Review
Chemistry, Multidisciplinary
Yusra Habib Khan, Ambreen Malik Uttra, Sumera Qasim, Tauqeer Hussain Mallhi, Nasser Hadal Alotaibi, Maria Rasheed, Abdulaziz Ibrahim Alzarea, Muhammad Shahid Iqbal, Nabil Khulaif Alruwaili, Salah-Ud-Din Khan, Abdullah Salah Alanazi
Summary: Breast cancer, estimated as one of the most prevalent malignancies globally, poses a significant healthcare burden with incident cases on the rise. Matrix metalloproteinases (MMPs) play a crucial role in breast carcinogenesis through various mechanisms, and phytochemicals have the potential to combat MMPs-induced breast cancer. The current systematic review focuses on natural lead molecules that can deter MMPs-provoked breast cancer, aiming to address limitations, challenges, and future directions in using these compounds for the management of the disease.
FRONTIERS IN CHEMISTRY
(2021)
Review
Oncology
Mi Jeong Kwon
Summary: Matrix metalloproteinases (MMPs) are key proteinases in tumorigenesis, initially recognized for their role in remodeling the extracellular matrix. However, accumulating evidence suggests that some MMPs have protective roles in cancer progression, and their effects can vary depending on cell type and cancer stage. MMPs are also involved in cancer progression through cell signaling and immune regulation, independent of their proteolytic activity. This review summarizes the current understanding of tumoral or stromal MMPs in breast cancer and discusses recent advances in the development of highly selective MMP inhibitors.
FRONTIERS IN ONCOLOGY
(2023)
Article
Oncology
Megan Brasher, Shawn C. Chafe, Paul C. McDonald, Oksana Nemirovsky, Genya Gorshtein, Zachary J. Gerbec, Wells S. Brown, Olivia R. Grafinger, Matthew Marchment, Esther Matus, Shoukat Dedhar, Marc G. Coppolino
Summary: This study demonstrates that disrupting the interaction between Stx4 and Munc18c can dramatically alter the progression of tumor metastasis, suggesting it as a potential therapeutic target.
MOLECULAR CANCER RESEARCH
(2022)
Review
Biochemistry & Molecular Biology
Katerina Strouhalova, Ondrej Tolde, Daniel Rosel, Jan Brabek
Summary: MT1-MMP (MMP-14) is a versatile protease involved in regulating extracellular matrix degradation, activation of other proteases, as well as various cellular processes such as migration and viability in both physiological and pathological conditions. The cytoplasmic tail of MT1-MMP, consisting of the final 20 C-terminal amino acids, plays a crucial role in determining its localization, signal transduction capabilities, and interaction with other proteins. This review summarizes the involvement of the cytoplasmic tail in regulating and executing the functions of MT1-MMP, providing insights into cellular adhesion and invasion mechanisms.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Luis Placido, Yair Romero, Mariel Maldonado, Fernanda Toscano-Marquez, Remedios Ramirez, Jazmin Calyeca, Ana L. Mora, Moises Selman, Annie Pardo
Summary: This study explored the role of MMP14 in idiopathic pulmonary fibrosis (IPF) and found that its deficiency exacerbates fibrotic injury and affects repair, possibly through its anti-senescent activity. Increased MMP14 in IPF may represent an anti-fibrotic mechanism overwhelmed by the strong profibrotic microenvironment of the disease.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Deanna Maybee, Nicole L. Ink, Mohammad A. M. Ali
Summary: This review article discusses the subcellular localization and intracellular roles of matrix metalloproteinases (MMPs), focusing on membrane-type-1 matrix metalloproteinase (MT1-MMP) and matrix metalloproteinase-2 (MMP-2). The article highlights the diverse subcellular localizations of these enzymes and their involvement in cell migration, gene expression, and tumor migration and invasion. The authors suggest that targeting nuclear MT1-MMP or MMP-2 may lead to the development of new therapies for cancer and other diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Multidisciplinary Sciences
Xuanming Guo, Jianli Cao, Jian-Piao Cai, Jiayan Wu, Jiangang Huang, Pallavi Asthana, Sheung Kin Ken Wong, Zi-Wei Ye, Susma Gurung, Yijing Zhang, Sheng Wang, Zening Wang, Xin Ge, Hiu Yee Kwan, Aiping Lyu, Kui Ming Chan, Nathalie Wong, Jiandong Huang, Zhongjun Zhou, Zhao-Xiang Bian, Shuofeng Yuan, Hoi Leong Xavier Wong
Summary: The study identifies MT1-MMP as a critical host protease for solACE2-mediated SARS-CoV-2 infection. SARS-CoV-2 infection leads to increased activation of MT1-MMP that is colocalized with ACE2 in human lung epithelium. MT1-MMP directly cleaves ACE2 to release solACE2, thus facilitating cell entry of SARS-CoV-2.
