Article
Pediatrics
Gregorio Serra, Sofia Felice, Vincenzo Antona, Maria Rita Di Pace, Mario Giuffre, Ettore Piro, Giovanni Corsello
Summary: Cardio-facio-cutaneous syndrome (CFCS) is a rare syndrome caused by mutations in genes of the RAS/MAPK pathway. It is characterized by facial dysmorphisms, growth failure, heart defects, developmental delay, and ectodermal abnormalities. The 19p13.3 microdeletion, including the MAP 2 K2 gene, has been associated with a more severe phenotype in CFCS patients.
ITALIAN JOURNAL OF PEDIATRICS
(2022)
Article
Biochemistry & Molecular Biology
Shang-Jun Yin, Jae-Rin Lee, Myong-Joon Hahn, Jun-Mo Yang, Guo-Ying Qian, Yong-Doo Park
Summary: Our study investigated tyrosinase-associated melanogenesis in melanoma cells using OMICS techniques. We characterized chromosome copy numbers in different melanoma cell lines and identified differences in the stability of 11q21 between TXM13, G361, and SK-MEL-28 cells. The proteomic profiling of TXM13 cells revealed key hub proteins linking tyrosinase-triggered melanogenesis and melanoma growth.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Medicine, General & Internal
Zefeng Li, Hu Ren, Xiaojie Zhang, Chongyuan Sun, He Fei, Zheng Li, Chunguang Guo, Susheng Shi, Yingtai Chen, Dongbing Zhao
Summary: This study compared the characteristics and survival outcomes between patients with gastric large-cell neuroendocrine carcinoma (GLNEC) and gastric small-cell neuroendocrine carcinoma (GSNEC), and concluded that there was no significant statistical difference in prognosis between the two types despite their different cell morphologies.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Genetics & Heredity
Liubing Lin, Renye Que, Jian Wang, Yi Zhu, Xiaolin Liu, Rongzhong Xu
Summary: SLC2A3 is highly expressed in gastric cancer and is associated with an unfavorable prognosis. It is involved in multiple immune pathways and regulated by several miRNAs. SLC2A3 can be used as an independent prognostic factor for gastric cancer, and SLC2A3 and related miRNAs may serve as potential prognostic biomarkers and therapeutic targets.
FRONTIERS IN GENETICS
(2022)
Article
Genetics & Heredity
Jihenne Ben Aissa-Haj, Hugo Pinheiro, Francois Cornelis, Molka Sebai, Didier Meseure, Adrien Briaux, Philippe Berteaux, Cedric Lefol, Gaetan Des Guetz, Martine Trassard, Denise Stevens, Francois Vialard, Ivan Bieche, Catherine Nogues, Roseline Tang, Carla Oliveira, Dominique Stoppat-Lyonnet, Rosette Lidereau, Etienne Rouleau
Summary: Rearrangements in the CDH1 gene are associated with breast cancer susceptibility, highlighting the importance of screening for large rearrangements in genetic testing.
Article
Surgery
Recep Caglar
Summary: This study aimed to determine the prognostic values of preoperative inflammatory biomarkers in patients undergoing curative surgery for gastric carcinoma and contribute to the development of prognostic modeling. The medical data of 91 patients who underwent gastrectomy for gastric carcinoma were retrospectively analyzed. The results showed that preoperative inflammatory markers such as neutrophil-lymphocyte ratio (NLR), platelet-lymphocyte ratio (PLR), lactate dehydrogenase albumin ratio (LAR), and advanced tumor stage had adverse effects on the survival of gastric carcinoma patients. Further studies with larger sample sizes are needed to validate these findings.
