Article
Oncology
Yang Li, Jun Cao, Jianfeng Wang, Weidong Wu, Liren Jiang, Xing Sun
Summary: This study found that IGF2BP3 plays an important role in the progression and distant metastasis of breast cancer and is closely associated with brain metastasis. Positive IGF2BP3 expression is related to decreased distant metastasis-free survival and the occurrence of brain metastasis in breast cancer patients. High IGF2BP3 expression is associated with the PD-1 checkpoint pathway, HER2-HER3 signaling, and epithelial-mesenchymal transition.
Article
Medicine, Research & Experimental
Lingxiang Lu, Fei Wang, Jianchun Chen, Chunchun Zhao, Shuai Guo, Da Dong, Minjun Jiang, Yuhua Huang
Summary: The study identified that the circTENM3 expression level is significantly decreased in prostate cancer and overexpression of circTENM3 can inhibit the progression of prostate cancer. Mechanistically, circTENM3 enhances RUNX3 levels through miR-558 sponge. Gain-of-function analysis revealed that circTENM3 overexpression can inhibit prostate cancer progression.
JOURNAL OF TRANSLATIONAL MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Emily A. Telford, Andrew J. Sanders, Sioned Owen, Fiona Ruge, Gregory M. Harrison, Wen G. Jiang, Tracey A. Martin
Summary: This study found that expression of HAVcR-1 is decreased in patients with prostate cancer, and the levels of HAVcR-1 ectodomain in serum are associated with the severity of the disease. In cell experiments, overexpression of HAVcR-1 led to changes in cell behavior and was associated with dysregulation of junctional complexes.
Article
Immunology
Zezhen Liu, Jiehui Zhong, Jie Zeng, Xiaolu Duan, Jianming Lu, Xinyuan Sun, Qinwei Liu, Yingke Liang, Zhuoyuan Lin, Weide Zhong, Wenzheng Wu, Chao Cai, Guohua Zeng
Summary: This study identified three distinct m6A regulation patterns in PCa, each with specific characteristics related to patient prognosis and tumor immune microenvironment. Among these patterns, patients in the low-m6Ascore group were more likely to benefit from ICIs therapy.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Ulrich Sommer, Tiziana Siciliano, Celina Ebersbach, Alicia-Marie K. Beier, Matthias B. Stope, Korinna Joehrens, Gustavo B. Baretton, Angelika Borkowetz, Christian Thomas, Holger H. H. Erb
Summary: PSMA protein plays an important role in the diagnosis and treatment of prostate cancer, and the activation and inhibition of androgen receptor (AR) can affect PSMA protein levels. This study found that AR activation and inhibition affect PSMA protein levels through a possible non-canonical mechanism, and low PSMA expression rates may be necessary to increase PSMA protein through androgen deprivation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Andrology
Zhaodong Han, Yuanfa Feng, Yulin Deng, Zhenfeng Tang, Shanghua Cai, Yangjia Zhuo, Yingke Liang, Jianheng Ye, Zhouda Cai, Shuai Yang, Yuxiang Liang, Chi Tin Hon, Jiahong Chen, Weide Zhong
Summary: The study indicates that AMIGO2 plays a critical role in numerous cancers, especially in prostate cancer (PCa). Lower expression of AMIGO2 inhibits PCa cell proliferation and colony formation. AMIGO2 serves as a reliable prognostic marker that can supplement the current prognosis evaluation system. AMIGO2 may promote PCa progression through inducing epithelial mesenchymal transition (EMT) and mediating docetaxel resistance.
TRANSLATIONAL ANDROLOGY AND UROLOGY
(2022)
Article
Chemistry, Multidisciplinary
Zhuangzhuang Zhang, Lijun Cheng, Qiongsi Zhang, Yifan Kong, Daheng He, Kunyu Li, Matthew Rea, Jianling Wang, Ruixin Wang, Jinghui Liu, Zhiguo Li, Chongli Yuan, Enze Liu, Yvonne N. Fondufe-Mittendorf, Lang Li, Chi Wang, Xiaoqi Liu, Tao Han
Summary: The study introduces a novel network-based systems biology approach, XDeath, to identify crosstalk of signaling pathways associated with PCa progression, and reveals the important roles of Plk1 and DNMT3a-related signaling pathways in PCa advancement, with a negative feedback mechanism between the two proteins.