NATURE COMMUNICATIONS
(2022)
Article
Chemistry, Analytical
Yuhong Duan, Lu Xu, Wenyu Song, Hui Gao, Lina Sun, Fangfang Chen, Fen Ma
Summary: In this study, an electrogenerated chemiluminescence (ECL) biosensor based on heterodimerization interaction between CD44 and PEX-14 was developed for highly sensitive quantification of CD44. The biosensor exhibited excellent sensitivity and a wide linear range, making it suitable for detecting CD44 expression in living cells.
MICROCHEMICAL JOURNAL
(2022)
Article
Cell Biology
Olivia R. Grafinger, Genya Gorshtein, Tyler Stirling, Jennifer Geddes-McAlister, Marc G. Coppolino
Summary: Integrin signaling is crucial for the establishment of focal adhesions and invadopodia formation in malignant cancer cells, promoting tumor cell invasion and metastasis through localized adhesion and degradation of the ECM. Inhibition of 81 integrin hinders the internalization and recycling of MT1-MMP, ultimately leading to a loss of invasive behavior.
CELLULAR SIGNALLING
(2021)
Article
Biology
Maren Hulsemann, Colline Sanchez, Polina V. Verkhusha, Vera Des Marais, Serena P. H. Mao, Sara K. Donnelly, Jeffrey E. Segall, Louis Hodgson
Summary: The study reveals that TC10 GTPase regulates MT1-MMP at invadopodia during breast cancer metastasis, with its activity and function modulated by p190RhoGAP and Exo70.
COMMUNICATIONS BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Anna M. M. Knapinska, Gary Drotleff, Cedric Chai, Destiny Twohill, Alexa Ernce, Dorota Tokmina-Roszyk, Isabella Grande, Michelle Rodriguez, Brad Larson, Gregg B. B. Fields
Summary: In this study, we used a fluorescent substrate, membrane type 1 matrix metalloproteinase (MT1-MMP), and collagen embedded tumor spheroids to quantify MT1-MMP activity. The results showed that MT1-MMP activity was closely correlated with glioma spheroid invasion. The application of MT1-MMP inhibitors reduced proteolytic activity and glioma spheroid invasion. The presence of MT1-MMP in glioma spheroids was confirmed. Thus, invasion was dependent on MT1-MMP activity, and inhibitors of MT1-MMP and invasion could be conveniently screened.
Article
Biochemistry & Molecular Biology
Catalina Lodillinsky, Laetitia Fuhrmann, Marie Irondelle, Olena Pylypenko, Xiao-Yan Li, Helene Bonsang-Kitzis, Fabien Reyal, Sophie Vacher, Claire Calmel, Olivier De Wever, Ivan Bieche, Marie-Lise Lacombe, Ana Maria Eijan, Anne Houdusse, Anne Vincent-Salomon, Stephen J. Weiss, Philippe Chavrier, Mathieu Boissan
Summary: The study reveals that NME1 plays a crucial role in the in situ-to-invasive transition of breast cancer, showing a negative correlation with MT1-MMP and impacting the invasive potential of breast cancer cells.
Article
Pharmacology & Pharmacy
Yen-Chang Chen, Jia-Hong Chen, Cheng-Fang Tsai, Chen-Teng Wu, Miao-Hsiang Wu, Pei-Chun Chang, Wei-Lan Yeh
Summary: The study found that nicardipine can inhibit the migration and colony formation of breast cancer cells, and increase the expression of Nrf2 and HO-1. The reduction of matrix metalloproteinase-9 by nicardipine is regulated by Nrf2/HO-1 axis and its catalytic end products.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Oncology
Noam Cohen, Dhanashree Mundhe, Sarah K. Deasy, Omer Adler, Nour Ershaid, Tamar Shami, Oshrat Levi-Galibov, Rina Wassermann, Ruth Scherz-Shouval, Neta Erez
Summary: Metastatic cancer is difficult to cure and is the main cause of cancer-related deaths. In this study, the researchers found that cancer-associated fibroblasts play a crucial role in creating a favorable microenvironment for metastasis by mediating inflammation. They also discovered that a protein called Activin A is secreted from breast tumors and promotes fibrosis in the lung, which enhances metastasis. This new mechanism could potentially be targeted for therapeutic intervention to inhibit metastatic relapse.
Article
Cell Biology
Tomoko Matsuzaki, Douglas R. Keene, Emi Nishimoto, Makoto Noda
Summary: The study suggests that RECK, ADAMTS10, and MT1-MMP cooperate to support the formation of robust FBN1 fibers by regulating proteolytic activity and morphology, despite their initially perceived opposing functions.
JOURNAL OF CELLULAR PHYSIOLOGY
(2021)