Article
Medicine, General & Internal
Chao Zhang, Can Cao, Xiu-li Liu, Tan Jun, Pei Liu
Summary: This study found that high expression of Cul4b is associated with poor prognosis in some cutaneous malignant melanoma patients, suggesting it may be an independent prognostic risk factor. Knocking down Cul4b can inhibit the proliferation ability of melanoma cells and downregulate the expression of CDKN2A, indicating its potential as a promising treatment target for cutaneous melanoma.
TOHOKU JOURNAL OF EXPERIMENTAL MEDICINE
(2021)
Article
Endocrinology & Metabolism
Hua Dong, Lei Pan, Yanhui Shen, Qinxuan Xu, Jinyu Hu, Zhiwei Hu, Yuchang Fei
Summary: This study used Mendelian randomization to investigate the causal relationship between thyroid dysfunction and cutaneous malignant melanoma (CMM). The results suggest that hypothyroidism may have a protective effect on CMM, while hyperthyroidism does not affect the risk of CMM.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Review
Oncology
Iyad Kobeissi, Ahmad A. Tarhini
Summary: The incidence of cutaneous melanoma continues to increase, posing a significant mortality risk. Surgical excision is often curative, but patients with resected stages IIB-IV are at high risk for relapse and death, requiring systemic adjuvant therapy. High-dose interferon-alpha, previously used, improved relapse-free survival and overall survival, but is no longer in use. Adjuvant therapy with ipilimumab at 10 mg/kg showed significant improvements in relapse-free survival and overall survival, but at a high cost in terms of toxicity. Nivolumab, pembrolizumab, and BRAF-MEK inhibitors have shown significant improvements in relapse-free survival compared to ipilimumab, leading to changes in adjuvant therapy for resected stages III-IV melanoma.
THERAPEUTIC ADVANCES IN MEDICAL ONCOLOGY
(2022)
Article
Oncology
Zichao Li, Xinrui Li, Xiaowei Yi, Tian Li, Xingning Huang, Xiaoya Ren, Tianyuan Ma, Kun Li, Hanfeng Guo, Shengxiu Chen, Yao Ma, Lei Shang, Baoqiang Song, Dahai Hu
Summary: The objective of this study was to explore the influence of solitary or multiple cancers on the prognosis of patients with cutaneous malignant melanoma (CMM). The study found that patients with different types of CMM have different prognostic characteristics and different risk of cause-specific death. These findings are of great significance for targeted intervention in the early period at both the population and individual levels.
FRONTIERS IN ONCOLOGY
(2022)
Article
Dermatology
Ida M. Heerfordt, Peter A. Philipsen, Jeppe D. Andersen, Linnea Langhans, Grethe Schmidt, Niels Morling, Hans Christian Wulf
Summary: Using tape strip derived RNA, this study developed a technique to differentiate cutaneous malignant melanoma (CMM) from nevi with 100% sensitivity. The technique reduced the unnecessary surgical removal of benign lesions by one-third without overlooking any CMMs.
JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY
(2023)
Article
Biotechnology & Applied Microbiology
Qingxiong Yu, Hainan Zhu, Huijing Wang, Rehanguli Aimaier, Manhon Chung, Zhichao Wang, Qingfeng Li
Summary: By analyzing gene expression levels of 25 m6A genes in CMM patients, we were able to divide them into two clusters and identified ELAVL1, ABCF1, and IGF2BP1 as the genes with the highest scores for predicting prognosis. CNV mutations in m6A genes had a negative impact on patient survival, and the mRNA expression levels of m6A genes were correlated with CNV. The selected m6A regulators were closely associated with inflammation and immune pathways, and m6A gene expressions were negatively correlated with immune cell infiltration.
