Article
Multidisciplinary Sciences
Qiang Zhao, Young-Min Han, Ping Song, Zhixue Liu, Zuyi Yuan, Ming-Hui Zou
Summary: In the bone marrow, dendritic cell development is regulated by endothelial cells. The expression of serine/threonine kinase 11 in endothelial cells impacts the differentiation of dendritic cell precursors by modulating the secretion of stem cell factor. Mutations in the tumor suppressor liver kinase b1 gene in endothelial cells disrupt the differentiation of dendritic cell precursors, leading to a reduction in mature dendritic cell numbers and the development of tumors.
NATURE COMMUNICATIONS
(2022)
Review
Allergy
Mindy Tsai, Peter Valent, Stephen J. Galli
Summary: The discovery of the cell surface receptor KIT and its ligand, stem cell factor (SCF), in 1987/1988 and 1990 has greatly contributed to our understanding of the development and function of various cell lineages. Mutations in KIT or SCF can have significant effects on the development and/or function of hematopoietic progenitors, melanocytes, germ cells, and mast cells. The biological importance of KIT in other cell types is still not well understood.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2022)
Article
Pharmacology & Pharmacy
Xi Chen, Shanshan Li, Xiaoli Liu, Jingjie Zhao, Lanting Wu, Ran You, Yanling Wang
Summary: This study investigates the role of endogenous c-kit(+) cells in retinal degeneration. Stimulation of these cells by stem cell factor (SCF) provides protection against retinal degeneration. SCF administration improves visual function and prevents the loss of retinal ganglion cells. Transcriptome analysis reveals that SCF-induced changes are closely correlated with eye development-related pathways.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Multidisciplinary Sciences
Hyuek Jong Lee, Jueun Lee, Myung Jin Yang, Young-Chan Kim, Seon Pyo Hong, Jung Mo Kim, Geum-Sook Hwang, Gou Young Koh
Summary: This study reveals that cellular crosstalk between endothelial cells and brown adipocytes plays a crucial role in lipid accumulation in brown adipose tissue (BAT). The stem cell factor (SCF) derived from endothelial cells promotes lipid accumulation by activating the c-Kit pathway. Understanding this mechanism is important for addressing metabolic diseases.
NATURE COMMUNICATIONS
(2023)
Article
Medicine, Research & Experimental
Yunqian Guan, Ren Wang, Xiaobo Li, Haiqiang Zou, Wenxiu Yu, Zhaohui Liang, Lei Li, Ling Chen, Liping Zhou, Zhiguo Chen
Summary: The study found that astrocytes, not microglia, were the main source of TNF-alpha expression in the infarct area of rats after ischemia. MSC transplantation was shown to suppress TNF-alpha expression by astrocytes.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Multidisciplinary Sciences
Akshata A. Almad, Arens Taga, Jessica Joseph, Sarah K. Gross, Connor Welsh, Aneesh Patankar, Jean -Philippe Richard, Khalil Rust, Aayush Pokharel, Caroline Plott, Mauricio Lillo, Raha Dastgheyb, Kevin Eggan, Norman Haughey, Jorge E. Contreras, Nicholas J. Maragakis
Summary: This study demonstrates that Cx43 hemichannels play a role in the progression of ALS by mediating astrocyte communication and that blocking these channels can provide neuroprotection for motor neurons. Additionally, Cx43 expression is up-regulated in ALS patients' tissue and cerebrospinal fluid.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Review
Biochemistry & Molecular Biology
Shelly Pathania, Olli T. Pentikainen, Pankaj Kumar Singh
Summary: Receptor tyrosine kinases, such as c-Kit, play crucial roles in cellular processes and their dysregulation can lead to diseases like cancer. Different mutant isoforms of c-Kit have been implicated in various cancers, making c-Kit inhibition a promising approach for cancer treatment. More research is needed to understand the structure, signaling pathways, and pharmacophores of c-Kit inhibitors for improved selectivity and efficacy in cancer therapy.
BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER
(2021)
Article
Biochemistry & Molecular Biology
Andrew D. Tieniber, Ferdinando Rossi, Andrew N. Hanna, Marion Liu, Mark S. Etherington, Jennifer K. Loo, Nesteene Param, Shan Zeng, Kevin Do, Laura Wang, Ronald P. DeMatteo
Summary: Gastrointestinal stromal tumor (GIST) is commonly driven by a single mutation in the Kit or PDGFRA receptor, and tyrosine kinase inhibitors (TKIs) are not curative. This study investigated the role of Kit ligand (KitL) in GIST oncogenesis and tumor growth. The researchers found that in addition to tumor cells, endothelia and smooth muscle cells produced KitL, and genetic reduction of KitL impaired tumor growth. They also observed heterogeneous KitL expression in human GIST specimens, with PDGFRA-mutant tumors showing higher expression. Elevated serum KitL was associated with imatinib resistance. Overall, KitL supports GIST growth and may serve as a biomarker and therapeutic target.
Article
Oncology
Amirhosein Kefayat, Alireza Amouheidari, Fatemeh Ghahremani, Zahra Alirezaei
Summary: The study aimed to assess the diagnostic and prognostic values of preoperative stem cell factor (SCF) plasma level in GBM patients. Results showed that the SCF plasma level can serve as a novel diagnostic blood-circulating biomarker for patients with GBM, but is not correlated with tumor volume, PFS, or OS in GBM patients.
Article
Pathology
Brittni M. Foster, Kendall L. Langsten, Ammar Mansour, Lihong Shi, Bethany A. Kerr
Summary: Stem cell factor (SCF) plays a crucial role in development, with continued expression in many cell types and tissues in adult humans and mice. High SCF expression in certain organs may be linked to an increased risk of SCF/CD117-related diseases.
EXPERIMENTAL AND MOLECULAR PATHOLOGY
(2021)
Article
Engineering, Biomedical
Zhongqian Liu, Shijie Mao, Yubin Hu, Feng Liu, Xiaowei Shao
Summary: This study developed an alginate hydrogel-based method to efficiently induce astrocytic differentiation from human neural stem cells, which significantly promoted differentiation within three days compared to conventional tissue culture materials. The regulatory mechanism underlying the enhanced differentiation was investigated, revealing the involvement of stretch-activated ion channels and a mechanosensitive transcription coactivator. These findings provide novel insights into the mechanism of astrocytic development through mechanical regulation.
MATERIALS TODAY BIO
(2023)
Article
Cell & Tissue Engineering
Toshiya Nishimura, Fabian P. Suchy, Joydeep Bhadury, Kyomi J. Igarashi, Carsten T. Charlesworth, Hiromitsu Nakauchi
Summary: The deletion of Igf1r in mouse embryos creates a permissive cell-competitive niche in multiple organs, significantly increasing both mouse intraspecies and mouse/rat interspecies donor chimerism.
Article
Cell Biology
Ayesha M. Yusuf, Rizwan Qaisar, Abaher O. Al-Tamimi, Manju Nidagodu Jayakumar, James R. Woodgett, Walter J. Koch, Firdos Ahmad
Summary: The loss of cardiomyocyte-GSK-3 beta promotes cardiomyocyte and resident CPC proliferation post-myocardial infarction, potentially regulated by dysregulated growth factors post-MI. Inhibiting cardiomyocyte-GSK-3 beta could be a helpful strategy for in situ cardiac regeneration post-ischemic injury.
JOURNAL OF CELLULAR PHYSIOLOGY
(2022)
Review
Cell Biology
Samantha N. Lanjewar, Steven A. Sloan
Summary: Research on human glial development and their role in neurodevelopmental disorders utilizes novel 2D cell culture protocols, 3D organoid models, and bioengineered systems derived from human stem cells.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Oncology
Brittni M. Foster, Lihong Shi, Koran S. Harris, Chirayu Patel, Victoria E. Surratt, Kendall L. Langsten, Bethany A. Kerr
Summary: Skeletal metastasis is a major cause of morbidity and mortality in prostate cancer, and stem cell factor (SCF) plays an important role in this process. Platelet-derived SCF is necessary for primary tumor growth, while osteoblast-derived SCF has no effect on tumor size. The effects of SCF are determined by its source and the genetic profile of prostate cancer.
