Article
Pharmacology & Pharmacy
Qian Lu, Chao Jiang, Jialong Hou, Hao Qian, Feifan Chu, Weiqi Zhang, Mengke Ye, Ziyi Chen, Jian Liu, Hanbing Yao, Jianfeng Zhang, Jiake Xu, Te Wang, Shunwu Fan, Qingqing Wang
Summary: The incidence of osteoporosis is increasing, especially in postmenopausal women. Patchouli alcohol (PA), a natural compound with anti-inflammatory effects, has shown inhibitory effects on osteoclasts and may be a potential treatment for osteoporosis in the future.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Medicine, Research & Experimental
Kebin Xu, Ziyi Chen, Jialong Hou, Chenlin Dong, Chengge Shi, Linglin Gao, Zhixian Huang, Ge Shen, Te Wang, Yan Zhou
Summary: The study showed that Praeruptorin B, a major component in the roots of Peucedanum praeruptorum Dunn, could suppress osteoporosis and alleviate symptoms in patients. This finding offers potential for using Praeruptorin B in the treatment of osteoporosis in the future.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Biochemistry & Molecular Biology
Yuria Jang, Hong Moon Sohn, Young Jong Ko, Hoon Hyun, Wonbong Lim
Summary: The mutant RANKL demonstrated the ability to inhibit osteoclastogenesis by competitively inhibiting RANKL, serving as a potential therapeutic agent for osteoporosis with fewer toxic side effects compared to traditional treatments.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Cell Biology
Xiang Li, Yuxin Wang, Liangping Li, Shengji Zhou, Fengchao Zhao
Summary: Osteoclasts are crucial for bone health but can cause problems like osteoporosis. Sclareol, a natural compound, has various biological activities including anti-tumor, anti-inflammatory, antibacterial, and immunomodulatory functions. This study found that Sclareol inhibited osteoclastogenesis and promoted osteoblastogenesis by regulating the expression of CCN1 via the MAPK pathway, offering a potential treatment option for osteoclast-related disorders.
CELL BIOLOGY AND TOXICOLOGY
(2021)
Article
Pharmacology & Pharmacy
Qiang Xu, Guiping Chen, Huaen Xu, Guoming Xia, Meisong Zhu, Haibo Zhan, Bin Zhang, Min Dai, Hongxian Fan, Xuqiang Liu
Summary: Celastrol has shown promising potential in preventing aseptic prosthetic loosening and osteoporosis by inhibiting osteoclast formation and function, making it a potential treatment for osteolytic diseases induced by disrupted osteoclast function.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Cell Biology
Hui Liu, Chuankun Zhou, Dahu Qi, Yutong Gao, Meipeng Zhu, Tenghui Tao, Xuying Sun, Jun Xiao
Summary: MAGL plays a role in osteoclast differentiation through the MAPK and NF-kappa B pathways. JZL184 inhibits osteoclast differentiation and bone resorption, alleviating bone loss effects. Targeting MAGL may be a potential therapeutic strategy for osteoporosis.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Medicine, Research & Experimental
Toshio Kukita, Hidenobu Hiura, Jiong-Yan Gu, Jing-Qi Zhang, Yukari Kyumoto-Nakamura, Norihisa Uehara, Sara Murata, Soichiro Sonoda, Takayoshi Yamaza, Ichiro Takahashi, Akiko Kukita
Summary: ADM significantly stimulates osteoclastogenesis in the presence of calcitonin, with ADM receptor expressed on mononuclear osteoclast precursors playing a crucial role. The presence of Kat1 antigen in these cells suggests a specific regulation mechanism for modulating bone remodeling therapeutically.
LABORATORY INVESTIGATION
(2021)
Article
Orthopedics
Wen Guo, Haijun Li, Yan Lou, Yue Zhang, Jia Wang, Ming Qian, Haifeng Wei, Jianru Xiao, Youjia Xu
Summary: Tyloxapol has been found to suppress RANKL-stimulated osteoclastogenesis in a dose-dependent manner and in the initial stage of osteoclastogenesis. Through in vitro experiments, it was observed that Tyloxapol has the ability to inhibit the function of mature osteoclasts. Animal studies demonstrated that Tyloxapol reduced OVX-induced bone loss by inhibiting osteoclast activity.
JOURNAL OF ORTHOPAEDIC TRANSLATION
(2021)
Article
Plant Sciences
Yo-Seob Seo, Hyang Lim, Jeong-Yeon Seo, Kyeong-Rok Kang, Do Kyung Kim, Hyun-Hwa Lee, Deuk-Sil Oh, Jae-Sung Kim
Summary: The purpose of this study was to evaluate the anti-osteoporosis effects of Osmanthus fragrans leaf ethanol extract (OFLEE) in both bone marrow-derived macrophages (BMM) and animals with osteoporosis. OFLEE was found to suppress the formation of osteoclasts and the activation of various factors involved in osteoclastogenesis. It also downregulated several inflammatory factors and prevented osteoporotic bone loss in animals. These findings suggest that OFLEE could be a potential treatment option for osteoporosis.