ASIAN JOURNAL OF SURGERY
(2023)
Article
Biochemistry & Molecular Biology
Serena Redaelli, Donatella Conconi, Elena Sala, Nicoletta Villa, Francesca Crosti, Gaia Roversi, Ilaria Catusi, Chiara Valtorta, Maria Paola Recalcati, Leda Dalpra, Marialuisa Lavitrano, Angela Bentivegna
Summary: Advancements in microarray-based comparative genomic hybridization technology have enabled high-resolution detection of genome-wide copy number alterations, particularly in chromosome 8p. This study focused on 12 cases of 8p rearrangements, revealing a continuum of fragility along the entire short arm with breakpoints concentrated in three intervals. The data expands the cohort of published patients with 8p aberrations and emphasizes the importance of paying special attention to these sequences to prevent the development of new chromosomal aberrations with pathological effects.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Cell Biology
Jie Zhou, Run-cong Nie, Yi-xin Yin, Yun Wang, Shu-qiang Yuan, Zi-han Zhao, Xin-ke Zhang, Jin-ling Duan, Ying-bo Chen, Zhi-wei Zhou, Dan Xie, Yuan-fang Li, Mu-yan Cai
Summary: This study investigates the relationship between pyroptosis and the tumor immune microenvironment (TIME) in gastric cancer. It identifies distinct clusters based on pyroptosis and constructs a risk scoring system. The low-pyroptosis risk score is associated with better immune cell fractions, higher MSI status, and increased response to immunotherapy. The study highlights the importance of the interaction between pyroptosis and TIME in gastric cancer, and the potential of the risk scoring system in predicting survival and response to immunotherapy.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Biophysics
Xiaojing Zhang, Runze Xiao, Bing Lu, Han Wu, Chunyi Jiang, Peng Li, Jianfei Huang
Summary: DYRK2, as a potential specific marker for gastric cancer, has a tumor-suppressing effect by inhibiting proliferation, migration, and invasion of cancer cells while promoting autophagy. Its high expression is associated with a better prognosis in patients, indicating its potential as a reference indicator for clinical diagnosis of GC.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2022)
Article
Oncology
Qing Wei, Yiding Gao, Changsong Qi, Xing Yuan, Jingjing Li, Qi Xu, Cong Luo, Lei Chen, Wei Zhuo, Zhiyuan Xu, Jieer Ying
Summary: A total of 11,363 gastric cancer patients were enrolled, with SRC patients more likely to occur in female and young patients. Significant factors for prognosis included age, tumor site, tumor size, T classification, N classification, TNM stage, and primary site surgery, as identified through univariate and multivariate analyses.
FRONTIERS IN ONCOLOGY
(2021)
Article
Genetics & Heredity
Siyuan Liu, Zhenghao Li, Huihuang Li, Xueyi Wen, Yu Wang, Qilin Chen, Xundi Xu
Summary: A TGF beta-associated signature has been developed and validated, which is capable of predicting the survival outcome and depicting the tumor microenvironment immune characteristics in gastric carcinoma (GC).
FRONTIERS IN GENETICS
(2022)
Article
Genetics & Heredity
Angela Verdoni, Jie Hu, Urvashi Surti, Melanie Babcock, Elizabeth Sheehan, Michele Clemens, Sarah Drewes, Leslie Walsh, Rebecca Clark, Sunita Katari, Joe Sanfilippo, Devereux N. Saller, Aleksandar Rajkovic, Svetlana A. Yatsenko
Summary: Patients with reciprocal balanced translocations (RBT) are at risk for recurrent pregnancy losses (RPL), affected children, and infertility. Factors such as chromosome-specific factors, female gender, age, and history of RPL influence pregnancy and in vitro fertilization success in RBT patients. Chromosomal microarray analysis of products of conception (POC) is necessary for accurate and timely diagnosis of patients with adverse reproductive outcomes.
GENETICS IN MEDICINE
(2021)
Article
Pathology
Seokhwi Kim, Won Jung Bae, Ji Mi Ahn, Jin-Hyung Heo, Kyoung-Mee Kim, Kyeong Woon Choi, Chang Ohk Sung, Dakeun Lee
Summary: The study identified unique miRNA expression profiles that can predict metastasis in intramucosal carcinomas (IMCs), with most miRNAs showing stepwise increased or decreased expression. A machine-learning algorithm could distinguish metastatic IMC from nonmetastatic IMC, and gene ontology and pathway analysis revealed enrichment of key signaling pathways. Furthermore, immunohistochemical staining indicated differential expression of pathway components between metastatic and nonmetastatic IMC.