FRONTIERS IN ONCOLOGY
(2022)
Article
Food Science & Technology
Lutz Grohmann, Anke Belter, Brigitte Speck, Ottmar Goerlich, Patrick Guertler, Alexandre Angers-Loustau, Alex Patak
JOURNAL OF CONSUMER PROTECTION AND FOOD SAFETY
(2017)
Article
Chemistry, Applied
Valentina Paracchini, Mauro Petrillo, Ralf Reiting, Alexandre Angers-Loustau, Daniela Wahler, Andrea Stolz, Birgit Schoenig, Anastasia Matthies, Joachim Bendiek, Dominik M. Meinel, Sven Pecoraro, Ulrich Busch, Alex Patak, Joachim Kreysa, Lutz Grohmann
Article
Food Science & Technology
Valentina Paracchini, Mauro Petrillo, Antoon Lievens, Antonio Puertas Gallardo, Jann Thorsten Martinsohn, Johann Hofherr, Alain Maquet, Ana Paula Barbosa Silva, Dafni Maria Kagkli, Maddalena Querci, Alex Patak, Alexandre Angers-Loustau
Article
Food Science & Technology
Sara Jacchia, Dafni-Maria Kagkli, Antoon Lievens, Alexandre Angers-Loustau, Christian Savini, Hendrik Emons, Marco Mazzara
Article
Biotechnology & Applied Microbiology
Erkko Ylosmaki, Cristina Malorzo, Cristian Capasso, Oona Honkasalo, Manlio Fusciello, Beatriz Martins, Leena Ylosmaki, Antti Louna, Sara Feola, Henrik Paavilainen, Karita Peltonen, Veijo Hukkanen, Tapani Viitala, Vincenzo Cerullo
Article
Cell Biology
Ting Wei, Saman M. Najmi, Hester Liu, Karita Peltonen, Alena Kucerova, David A. Schneider, Marikki Laiho
Article
Oncology
S. Feola, C. Capasso, M. Fusciello, B. Martins, S. Tahtinen, M. Medeot, S. Carpi, F. Frascaro, E. Ylosmaki, K. Peltonen, L. Pastore, V. Cerullo
Article
Multidisciplinary Sciences
Leena Ylosmaki, Beatrice Polini, Sara Carpi, Beatriz Martins, Elena Smertina, Sara Feola, Manlio Fusciello, Karita Peltonen, Paola Nieri, Erkko Ylosmaki, Vincenzo Cerullo
Article
Oncology
Siri Tahtinen, Sara Feola, Cristian Capasso, Netta Laustio, Christianne Groeneveldt, Erkko O. Ylosmaki, Leena Ylosmaki, Beatriz Martins, Manlio Fusciello, Marta Medeot, Maria Tagliamonte, Jacopo Chiaro, Firas Hamdan, Karita Peltonen, Tuuli Ranki, Luigi Buonaguro, Vincenzo Cerullo
Article
Multidisciplinary Sciences
Manlio Fusciello, Flavia Fontana, Siri Tahtinen, Cristian Capasso, Sara Feola, Beatriz Martins, Jacopo Chiaro, Karita Peltonen, Leena Ylosmaki, Erkko Ylosmaki, Firas Hamdan, Otto K. Kari, Joseph Ndika, Harri Alenius, Arto Urtti, Jouni T. Hirvonen, Helder A. Santos, Vincenzo Cerullo
NATURE COMMUNICATIONS
(2019)
Article
Oncology
Jacopo Chiaro, Henna H. E. Kasanen, Thomas Whalley, Cristian Capasso, Mikaela Gronholm, Sara Feola, Karita Peltonen, Firas Hamdan, Micaela Hernberg, Siru Makela, Hanna Karhapaa, Paul E. Brown, Beatriz Martins, Manlio Fusciello, Erkko O. Ylosmaki, Dario Greco, Anna S. Kreutzman, Satu Mustjoki, Barbara Szomolay, Vincenzo Cerullo
Summary: This study examined the impact of molecular mimicry on cancer immunotherapy, demonstrating that preexisting antiviral immunity may enhance the effectiveness of cancer immunotherapy through molecular mimicry. It was also observed that high levels of CMV-specific antibodies were associated with prolonged progression-free survival in melanoma patients undergoing anti-PD1 treatment, suggesting a potential link between immune responses to viruses and cancer. Additionally, T-cell receptor sequencing revealed expansion of specific CD8(+) T-cell clones indicating cross-reactivity between tumor and viral peptides.
