Article
Medicine, General & Internal
Gian Paolo Caviglia, Giorgio Martini, Angelo Armandi, Chiara Rosso, Marta Vernero, Elisabetta Bugianesi, Marco Astegiano, Giorgio Maria Saracco, Davide Giuseppe Ribaldone
Summary: The study found that patients with IBD have a similar risk of developing urothelial cancer compared to the general population, but males with a history of smoking are at increased risk.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Gastroenterology & Hepatology
Jonas F. Halfvarson, Jonas F. Ludvigsson, Francesca Bresso, Johan Askling, Michael C. Sachs, Ola Olen
Summary: This study found that there is familial aggregation of inflammatory bowel disease (IBD) and the association is stronger in first-degree relatives (FDRs) of IBD patients. The strength of association varies by IBD subtype and age of diagnosis, with the highest risk observed in pediatric-onset cases of Crohn's disease and ulcerative colitis. The future risk of IBD is also increased in relatives of IBD patients. These findings suggest the presence of genetic predisposition and call for targeted screening programs.
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2022)
Article
Immunology
Wen Cheng, Yang Liao, Ruiyu Mou, Xian Xiao, Yingjie Jia
Summary: Using mendelian randomization (MR) analysis, this study finds no causal association between inflammatory bowel disease (IBD) and prostate cancer (PCa), contradicting most observational studies.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Biology
Istvan Fedor, Eva Zold, Zsolt Barta
Summary: The prevalence of autoimmune diseases is higher in patients with colonic involvement in inflammatory bowel diseases than in those with ileal involvement. Crohn's disease patients have a higher rate of gluten-related disorders compared to ulcerative colitis and microscopic colitis patients. Ulcerative colitis patients may have laboratory markers of autoimmunity without fulfilling the diagnostic criteria for definite autoimmune disorders.
Article
Gastroenterology & Hepatology
Jordan E. Axelrad, Ola Olen, Michael C. Sachs, Rune Erichsen, Lars Pedersen, Jonas Halfvarson, Johan Askling, Anders Ekbom, Henrik Toft Sorensen, Jonas F. Ludvigsson
Summary: Crohn's disease patients are at increased risk of developing small bowel cancer and dying from it, with higher risks for recently diagnosed patients and those with childhood-onset, ileal, and stricturing CD. However, the absolute risks are low overall.
Review
Gastroenterology & Hepatology
Noreen Singh, Charles N. Bernstein
Summary: This article reviews the impact of environmental risk factors, such as early life exposures, lifestyle and hygiene, vaccinations, surgeries, exposure to drugs and gastrointestinal pathogens, on the risk of developing IBD.
UNITED EUROPEAN GASTROENTEROLOGY JOURNAL
(2022)
Article
Medicine, General & Internal
Wei-Sheng Chung, Sunny Chung, Chung-Y Hsu, Cheng-Li Lin
Summary: The study suggests that regardless of the presence of appendicitis, appendectomy increases the risks of ulcerative colitis and Crohn's disease.
FRONTIERS IN MEDICINE
(2021)
Article
Oncology
Benedetto Neri, Maria Lia Scribano, Alessandro Armuzzi, Fabiana Castiglione, Renata D'Inca, Ambrogio Orlando, Stefano Festa, Gabriele Riegler, Walter Fries, Gianmichele Meucci, Patrizia Alvisi, Filippo Mocciaro, Claudio Papi, Michelangela Mossa, Giorgia Sena, Luisa Guidi, Anna Testa, Sara Renna, Iris Frankovic, Anna Viola, Marta Patturelli, Carlo Chiaramonte, Livia Biancone
Summary: The sequence chronic inflammation-dysplasia-cancer is involved in the development of several gastrointestinal cancers. The characteristics of IBD, including CRC-related symptoms at onset, play a role in the long-term outcome of CRC in IBD patients. CRC has a higher incidence in UC and CD patients. Surveillance programs should focus on high-risk subgroups of patients.
Article
Gastroenterology & Hepatology
Emily W. Lopes, Paul Lochhead, Kristin E. Burke, James M. Richter, Ashwin N. Ananthakrishnan, Andrew T. Chan, Hamed Khalili
Summary: In this prospective study, it was found that dietary and lifestyle risk factors for inflammatory bowel disease may differ according to disease phenotype.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2022)
Article
Microbiology
Christopher H. Arehart, John D. Sterrett, Rosanna L. Garris, Ruth E. Quispe-Pilco, Christopher R. Gignoux, Luke M. Evans, Maggie A. Stanislawski
Summary: Inflammatory bowel disease (IBD) is a complex condition with disrupted colonic ecosystem. A framework for multi-omic data analysis was used to study the gut ecosystem in IBD. Metabolomics and viromics were found to be more predictive than metagenomics or metatranscriptomics, and combining all four scores improved disease diagnosis prediction.
