Article
Food Science & Technology
Yan Luan, Daniel Leclerc, Marta Cosin-Tomas, Olga V. Malysheva, Brandi Wasek, Teodoro Bottiglieri, Marie A. Caudill, Rima Rozen
Summary: High folic acid intake during pregnancy can lead to placental metabolic and gene expression changes, particularly in angiogenesis, which may contribute to abnormal behavior in pups. These results are relevant for determining a safe upper limit for folate intake during pregnancy.
MOLECULAR NUTRITION & FOOD RESEARCH
(2021)
Review
Biochemistry & Molecular Biology
Karpinski Pawel, Sasiadek Maria Malgorzata
Summary: The CpG island methylator phenotype (CIMP) is an important manifestation of epigenetic instability in cancer. It has been extensively studied in various tumor types, but its use as a diagnostic marker and therapeutic target in solid tumors is limited by the lack of generalizability and reproducibility of epigenetic markers, as well as its poor predictive value in clinical outcomes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Multidisciplinary Sciences
Andrea Lauria, Guohua Meng, Valentina Proserpio, Stefania Rapelli, Mara Maldotti, Isabelle Laurence Polignano, Francesca Anselmi, Danny Incarnato, Anna Krepelova, Daniela Donna, Chiara Levra Levron, Giacomo Donati, Ivan Molineris, Francesco Neri, Salvatore Oliviero
Summary: The establishment of DNA methylation patterns during mouse early development is crucial for cell fate determination. However, the specific molecular targets and mechanisms of de novo methylation machinery during differentiation are not fully understood. In this study, the researchers identified DNMT3B-dependent regulatory elements that play a critical role in cell fate determination. They found that DNMT3B-dependent DNA methylation is essential for proper differentiation and lineage determination, and ectopic expression of DNMT3B can restore normal gene expression and cell fate. This study provides important insights into the role of DNA methylation in early development and cell fate determination.
NATURE COMMUNICATIONS
(2023)
Review
Cell Biology
Xiaxia Man, Qi Li, Baogang Wang, He Zhang, Songling Zhang, Ziyi Li
Summary: This article reviews the roles of DNMT3A and DNMT3B in breast tumorigenesis and development, discusses their SNP and mutations in breast cancer, and summarizes how they are regulated by non-coding RNAs and signaling pathways. It emphasizes that targeting the expression levels of DNMT3A and DNMT3B may be a promising therapeutic approach for breast cancer.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Malgorzata Wrzosek, Klaudia Slusarczyk
Summary: This study examined the influence of the MTHFR C677T variant on BMI and its role as a risk factor for obesity. The results showed that the MTHFR 677TT genotype is not directly related to a higher BMI in Polish adults but has a detrimental effect on folate concentrations in individuals with high BMI values.
Article
Oncology
Harumi Yamada, Hideyuki Takeshima, Ryoji Fujiki, Satoshi Yamashita, Shigeki Sekine, Takayuki Ando, Naoko Hattori, Atsushi Okabe, Takaki Yoshikawa, Kazutaka Obama, Hitoshi Katai, Atsushi Kaneda, Toshikazu Ushijima
Summary: The CpG island methylator phenotype (CIMP) is associated with prognosis and drug sensitivity in multiple cancer types. This study demonstrates that mutations in the SWI/SNF chromatin remodeling complex, particularly ARID1A, are associated with CIMP induction in gastric cancer, as well as in uterine endometrial and colorectal cancers. The loss of ARID1A function causes aberrant DNA methylation and is likely a potential mechanism for CIMP induction.
Review
Biochemistry & Molecular Biology
Lyazzat Kaldygulova, Talshyn Ukybassova, Gulzhanat Aimagambetova, Andrey Gaiday, Akylbek Tussupkaliyev
Summary: The rationale and importance of folic acid supplementation during pregnancy for preventing fetal congenital defects are widely accepted. Adequate folate levels can reduce the risk of spontaneous abortions and support normal placental blood flow, promoting appropriate fetal growth. Additionally, there is emerging evidence that long-term folic acid supplementation can effectively prevent preeclampsia, a complication unique to humans during pregnancy that contributes to worldwide maternal and perinatal mortality. Folate supplementation helps to decrease elevated levels of homocysteine, which is associated with the risk of preeclampsia.