Article
Immunology
Kezhu Li, Nan Xu, Shu Guo
Summary: This study found that Siglecs play an important role in the occurrence and development of melanoma through the analysis of Siglec family genes. Typing constructed using Siglecs can stratify risk and prognostic models can predict a patient's risk score. In summary, Siglec family genes are potential targets for melanoma treatment as well as prognostic markers that can direct individualized treatments and improve overall survival.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Multidisciplinary Sciences
Ke-Jun Chen, Feng-Zeng Li, Qian Ye, Meng Jia, Sheng Fang
Summary: Heat shock protein 105 (HSP105) is overexpressed in cutaneous malignant melanoma (CMM) and is closely associated with different clinicopathological variables. Lesions in exposed sites, recurrent and metastatic lesions, nodular melanoma, and lentigo maligna melanoma show higher HSP105 expression, suggesting HSP105 as a potential target for the diagnosis, treatment, and prognostic prediction of CMM.
Review
Biochemistry & Molecular Biology
Madison Ernst, Alessio Giubellino
Summary: Malignant melanoma is the leading cause of death among cutaneous malignancies. The introduction of immunotherapies and targeted therapies have contributed to a small decrease in mortality rate. However, toxicity and resistance remain critical challenges in the field.
Article
Surgery
O. Sharp, J. Garioch, M. Moncrieff
Summary: This study investigated the impact of seasonality on malignant melanoma and found that the diagnosis rate of melanoma is highest in summer, and there are more male melanoma diagnoses in winter. Seasonality does not significantly affect melanoma characteristics such as Breslow thickness, ulceration, lymphovascular invasion, and perineural invasion. However, microsatellites are more likely to be diagnosed in winter, lymphovascular invasion is more likely to be diagnosed in autumn, and perineural invasion is more likely to be diagnosed in summer.
JOURNAL OF PLASTIC RECONSTRUCTIVE AND AESTHETIC SURGERY
(2022)
Article
Dermatology
M. Scatolini, A. Patel, E. Grosso, M. Mello-Grand, P. Ostano, R. Coppo, M. Vitiello, T. Venesio, A. Zaccagna, A. Pisacane, I Sarotto, D. Taverna, L. Poliseno, D. Bergamaschi, G. Chiorino
Summary: The study identified a significant association between metastases, BRAF mutation, and low GJB5 expression in melanoma, suggesting a potential prognostic role for GJB5 in cutaneous melanoma.
BRITISH JOURNAL OF DERMATOLOGY
(2022)
Article
Medicine, General & Internal
Hai Yu, Wei Yang, Shi Wu, Shaohui Xi, Xichun Xia, Qi Zhao, Wai-Kit Ming, Lifang Wu, Yunfeng Hu, Liehua Deng, Jun Lyu
Summary: This study used a deep learning and neural network model (DeepSurv) to predict the survival rate of patients with cutaneous malignant melanoma (CMM). The DeepSurv model was found to be more accurate in predicting the survival time of CMM patients compared to the Cox proportional-hazards (CoxPH) model.
FRONTIERS IN MEDICINE
(2023)
Article
Oncology
Fernanda Costa Svedman, Ishani Das, Rainer Tuominen, Eva Darai Ramqvist, Veronica Hoiom, Suzanne Egyhazi Brage
Summary: The introduction of targeted therapies and immunotherapies has greatly improved the clinical outcomes for patients with advanced cutaneous melanoma. However, only a subset of patients benefit from these treatments in the long term. This study aims to identify gene signatures that can predict the treatment outcomes in melanoma patients. The findings suggest that up-regulation of immune-related genes is associated with better outcomes in targeted therapy, while down-regulation of proliferation and up-regulation of allograft rejection genes favor patients treated with immune checkpoint inhibitors.
Editorial Material
Ophthalmology
Jerome Chartier, Pierre-Jean Pisella, Raoul Kanav Khanna
Summary: This case report presents a rare occurrence of cutaneous malignant melanoma metastasizing to the intraocular lens.