Review
Oncology
Viviana Laredo, Sandra Garcia-Mateo, Samuel J. Martinez-Dominguez, Julia Lopez de la Cruz, Carla J. Gargallo-Puyuelo, Fernando Gomollon
Summary: Inflammatory Bowel Diseases (IBDs) are associated with an increased risk of colorectal cancer, small bowel cancer, intestinal lymphoma, and cholangiocarcinoma due to chronic inflammation. Treatment for IBD, such as Thiopurines and anti-TNFs, also carries an increased risk of neoplasms. However, other biologic agents like ustekinumab and vedolizumab have not shown an increased risk of neoplasms. Prospective studies are needed to determine the safety and management of IBD patients with current or prior history of cancer.
Article
Oncology
Qianyi Wan, Rui Zhao, Lin Xia, Yutao Wu, Yong Zhou, Yong Wang, Yaping Cui, Xiaoding Shen, Xiao-Ting Wu
Summary: This meta-analysis assessed the associations between inflammatory bowel disease (IBD) and the risk of gastric, small bowel, and colorectal cancer. The results showed that IBD is mainly associated with an increased risk of cancers in the lower gastrointestinal tract, including small bowel cancer and colorectal cancer. More observational studies are needed in the future to explore the association between IBD and gastric cancer, especially in Asian populations.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2021)
Article
Medicine, General & Internal
Naim Abu-Freha, Bracha Cohen, Michal Gordon, Sarah Weissmann, Emily H. Kestenbaum, Sergei Vosko, Muhammad Abu-Tailakh, Liza Ben-Shoshan, Daniel L. Cohen, Haim Shirin
Summary: This study investigated the prevalence and risk factors of CRC among a large cohort of IBD patients. The results showed that the rate of CRC was higher in CD and UC patients compared to the general population. Age, primary sclerosing cholangitis, diabetes mellitus, and glucocorticoids treatment were found to be predictors of CRC. Therefore, IBD patients, especially those with risk factors, should be closely monitored for CRC.
FRONTIERS IN MEDICINE
(2023)
Article
Gastroenterology & Hepatology
Amiko M. Uchida, John J. Garber, Ashley Pyne, Kathryn Peterson, Bjorn Roelstraete, Ola Olen, Jonas Halfvarson, Jonas F. Ludvigsson
Summary: In this nationwide cohort study, EoE was found to be associated with a 3.5-fold increased risk of later IBD diagnosis, possibly due to genetic or early environmental risk factors.
UNITED EUROPEAN GASTROENTEROLOGY JOURNAL
(2023)
Article
Gastroenterology & Hepatology
Bharati Kochar, Yue Jiang, Millie D. Long
Summary: The study found that patients with inflammatory bowel disease (IBD) have an increased risk of meningitis compared to non-IBD patients. Treatment with mesalamine was associated with a lower risk of meningitis, while comorbidities increased the odds of meningitis in patients.
JOURNAL OF CLINICAL GASTROENTEROLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Xinjun Li, Jan Sundquist, Per-Ola Forsberg, Kristina Sundquist
JOURNAL OF CARDIAC FAILURE
(2020)
Article
Pediatrics
Per Wandell, Axel C. Carlsson, Xinjun Li, Jan Sundquist, Kristina Sundquist
Summary: The risk of urolithiasis in second-generation immigrants was not significantly different from that of children with Swedish-born parents.
Article
Pediatrics
Per Wandell, Xinjun Li, Axel C. Carlsson, Jan Sundquist, Kristina Sundquist
Summary: The risk of extended sensorineural hearing impairment was higher in boys with parents from Asia, especially from Iraq.
Article
Pediatrics
Per Wandell, Xinjun Li, Axel C. Carlsson, Jan Sundquist, Kristina Sundquist
Article
Medicine, General & Internal
Christoffer Sundqvist, Xinjun Li, Kristina Sundquist, Filip Jansaker
Summary: This study reveals novel risk factors associated with female urinary incontinence (UI). The findings provide new knowledge about the burden of this disease among women, which can be utilized to promote more equitable healthcare for these patients in the future. Previous research aligned with these findings suggests the need for a comprehensive approach to address health disparities.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Infectious Diseases
Xinjun Li, Kristina Sundquist, Filip Jansaker
Summary: This study used nationwide primary healthcare data to explore antibiotic treatments for cystitis and investigate factors beyond the infection. The results showed that the trends of specific classes of antibiotics redeemed within five days from the diagnosis were similar to the national surveillance program. Factors such as sociodemographic factors were weakly associated with antibiotic treatment.