Article
Medicine, Research & Experimental
Pengyu Liu, Wenxuan Wang, Fei Wang, Jiaqi Fan, Jinan Guo, Tao Wu, Dongliang Lu, Qingchun Zhou, Zhuohao Liu, Yuliang Wang, Zhiqun Shang, Franky Leung Chan, Wei Yang, Xin Li, Shan-Chao Zhao, Qingyou Zheng, Dinglan Wu
Summary: In this study, proteomic and metabolomic analysis of exosomes from prostate cancer (PCa) patients was performed. Several potential biomarkers for PCa and castration resistant prostate cancer (CRPC) were identified, including the proteins LRG1 and ITIH3. Metabolomic evaluation also revealed differentially expressed metabolites. These findings suggest the potential of exosomal proteins and metabolites as markers for CRPC and confirm the important role of the protein LRG1 in PCa progression.
JOURNAL OF TRANSLATIONAL MEDICINE
(2023)
Article
Multidisciplinary Sciences
Yutaro Kase, Katsuhiro Uzawa, Sho Wagai, Shusaku Yoshimura, Jun-Ichiro Yamamoto, Yuriko Toeda, Megumi Okubo, Keitaro Eizuka, Toshiaki Ando, Takafumi Nobuchi, Kohei Kawasaki, Tomoaki Saito, Manabu Iyoda, Dai Nakashima, Atsushi Kasamatsu, Hideki Tanzawa
Summary: Exosomes, engineered to contain therapeutic agents, have shown potential in attenuating the oncogenic activity of human cancer cells. Specifically targeting oral squamous cell carcinoma (OSCC) with engineered exosomes (octExosomes) loaded with siRNA has demonstrated significant tumor-suppressive effects both in vitro and in vivo, providing a valuable tool for inhibiting tumor cells.
SCIENTIFIC REPORTS
(2021)
Article
Biochemistry & Molecular Biology
Maria Goulielmaki, Savvas Stokidis, Theodoros Anagnostou, Ioannis F. Voutsas, Angelos D. Gritzapis, Constantin N. Baxevanis, Sotirios P. Fortis
Summary: This study investigated the prognostic role of HER-2/neu-specific T cell immunity in prostate cancer patients. The results showed that high frequencies of HER-2/neu-specific CD8+ T lymphocytes were associated with better progression-free survival and lower levels of TGF-beta and IL-8 in patients receiving standard treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Katarina Vlajic, Hannah Pennington Kluger, Wenjun Bie, Bradley J. Merrill, Larisa Nonn, Andre Kajdacsy-Balla, Angela L. Tyner
Summary: The example illustrates the role of tuft cells in prostate cancer, which are activated early in cancer development and increase in number with disease progression. Tuft cells contribute to the prostate cancer microenvironment and may promote the development of more advanced disease.
Article
Endocrinology & Metabolism
Mikaela M. Mallin, Kenneth J. Pienta, Sarah R. Amend
Summary: Metastatic cancer, especially bone metastases, is highly lethal. The determinants of bone-specific metastasis have remained unknown, although the sequential steps of metastasis have been studied extensively. This study proposes a new perspective on metastatic organotropism by applying ecological principles to cancer biology models. It suggests that bone-specific metastasis is the result of habitat selection by foraging cancer cells and that only a small subset of cells in a primary tumor possess this ability.
Editorial Material
Radiology, Nuclear Medicine & Medical Imaging
Fumihiko Soeda, Tadashi Watabe, Hiroki Kato, Motohide Uemura, Norio Nonomura
Summary: A 76-year-old man with dyspnea and initial prostate-specific antigen of 216 ng/mL was diagnosed with prostate cancer. Despite initial therapy, he later developed castration-resistant state with additional tumors detected. The use of PET/CT scans revealed metastasis to T5 vertebra and duodenum.
CLINICAL NUCLEAR MEDICINE
(2021)
Article
Oncology
Lei Dou, Xinxin Zhang
Summary: The study found that CCT3 expression was significantly upregulated in CESC, which was associated with a poor prognosis. Silencing CCT3 suppressed CESC cell proliferation, migration, and invasiveness in vitro. Additionally, CCT3-knockdown promoted CESC cell apoptosis, cell cycle arrest, and suppressed FN1 protein expression.
MOLECULAR MEDICINE REPORTS
(2021)
Article
Oncology
Jian-Hua Hong, Sung-Tzu Liang, Alexander Sheng-Shin Wang, Chia-Ming Yeh, Hsiang-Po Huang, Chia-Dong Sun, Zong-Han Zhang, Shih-Yu Lu, Yen-Hsiang Chao, Chung-Hsin Chen, Yeong-Shiau Pu
Summary: Prostate cancer is common among men in the Western world, but there are currently no reliable biomarkers to differentiate between aggressive and indolent cancer. Studies have shown that LMNB1 may play a role in the progression of prostate cancer, but the results have been inconsistent.
AMERICAN JOURNAL OF CANCER RESEARCH
(2022)