Article
Biochemistry & Molecular Biology
Swathi Ramakrishnan, Rick A. Kittles, Wendy J. Huss, Jianmin Wang, Kristopher Attwood, Anna Woloszynska
Summary: Dihydrotestosterone (DHT) and testosterone (T) play crucial roles in the proliferation and survival of prostate cancer cells. This study found significant differences in the serum levels of metabolites involved in DHT/T biosynthesis between African American (AA) and European American (EA) men with prostate cancer. The study also revealed higher frequencies of gene polymorphisms related to corticosterone-aldosterone conversion in AA men. Additionally, higher levels of T and pregnenolone were associated with a lower risk of progression-free survival only in AA men.
Review
Biochemistry & Molecular Biology
Demitria M. Vasilatis, Christopher A. Lucchesi, Paramita M. Ghosh
Summary: Dogs naturally develop prostate cancer similar to aggressive forms found in humans. Prostate cancer samples in dogs often lack androgen receptor (AR), which can enhance our understanding of AR-indifferent prostate cancer in humans. This review highlights the molecular similarities between dog and human prostate cancer variants, suggesting the potential use of dogs as pre-clinical animal models for developing new therapies and diagnostics that can benefit both species.
Editorial Material
Cell Biology
Li Xin
Summary: EZH2 has been shown to promote the development of castration-resistant prostate cancer (CRPC) by interacting with the androgen receptor (AR) to reprogram its transcriptional activity, facilitating the transition of CRPC into a lineage infidelity state.
NATURE CELL BIOLOGY
(2021)
Article
Medicine, General & Internal
Mallika Marar, Qi Long, Ronac Mamtani, Vivek Narayan, Neha Vapiwala, Ravi B. Parikh
Summary: This study investigated the differences in outcomes between African American and non-Hispanic White men with metastatic castration-resistant prostate cancer (mCRPC) who received first-line abiraterone therapy. The results showed that African American men had a higher overall survival when receiving first-line abiraterone compared to non-Hispanic White men. However, there was a difference in outcomes between the two groups for first-line enzalutamide treatment.
Review
Biochemistry & Molecular Biology
Haozhe Zhang, Yi Zhou, Zengzhen Xing, Rajiv Kumar Sah, Junqi Hu, Hailiang Hu
Summary: This review discusses the close relationship between the evolution of prostate cancer and androgen levels and the status of the androgen receptor. It also explores how alterations in androgen metabolism contribute to the resistance to anti-androgen therapy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Margherita Corti, Stefano Lorenzetti, Alessandro Ubaldi, Romano Zilli, Daniele Marcoccia
Summary: The role of endocrine disruptors in the human prostate gland is overlooked, but they can influence the homeostasis and diseases of the prostate, including prostate cancer.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Tae Jin Kim, Young Hwa Lee, Kyo Chul Koo
Summary: The androgen receptor (AR) plays a crucial role in the development and progression of prostate cancer (PCa), and treatment for hormone-sensitive prostate cancer (HSPC) relies heavily on androgen deprivation therapy (ADT). Despite most patients progressing to castration-resistant prostate cancer (CRPC), studies suggest that manipulating alternative molecular pathways can help improve current treatments and develop novel therapies for CRPC management.
Article
Oncology
Xiaolei Shi, Abderrahman Day, Hannah E. Bergom, Sydney Tape, Sylvan C. Baca, Zoi E. Sychev, Gabrianne Larson, Asha Bozicevich, Justin M. Drake, Nicholas Zorko, Jinhua Wang, Charles J. Ryan, Emmanuel S. Antonarakis, Justin Hwang
Summary: The study identifies B7-H3 as an immune checkpoint overexpressed in prostate cancer, particularly in metastatic castration-resistant prostate cancer (mCRPC). Enzalutamide-resistant mCRPC cells show increased expression of B7-H3, and it is associated with resistance signaling pathways. The gene network of B7-H3 is strongly correlated with androgen receptor (AR) and its co-factors, suggesting potential therapeutic targets for mCRPC.
NPJ PRECISION ONCOLOGY
(2022)
Article
Oncology
Zemin Hou, Shengsong Huang, Zhenfei Li
Summary: Androgens are crucial in the development of prostate cancer, and targeting steroidogenesis and the androgen receptor has been effective in delaying disease progression. New generation androgen receptor pathway inhibitors like abiraterone and enzalutamide continue to emphasize the role of the androgen-AR axis, even in cases of resistance. The importance of this axis in managing the disease after resistance to current treatments, particularly in neuroendocrine prostate cancer, remains uncertain.
Article
Medicine, Research & Experimental
Sue Jin Moon, Byong Chang Jeong, Hwa Jin Kim, Joung Eun Lim, Hye-Jeong Kim, Ghee Young Kwon, Joshua A. Jackman, Jeong Hoon Kim
Summary: The study identified BCT as a potent inhibitor targeting both AR-FL and AR-V7 activities in CRPC, effectively suppressing tumor growth and metastasis. Mechanistically, BCT disrupts the interaction of HSP90 with AR-FL/AR-V7, leading to their degradation and showing promising therapeutic potential against CRPC.
