Review
Biochemistry & Molecular Biology
Sindhu Nair, James A. Bonner, Markus Bredel
Summary: EGFR is overexpressed in head and neck squamous cell carcinoma and anti-EGFR strategies have shown some clinical benefit but often lead to resistance. Mutations in various domains of the EGFR gene can impact drug binding, radiation response, and overall survival in HNSCC patients. Understanding the EGFR mutational landscape and its effects on treatment resistance can help stratify patients for targeted therapies and maximize therapeutic benefits.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Xin Zhou, Xiaoshen Wang
Summary: This review provides a detailed illustration of the biology, genomic features, and immune landscapes of HPV-associated HNSCC, supporting the synergistic effect of radioimmunotherapy. Current evidence and ongoing clinical trials suggest the potential of radioimmunotherapy in recurrent/metastatic or definitive settings. Future challenges include optimization of radiotherapy and the incorporation of novel therapeutic options.
Review
Medicine, General & Internal
Kamila Romanowska, Agnieszka Sobecka, Agnieszka A. Rawluszko-Wieczorek, Wiktoria M. Suchorska, Wojciech Golusinski
Summary: Head and neck squamous carcinoma (HNSCC) is the sixth most prevalent cancer worldwide, with molecular pathogenesis involving cell cycle disorders, intercellular signaling, proliferation, squamous cell differentiation, and apoptosis. In addition to genetic mutations, epigenetic alterations such as DNA methylation and histone modifications play a key role in promoting cancer formation and progression, making them potential biomarkers and therapeutic targets for HNSCC.
Review
Biochemistry & Molecular Biology
Ching-Yun Hsieh, Ching-Chan Lin, Wei-Chao Chang
Summary: Taxanes, especially docetaxel, are widely used in combination therapy for head and neck squamous cell carcinoma (HNSCC) and have shown advantages in improving patient outcomes. Taxanes not only function as antimitotics, but also impair various oncogenic signaling pathways. However, the development of drug resistance remains a major obstacle to treatment response.
Review
Biochemistry & Molecular Biology
Shengjian Jin, Yasusei Kudo, Taigo Horiguchi
Summary: Ubiquitination and deubiquitination are two common post-translational modifications of proteins, affecting their intracellular localization, stability, and function. Deubiquitination is involved in various cellular processes, including histone modification, cell cycle regulation, apoptosis, and cancer development. This review focuses on the understanding of the function of deubiquitinating enzymes in head and neck squamous cell carcinoma (HNSCC) and discusses potential therapeutic strategies for HNSCC patients.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Medicine, Research & Experimental
Vaishali Chandel, Saurabh Maru, Arun Kumar, Ashok Kumar, Ashok Sharma, Brijesh Rathi, Dhruv Kumar
Summary: Head and Neck tumors exhibit highly altered metabolism, with cancer cells utilizing different pathways for energy production. Monocarboxylate transporters play a crucial role in regulating lactate and maintaining pH balance, essential for cancer cell survival and growth control.
Article
Oncology
Zongtai Qi, Yating Liu, Michael Mints, Riley Mullins, Reilly Sample, Travis Law, Thomas Barrett, Angela L. Mazul, Ryan S. Jackson, Stephen Y. Kang, Patrik Pipkorn, Anuraag S. Parikh, Itay Tirosh, Joseph Dougherty, Sidharth V. Puram
Summary: Tumors are composed of diverse cells rather than a uniform ball of cells. Recent studies have shown that deconvolution algorithms can be used to computationally estimate cell-type proportions from gene expression data, although their performance in tumor tissues remains unclear.
Article
Dentistry, Oral Surgery & Medicine
Fengyang Jing, Lijing Zhu, Jiaying Bai, Xinjia Cai, Xuan Zhou, Jianyun Zhang, Heyu Zhang, Tiejun Li
Summary: This study reveals the mechanisms and signaling pathways underlying the EGCG-mediated inhibition of carcinogenesis. EGCG significantly inhibits OSCC cell proliferation. A total of eleven potential EGCG target genes have been identified.
ARCHIVES OF ORAL BIOLOGY
(2023)
Article
Cell Biology
Julia Ingruber, Dragana Savic, Teresa Bernadette Steinbichler, Susanne Sprung, Felix Fleischer, Rudolf Glueckert, Gabriele Schweigl, Ira-Ida Skvortsova, Herbert Riechelmann, Jozsef Dudas
Summary: The study found that in head and neck squamous cell carcinoma, Slug gene expression was significantly higher while KLF4 gene expression was significantly lower. There was a significant negative correlation between KLF4 and Slug gene expression in the majority of HNSCC samples. TGF-β1 contributed to the downregulation of KLF4 and the upregulation of Slug.
