Yuanhang Wang, Hao Fan, Quan Cheng, Xinyi Zhou, Li Hu, Gang Wang, Zekuan Xu, Li Yang
Summary: This study found that high BMI significantly increases the risk of lymph node metastasis (LNM) in gastric cancer (GC) and promotes lipid accumulation in LNM. Increased low-density lipoprotein cholesterol is a risk factor in females. Functional enrichment analysis reveals a connection between lipid metabolism and LNM.
LIPIDS IN HEALTH AND DISEASE
(2022)
Article
Oncology
Vishwajeet Singh, Amit Kumar Madeshiya, Nasreen Ghazi Ansari, Mukul Kumar Singh, Amar Abhishek
Summary: This study found an association between heavy metal toxicity (lead and cadmium) and an increased risk of benign prostatic hyperplasia (BPH) and prostate cancer (CaP). Additionally, individuals with heavy metal toxicity in BPH have a high-risk genetic susceptibility to the CYP1A1 gene in the north Indian population.
UROLOGIC ONCOLOGY-SEMINARS AND ORIGINAL INVESTIGATIONS
(2023)
Article
Oncology
Santosh Gupta, Susan Halabi, Qian Yang, Akash Roy, Alisa Tubbs, Yamini Gore, Daniel J. George, David M. Nanus, Emmanuel S. Antonarakis, Daniel C. Danila, Russell Z. Szmulewitz, Richard Wenstrup, Andrew J. Armstrong
Summary: PSMA-targeted radioligand therapy has significantly improved clinical outcomes in men with mCRPC. A liquid biopsy characterizing PSMA expression could be useful in guiding optimal therapy.
CLINICAL CANCER RESEARCH
(2023)
Article
Oncology
Idris Olasunmbo Ola, Kirsi Talala, Teuvo Tammela, Kimmo Taari, Teemu Murtola, Paula Kujala, Jani Raitanen, Anssi Auvinen
Summary: PSA-based screening can reduce prostate cancer mortality, but may also lead to overdetection of low-risk disease. The incidence of prostate cancer is associated with PSA levels, with higher PSA values indicating an increased risk of aggressive disease. Risk stratification and appropriate rescreening intervals can help reduce overdetection.
INTERNATIONAL JOURNAL OF CANCER
(2023)
Article
Oncology
Ngoc-Lan Thi Nguyen, Ngoc-Dzung Thi Dang, Quang-Huy Dang, Van-Chuc Tran, Hoang-Long Vo, Masamitsu Yamaguchi, Thanh-Van Ta
Summary: The study found that the polymorphisms of Mucin 1 gene, specifically rs4072037 and rs2070803, are associated with gastric cancer risk, with the AA genotype potentially increasing risk while the AG genotype may lower it. Combining factors such as age, gender, alcoholism, and personal history of gastric disease significantly elevate the risk of gastric cancer.
FRONTIERS IN ONCOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Ashutosh S. Yende, Emily C. Williams, Andrew Pletcher, Alexandra Helfand, Helen Ibeawuchi, Tanya M. North, Patricia S. Latham, Anelia Horvath, Maho Shibata
Summary: TRIM28 is found to be significantly upregulated in high-grade and metastatic prostate cancers. Through a genetically-engineered mouse model, scientists discovered that TRIM28 plays an important role in the progression of prostate cancer. Despite a reduction in luminal cells resembling proximal luminal lineage cells, the mouse prostates still evolved into invasive prostate carcinoma with a shorter overall survival.
Article
Oncology
Yuriko N. Koyanagi, Isao Oze, Yumiko Kasugai, Yukino Kawakatsu, Yukari Taniyama, Kazuo Hara, Yasuhiro Shimizu, Issei Imoto, Hidemi Ito, Keitaro Matsuo
Summary: A functional variant on ALDH2 rs671 (G>A) protects against alcohol-induced carcinogenesis by decreasing alcohol consumption, but also contributes to the accumulation of carcinogens, resulting in a direct carcinogenic effect. This study quantified the opposing effects of the rs671 A allele on pancreatic cancer risk and explored the impact of the rs671 A allele and alcohol consumption on pancreatic carcinogenesis. The results showed that alcohol consumption was associated with an increased risk of pancreatic cancer, but the effect did not vary by genotype. This study supports the association between alcohol consumption and pancreatic cancer risk and suggests the potential contribution of the rs671 A allele to pancreatic carcinogenesis through impaired metabolism.