Article
Oncology
Oscar Murcia, Alejandro Martinez-Roca, Miriam Juarez, Mar Giner-Calabuig, Miren Alustiza, Cristina Mira, Carolina Mangas-Sanjuan, Eva Serrano, Francisco Antonio Ruiz-Gomez, Sandra Baile-Maxia, Lucia Medina, Cristina Alenda, Artemio Paya, Maria Rodriguez-Soler, Pedro Zapater, Rodrigo Jover
Summary: The study suggests that CIMP may be a useful marker for endoscopic surveillance after polypectomy, improving the accuracy in predicting the risk of metachronous advanced colorectal lesions (MACLs). Patients with CIMP+ polyps show a higher risk and shorter time to MACL development, even after adjustment for other factors. The addition of CIMP analysis enhances the sensitivity, negative predictive value, and overall accuracy in estimating MACL risk.
Review
Oncology
Guang Yang, Xi (Richard) Yu, Daniel J. J. Weisenberger, Tao Lu, Gangning Liang
Summary: Human colorectal cancer (CRC) is a global health burden, especially for minority populations. The disease is complex, with diverse molecular features linked to the location of the primary tumor, posing challenges to treatment and patient outcome improvement. Liver and other organ system metastases are major causes of CRC-related mortality and obstacles to improving outcomes. This review summarizes CRC tumor subgroups, molecular features, treatments, outcomes, and disparities in health and metastases.
Review
Oncology
Hyun Jin Shin, Junjie T. Hua, Haolong Li
Summary: Epigenetic modifications, particularly DNA methylation, are extensively studied in cancer and have been shown to distinguish between benign and malignant tumors in various cancers, including prostate cancer. Aberrant DNA methylation patterns, such as the CpG island hypermethylator phenotype (CIMP), are associated with aggressive subtypes, higher Gleason score, and overall worse prognosis in prostate cancer. DNA methylation alterations can serve as potential biomarkers for prostate cancer and have the potential for targeted treatment development.
FRONTIERS IN ONCOLOGY
(2023)
Article
Public, Environmental & Occupational Health
Derrick A. Bennett, Sarah Parish, Iona Y. Millwood, Yu Guo, Yiping Chen, Iain Turnbull, Ling Yang, Jun Lv, Canqing Yu, George Davey Smith, Yongjun Wang, Yilong Wang, Richard Peto, Rory Collins, Robin G. Walters, Liming Li, Zhengming Chen, Robert Clarke
Summary: In Chinese adults, the MTHFR C677T polymorphism is associated with an increased risk of stroke, highlighting the importance of further trials involving folic acid and mandatory folic acid fortification programs for stroke prevention in low-folate populations.
INTERNATIONAL JOURNAL OF EPIDEMIOLOGY
(2023)
Review
Genetics & Heredity
Melissa Roufael, Tania Bitar, Yonna Sacre, Christian Andres, Walid Hleihel
Summary: Autism Spectrum Disorder (ASD) has seen a rapid increase in incidence and disturbances in folate or methionine metabolism have been found in individuals with ASD. Changes in metabolite concentrations associated with this cycle could be potential biomarkers and therapeutic targets for ASD. High levels of homocysteine and low levels of vitamins B12 and folate, influenced by poor diet and genetic predispositions, have been linked to ASD. Nutritional supplements have shown potential benefits for treating ASD, but more research is needed.
Article
Biochemistry & Molecular Biology
Estefania Tarazon, Lorena Perez-Carrillo, Isaac Gimenez-Escamilla, Maria Garcia-Manzanares, Luis Martinez-Dolz, Manuel Portoles, Esther Rosello-Lleti
Summary: We conducted a study on the DNA methylation process in human cardiac tissue of ischemic cardiomyopathy patients and found dysregulation in this process. We observed genome-wide hypomethylation along with overexpression of genes involved in methyl group elimination and underexpression of molecules involved in methylation maintenance. Despite the upregulation of DNMT3B and downregulation of miR-133a-3p, we identified relevant alterations that counteracted the observed upregulation. We also found changes in molecules regulating Dnmts activity. Our findings reveal genome-wide hypomethylation and dysregulation in the DNA methylation machinery in ischemic cardiomyopathy.
