Article
Agriculture, Multidisciplinary
S. Kanagasubbulakshmi, K. Kadirvelu
Summary: An easy-to-use field-deployable methodology was developed for onsite detection of pesticidal crystal protein Cry2Ab from transgenic cotton crops. Anti Cry2Ab IgG and IgY antibodies were successfully developed and showed high sensitivity and specificity. The detection method offers a new approach to reduce seed adulteration.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2021)
Article
Chemistry, Inorganic & Nuclear
Xiaolin Guan, Jiaming Zhang, Shoujun Lai, Kang Wang, Wentao Zhang, Yang Han, Yuwen Fan, Chenghao Li, Jinhui Tong
Summary: A simple and environmentally friendly method for the synthesis of CuInS2 QDs based on polysaccharide has been developed, which shows excellent fluorescence properties and high sensitivity for Pb2+ detection.
INORGANIC CHEMISTRY
(2023)
Article
Engineering, Biomedical
Iqra Fatima, Abbas Rahdar, Saman Sargazi, Mahmood Barani, Mohadeseh Hassanisaadi, Vijay Kumar Thakur
Summary: Breast cancer research focuses on the biomarker HER2 and its application in targeted therapy. Nanotechnology and quantum dots have made significant advancements in imaging and treatment, promising to improve the efficacy of breast cancer treatment.
JOURNAL OF FUNCTIONAL BIOMATERIALS
(2021)
Review
Immunology
Saeed Yakhkeshi, Rao Wu, Brindha Chelliappan, Xiaoying Zhang
Summary: IgY technology involves a cost-effective production process of generating avian immunoglobulin for various applications in human and veterinary medicine. Recent progress in this field includes an increase in patent applications and clinical trials. Prospective analysis of the commercialization potential of IgY-based products is crucial.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Chemistry, Analytical
Yujie Sun, Qi Dong, Huan Yang, Weiling Song, Hong Zhou
Summary: In this study, a ratiometric electrochemical biosensor based on CuS quantum dots (CuS QDs) regulated by DNAzyme was developed for telomerase detection. Telomerase activity was measured by extending the substrate probe with repeated sequence, releasing CuS QDs as an input to the DNAzyme-modified electrode. The detection range was 1.0 x 10-12 - 1.0 x 10-6 IU/L, with a limit of detection of 2.75 x 10-14 IU/L. Telomerase activity in HeLa extracts was also tested to demonstrate its clinical application.
ANALYTICA CHIMICA ACTA
(2023)
Article
Chemistry, Analytical
Chunhua Wang, Yu Zhang, Wei Tang, Chao Wang, Yingkuan Han, Le Qiang, Jianwei Gao, Hong Liu, Lin Han
Summary: The developed universal biosensing platform combines the unique nanostructure and biochemistry properties of graphene oxide quantum dots with the high throughput and low cost of microfluidic chips, enabling reliable and simultaneous detection of multiple cancer biomarkers. This platform has a wide linear quantification range and ultra-low detection limits, allowing for simultaneous detection of multiple biomarkers from multiple individuals in a short time, significantly reducing detection costs and time.
ANALYTICA CHIMICA ACTA
(2021)
Article
Veterinary Sciences
Shikun Ge, Xingxing Zhang, Fagang Zhong, Xiang Liu, Xiaoying Zhang
Summary: A novel antibody mimetic, chicken IgY mimetic peptide, was developed in this study, showing excellent protective properties against canine parvovirus without cross-reactivity with other viruses. This study demonstrates the feasibility and ease of generating such novel antibody-like functional molecules for biomedical purposes.
VETERINARY RESEARCH
(2021)
Article
Chemistry, Analytical
Ankita Deb, Gaurav Raghunath Nalkar, Devasish Chowdhury
Summary: The dynamic interplay between nanotechnology and immunoassay has led to the development of a novel immunosensor using carbon dots for the detection of the disease biomarker VEGF. Carbon dots synthesized from a biogenic source were conjugated with a detection antibody and used as fluorescent labels. The immunosensor showed a wide linear range and low detection limit, demonstrating the potential of carbon dots as fluorescent labels in immunoassay techniques.
ANALYTICA CHIMICA ACTA
(2023)
Article
Biochemistry & Molecular Biology
Yesurajan Allwin Richard, Sebastinbaskar Aniu Lincy, Shakkthivel Piraman, Venkataraman Dharuman
Summary: To prevent the rising death rate, early detection of lung cancer is crucial. This paper presents a novel label-free electrochemical biosensor, based on composites of tin oxide quantum dots and gold nanoparticles (SnO2-QD-Au), for sensitive and precise detection of lung cancer DNA.