JAMA OPHTHALMOLOGY
(2021)
Editorial Material
Radiology, Nuclear Medicine & Medical Imaging
Ahmad Shariftabrizi, Ravishankar Pillenahalli Maheshwarappa, Daniel Kahn, Janet Pollard
Summary: A 63-year-old man with high-risk prostate adenocarcinoma was referred for F-18-fluciclovine PET/CT to rule out metastasis in the setting of elevated PSA levels. He had a history of nodular melanoma with previous PET/CT showing metastasis, but the current PET/CT revealed false-positive uptake.
CLINICAL NUCLEAR MEDICINE
(2021)
Article
Genetics & Heredity
Minsun Song, William Wheeler, Neil E. Caporaso, Maria Teresa Landi, Nilanjan Chatterjee
GENETIC EPIDEMIOLOGY
(2018)
Article
Oncology
Naomi Walsh, Han Zhang, Paula L. Hyland, Qi Yang, Evelina Mocci, Mingfeng Zhang, Erica J. Childs, Irene Collins, Zhaoming Wang, Alan A. Arslan, Laura Beane-Freeman, Paige M. Bracci, Paul Brennan, Federico Canzian, Eric J. Duell, Steven Gallinger, Graham G. Giles, Michael Goggins, Gary E. Goodman, Phyllis J. Goodman, Rayjean J. Hung, Charles Kooperberg, Robert C. Kurtz, Nuria Malats, Loic LeMarchand, Rachel E. Neale, Sara H. Olson, Ghislaine Scelo, Xiao O. Shu, Stephen K. Van den Eeden, Kala Visvanathan, Emily White, Wei Zheng, Demetrius Albanes, Gabriella Andreotti, Ana Babic, William R. Bamlet, Sonja I. Berndt, Ayelet Borgida, Marie-Christine Boutron-Ruault, Lauren Brais, Bas Bueno-de-Mesquita, Julie Buring, Kari G. Chaffee, Stephen Chanock, Sean Cleary, Michelle Cotterchio, Lenka Foretova, Charles Fuchs, J. Michael M. Gaziano, Edward Giovannucci, Thilo Hackert, Christopher Haiman, Patricia Hartge, Manal Hasan, Kathy J. Helzlsouer, Joseph Herman, Ivana Holcatova, Elizabeth A. Holly, Robert Hoover, Vladimir Janout, Eric A. Klein, Daniel Laheru, I-Min Lee, Lingeng Lu, Satu Mannisto, Roger L. Milne, Ann L. Oberg, Irene Orlow, Alpa V. Patel, Ulrike Peters, Miquel Porta, Francisco X. Real, Nathaniel Rothman, Howard D. Sesso, Gianluca Severi, Debra Silverman, Oliver Strobel, Malin Sund, Mark D. Thornquist, Geoffrey S. Tobias, Jean Wactawski-Wende, Nick Wareham, Elisabete Weiderpass, Nicolas Wentzensen, William Wheeler, Herbert Yu, Anne Zeleniuch-Jacquotte, Peter Kraft, Donghui Li, Eric J. Jacobs, Gloria M. Petersen, Brian M. Wolpin, Harvey A. Risch, Laufey T. Amundadottir, Kai Yu, Alison P. Klein, Rachael Z. Stolzenberg-Solomon
JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE
(2019)
Meeting Abstract
Oncology
S. Julian-Serrano, F. Yuan, B. Benyamin, W. Wheeler, L. Amundadottir, E. Jacobs, P. Kraft, D. Li, G. M. Petersen, H. A. Risch, B. Wolpin, K. Yu, A. P. Klein, R. Stolzenberg-Solomon
CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION
(2020)
Article
Oncology
