Article
Multidisciplinary Sciences
Joshua Southern, Guadalupe Gonzalez, Pia Borgas, Liam Poynter, Ivan Laponogov, Yoyo Zhong, Reza Mirnezami, Dennis Veselkov, Michael Bronstein, Kirill Veselkov
Summary: This study utilizes machine learning to explore the space of bioactive molecules in food, identifying potential modulators that can improve radiotherapy outcomes. It provides phytochemically-enriched recipes that encapsulate the benefits of discovered radiotherapy modulators. Through genomic-driven network machine learning and domain knowledge, potential radioresponse modulators were identified.
SCIENTIFIC REPORTS
(2023)
Article
Oncology
J. M. van Rees, S. Nordkamp, P. W. Harmsen, H. Rutten, J. W. A. Burger, C. Verhoef
Summary: This study aimed to investigate the impact of distant metastases on oncological outcomes in patients with locally recurrent rectal cancer (LRRC) undergoing curative treatment. The study found that LRRC patients with synchronous distant metastases undergoing curative surgery have relatively poor prognosis, but LRRC patients with a history of distant metastases diagnosed nearby the primary tumor have comparable oncological survival as LRRC patients without distant metastases.
Article
Oncology
Francesca De Felice, Vincenzo Tombolini, Enrico Cortesi
Summary: Locally advanced rectal cancer requires a multidisciplinary management involving neoadjuvant radiotherapy, conservative surgery, and chemotherapy. Recent studies have examined the potential benefits of altering the sequencing or intensity of the standard trimodal therapy components, with a focus on the clinical significance of total neoadjuvant treatment. More long-term results and prospective studies are needed to accurately determine the clinical benefits and establish the role of total neoadjuvant therapy in locally advanced rectal cancer.
TRANSLATIONAL ONCOLOGY
(2021)
Review
Oncology
Ioannis M. Koukourakis, Vassilis Kouloulias, Dina Tiniakos, Ioannis Georgakopoulos, Anna Zygogianni
Summary: Rectal cancer treatment has advanced over the years, with surgery initially being the primary method. The addition of radiation and chemotherapy has improved postoperative treatments. Trials have shown the efficacy of neoadjuvant radiation or chemoradiotherapy, making them the standard choice for advanced cases. Total neoadjuvant therapy, delivering the entire course of treatment before surgery, has also shown promise. While targeted therapies have not shown benefit, immunotherapy may be effective in rectal carcinomas with mismatch-repair deficiency. This review provides a critical overview of significant randomized trials and discusses future trends in treatment.
CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY
(2023)
Article
Oncology
Shouki Bazarbashi, Mahmoud A. Elshenawy, Ahmed Badran, Ali Aljubran, Ahmed Alzahrani, Hadeel Almanea, Abdullah Alsuhaibani, Ahmed Alashwah, Mohamed Neimatallah, Alaa Abduljabbar, Luai Ashari, Samar Alhomoud, Hazem Ghebeh, Tusneem Elhassan, Nasser Alsanea, Mohammed Mohiuddin
Summary: The efficacy and toxicity of preoperative concurrent infusional gemcitabine and radiotherapy in locally advanced rectal cancer were tested in this study. The results showed that this treatment achieved an encouraging degree of local control with manageable toxicity.
Article
Surgery
Stefi Nordkamp, Eva L. K. Voogt, Desley M. G. van Zoggel, Anna Martling, Torbjorn Holm, Gabriella Jansson Palmer, Chikako Suzuki, Joost Nederend, Miranda Kusters, Jacobus W. A. Burger, Harm J. T. Rutten, Henrik Iversen
Summary: No standard of care has been defined in the treatment of locally recurrent rectal cancer due to its heterogeneous nature, low incidence, and varied treatment options. This study compared data from two tertiary hospitals and found that aiming for wide resection margins increased the R0 resection rate and local re-recurrence-free survival. Neoadjuvant full-course chemoradiotherapy improved survival, while reirradiation showed no benefit.
BRITISH JOURNAL OF SURGERY
(2022)
Article
Medicine, General & Internal
Takashi Akiyoshi, Eiji Shinozaki, Senzo Taguchi, Akiko Chino, Makiko Hiratsuka, Tetsuro Tominaga, Takashi Nonaka, Shigeo Toda, Shuichiro Matoba, Shimpei Matsui, Koji Okabayashi, Toshiki Mukai, Yukiharu Hiyoshi, Tomohiro Yamaguchi, Toshiya Nagasaki, Kensei Yamaguchi, Masashi Ueno, Hiroya Kuroyanagi, Yosuke Fukunaga, Naoki Ishizuka, Tsuyoshi Konishi
Summary: This study aims to compare two total neoadjuvant therapy regimens for locally advanced rectal cancer (LARC) and select the more optimal regimen for patients. The study will recruit 66 patients and evaluate the efficacy, safety, and quality of life of the treatment.