Article
Clinical Neurology
Emily A. Bopp, Ethan A. Poweleit, Marley O. Cox, Jenni E. Farrow, Jeffrey R. Strawn, Luis R. Patino Duran, Cynthia A. Prows, Melissa P. DelBello, Laura B. Ramsey
Summary: This study retrospectively examined the use of adjunctive L-methylfolate in adolescents with depression. The results showed that the MTHFR genotype of the patients influenced the prescription of L-methylfolate, but augmentation with L-methylfolate was not significantly associated with treatment response. Limitations of this study included its retrospective design and limited data availability.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Article
Multidisciplinary Sciences
Jaqueline Loaeza-Loaeza, Angel Josue Cerecedo-Castillo, Hugo Alberto Rodriguez-Ruiz, Yaneth Castro-Coronel, Oscar Del Moral-Hernandez, Felix Recillas-Targa, Daniel Hernandez-Sotelo
Summary: DNA methylation is an important epigenetic modification that regulates gene expression in mammalian cells. Abnormal DNA methylation in gene promoters is common in human cancer. DNMT3B is a methyltransferase that is enhanced in several primary tumors. However, the mechanism by which de novo methylation is established in genes related to cancer is not well understood.
SCIENTIFIC REPORTS
(2022)
Article
Pathology
Jessica Katherine Cameron, Lin Fritschi, David M. Ross, Lesley Ann Anderson, Peter Baade
Summary: Myeloproliferative neoplasms (MPNs) are uncommon blood cancers with complex diagnosis methods, resulting in under-diagnosis and under-reporting. Analysis of Australian cancer database reveals significant variation in incidence and survival of MPNs across different geographical regions, with lower incidence associated with poorer survival.
Article
Allergy
Olivia Lall, Gayan Bowatte, Samath Dharmaratne, Adrian J. Lowe, Alicia Vakalopoulos, Isabella Ambrose, Pasan Jayasinghe, Duminda Yasaratne, Jane Heyworth, Shyamali C. Dharmage
Summary: The use of biomass fuel and traditional biomass stoves in rural Sri Lankan communities is associated with an increased risk of wheeze and allergies in children.
Article
Medicine, General & Internal
Kate Lewkowski, Jane Heyworth, Elinor Ytterstad, Warwick Williams, Helen Goulios, Lin Fritschi
Summary: The prevalence of tinnitus is high among Australian working people, with men and older individuals more likely to experience constant tinnitus. Certain occupations like automotive workers, drivers, and farmers have a higher prevalence of constant tinnitus. Workplace practices and conditions that increase the risk of tinnitus should be examined and targeted prevention strategies should be developed.
MEDICAL JOURNAL OF AUSTRALIA
(2022)
Article
Public, Environmental & Occupational Health
Nina Lazarevic, Adrian G. Barnett, Peter D. Sly, Anna C. Callan, Ania Stasinska, Jane S. Heyworth, Andrea L. Hinwood, Luke D. Knibbs
Summary: The study did not find associations between mixtures of polybrominated diphenyl ethers, organochlorine pesticides, metals, and perfluorinated alkyl substances and fetal growth outcomes. Results suggested no meaningful associations between exposure to these chemicals and birth weight, length, and head circumference. Non-linear relationships with some chemicals were identified.
INTERNATIONAL JOURNAL OF HYGIENE AND ENVIRONMENTAL HEALTH
(2022)
Article
Oncology
Belle H. de Rooij, Imogen Ramsey, Felix J. Clouth, Nadia Corsini, Jane S. Heyworth, Brigid M. Lynch, Jeff K. Vallance, Terry Boyle
Summary: This study aimed to identify subgroups of breast cancer survivors based on symptoms of fatigue, insomnia, and depression, and assess the association between circadian parameters and these subgroups over time. The results showed that survivors with a late chronotype or low circadian amplitude were more likely to have moderate or high symptom burden. Most survivors with moderate or high symptom burden at T1 continued to have symptoms at T2.
JOURNAL OF CANCER SURVIVORSHIP
(2023)
Article
Multidisciplinary Sciences
David Michael Lowry, Lin Fritschi, Benjamin J. Mullins, Rebecca A. O'Leary
Summary: This study evaluates the importance of professional judgement in exposure assessments for occupational hygienists. A new elicitation approach is used and compared to measured data, which shows that the participating experts tend to overestimate exposures.