Article
Public, Environmental & Occupational Health
Zhiwu Wang, Qiong Wu, Yankun Liu, Qingke Li, Jingwu Li
Summary: This study identified prognostic AS events in gastric cancer (GC) and constructed multi-AS-based signatures using RNA-Seq data. The study found that these AS events served as prognostic biomarkers and were correlated with the expression of splicing factors. The findings provide valuable evidence for understanding the prognosis and potential therapeutic targets in GC.
ARCHIVES OF PUBLIC HEALTH
(2022)
Article
Gastroenterology & Hepatology
Yubo Ma, Shengjie Zhang, Yi Wang, Can Hu, Jinxia Chen, Chuhong Pang, Chen Liang, Li Yuan, Yian Du
Summary: In this study, the prognosis and clinicopathological characteristics of mucinous gastric carcinoma (MGC) were compared to other types of gastric cancer (GC) using data from 4,417 hospitalized patients. MGC patients exhibited more advanced tumor infiltration, lower tumor differentiation, and higher rates of preoperative tumor marker positivity compared to adenocarcinoma. However, MGC surprisingly exhibited a better prognosis than adenocarcinoma after eliminating confounding factors, and age, pN stage, and preoperative levels of CA125 and CA724 were identified as independent prognostic markers.
JOURNAL OF GASTROINTESTINAL SURGERY
(2023)
Article
Automation & Control Systems
Chen Liu, Gang Wang, Xin Guan, Chutong Huang
Summary: In this paper, a framework that combines M-estimation and information-theoretic learning (ITL)-based Kalman filter under impulsive noises is proposed. The proposed framework inhibits the divergence trend of ITL-based Kalman filters at low kernel bandwidth and improves the performance at large kernel bandwidth. Monte Carlo simulations demonstrate the robustness and effectiveness of the proposed algorithm.
Review
Plant Sciences
Denise L. Lindsay, Joanna Freeland, Ping Gong, Xin Guan, Nathan E. Harms, Kurt P. Kowalski, Richard F. Lance, Dong-Ha Oh, Bradley T. Sartain, Douglas L. Wendell
Summary: Phragmites australis subsp. australis is an invasive and ecologically detrimental plant in North America. Differentiating between subspecies or haplotypes is necessary for targeted management of the invader. This review discusses current genetic discrimination methods, control tools, and implications for implementation, highlighting the need for faster and more accurate differentiation among native and introduced subspecies.
Article
Physics, Multidisciplinary
Xin Guan, Huan Shen, Charles Okanda Nyatega, Qiang Li
Summary: Recently, convolutional neural networks have made significant advancements in hand pose estimation from RGB images. However, accurately inferring occluded keypoints remains challenging. To address this, we propose a new network that leverages contextual information and relationships between different levels of features to learn rich representations of keypoints. Our network, consisting of GlobalNet and RegionalNet, uses a feature pyramid structure to roughly locate hand joints and a four-stage cross-scale feature fusion network to refine keypoint representation learning. Experimental results demonstrate that our method outperforms state-of-the-art approaches on two public datasets, STB and RHD.
Article
Automation & Control Systems
Jianping Li, Shichu Chen, Lidong He, Jiwen Jian, Yili Hu, Jianming Wen, Song Chen, Junwu Kan
Summary: This article proposes a bionic type piezoelectric actuator based on the walking motion of L-shaped flexure mechanisms, which can improve motion efficiency and achieve large working stroke with high output load. By eliminating backward motion and using two flexure mechanisms for bionic walking motion, the motion speed and maximum load can be significantly improved.
IEEE-ASME TRANSACTIONS ON MECHATRONICS
(2023)
Article
Engineering, Mechanical
Shengrong Lin, Jijie Ma, Jianping Li, Shengjie Li, Minghao Wang, Yili Hu, Jianming Wen
Summary: Inertial piezoelectric actuators based on the impact principle have attracted attention in precision positioning applications. However, the control strategy to optimize their motion states and output performances is yet to be studied. This work proposes a novel inertial impact piezoelectric actuator with adjustable angle vibrators. Static and dynamic analysis, along with experimental results, verify the theories and reveal the effects of vibrator angle on resolution and velocity. The control strategy successfully optimizes the actuator's motion state and output performances by adjusting its inclination angle.