Article
Oncology
Chuan-Yin Fang, Hsuan-Yu Chen, Hsin-Yi Yang, Yuk-Wah Tsang, Cheng-Yen Lee, Chih-Chia Chang, I-Chen Lin, Yun-Jhong Huang, Chun-Ting Chu, Yu-Wen Wang
Summary: This study found that the combination of intensity-modulated radiotherapy (IMRT) with chemotherapy (CTx) does not provide significant advantages in terms of locoregional recurrence-free survival (LRRFS) for patients with proximal pT3N0 rectal cancer, unless there are high-risk scenarios or perforation involved.
Article
Oncology
Anais Bordron, Emmanuel Rio, Bogdan Badic, Omar Miranda, Olivier Pradier, Mathieu Hatt, Dimitris Visvikis, Francois Lucia, Ulrike Schick, Vincent Bourbonne
Summary: Developing a radiomics model based on MRI and CE-CT using a neural network approach, this study aimed to predict pCR in LARC patients undergoing neoadjuvant treatment. By identifying the most predictive features and validating on datasets from two separate institutions, it was found that adding radiomic features improves the prediction accuracy for pCR.
Review
Medicine, General & Internal
Lili Zhu, Mojin Wang, Na Chen, Yujie Zhang, Tao Xu, Wen Zhuang, Shuomeng Xiao, Lei Dai
Summary: miRNAs play important roles in signaling pathways related to apoptosis, autophagy, the cell cycle, DNA damage repair, proliferation, and metastasis during radiotherapy in patients with rectal cancer, and may serve as potential radiotherapeutic biomarkers for rectal cancer.
CHINESE MEDICAL JOURNAL
(2022)
Article
Oncology
Esmee A. Dijkstra, Veronique E. M. Mul, Patrick H. J. Hemmer, Klaas Havenga, Geke A. P. Hospers, Christina T. Muijs, Boudewijn van Etten
Summary: The study evaluates toxicity and oncological outcomes after re-irradiation in patients with locally advanced recurrent rectal cancer (RRC) and finds that re-irradiation is comparable to long-course CRT regarding toxicity and oncological outcomes. Patients in the long-course CRT group reported more skin toxicity after radiotherapy.
ANNALS OF SURGICAL ONCOLOGY
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Xiaofeng Jiang, Hengyu Zhao, Oliver Lester Saldanha, Sven Nebelung, Christiane Kuhl, Iakovos Amygdalos, Sven Arke Lang, Xiaojian Wu, Xiaochun Meng, Daniel Truhn, Jakob Nikolas Kather, Jia Ke
Summary: A deep learning model based on preoperative MRI scans was developed and validated to predict survival in patients with rectal cancer.
Review
Gastroenterology & Hepatology
Francesca De Felice, Daniele Crocetti, Niccolo Petrucciani, Liliana Belgioia, Paolo Sapienza, Nadia Bulzonetti, Francesco Marampon, Daniela Musio, Vincenzo Tombolini
Summary: The study found that the United States is the main contributor to research on locally advanced rectal cancer treatment, with neoadjuvant treatment being the most highly cited topic and new keywords appearing in the past two years. The quantity of publications since 2000 has shown a growing research field.
THERAPEUTIC ADVANCES IN GASTROENTEROLOGY
(2021)
Article
Oncology
Kevin Biju, George Q. Zhang, Miloslawa Stem, Rebecca Sahyoun, Bashar Safar, Chady Atallah, Jonathan E. Efron, Ashwani Rajput
Summary: The study found that a greater degree of care coordination within the same facility is associated with better overall survival in patients with rectal cancer. This highlights the importance of interdisciplinary collaboration in multimodal rectal cancer therapy.
CLINICAL COLORECTAL CANCER
(2021)
Article
Medicine, General & Internal
Deborah Schrag, Qian Shi, Martin R. Weiser, Marc J. Gollub, Leonard B. Saltz, Benjamin L. Musher, Joel Goldberg, Tareq Al Baghdadi, Karyn A. Goodman, Robert R. McWilliams, Jeffrey M. Farma, Thomas J. George, Hagen F. Kennecke, Ardaman Shergill, Michael Montemurro, Garth D. Nelson, Brian Colgrove, Vallerie Gordon, Alan P. Venook, Eileen M. O'Reilly, Jeffrey A. Meyerhardt, Amylou C. Dueck, Ethan Basch, George J. Chang, Harvey J. Mamon
Summary: Preoperative FOLFOX chemotherapy is as effective as preoperative chemoradiotherapy for locally advanced rectal cancer eligible for sphincter-sparing surgery.