Article
Multidisciplinary Sciences
David Michael Lowry, Lin Fritschi, Benjamin J. Mullins
Summary: This study aimed to evaluate the effectiveness of using a combination of area noise measurements and task activity diaries to estimate full-shift dosimeter measurements in utility workers. The results showed a strong correlation between task-based area measurements and full-shift TWA measurements.
Review
Public, Environmental & Occupational Health
Anneclaire J. De Roos, Lin Fritschi, Mary H. Ward, Alain Monnereau, Jonathan Hofmann, Leslie Bernstein, Parveen Bhatti, Yolanda Benavente Moreno, Geza Benke, Delphine Casabonne, Jacqueline Clavel, Pierluigi Cocco, Tran Huynh, Andrea 't Mannetje, Lucia Miligi, Sara Piro, Nathaniel Rothman, Leah H. Schinasi, Claire M. Vajdic, Sophia S. Wang, Yawei Zhang, Susan L. Slager, James R. Cerhan
Summary: This study suggests that most herbicides are not associated with the risk of non-Hodgkin's lymphoma (NHL), but phenoxy herbicides and glyphosate are associated with specific NHL subtypes.
OCCUPATIONAL AND ENVIRONMENTAL MEDICINE
(2022)
Article
Environmental Sciences
Iffat Elbarazi, Sonia El-Zaemey, Basema Saddik, Balazs Adam, Mohamed El Sadig, Aminu S. Abdullahi, Lin Fritschi, Mohamud Sheek-Hussein
Summary: Occupational exposure to carcinogens is common among migrant workers in the UAE, with a considerable prevalence of exposure to 20 different carcinogens. Workers exposed to carcinogens have lower self-rated health.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)
Article
Multidisciplinary Sciences
Farhad Salimi, Ania Stasinska, Geoffrey G. Morgan, Graeme J. Hankey, Osvaldo Almeida, Bu Yeap, Leon Flicker, Jane Heyworth
Summary: This study investigated the associations between long-term exposures to PM2.5, PM2.5 absorbance, and NO2 and hospitalisation for respiratory diseases in older men living in Perth, Australia. The results showed no significant associations between increased long-term exposure to low-level air pollution and increased risk of hospitalisation for respiratory diseases.
Editorial Material
Public, Environmental & Occupational Health
Mary K. Schubauer-Berigan, David B. Richardson, Matthew P. Fox, Lin Fritschi, Irina Guseva Canu, Neil Pearce, Leslie Stayner, Amy Berrington de Gonzalez
OCCUPATIONAL AND ENVIRONMENTAL MEDICINE
(2023)
Article
Multidisciplinary Sciences
Corey J. A. M. Bradshaw, Claire Perry, Melinda A. N. Judge, Chitra M. Saraswati, Jane Heyworth, Peter N. Le Souef
Summary: Although average contraceptive use has increased globally, a large number of women still have an unmet need for family planning. The relationships between contraception, family planning, infant mortality, and fertility have not been extensively studied in low- and middle-income countries.
Article
Environmental Sciences
Joshua S. Jones, Lee Nedkoff, Jane S. Heyworth, Osvaldo P. Almeida, Leon Flicker, Jonathan Golledge, Graeme J. Hankey, Elizabeth H. Lim, Mark Nieuwenhuijsen, Bu B. Yeap, Michelle L. Trevenen
Summary: This study aimed to determine the dose-response relationship between long-term exposure to low-concentration PM2.5 air pollution and incident ischemic heart disease (IHD), heart failure (HF), and atrial fibrillation (AF) in older men. The results showed a trend of increased incidence of IHD, HF, and AF, but none were statistically significant under low-concentration PM2.5 air pollution exposure.
ENVIRONMENTAL EPIDEMIOLOGY
(2023)
Article
Audiology & Speech-Language Pathology
Kate Lewkowski, Jane S. Heyworth, Warwick Williams, Helen Goulios, Kahlia McCausland, Corie Gray, Lin Fritschi
Summary: Occupational exposures to lead, toluene, and carbon monoxide, in addition to workplace noise, are associated with tinnitus in the Australian working population.
Article
Respiratory System
Francesca Sanna, Francesca Locatelli, Peter D. Sly, Elisha White, David Blake, Jane Heyworth, Graham L. Hall, Rachel E. Foong
Summary: This study aims to identify early-life risk factors and their impact on lung function trajectories. The findings suggest that asthma, maternal smoking, and early-life exposure to PM2.5Absorbance are risk factors for low lung function trajectories.