Article
Peripheral Vascular Disease
Shohei Chatani, Ryota Tsukii, Kyohei Nagasawa, Takaaki Hasegawa, Shinichi Murata, Mina Kato, Hidekazu Yamaura, Hiroaki Onaya, Keitaro Matsuo, Yoshiyuki Watanabe, Yoshitaka Inaba
Summary: This study investigated the difficulty in removing totally implantable venous access devices (TIVADs) and identified associated risk factors. Interventional radiology (IR) approaches for difficult removal were also explored. The results showed that indwelling duration and subcutaneous leakage of fluid were significant risk factors for difficult removal. IR techniques were found to be minimally invasive and useful in some cases.
JOURNAL OF VASCULAR ACCESS
(2023)
Article
Oncology
Xiang Shu, Zhishan Chen, Jirong Long, Xingyi Guo, Yaohua Yang, Conghui Qu, Yoon-Ok Ahn, Qiuyin Cai, Graham Casey, Stephen B. Gruber, Jeroen R. Huyghe, Sun Ha Jee, Mark A. Jenkins, Wei-Hua Jia, Keum Ji Jung, Yoichiro Kamatani, Dong-Hyun Kim, Jeongseon Kim, Sun-Seog Kweon, Loic Le Marchand, Koichi Matsuda, Keitaro Matsuo, Polly A. Newcomb, Jae Hwan Oh, Jennifer Ose, Isao Oze, Rish K. Pai, Zhi-Zhong Pan, Paul D. P. Pharoah, Mary C. Playdon, Ze-Fang Ren, Robert E. Schoen, Aesun Shin, Min-Ho Shin, Xiao-Ou Shu, Xiaohui Sun, Catherine M. Tangen, Chizu Tanikawa, Cornelia M. Ulrich, Franzel J. B. van Duijnhoven, Bethany Van Guelpen, Alicja Wolk, Michael O. Woods, Anna H. Wu, Ulrike Peters, Wei Zheng
Summary: This study identified potential novel risk biomarkers for colorectal cancer by integrating genetics and circulating metabolomics data. The results highlight the importance of lipids, especially certain glycerophospholipids and triacylglycerols, in the etiology of colorectal cancer.
CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION
(2022)
Article
Dentistry, Oral Surgery & Medicine
Neerav Goyal, Max Hennessy, Erik Lehman, Wenxue Lin, Antonio Agudo, Wolfgang Ahrens, Stefania Boccia, Paul Brennan, Hermann Brenner, Gabriella Cadoni, Cristina Canova, Chu Chen, David Conway, Maria Paula Curado, Luigino Dal Maso, Alexander W. Daudt, Valeria Edefonti, Eleonora Fabianova, Leticia Fernandez, Silvia Franceschi, Werner Garavello, Maura Gillison, Richard B. Hayes, Claire Healy, Rolando Herrero, Ivana Holcatova, Jossy L. Kanda, Karl Kelsey, Bo T. Hansen, Rosalina Koifman, Pagona Lagiou, Carlo La Vecchia, Fabio Levi, Guojun Li, Jolanta Lissowska, Rossana Mendoza Lopez, Daniele Luce, Gary Macfarlane, Dana Mates, Keitaro Matsuo, Michael McClean, Ana Menezes, Gwenn Menvielle, Hal Morgenstern, Kirsten Moysich, Eva Negri, Andrew F. Olshan, Tamas Pandics, Jerry Polesel, Mark Purdue, Loredana Radoi, Heribert Ramroth, Lorenzo Richiardi, Stimson Schantz, Stephen M. Schwartz, Diego Serraino, Oxana Shangina, Elaine Smith, Erich M. Sturgis, Beata Swiatkowska, Peter Thomson, Thomas L. Vaughan, Marta Vilensky, Deborah M. Winn, Victor Wunsch-Filho, Guo-Pei Yu, Jose P. Zevallos, Zuo-Feng Zhang, Tongzhang Zheng, Ariana Znaor, Paolo Boffetta, Mia Hashibe, Yuan-Chin A. Lee, Joshua E. Muscat
Summary: This study analyzed the relationship between cigarette smoking, alcohol consumption, and head and neck cancer risk factors in less developed and more developed countries. The results showed that the duration of smoking and alcohol consumption had different effects on the risk of specific cancer sites depending on the country's level of development. These findings suggest that the degree of industrialization and economic development affects the relationship between smoking, alcohol, and head and neck cancer.
