期刊
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
卷 10, 期 3, 页码 321-326出版社
IVYSPRING INT PUBL
DOI: 10.7150/ijbs.8456
关键词
STAMP2; mitochondria; metalloreductase; metabolism; inflammation; insulin resistance
资金
- National Research Foundation of Korea (NRF) grant
- Korea government (MSIP) [2013 041811]
Six transmembrane protein of prostate 2 (STAMP2) is a protein that has been extensively studied due to its association with prostate cancer. Currently, STAMP2 is well known for its critical role in metabolism and modulating inflammatory signals. Even so, the molecular mechanism of STAMP2 activity and its downstream effectors are still largely unknown. Here, we review the current knowledge of STAMP2, and suggest possible explanations for some of its less well-understood features. A few studies suggest that STAMP2 may interact with mitochondria. Considering STAMP2 functions as a potential component of mitochondrial biology may yield valuable insight into this protein.
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