Fangcheng Yuan, Rayjean J. Hung, Naomi Walsh, Han Zhang, Elizabeth A. Platz, William Wheeler, Lei Song, Alan A. Arslan, Laura E. Beane Freeman, Paige Bracci, Federico Canzian, Mengmeng Du, Steven Gallinger, Graham G. Giles, Phyllis J. Goodman, Charles Kooperberg, Loic Le Marchand, Rachel E. Neale, Jonas Rosendahl, Ghislaine Scelo, Xiao-Ou Shu, Kala Visvanathan, Emily White, Wei Zheng, Demetrius Albanes, Pilar Amiano, Gabriella Andreotti, Ana Babic, William R. Bamlet, Sonja I. Berndt, Paul Brennan, Bas Bueno-de-Mesquita, Julie E. Buring, Peter T. Campbell, Stephen J. Chanock, Charles S. Fuchs, J. Michael Gaziano, Michael G. Goggins, Thilo Hackert, Patricia Hartge, Manal M. Hassan, Elizabeth A. Holly, Robert N. Hoover, Verena Katzke, Holger Kirsten, Robert C. Kurtz, I-Min Lee, Nuria Malats, Roger L. Milne, Neil Murphy, Kimmie Ng, Ann L. Oberg, Miquel Porta, Kari G. Rabe, Francisco X. Real, Nathaniel Rothman, Howard D. Sesso, Debra T. Silverman, Ian M. Thompson, Jean Wactawski-Wende, Xiaoliang Wang, Nicolas Wentzensen, Lynne R. Wilkens, Herbert Yu, Anne Zeleniuch-Jacquotte, Jianxin Shi, Eric J. Duell, Laufey T. Amundadottir, Donghui Li, Gloria M. Petersen, Brian M. Wolpin, Harvey A. Risch, Kai Yu, Alison P. Klein, Rachael Stolzenberg-Solomon
Article
Biology
Han Zhang, Lu Deng, William Wheeler, Jing Qin, Kai Yu
Summary: This paper introduces a flexible inference procedure that integrates individual-level data collected from internal studies with summary data borrowed from external studies, addressing the challenges of sharing individual data among studies. The procedure is built on a retrospective empirical likelihood framework, able to be applied to external studies in different populations and showing efficiency advantages over other methods both theoretically and numerically.
Article
Nutrition & Dietetics
Sachelly Julian-Serrano, Fangcheng Yuan, William Wheeler, Beben Benyamin, Mitchell J. Machiela, Alan A. Arslan, Laura E. Beane-Freeman, Paige M. Bracci, Eric J. Duell, Mengmeng Du, Steven Gallinger, Graham G. Giles, Phyllis J. Goodman, Charles Kooperberg, Loic Le Marchand, Rachel E. Neale, Xiao-Ou Shu, Stephen K. Van den Eeden, Kala Visvanathan, Wei Zheng, Demetrius Albanes, Gabriella Andreotti, Eva Ardanaz, Ana Babic, Sonja Berndt, Lauren K. Brais, Paul Brennan, Bas Bueno-de-Mesquita, Julie E. Buring, Stephen J. Chanock, Erica J. Childs, Charles C. Chung, Eleonora Fabianova, Lenka Foretova, Charles S. Fuchs, J. Michael Gaziano, Manuel Gentiluomo, Edward L. Giovannucci, Michael G. Goggins, Thilo Hackert, Patricia Hartge, Manal M. Hassan, Ivana Holcatova, Elizabeth A. Holly, Rayjean Hung, Vladimir Janout, Robert C. Kurtz, I-Min Lee, Nuria Malats, David McKean, Roger L. Milne, Christina C. Newton, Ann L. Oberg, Sandra Perdomo, Ulrike Peters, Miquel Porta, Nathaniel Rothman, Matthias B. Schulze, Howard D. Sesso, Debra T. Silverman, Ian M. Thompson, Jean Wactawski-Wende, Elisabete Weiderpass, Nicolas Wenstzensen, Emily White, Lynne R. Wilkens, Herbert Yu, Anne Zeleniuch-Jacquotte, Jun Zhong, Peter Kraft, Dounghui Li, Peter T. Campbell, Gloria M. Petersen, Brian M. Wolpin, Harvey A. Risch, Laufey T. Amundadottir, Alison P. Klein, Kai Yu, Rachael Z. Stolzenberg-Solomon
Summary: The study found that the hepcidin-regulating gene pathway is associated with the risk of pancreatic ductal adenocarcinoma, with HJV, TFR2, TFR1, BMP6 and HAMP genes contributing the most to the association.