INTERNATIONAL JOURNAL OF MECHANICAL SCIENCES
(2023)
Article
Engineering, Mechanical
Xin-long Liu, Chao-wei Zhou, Xin-jian Zhou, Ming-jie Hu, Dong-yun Wang, Qian Xiao, Xin Guan, Wu-lue Zhang, Song Zhang, Zhi-biao Xu
Summary: The probability of arc erosion is increased with the development of high-speed railways, especially in cold climates with ice-covered contact wires. This study investigates the wear properties of two carbon skateboards (copper-impregnated and pure carbon) with different surface treatments under rigid temperature conditions. The results show that the coefficient of friction and contact resistance increase with the duration of arc erosion, and the wear mechanism evolves differently for the two skateboards.
Article
Chemistry, Multidisciplinary
Difei Zhao, Jiaming Zhang, Xin Guan, Dandan Liu, Qinxia Wang, Weiwei Jiao, Xueqing Zhou, Yingjie Li, Geoff Wang, Yinghai Guo
Summary: Coal-bearing strata in the Transitional Upper Carboniferous Shanxi Formation in the Qinshui Basin have been proven to be mixed unconventional gas-bearing reservoirs forming a multi-superimposed gas system. The pore networks in high-rank coal, shale, and tight sandstone reservoirs from the Shanxi Formation were compared using different experimental methods. The results showed significant genetic and structural differences in pore types, morphology, abundance, and proportion, reflecting strong heterogeneity characteristics. Coal and tight sandstone reservoirs provide important spaces for adsorbed and free gas, while continuously developed shales of a specific thickness often divide the superimposed gas-bearing system.
APPLIED SCIENCES-BASEL
(2023)
Article
Construction & Building Technology
Jingcai Zhang, Yong Ding, Xinchun Guan, Jinping Ou
Summary: A new prefabricated seismic isolation system called FPB-CFST was proposed to enhance the mechanical performance and speed up the construction process of the isolation layer. Unlike traditional FPB-Pier systems, the CFST was used as the main support structure, with a spherical curvature surface (SCS) attached to allow sliding of the superstructure. A construction procedure for the FPB-CFST was proposed and various FPB-CFST specimens with different SCS radii were fabricated. Experimental investigations were conducted on the axial local compressive and compressive shear behaviors of the FPB-CFST. Friction coefficient tests and evaluations on the effects of sliding velocity and equivalent pressure were also performed.
JOURNAL OF BUILDING ENGINEERING
(2023)
Article
Soil Science
Renshan Li, Yu Wang, Congying Yuan, Weidong Zhang, Qingkui Wang, Xin Guan, Longchi Chen, Silong Wang, Jianming Han, Qingpeng Yang
Summary: The effects of leaf economic spectrum (LES) and nutrient resorption on litter decomposition temperature sensitivity (Q(10)) were investigated in 15 subtropical woody species. The results showed that Q(10) values were correlated with LES, with resource-conservative species having higher Q(10) values. Leaf nitrogen concentration, C:N ratio, and lignin:N ratio were correlated with Q(10), while leaf phosphorus and lignin concentrations, specific leaf area, and C:P ratio showed no relationships. Also, there was no correlation between LES and species-specific nitrogen and phosphorus resorption efficiency (NRE and PRE) with Q(10). These findings suggest an association between plant functional features and forest carbon dynamics in a warmer future.
BIOLOGY AND FERTILITY OF SOILS
(2023)
Article
Computer Science, Hardware & Architecture
Dan Xia, Jianhua Shi, Ke Wan, Jiafu Wan, Miguel Martinez-Garcia, Xin Guan
Summary: This article proposes a DT-based system architecture and a mobile-enhanced edge computing-cloud collaborative mechanism for intelligent planning and deployment of 6G networks, aiming to improve network performance and reduce operational costs.