Article
Dentistry, Oral Surgery & Medicine
Shijin Yu, Zongjun Ma, Tao Chen, Hong Wang, Qin Yao, Jin Li, Jie Cheng
Summary: The overexpression of ETV5 in head and neck squamous cell carcinoma is associated with aggressive features and reduced survival. Silencing ETV5 inhibits cell proliferation, migration, invasion, and induces apoptosis in vitro, and impairs tumor growth in vivo. ETV5 activates Slug transcription by binding its promoter region in HNSCC cells. Patients with ETV5highSlughigh have the worst survival outcomes.
Article
Oncology
Julia Schnoell, Alexandra Scheiflinger, Sega Al-Gboore, Lorenz Kadletz-Wanke, Lukas Kenner, Gregor Heiduschka, Bernhard J. Jank
Summary: PSMD14 is commonly expressed in HNSCC patients and associated with advanced stages. High expression of PSMD14 mRNA is associated with a worse outcome, but this may be due to the association of PSMD14 with poor prognosticators.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2023)
Review
Cell Biology
Chenhang Yu, Qiang Li, Yu Zhang, Zhi-Fa Wen, Heng Dong, Yongbin Mou
Summary: Head and neck squamous cell carcinoma (HNSCC) has a high incidence and mortality rate. Immunotherapy, with its potential for a broad and long-lasting antitumor response, has become an important therapeutic strategy for HNSCC. However, immune escape limits the effectiveness of immunotherapy. Various immunotherapy strategies, including immune checkpoint inhibitors, costimulatory agonists, antigenic vaccines, oncolytic virus therapy, adoptive T cell transfer, and targeted therapy, have been developed for HNSCC. Each strategy has its unique advantages, and their appropriate application has significant value for the treatment of HNSCC.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Oncology
Ruoyan Cao, Lin Cui, Jiayu Zhang, Xianyue Ren, Bin Cheng, Juan Xia
Summary: This study identifies subtypes of head and neck squamous cell carcinoma based on immune-related lncRNAs and characterizes their biological behaviors. The researchers found that certain subtypes are associated with good prognosis and sensitivity to immunotherapy, and identified a critical lncRNA TRG-AS1 involved in the tumor microenvironment. This provides new potential targets for the treatment of this subtype.
CANCER CELL INTERNATIONAL
(2022)
Article
Immunology
Yucheol Cheong, Minjin Kim, Jina Ahn, Hana Oh, Jongkwan Lim, Wonil Chae, Seung Won Yang, Min Seok Kim, Ji Eun Yu, Sanguine Byun, Yo Han Jang, Baik Lin Seong
Summary: The study investigated the potential use of catechins derived from green tea as adjuvants for subunit and inactivated vaccines, demonstrating their ability to enhance immune responses and provide protection against vaccines, including influenza virus.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Oncology
Kainan Wu, Fen Chang, Wenming Li, Tongdong Su, Dapeng Lei
Summary: IGF2BPs are RNA-bound proteins that play a crucial part in various cell functions and act as members of the m6A reader family. They are particularly important in tumor metabolism, specifically in head and neck squamous cell carcinoma.