Article
Pharmacology & Pharmacy
Huijiang Liu, Ronghe Gu, Qian Huang, Yun Liu, Chong Liu, Shijie Liao, Wenyu Feng, Tianyu Xie, Jinmin Zhao, Jiake Xu, Qian Liu, Xinli Zhan
Summary: This study found that isoliensinine can inhibit the differentiation of osteoclasts and reduce bone loss, showing great potential for treating osteoporosis.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Oncology
Tao Yu, Ce Dou, Yanzhu Lu, Lianli Duan, Jiulin Tan, Jianmei Li, Fei Kang, Shiwu Dong, Yun Bai, Jianzhong Xu, S. Dong, Yun Bai
Summary: The study found that Klotho deficiency impaired osteoclastogenesis, while Klotho promoted RANKL-induced osteoclastogenesis by activating the NF-Kappa B signaling pathway. Targeting Klotho may be an attractive therapeutic method for osteopenic diseases.
ANNALS OF TRANSLATIONAL MEDICINE
(2021)
Article
Medicine, Research & Experimental
Wei Yu, Leilei Zhong, Lutian Yao, Yulong Wei, Tao Gui, Ziqing Li, Hyunsoo Kim, Nicholas Holdreith, Xi Jiang, Wei Tong, Nathaniel Dyment, X. Sherry Liu, Shuying Yang, Yongwon Choi, Jaimo Ahn, Ling Qin
Summary: Our study identified marrow adipogenic lineage precursors (MALPs) as a critical player in controlling bone remodeling during normal bone metabolism and pathological bone loss in a RANKL-dependent fashion.
JOURNAL OF CLINICAL INVESTIGATION
(2021)
Review
Cell Biology
Luodan Zhang, Fa Zeng, Minmin Jiang, Maozhen Han, Binbin Huang
Summary: This article reviews the potential role and therapeutic potential of osteoprotegerin in endocrine and metabolic diseases. It mainly focuses on the effects of osteoprotegerin through the RANKL/RANK/OPG system on various processes such as bone remodeling, vascular calcification, and beta-cell proliferation, providing a comprehensive understanding of osteoprotegerin as a potential drug for these diseases.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Review
Endocrinology & Metabolism
Shu-ting Lin, Yi-zhong Li, Xiao-qi Sun, Qian-qian Chen, Shun-fa Huang, Shu Lin, Si-qing Cai
Summary: The relationship between breast cancer and osteoporosis is influenced by factors such as estrogen, RANKL, and NPY. Treatment for breast cancer may increase the risk of osteoporosis, while Y1 and Y5 receptors are highly expressed in breast cancer and Y1 and Y2 receptors may affect osteogenic response.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Dentistry, Oral Surgery & Medicine
Rui Wang, Huikun Luo, Di Yang, Bo Yu, Jiajie Guo, Lina Shao, Hirohiko Okamura, Lihong Qiu
Summary: The histone demethylase Jumonji domain-containing 3 (Jmjd3) plays a crucial role in regulating the communication between osteoblasts and osteoclasts. Jmjd3 inhibition in osteoblasts promotes osteoclastogenesis and upregulates RANKL expression, while decreasing EphB4 expression. Conversely, overexpression of EphB4 in osteoblasts inhibits osteoclastogenesis and RANKL expression.
Article
Biochemistry & Molecular Biology
Sandra Jose, Sreevidya S. Devi, Anjana Sajeev, Sosmitha Girisa, Mohammed S. Alqahtani, Mohamed Abbas, Abdulrahman Alshammari, Gautam Sethi, Ajaikumar B. Kunnumakkara
Summary: Farnesoid X receptor (FXR) regulates genes involved in lipid, carbohydrate, and inflammatory processes. It is a possible tumor suppressor and its down-regulation is associated with various diseases. FXR agonism has been shown to improve survival in certain cancers, and the development of novel agonists could have therapeutic potential. Computer-aided drug design can be used to identify potential candidates, and alvimopan and montelukast were found to have strong binding affinity with FXR in this study.