NEW ENGLAND JOURNAL OF MEDICINE
(2023)
Article
Pharmacology & Pharmacy
Ragna M. S. Haegebaert, Maxime Kempers, Wim Ceelen, Ine Lentacker, Katrien Remaut
Summary: Colorectal cancer accounts for 10% of global cancer cases, and conventional treatment has limited success. The use of TLR agonists to stimulate the innate immune system for CRC treatment is challenging, as specific cell targeting and side effects need to be considered. Nanoparticle delivery systems show promise in addressing these challenges, and this review discusses the recent advances in nanoparticle formulations containing TLR agonists.
EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS
(2022)
Review
Oncology
Yong Xiang Gwee, Daryl Kai Ann Chia, Jimmy So, Wim Ceelen, Wei Peng Yong, Patrick Tan, Chin-Ann Johnny Ong, Raghav Sundar
Summary: Peritoneal metastasis is a common occurrence in advanced gastric cancer and is associated with a poor prognosis. Traditional systemic therapy is often ineffective in treating this specific disease state. Recent studies and clinical trials have focused on understanding the biology of peritoneal metastasis and identifying potential molecular targets. Peritoneal-specific clinical trials are being designed to combine local and systemic therapy for a more effective treatment approach.
JOURNAL OF CLINICAL ONCOLOGY
(2022)
Article
Surgery
Frederic Mercier, Guillaume Passot, Pierre-Emmanuel Bonnot, Peter Cashin, Wim Ceelen, Evelyne Decullier, Laurent Villeneuve, Thomas Walter, Edward A. Levine, Olivier Glehen
Summary: Cytoreductive surgery (CRS) and hyperthermic intra peritoneal chemotherapy (HIPEC) may increase long-term survival in selected patients with peritoneal metastases of appendiceal goblet cell carcinoma (A-GCC) origin, especially when complete CRS is achieved. Further studies are needed to confirm the role of CRS and HIPEC in this pathology.
WORLD JOURNAL OF SURGERY
(2022)
Article
Multidisciplinary Sciences
Mohammad Rahimi-Gorji, Charlotte Debbaut, Ghader Ghorbaniasl, Sarah Cosyns, Wouter Willaert, Wim Ceelen
Summary: Computational fluid dynamics modeling combined with experimental validation was used to investigate the spatial distribution of IP aerosol. The study found that small droplet sizes and an optimal liquid flow rate resulted in optimal aerosol distribution. Higher viscosity liquids and the addition of an electrostatic field affected the homogeneity of aerosol distribution. These findings can help optimize the delivery of IP aerosolized drugs and enhance their anticancer effect.
SCIENTIFIC REPORTS
(2022)
Article
Gastroenterology & Hepatology
Elke Van Daele, Eefje Stuer, Hanne Vanommeslaeghe, Wim Ceelen, Piet Pattyn, Eva Pape
Summary: Minimally invasive esophagectomy (MIE) can improve the quality of life for patients with esophageal cancer, although long-term functional, nutritional, and gastrointestinal issues may persist.
Article
Biology
Hooman Salavati, Pim Pullens, Wim Ceelen, Charlotte Debbaut
Summary: This study introduces a novel computational modeling approach to account for the regional heterogeneities and lymphatic drainage effects in solid tumor perfusion and drug delivery. The results suggest that tumor size, shape, and heterogeneity have a significant impact on interstitial fluid flow and drug penetration.
COMPUTERS IN BIOLOGY AND MEDICINE
(2023)
Review
Oncology
Wim Ceelen, Kjetil Soreide
Summary: Surgery is crucial for the treatment of solid cancers and plays an important role in multimodal cancer management. Surgeons and multidisciplinary teams make decisions based on reliable data, preferably from trials, to provide the best care for cancer patients. Enhancing research literacy among surgical candidates is a priority for the development of the ESSO core curriculum, and a set of principles and emerging concepts is presented to guide surgical oncologists in reading, understanding, planning, and contributing to future surgeon-led cancer trials.
Article
Oncology
A. Arjona-Sanchez, A. Martinez-Lopez, M. T. Moreno-Montilla, J. Mulsow, P. Lozano-Lominchar, B. Martinez-Torres, B. Rau, E. Canbay, A. Sommariva, M. Milione, M. Deraco, O. Sgarbura, A. Torgunrud, V. Kepenekian, N. J. Carr, A. Hoorens, J. B. Delhorme, R. Wernert, D. Goere, L. Martin-Roman, S. Cosyns, K. Flatmark, B. Davidson, L. Khellaf, F. Pereira-Perez, L. Rodriguez-Ortiz, A. Ibanez-Costa, A. Romero-Ruiz
Summary: This study validates the classification of pseudomyxoma peritonei (PMP), dividing it into two subcategories that can predict the survival and disease-free survival rates of patients. The inclusion of the Ki67 proliferation index in the pathology report for these patients is shown to be significant.