Article
Ophthalmology
Akiko Hanyuda, Atsushi Goto, Masahiro Nakatochi, Yoichi Sutoh, Akira Narita, Shiori Nakano, Ryoko Katagiri, Kenji Wakai, Naoyuki Takashima, Teruhide Koyama, Kokichi Arisawa, Issei Imoto, Yukihide Momozawa, Kozo Tanno, Atsushi Shimizu, Atsushi Hozawa, Kengo Kinoshita, Taiki Yamaji, Norie Sawada, Masao Iwagami, Kenya Yuki, Kazuo Tsubota, Kazuno Negishi, Keitaro Matsuo, Masayuki Yamamoto, Makoto Sasaki, Shoichiro Tsugane, Motoki Iwasaki
Summary: This study conducted a Mendelian randomization analysis to assess the causal association between genetically predicted glycemic traits and the risk of primary open-angle glaucoma (POAG). The results did not provide strong evidence to support the association between genetically predicted glycemic traits and POAG in the Japanese population.
AMERICAN JOURNAL OF OPHTHALMOLOGY
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Takaaki Hasegawa, Haruyuki Takaki, Hiroshi Kodama, Keitaro Matsuo, Takashi Yamanaka, Atsuhiro Nakatsuka, Motoshi Takao, Hideo Gobara, Sadao Hayashi, Yoshitaka Inaba, Koichiro Yamakado
Summary: The purpose of this study was to explore the impact of ablative margin depicted by CT immediately after RF ablation on reducing LTP for CRC lung metastases. A retrospective study was conducted on 70 patients who underwent RF ablation for CRC lung metastases. The results indicated that an ablative margin of at least 2 mm is important to reduce LTP after RF ablation for CRC lung metastases.
JOURNAL OF VASCULAR AND INTERVENTIONAL RADIOLOGY
(2023)
Letter
Rheumatology
Yu Toyoda, Masahiro Nakatochi, Akiyoshi Nakayama, Yusuke Kawamura, Hirofumi Nakaoka, Kenji Wakai, Keitaro Matsuo, Hirotaka Matsuo
Article
Rheumatology
Ai Yaku, Yuki Ishikawa, Takeshi Iwasaki, Ryosuke Hiwa, Keitaro Matsuo, Hiroh Saji, Kimiko Yurugi, Yasuo Miura, Moritoshi Furu, Hiromu Ito, Takao Fujii, Taira Maekawa, Motomu Hashimoto, Koichiro Ohmura, Tsuneyo Mimori, Chikashi Terao
Summary: Objective HLA-DRB1 alleles, particularly the shared epitope (SE) alleles, are strongly associated with RA. Different genetic structures underlie the production of the various autoantibodies in RA. However, the genetic architecture underlying IgG-RF, which is associated with rheumatoid vasculitis, is not well understood.
Article
Oncology
Yukari Taniyama, Isao Oze, Yuriko N. Koyanagi, Yukino Kawakatsu, Yuri Ito, Tomohiro Matsuda, Keitaro Matsuo, Tetsuya Mitsudomi, Hidemi Ito
Summary: Introduction of EGFR-TKIs and EGFR mutation testing has led to improved survival in NSCLC patients, particularly in women with adenocarcinoma and at advanced stages.
Article
Oncology
Zhuxuan Fu, Maria Mori Brooks, Sarah Irvin, Susan Jordan, Katja K. H. Aben, Hoda Anton-Culver, Elisa Bandera, Matthias W. Beckmann, Andrew Berchuck, Angela Brooks-Wilson, Jenny Chang-Claude, Linda S. Cook, Daniel W. Cramer, Kara L. Cushing-Haugen, Jennifer A. Doherty, Arif B. Ekici, Peter A. Fasching, Renee T. Fortner, Simon A. Gayther, Aleksandra Gentry-Maharaj, Graham G. Giles, Ellen L. Goode, Marc T. Goodman, Holly R. Harris, Alexander Hein, Rudolf Kaaks, Lambertus A. Kiemeney, Martin Koebel, Joanne Kotsopoulos, Nhu D. Le, Alice W. Lee, Keitaro Matsuo, Valerie McGuire, John R. McLaughlin, Usha Menon, Roger L. Milne, Kirsten B. Moysich, Celeste Leigh Pearce, Malcolm C. Pike, Bo Qin, Susan J. Ramus, Marjorie J. Riggan, Joseph H. Rothstein, Joellen M. Schildkraut, Weiva Sieh, Rebecca Sutphen, Kathryn L. Terry, Pamela J. Thompson, Linda Titus, Anne M. van Altena, Emily White, Alice S. Whittemore, Anna H. Wu, Wei Zheng, Argyrios Ziogas, Sarah E. Taylor, Lu Tang, Thomas Songer, Nicolas Wentzensen, Penelope M. Webb, Harvey A. Risch, Francesmary Modugno
Summary: The lifetime ovulatory years (LOY) are positively associated with nonmucinous epithelial ovarian cancer (EOC) risk, implicating factors beyond ovulation in the development of EOC. The protective effects of parity and oral contraceptive use may not solely depend on anovulation.
JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE
(2023)
Article
Oncology
Tomoharu Mori, Yusuke Okamoto, Anfeng Mu, Yoshimi Ide, Akiyo Yoshimura, Noriko Senda, Yukiko Inagaki-Kawata, Masahiro Kawashima, Hiroyuki Kitao, Eriko Tokunaga, Yasuo Miyoshi, Shozo Ohsumi, Koichiro Tsugawa, Tomohiko Ohta, Toyomasa Katagiri, Shigeru Ohtsuru, Kaoru Koike, Seishi Ogawa, Masakazu Toi, Hiroji Iwata, Seigo Nakamura, Keitaro Matsuo, Minoru Takata
Summary: The ALDH2 enzyme's ability to break down aldehydes is impaired by a specific gene polymorphism, leading to alcohol flushing and an increased risk of esophageal cancer in East Asians. Recent studies suggest that this gene variant may result in higher levels of DNA damage caused by naturally occurring aldehydes. However, in breast epithelial cells, this loss of function does not appear to have an impact on the initiation and development of cancer.
Article
Oncology
Yuriko Koyanagi, Keitaro Matsuo, Hidemi Ito, Chaochen Wang, Akiko Tamakoshi, Yumi Sugawara, Ichiro Tsuji, Ayami Ono, Shoichiro Tsugane, Norie Sawada, Keiko Wada, Chisato Nagata, Taro Takeuchi, Tetsuhisa Kitamura, Mai Utada, Ritsu Sakata, Tetsuya Mizoue, Sarah Krull Abe, Manami Inoue
Summary: The effect of body mass index (BMI) on esophageal and gastric carcinogenesis varies depending on subtype or subsite. In this study, a pooled analysis of 10 population-based cohort studies in Japan, we observed an inverse association between BMI and esophageal squamous cell carcinoma, but a positive association with gastric cardia cancer. Additionally, a positive association was found for overweight or obese individuals with esophageal adenocarcinoma and gastric cardia cancer. The study highlights the subtype- or subsite-specific impact of BMI on upper gastrointestinal cancer in the Japanese population.
Article
Oncology
Yoshiaki Usui, Hidemi Ito, Kota Katanoda, Tomohiro Matsuda, Yoshinobu Maeda, Keitaro Matsuo
Summary: The introduction of rituximab has led to a decline in mortality rates of non-Hodgkin lymphoma in both Japan and the United States, despite an increase in incidence. However, the trends in mortality rates have differed between the two countries, with the mortality rate declining continuously in the United States but stopping in Japan.
Article
Multidisciplinary Sciences
Yasushi Kojima, Emi Mishiro-Sato, Teruaki Fujishita, Kiyotoshi Satoh, Rie Kajino-Sakamoto, Isao Oze, Kazuki Nozawa, Yukiya Narita, Takatsugu Ogata, Keitaro Matsuo, Kei Muro, Makoto Mark Taketo, Tomoyoshi Soga, Masahiro Aoki
Summary: Cancer cachexia is a metabolic disorder characterized by a decrease in B vitamin-related liver enzymes. The relationship between enzymes and their associated metabolites may depend on protein abundance and cofactor subtype. These metabolic/proteomic changes can be utilized for the diagnosis of cancer cachexia through blood samples.
NATURE COMMUNICATIONS
(2023)
Article
Oncology
Michi Sawabe, Daisuke Kawakita, Isao Oze, Shinichi Iwasaki, Yasuhisa Hasegawa, Shingo Murakami, Hidemi Ito, Nobuhiro Hanai, Keitaro Matsuo
Summary: This study is the first to suggest an association between prediagnostic folate intake and head and neck squamous cell carcinoma (HNSCC) survival that differs based on fluorouracil (FU)-containing chemotherapy. In the FU-containing chemotherapy group, higher folate intake is associated with better overall survival, while no clear association is observed in the non-FU-containing chemotherapy group. This finding indicates that the folate status affects the heterogeneity of one-carbon metabolism in HNSCC.