FRONTIERS IN ONCOLOGY
(2022)
Article
Oncology
Madhusmita Behera, Conor E. Steuer, Yuan Liu, Felix Fernandez, Chao Fu, Kristin A. Higgins, Theresa W. Gillespie, Suchita Pakkala, Rathi N. Pillai, Seth Force, Chandra P. Belani, Fadlo R. Khuri, Walter J. Curran, Suresh S. Ramalingam
Correction
Oncology
Abedul Haque, Mohammad Aminur Rahman, James R. Fuchs, Zhuo Chen (Georgia), Fadlo R. Khuri, Dong M. Shin, A. R. M. Ruhul Amin
Article
Oncology
Arafat Tfayli, Majd Al Assaad, Ghina Fakhri, Reem Akel, Hanine Atwi, Hady Ghanem, Fadi El Karak, Fadi Farhat, Kamal Al Rabi, Pierre Sfeir, Pierre Youssef, Ziad Mansour, Hazem Assi, Mohamad Haidar, Alain Abi Ghanem, Ibrahim Khalifeh, Fouad Boulos, Ramy Mahfouz, Bassem Youssef, Youssef Zeidan, Rachelle Bejjany, Fadlo Khuri
Article
Oncology
Suchita Pakkala, Kristin Higgins, Zhengjia Chen, Gabriel Sica, Conor Steuer, Chao Zhang, Guojing Zhang, Shuhua Wang, Mohammad S. Hossain, Bassel Nazha, Tyler Beardslee, Fadlo R. Khuri, Walter Curran, Sagar Lonial, Edmund K. Waller, Suresh Ramalingam, Taofeek K. Owonikoko
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2020)
Article
Oncology
Taofeek K. Owonikoko, Bhakti Dwivedi, Zhengjia Chen, Chao Zhang, Benjamin Barwick, Vinicius Ernani, Guojing Zhang, Melissa Gilbert-Ross, Jennifer Carlisle, Fadlo R. Khuri, Walter J. Curran, Andrey A. Ivanov, Haian Fu, Sagar Lonial, Suresh S. Ramalingam, Shi-Yong Sun, Edmund K. Waller, Gabriel L. Sica
Summary: This study identified four subtypes of SCLC using RNA sequencing and immunohistochemistry, with the SCLC-Y subtype associated with an inflamed phenotype and favorable prognosis. Upregulation of interferon-gamma response genes was observed in long-term survivors, with higher expression in patients of the SCLC-Y subtype.
JOURNAL OF THORACIC ONCOLOGY
(2021)
Correction
Oncology
Fakeng Liu, Yuan Liu, Xiuju Liu, Kaisheng Mao, Diansheng Zhong, Adam I. Marcus, Fadlo R. Khuri, Shi-Yong Sun, Yulong He, Wei Zhou
Correction
Oncology
Kaisheng Mao, Fakeng Liu, Xiuju Liu, Fadlo R. Khuri, Adam Marcus, Mingsong Li, Wei Zhou
Editorial Material
Oncology
Fadlo R. Khuri
Summary: The COVID-19 pandemic has brought attention to health and vaccine disparities, and the collaborative development of targeted therapies for lung cancer has shown a promising path forward for improving survival rates.
Article
Oncology
Arafat H. Tfayli, Pierre M. Sfeir, Bassem Y. Youssef, Fadlo R. Khuri
CA-A CANCER JOURNAL FOR CLINICIANS
(2021)
Editorial Material
Oncology
Fadlo R. Khuri
Editorial Material
Oncology
Suresh S. Ramalingam, Fadlo R. Khuri
Article
Oncology
Fadlo R. Khuri
Letter
Medicine, General & Internal
Hana A. Mansour, Eugenie Bitar, Youssef Fares, Assad A. Makdessi, Antoine Maalouf, Mahmoud El Ghoul, Mohamad A. Mansour, Antoine Chami, Michel Khalil, Alex Jalkh, Daniel Cherfan, Jawad Fares, Fadlo R. Khuri, Ahmad M. Mansour
Article
Biochemistry & Molecular Biology
Fadlo R. Khuri
Summary: Higher education and healthcare sectors are facing challenges due to the COVID-19 pandemic. The Faculty of Medicine at the American University of Beirut is adapting to the situation and focusing on improving medical education to survive the crisis.
Article
Oncology
Jennifer A. Marks, Jeffrey M. Switchenko, Conor E. Steuer, Martha Ryan, Mihir R. Patel, Mark W. McDonald, Kristin Higgins, Johnathan J. Beitler, Dong M. Shin, Theresa W. Gillespie, Nabil F. Saba
Summary: The study found that in patients with oropharyngeal squamous cell carcinoma, HPV-positive patients with private insurance had improved overall survival compared to those without insurance; HPV-negative patients with private insurance also had improved survival compared to those without insurance. Additionally, there were statistical differences in the impact of insurance status, rural-urban status, and facility location on survival between HPV-positive and HPV-negative patients.
JCO ONCOLOGY PRACTICE
(2021)
Article
Oncology
Yuxin Liu, Swati Bhardwaj, Keith Sigel, John Winters, Joseph Terlizzi, Michael M. Gaisa
Summary: This study investigated the prevalence and severity of anal HPV disease among MSM LWH under the age of 35, finding a high prevalence of HPV infection and precancer but no cases of invasive anal cancer. This supports the adoption of age-based anal cancer screening for this population.
INTERNATIONAL JOURNAL OF CANCER
(2024)
Correction
Oncology
J. Gu, S. Xie, S. Wang
INTERNATIONAL JOURNAL OF CANCER
(2024)