IEEE WIRELESS COMMUNICATIONS
(2023)
Article
Materials Science, Multidisciplinary
Xin-long Liu, Song Zhang, Ti-Ming Zhang, Qian Xiao, Xin Guan, Wu-lue Zhang, Yi-ting Zheng, Ming-sheng Gao, Dao-yun Chen, Wen-bing Yang
Summary: In this paper, the electrical contact sliding wear and tribology properties of three kinds of surface coating (gold, silver, and tin) terminals at low temperature (-20 & DEG;C) were studied. It was found that an increase in current leads to large fluctuations in the coefficient of friction and increases the wear degree on the terminal surface. The surface gold-coating terminals mainly experience adhesive wear, the surface of silver-coating terminals mainly experience abrasive wear, and the tin-coating terminals mainly experience adhesive wear and a small amount of abrasive wear during the friction test.
Article
Chemistry, Multidisciplinary
Xin Guan, Guangyao Cheng, Yi-Ping Ho, Bernard P. P. Binks, To Ngai
Summary: In the past decades, various stimuli-responsive materials have been developed for droplet manipulation, with light being a flexible option for contactless control in three-dimensional space. This study presents a synthesis of plasmonic hybrid microgels through electrostatic heterocoagulation, which are effective stabilizers of oil-in-water Pickering emulsions. Laser irradiation on Au nanoparticles induces a cascade effect to thermally responsive microgels, causing microgel desorption and emulsion destabilization. The localized heating from a focused laser leads to the formation of air-in-oil-in-water emulsions, capable of mimicking natural microswimmers and achieving on-demand droplet merging and chemical communication.
Article
Green & Sustainable Science & Technology
Shuhui Yu, Xin Guan, Junfan Zhu, Zeyu Wang, Youting Jian, Weijia Wang, Ya Yang
Summary: Urban road green belts are crucial for improving the urban environment and protecting public health. This study uses Long Short-Term Memory (LSTM) to optimize the planning and design methods of Urban Green Space (UGS) in urban road green belts. The sensitivity-based self-organizing LSTM model outperforms LSTM, XGBoost, and SVR, with lower errors in RMSE, MAE, and MAPE. Different plant community configurations in the improved LSTM model have distinct effects on reducing PM 2.5 concentrations, with multi-layered green space and high canopy density showing better impact than single-layer green space with low canopy density. Evaluating the reduction function of green road spaces on PM 2.5, the study reveals that green space significantly reduces PM 2.5 under zero or slight pollution conditions (PM 2.5 < 100 μg/m³). The proposed model can aid UGS planning by identifying spatial morphology indicators that impact PM 2.5 reduction, facilitating the formulation of appropriate green space planning strategies.
Article
Engineering, Electrical & Electronic
Shan Chengxiang, Li Qiang, Guan Xin
Summary: This paper proposes a lightweight multi-view convolutional brain tumor segmentation algorithm. It effectively fuses information between channels, adds extraction ability for nonlinear features, performs convolution from different positions, and uses group convolution to save resources. It also weighs the importance of features extracted from different views. Experimental results show that the proposed algorithm achieves high segmentation accuracy with reduced parameters and floating-point operations.
LASER & OPTOELECTRONICS PROGRESS
(2023)
Article
Engineering, Electrical & Electronic
Qiang Li, Xu Wang, Xin Guan
Summary: In recent years, remarkable research progress has been made in the task of chest film disease classification with CNN in medical image processing. Dual-path network, compared with single structure CNN, can combine the characteristics of different CNN to improve the ability of disease classification. The attention mechanism helps the model to extract different pathological features and improve the classification accuracy. The proposed TADPN, a dual path convolution neural network combined with a triple attention mechanism, shows effectiveness with improved network complexity and classification accuracy while maintaining parameter stability, achieving an average AUC value of 0.8185 on the ChestXray14 dataset.
JOURNAL OF ELECTRONICS & INFORMATION TECHNOLOGY
(2023)