BIOELECTROCHEMISTRY
(2023)
Review
Oncology
Gavin P. Dowling, Stephen Keelan, Sinead Toomey, Gordon R. Daly, Bryan T. Hennessy, Arnold D. K. Hill
Summary: This article reviews the evolving treatment strategies in the neoadjuvant setting of HER2-positive breast cancer, discussing current challenges and future perspectives. The current standard of care combines chemotherapy with dual anti-HER2 therapy for high-risk HER2-positive breast cancer, aiming for a synergistic anti-tumor effect. De-escalation strategies are being investigated to safely reduce chemotherapy while optimizing HER2-targeted therapies, and promising novel therapies are being explored to improve outcomes in HER2-positive breast cancer.
FRONTIERS IN ONCOLOGY
(2023)
Review
Chemistry, Inorganic & Nuclear
Qian Zhang, Xinyi Zhang, Fei Ma, Chun-yang Zhang
Summary: DNA-modifying enzymes play crucial roles in genetic functions and their malfunction can lead to various human diseases. Detection of DNA-modifying enzymes is essential for fundamental research, drug discovery, and clinical diagnosis.
COORDINATION CHEMISTRY REVIEWS
(2022)
Article
Chemistry, Multidisciplinary
Emel Kirbas Cilingir, Meghana Sankaran, Jordan M. Garber, Frederic Anthony Vallejo, Mattia Bartoli, Alberto Tagliaferro, Steven Vanni, Regina M. Graham, Roger M. Leblanc
Summary: Carbon dots (CDs) have gained attention for their biocompatibility and tunable photoluminescence, but further analysis is needed before their use in clinical trials. A new type of carbon nitride dot (CND) has been found to selectively uptake cancer cells due to structural similarities with glutamine. The study investigates the effects of surface structural differences on the cellular uptake of CNDs and finds that the uptake mechanism is linked with ASCT2 and LAT1 transporters. CNDs show promise for selective cancer cell targeting by utilizing highly expressed transporters on cancer cells.
Article
Chemistry, Applied
Vishal Kansay, Varun Dutt Sharma, G. Chandan, Indu Sharma, Anita Bhatia, S. Chakrabarti, M. K. Bera
Summary: This study developed a one-step hydrothermal method to synthesize biocompatible fluorescent carbon quantum dots (CQDs) from Aegle marmelos fruit extract. The CQDs had a naturally distributed size, unintentional doping with heteroatoms, and exhibited strong photostability and water solubility. The study also explored the variables affecting CQD photoluminescence and demonstrated the potential of Ca, K, N-doped CQDs as fluorescent biomarkers for bio-imaging applications, with satisfactory cell survival and cytotoxicity results.
Article
Chemistry, Analytical
Bao-Yu Liao, Chi-Jung Chang, Chih-Feng Wang, Chien-Hsing Lu, Jem-Kun Chen
Summary: The sensitivity of an electrochemiluminescence (ECL) immunosensor was enhanced by controlled antibody orientation using modified Fe3O4 nanoparticles (FNs) and CdTe quantum dots (QDs) as nanocarriers and luminance labels. The developed immunosensor showed significantly improved fluorescence and ECL intensities with controlled antibody orientation, leading to a wider linear range and lower detection limits for quantifying human serum albumin (HSA). Results indicate that antibody orientation substantially improves the sensitivity of sandwich-structured ECL immunosensors for clinical bioassays.
SENSORS AND ACTUATORS B-CHEMICAL
(2021)
Article
Chemistry, Analytical
Hongyi Li, Xiaokun Wen, Yadan Ding, Guorui Wang, Hancheng Zhu, Junping Liu, Huiying Zhao, Xia Hong
Summary: A dual-mode immunoassay strategy based on CdS nanoparticles was developed, which has both photoluminescent and multi-phonon resonance Raman scattering properties. This strategy enables sensitive and specific detection of human immunoglobulin G (HIgG). It demonstrates advantages in detection sensitivity and working range compared to previous methods, with good stability and repeatability.
Article
Oncology
Yuxin Liu, Swati Bhardwaj, Keith Sigel, John Winters, Joseph Terlizzi, Michael M. Gaisa
Summary: This study investigated the prevalence and severity of anal HPV disease among MSM LWH under the age of 35, finding a high prevalence of HPV infection and precancer but no cases of invasive anal cancer. This supports the adoption of age-based anal cancer screening for this population.
INTERNATIONAL JOURNAL OF CANCER
(2024)
Correction
Oncology
J. Gu, S. Xie, S. Wang
INTERNATIONAL JOURNAL OF CANCER
(2024)