Article
Nanoscience & Nanotechnology
Helena Braet, Peter-Paul Fransen, Remco Marien, Giovanna Lollo, Wim Ceelen, Chris Vervaet, Lieve Balcaen, Frank Vanhaecke, Christian Vanhove, Stefan van der Vegte, Elke Gasthuys, An Vermeulen, Patricia Y. W. Dankers, Stefaan C. De Smedt, Katrien Remaut
Summary: This study aimed to improve the treatment of peritoneal metastasis from ovarian cancer by evaluating a nanoparticle-loaded, pH-switchable supramolecular polymer hydrogel as a controlled release drug delivery system. The research demonstrated that acidifying the nebulized hydrogel solution with carbon dioxide stimulated in situ gelation, prolonging the retention of the hydrogel in the peritoneal cavity. In vitro experiments showed that the drug was gradually released from the hydrogel and maintained cytotoxicity for 10 days. Furthermore, aerosolization of the hydrogel delayed tumor progression and significantly increased overall survival time in a xenograft model of peritoneal metastasis.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Review
Oncology
Daryl K. A. Chia, Jesse Demuytere, Sam Ernst, Hooman Salavati, Wim Ceelen
Summary: The treatment of peritoneal metastases involves heated chemotherapy combined with surgery. The effects of high temperatures on cancer cells and immune cells are still unclear. This review summarizes available data and highlights the need for further study to distinguish the positive and negative effects.
Article
Engineering, Biomedical
Elly De Vlieghere, Koen Van de Vijver, Eva Blondeel, Nathan Carpentier, Rouba Ghobeira, Jarne Pauwels, Sebastian Riemann, Manon Minsart, Charlotte Fieuws, Johanna Mestach, Ans Baeyens, Nathalie De Geyter, Charlotte Debbaut, Hannelore Denys, Benedicte Descamps, Kathleen Claes, Anne Vral, Jo Van Dorpe, Kris Gevaert, Bruno G. De Geest, Wim Ceelen, Sandra Van Vlierberghe, Olivier De Wever
Summary: Background: Long-term drug evaluation often relies on rodent models. This study presents a three-dimensional tumor model that allows for long-term drug evaluation, potentially reducing the need for animal models in drug discovery.
BIOMATERIALS RESEARCH
(2023)
Letter
Surgery
Kozo Kataoka, Kanae Takahashi, Jiro Takeuchi, Kazuma Ito, Naohito Beppu, Wim Ceelen, Yukihide Kanemitsu, Yoichi Ajioka, Itaru Endo, Kiyoshi Hasegawa, Keiichi Takahashi, Masataka Ikeda
BRITISH JOURNAL OF SURGERY
(2023)
Article
Surgery
Kozo Kataoka, Kanae Takahashi, Jiro Takeuchi, Kazuma Ito, Naohito Beppu, Wim Ceelen, Yukihide Kanemitsu, Yoichi Ajioka, Itaru Endo, Kiyoshi Hasegawa, Keiichi Takahashi, Masataka Ikeda
Summary: This study compared the correlation between recurrence-free survival (RFS) and overall survival (OS) in patients who underwent surgery for colorectal liver metastases. The results showed a strong correlation between RFS and OS, regardless of the adjuvant chemotherapy regimen used.
BRITISH JOURNAL OF SURGERY
(2023)
Article
Surgery
Mathieu Vandeputte, Franky Vansteenkiste, Wim Ceelen, Celine De Meyere, Mathieu D'Hondt
Summary: We aimed to define the place of minimally invasive pancreatoduodenectomy by comparing it with the traditional open approach. The study found that laparoscopic pancreatoduodenectomy provided acceptable short-term and oncological outcomes, with a higher major complication rate compared to open pancreatoduodenectomy, but without compromising surgical safety or oncological outcomes.
LANGENBECKS ARCHIVES OF SURGERY
(2023)
Article
Biotechnology & Applied Microbiology
Hooman Salavati, Pim Pullens, Charlotte Debbaut, Wim Ceelen
Summary: This study measured the hydraulic conductivity of tumor tissue and found that it is very limited in human tumor tissue. Moreover, the values of hydraulic conductivity varied significantly between different tumor types and samples.
BIOENGINEERING & TRANSLATIONAL MEDICINE
(2023)