CANCER IMMUNOLOGY RESEARCH
(2021)
Article
Oncology
Karita Peltonen, Sara Feola, Husen M. Umer, Jacopo Chiaro, Georgios Mermelekas, Erkko Ylosmaki, Sari Pesonen, Rui M. M. Branca, Janne Lehtio, Vincenzo Cerullo
Summary: This study explores a novel oncolytic adenovirus vaccine platform as immunotherapy in resistant tumors, customized for improved tumor targeting based on experimentally discovered tumor antigens; the pipeline may be applied for designing personalized therapeutic cancer vaccines, which is crucial for broader design and utility of therapeutic cancer vaccines. The study integrates immunopeptidome analysis-driven antigen discovery with a therapeutic cancer vaccine platform for improved personalized oncolytic immunotherapy, showing promising control of established tumors using a flexible and specific tumor targeting oncolytic adenovirus platform.
Article
Chemistry, Multidisciplinary
Sara Feola, Markus Haapala, Karita Peltonen, Cristian Capasso, Beatriz Martins, Gabriella Antignani, Antonio Federico, Vilja Pietiainen, Jacopo Chiaro, Michaela Feodoroff, Salvatore Russo, Antti Rannikko, Manlio Fusciello, Satu Koskela, Jukka Partanen, Firas Hamdan, Sari M. Tahka, Erkko Ylosmaki, Dario Greco, Mikaela Gronholm, Tuija Kekarainen, Masoumeh Eshaghi, Olga L. Gurvich, Seppo Yla-Herttuala, Rui M. M. Branca, Janne Lehtio, Tiina M. Sikanen, Vincenzo Cerullo
Summary: This study successfully identified and characterized tumor-specific ligands using a microfluidic-based chip, highlighting the potential for personalized cancer therapeutic vaccine design. The developed technology showed improved efficiency in isolating peptides and has the capability for high-throughput analysis with potential clinical applications.
Article
Medicine, Research & Experimental
Jani Huuhtanen, Henna Kasanen, Katriina Peltola, Tapio Lonnberg, Virpi Glumoff, Oscar Bruck, Olli Dufva, Karita Peltonen, Johanna Vikkula, Emmi Jokinen, Mette Ilander, Moon Hee Lee, Siru Makela, Marta Nyakas, Bin Li, Micaela Hernberg, Petri Bono, Harri Lahdesmaki, Anna Kreutzman, Satu Mustjoki
Summary: Relatlimab plus nivolumab (anti-LAG-3+anti-PD-1) has been approved by the FDA for first-line therapy in stage III/IV melanoma, but its impact on the immune system is not well understood. This study evaluated blood samples from 40 metastatic melanoma patients treated with anti-LAG-3+anti-PD-1 and found significant changes in NK cells, Tregs, and CD8+ T cells during the treatment. The study also observed differences in the transcriptome profile and TCR clonality between responders and non-responders.
JOURNAL OF CLINICAL INVESTIGATION
(2023)
Meeting Abstract
Biotechnology & Applied Microbiology
Sara Feola, Markus Haapala, Karita Peltonen, Cristian Capasso, Beatriz Martins, Gabriella Antignani, Antonio Federico, Vilja Pietiainen, Jacopo Chiaro, Michaela Feodoroff, Antti Ranniko, Manlio Fusciello, Satu Koskela, Jukka Partanen, Firas Hamdan, Sari Tahka, Erkko Ylosmaki, Dario Greco, Mikaela Gronholm, Tuija Kekarainen, Masoumeh Eshaghi, Olga L. Gurvich, Seppo Yla-Herttuala, Rui M. M. Branca, Janne Lehtio, Tiina Sikanen, Vincenzo Cerullo