AMERICAN JOURNAL OF CLINICAL NUTRITION
(2021)
Article
Oncology
Emily Vogtmann, Xing Hua, Guoqin Yu, Vaishnavi Purandare, Autumn G. Hullings, Dantong Shao, Yunhu Wan, Shilan Li, Casey L. Dagnall, Kristine Jones, Belynda D. Hicks, Amy Hutchinson, J. Gregory Caporaso, William Wheeler, Dale P. Sandler, Laura E. Beane Freeman, Linda M. Liao, Wen-Yi Huang, Neal D. Freedman, Neil E. Caporaso, Rashmi Sinha, Mitchell H. Gail, Jianxin Shi, Christian C. Abnet
Summary: This study found prospective associations between oral microbiota and lung cancer risk in 3 US cohort studies, with variations based on smoking history and histological subtype.
JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE
(2022)
Article
Pharmacology & Pharmacy
Paula L. L. Hyland, Lakshmi Manasa S. Chekka, Deepti P. P. Samarth, Barry A. A. Rosenzweig, Erica Decker, Esraa G. G. Mohamed, Yan Guo, Murali K. K. Matta, Qin Sun, William Wheeler, Carlos Sanabria, James L. Weaver, Sarah J. Schrieber, Jeffry Florian, Yow-Ming Wang, David G. G. Strauss
Summary: Proteomics is used to identify pharmacodynamic biomarkers for biosimilars evaluation. The study evaluated the utility of proteomic assay for interferon-beta 1a products and identified potential candidate biomarkers. This research supports clinical pharmacology studies of biosimilars with complex mechanisms or without previously characterized biomarkers.
CLINICAL PHARMACOLOGY & THERAPEUTICS
(2023)
Meeting Abstract
Oncology
Prosenjit Kundu, Evelina Mocci, William Wheeler, Laufey T. Amundadottir, Donghui Li, Eric J. Jacobs, Gloria M. Petersen, Brian M. Wolpin, Harvey A. Risch, Peter Kraft, Nilanjan Chatterjee, Alison P. Klein, Rachael Z. Stolzenberg-Solomon
Article
Economics
Joel Corona, Todd Doley, Charles Griffiths, Matthew Massey, Chris Moore, Stephen Muela, Brenda Rashleigh, William Wheeler, Stephen D. Whitlock, Julie Hewitt
Meeting Abstract
Oncology
Emily Vogtmann, Xing Hua, Guoqin Yu, Autumn Hullings, Yunhu Wan, Casey L. Dagnall, Kristine Jones, Belynda D. Hicks, Amy Hutchinson, Shalabh Suman, Bin Zhu, Barry Graubard, Mitchell H. Gail, J. Gregory Caporaso, William Wheeler, Dale Sandler, Laura E. Beane Freeman, Linda Liao, Neal D. Freedman, Neil Caporaso, Rashmi Sinha, Jianxin Shi, Christian C. Abnet
Article
Environmental Studies
William Wheeler
ENVIRONMENT AND PLANNING C-POLITICS AND SPACE
(2019)
Meeting Abstract
Gastroenterology & Hepatology
Fangcheng Yuan, Rayjean Hung, Han Zhang, William Wheeler, Elizabeth Platz, Laufey Amundadottir, Eric Jacobs, Peter Kraft, Donghui Li, Gloria M. Petersen, Harvey Risch, Brian Wolpin, Kai Yu, Alison Klein, Rachael Stolzenberg-Solomon
Article
Biochemical Research Methods
Han Zhang, William Wheeler, Lei Song, Kai Yu
BRIEFINGS IN BIOINFORMATICS
(2018)
Article
Environmental Studies
William Wheeler
GLOBAL ENVIRONMENT
(2018)