BIOSCIENCE REPORTS
(2023)
Review
Biotechnology & Applied Microbiology
Milad Ashrafizadeh, Ali Zarrabi, Hassan Karimi-Maleh, Afshin Taheriazam, Sepideh Mirzaei, Mehrdad Hashemi, Kiavash Hushmandi, Pooyan Makvandi, Ehsan Nazarzadeh Zare, Esmaeel Sharifi, Arul Goel, Lingzhi Wang, Jun Ren, Yavuz Nuri Ertas, Alan Prem Kumar, Yuzhuo Wang, Navid Rabiee, Gautam Sethi, Zhaowu Ma
Summary: Nanomedicine has great potential in the treatment of bladder cancer, including improving drug efficacy, regulating gene expression, providing photodynamic and photothermal therapy, remodeling tumor microenvironment and infiltration of immune cells, timely diagnosis, and targeted therapy for bladder cancer.
BIOENGINEERING & TRANSLATIONAL MEDICINE
(2023)
Correction
Chemistry, Medicinal
Elina Khatoon, Mangala Hegde, Aviral Kumar, Uzini Devi Daimary, Gautam Sethi, Anupam Bishayee, Ajaikumar B. Kunnumakkara
ARCHIVES OF PHARMACAL RESEARCH
(2023)
Article
Oncology
Mangala Hegde, Nikunj Naliyadhara, Jyothsna Unnikrishnan, Mohammed S. Alqahtani, Mohamed Abbas, Sosmitha Girisa, Gautam Sethi, Ajaikumar B. Kunnumakkara
Summary: Metastasis is the main cause of cancer-related deaths, and despite advancements in treatment methods, it remains difficult to treat. Nanotechnology has shown promising applications in the diagnosis and treatment of metastatic cancer, with nanoparticles demonstrating the ability to target specific cells within metastatic regions. This review summarizes the current state of nanotechnology in the field and discusses its potential in various imaging techniques and combination therapies.
Review
Biochemistry & Molecular Biology
Mangala Hegde, Aviral Kumar, Sosmitha Girisa, Mohammed S. Alqahtani, Mohamed Abbas, Akul Goel, Kam Man Hui, Gautam Sethi, Ajaikumar B. Kunnumakkara
Summary: The hallmark of chronic inflammatory diseases is immune evasion, and exosomes play a critical role in immunomodulation and lipid metabolism during the development and progression of these diseases.
CYTOKINE & GROWTH FACTOR REVIEWS
(2023)
Review
Cell Biology
Wei Shi, Gautam Sethi
Summary: A novel form of cell death called ferroptosis, which is iron-dependent and nonapoptotic, is triggered by lipid peroxidation. The regulation of ferroptosis has been found to play a crucial role in various pathological processes, including cancer. Recent studies suggest that understanding and targeting ferroptosis may provide a potential therapeutic strategy for cancer management, especially in the context of resistance to standard chemoradiotherapy. Long noncoding RNAs (lncRNAs) have been implicated in tumorigenesis and have been identified as regulators of ferroptosis, presenting an exciting avenue for cancer therapy. However, further research is needed to fully understand the mechanisms and potential treatments involving lncRNAs in the context of ferroptosis.
JOURNAL OF CELLULAR PHYSIOLOGY
(2023)
Review
Chemistry, Medicinal
Milad Ashrafizadeh, Chakrabhavi D. Mohan, Shobith Rangappa, Ali Zarrabi, Kiavash Hushmandi, Alan Prem Kumar, Gautam Sethi, Kanchugarakoppal S. Rangappa
Summary: Gastrointestinal (GI) tumors are a major cause of death worldwide. STAT3 is an oncogenic transcription factor that promotes tumor progression, metastasis, and drug resistance. Recent research has shown that noncoding RNAs (ncRNAs) play a major role in regulating the STAT3 pathway. This article discusses the role of STAT3 signaling in promoting GI tumors and comprehensively explores the oncogenic and tumor suppressor functions of ncRNAs that modulate STAT3 signaling in GI cancers.
MEDICINAL RESEARCH REVIEWS
(2023)
Review
Chemistry, Medicinal
Hui Li Ang, Chakrabhavi Dhananjaya Mohan, Muthu K. Shanmugam, Hin Chong Leong, Pooyan Makvandi, Kanchugarakoppal S. Rangappa, Anupam Bishyaee, Alan Prem Kumar, Gautam Sethi
Summary: Epithelial-mesenchymal transition (EMT) is a crucial process in which epithelial cells transform into mesenchymal cells, playing a significant role in tumor progression and resistance to therapy. Various factors, such as signaling pathways, transcriptional regulators, noncoding RNAs, and epigenetic alterations, are involved in the regulation of EMT. However, despite preclinical data, there is a lack of clinical translation in targeting EMT therapeutically. This review discusses the role of these factors in EMT regulation, the contribution of EMT to drug resistance, and potential therapeutic interventions using natural products and nano-formulations as EMT blockers.