Article
Oncology
Kari Hemminki, Kristina Sundquist, Jan Sundquist, Asta Foersti, Vaclav Liska, Akseli Hemminki, Xinjun Li
Summary: Familial risk of liver and gallbladder cancer is relatively high, and it is associated with other cancers. Prevention of these cancers should focus on avoiding risk factors, such as alcohol, smoking, and overweight, and seeking medical care for diabetes and liver infections.
Article
Obstetrics & Gynecology
Filip Jansaker, Xinjun Li, Avalon Sundqvist, Kristina Sundquist, Christer Borgfeldt
Summary: This study aimed to estimate the association between sociodemographic factors and cervical neoplasia. The results showed that women with low education and women from Eastern Europe are more likely to suffer from cervical cancer, while women from non-Western regions have a lower risk of cervical cancer and carcinoma in situ. Women with chronic obstructive pulmonary disease (COPD) as a proxy for tobacco abuse are more susceptible to cervical cancer compared to women with a high education level.
ACTA OBSTETRICIA ET GYNECOLOGICA SCANDINAVICA
(2023)
Article
Cardiac & Cardiovascular Systems
Per Wandell, Xinjun Li, Axel C. Carlsson, Jan Sundquist, Kristina Sundquist
Summary: The study found that foreign-born individuals generally have a lower risk of cardiomyopathies, but men from Africa and Asia have a higher risk of hypertrophic cardiomyopathies, and men from Nordic countries have a higher risk of dilated cardiomyopathies.
BMC CARDIOVASCULAR DISORDERS
(2022)
Article
Oncology
Kari Hemminki, Kristina Sundquist, Jan Sundquist, Asta Forsti, Vaclav Liska, Akseli Hemminki, Xinjun Li
Summary: This study found a significant association between autoimmune diseases and hepatobiliary cancers through long-term tracking in the Swedish population. Several autoimmune diseases, particularly autoimmune hepatitis and primary biliary cirrhosis, were strongly linked with hepatobiliary cancers. Therefore, it is important to manage autoimmune disease symptoms carefully in each patient and promote a healthy lifestyle.
Article
Infectious Diseases
Filip Jansaker, Xinjun Li, Ingvild Vik, Niels Frimodt-Moller, Jenny Dahl Knudsen, Kristina Sundquist
Summary: This study aimed to explore the risk of pyelonephritis in women following cystitis and its relationship with antibiotic treatment, cervical cancer, parity, and sociodemographic factors. The results showed a negative correlation between antibiotic treatment and the occurrence of pyelonephritis, although the absolute risk reduction was low. Except for age and region of residency, other sociodemographic factors, parity, and cervical cancer were not associated with pyelonephritis.
Article
Clinical Neurology
Filip Jansaker, Jan Sundquist, Kristina Sundquist, Xinjun Li
Summary: This study aimed to explore the association between neighborhood deprivation and mortality in patients with schizophrenia and bipolar disorder. The findings revealed a significant association between neighborhood deprivation and all-cause mortality, as well as cause-specific mortalities, in both patient groups. These findings have implications for healthcare resource allocation and clinical management in deprived neighborhoods.
Article
Oncology
Kari Hemminki, Kristina Sundquist, Jan Sundquist, Asta Foersti, Vaclav Liska, Akseli Hemminki, Xinjun Li
Summary: Liver cancer, including hepatocellular carcinoma, gallbladder cancer, and bile duct cancer, is influenced by various risk factors such as alcohol, viral hepatitis, gallstones, infections, autoimmune diseases, and diabetes. This study demonstrates that the combination of these risk factors can account for at least 50% of the causes of these cancers, highlighting the significance of chronic inflammation as an underlying mechanism. The use of national hospital records in Sweden provides valuable insights into the potential comorbidities associated with hepatobiliary cancers.
Article
Psychology, Applied
Xinjun Li, Filip Jansaker, Jan Sundquist, Kristina Sundquist
Summary: Patients with bipolar disorder living in high deprivation neighbourhoods have a significantly higher risk of developing type 2 diabetes compared to those living in low deprivation neighbourhoods.
Article
Geriatrics & Gerontology
Per Wandell, Axel C. Carlsson, Xinjun Li, Jan Sundquist, Kristina Sundquist
AGING CLINICAL AND EXPERIMENTAL RESEARCH
(2020)
Article
Oncology
Yuxin Liu, Swati Bhardwaj, Keith Sigel, John Winters, Joseph Terlizzi, Michael M. Gaisa
Summary: This study investigated the prevalence and severity of anal HPV disease among MSM LWH under the age of 35, finding a high prevalence of HPV infection and precancer but no cases of invasive anal cancer. This supports the adoption of age-based anal cancer screening for this population.
INTERNATIONAL JOURNAL OF CANCER
(2024)
Correction
Oncology
J. Gu, S. Xie, S. Wang
INTERNATIONAL JOURNAL OF CANCER
(2024)