MEDICINAL RESEARCH REVIEWS
(2023)
Article
Chemistry, Medicinal
Naisarg Gamit, Manasi Patil, Soumya B. Sundrappa, S. Mohana Sundaram, Gautam Sethi, Arun Dharmarajan, Sudha Warrier
Summary: A reliable and efficient in vitro model using amniotic membrane-derived mesenchymal stem cells (AM-MSCs) has been developed for screening drugs for Alzheimer's disease (AD). This model can assess the neuroprotective ability of different drugs and quickly test a large number of potential compounds. The study found that the novel drugs probucol and NMJ-2 have protective effects against neurodegeneration.
DRUG DEVELOPMENT RESEARCH
(2023)
Article
Chemistry, Medicinal
Rajaghatta N. Suresh, Young Y. Jung, Chakrabhavi D. Mohan, Shalini V. Gowda, Kachigere B. Harsha, Kempegowda Mantelingu, Gautam Sethi, Kwang S. Ahn, Kanchugarakoppal S. Rangappa
Summary: In this study, new compounds called DTI were synthesized and found to exhibit selective cytotoxicity against gastric cancer cells. The cytotoxic effect was achieved by inhibiting the phosphorylation of STAT3 and STAT5, which are transcription factors involved in cancer development. Further investigation revealed that the inhibition of STAT proteins was mediated through the suppression of upstream kinases such as JAK1, JAK2, and Src. The involvement of tyrosine phosphatase and negative regulator PTP & epsilon;C in the DTI-induced STATs inhibition was also demonstrated. Overall, triazolyl-indolo-quinoxaline compounds like DTI show promise as inhibitors of the STAT3/STAT5 pathway in gastric cancer cells.
DRUG DEVELOPMENT RESEARCH
(2023)
Article
Pharmacology & Pharmacy
Milad Ashrafizadeh, Wei Zhang, Rongjun Zou, Gautam Sethi, Daniel J. Klionsky, Xianbin Zhang
Summary: Pancreatic cancer is a serious gastrointestinal tract disease with a low 5-year survival rate. Genomic profile alterations and dysregulated biological mechanisms commonly occur in pancreatic cancer. Autophagy plays a crucial role in promoting the growth and metastasis of pancreatic cancer cells, as well as controlling their metabolism and drug resistance.
PHARMACOLOGICAL RESEARCH
(2023)
Article
Oncology
Yi Qin, Shengjun Xiong, Jun Ren, Gautam Sethi
Summary: Autophagy plays an important regulatory role in glioblastoma, and its dysregulation can lead to drug resistance and radioresistance. It also affects stem cell characteristics, overall growth, and metastasis. Therefore, autophagy is a promising target for glioblastoma therapy.
Article
Food Science & Technology
Mangala Hegde, Aviral Kumar, Sosmitha Girisa, Babu Santha Aswani, Ravichandran Vishwa, Gautam Sethi, Ajaikumar B. Kunnumakkara
Summary: Cancer is a complex disease with diverse characteristics and treatment responses. Overcoming the recurrence and resistance to therapy, as well as minimizing side effects, is crucial for improving the quality of life in cancer patients. This review explores the potential benefits of nanocurcumin, a nanotechnology-based formulation of the natural compound curcumin, in cancer treatment. Various types of curcumin nanoformulations are discussed, along with their anticancer activities and cellular mechanisms. The review also highlights the potential of nanocurcumin as a preventive or adjuvant therapy with conventional drugs.
Article
Oncology
Naveen Kumar, Gautam Sethi
Summary: Transformed cells acquire specific characteristics to become malignant. Telomerase, an enzyme complex, plays a significant role in maintaining telomere length. Its main component, TERT, interacts with various signaling molecules and promotes cancer hallmarks such as cell death resistance, sustained proliferation, angiogenesis activation, and metastasis. Understanding the role of telomerase in promoting cancer hallmarks is crucial for understanding the mechanism of cancer development and progression.
Review
Chemistry, Multidisciplinary
Hardeep Singh Tuli, Ruchira Joshi, Ginpreet Kaur, Vivek Kumar Garg, Katrin Sak, Mehmet Varol, Jagjit Kaur, Sulaiman Ali Alharbi, Tahani Awad Alahmadi, Diwakar Aggarwal, Kuldeep Dhama, Vivek Sheel Jaswal, Sonam Mittal, Gautam Sethi
Summary: Nanotechnology has led to the development of new materials (metal nanoparticles) that have specific applications in healthcare, particularly in the diagnosis and treatment of cancer. Metal nanoparticles can modulate molecular expression in the tumor microenvironment and have anti-cancer effects by inducing apoptosis and cell cycle arrest. They can also inhibit tumor angiogenesis, metastasis, and inflammation, thus preventing cancer proliferation.
JOURNAL OF NANOSTRUCTURE IN CHEMISTRY
(2023)