Article
Oncology
Cheng Qian, Dan Li, Yu Chen
Summary: The ETS family of proteins plays critical roles in prostate cancer, and gene fusion and overexpression of certain members have been linked to the development of this cancer. This review provides an overview of the discovery, classification, and therapeutic targeting of ETS family members in prostate cancer.
Article
Cell Biology
Anindita Ravindran, Kimiko L. Krieger, Akash K. Kaushik, Helene Hovington, Sadia Mehdi, Danthasinghe Waduge Badrajee Piyarathna, Vasanta Putluri, Paul Basil, Uttam Rasaily, Franklin Gu, Truong Dang, Jong Min Choi, Rajni Sonavane, Sung Yun Jung, Lisha Wang, Rohit Mehra, Nancy L. Weigel, Nagireddy Putluri, David R. Rowley, Ganesh S. Palapattu, Chantal Guillemette, Louis Lacombe, Eric Levesque, Arun Sreekumar
Summary: UGT2B28 gene plays a key role in promoting prostate tumor growth, with higher expression levels observed in African American men with prostate cancer and regulated by full-length androgen receptor.
Review
Biochemistry & Molecular Biology
Navid Sobhani, Praveen Kumar Neeli, Alberto D'Angelo, Matteo Pittacolo, Marianna Sirico, Ilaria Camilla Galli, Giandomenico Roviello, Gabriella Nesi
Summary: Metastatic prostate cancer is the most common cancer in males with a poor prognosis, and many patients develop the AR-V7 variant. AR-V7 acts as a transcription factor in the nucleus, repressing crucial tumor suppressor genes. Anti-AR-V7 drugs show promise for this subset of patients.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Multidisciplinary Sciences
Zhao Wei, Song Wang, Yaning Xu, Wenzheng Wang, Fraser Soares, Musaddeque Ahmed, Ping Su, Tingting Wang, Elias Orouji, Xin Xu, Yong Zeng, Sujun Chen, Xiaoyu Liu, Tianwei Jia, Zhaojian Liu, Lutao Du, Yunshan Wang, Shaoyong Chen, Chuanxin Wang, Housheng Hansen He, Haiyang Guo
Summary: This study reveals that MYC interacts with CTCF protein and rewires the chromatin architecture in prostate cancer by modifying CTCF-mediated chromatin looping. MYC colocalizes with CTCF at certain genomic sites, enhancing CTCF occupancy and promoting CTCF-mediated chromatin looping, which disrupts the enhancer-promoter loops of genes related to neuroendocrine lineage plasticity.
NATURE COMMUNICATIONS
(2023)
Review
Medicine, Research & Experimental
Joanna Dulinska-Litewka, Dominik Felkle, Kacper Dykas, Zuzanna Handziuk, Marta Krzysztofik, Bartosz Gasiorkiewicz
Summary: The role of cyclins in hormone-dependent neoplasms, especially breast cancer, is crucial. However, cyclins in prostate cancer are less studied, particularly the role of other cyclins that requires further investigation. Recent studies have shown that cyclins not only regulate the cell cycle but also interact with other signaling pathways. The androgen signaling axis plays a significant role in prostate cancer progression and interferes with cyclin pathways.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Environmental Sciences
Leonor C. Costa, Iram Mohmood, Tito Trindade, Mohammad Saleem, Armando C. Duarte, Eduarda Pereira, Iqbal Ahmad
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2015)
Meeting Abstract
Urology & Nephrology
Mohammad Saleem, Badrinath Konety, Aijaz Parray, Hifzur Siddique, Robert Matusik, Mikihik Naito, Alyssa Langfald
JOURNAL OF UROLOGY
(2015)
Review
Chemistry, Medicinal
Maryam Abbaspour Babaei, Behnam Kamalidehghan, Mohammad Saleem, Hasniza Zaman Huri, Fatemeh Ahmadipour
DRUG DESIGN DEVELOPMENT AND THERAPY
(2016)
Article
Oncology
Yuqiao Sheng, Kangdong Liu, Qiong Wu, Naomi Oi, Hanyong Chen, Kanamata Reddy, Yanan Jiang, Ke Yao, Haitao Li, Wei Li, Yi Zhang, Mohammad Saleem, Wei-Ya Ma, Ann M. Bode, Ziming Dong, Zigang Dong
Article
Medicine, General & Internal
Lei Wang, Ji Wang, Hua Xiong, Fengxia Wu, Tian Lan, Yingjie Zhang, Xiaolan Guo, Huanan Wang, Mohammad Saleem, Cheng Jiang, Junxuan Lu, Yibin Deng
Article
Oncology
Aijaz Parray, Hifzur R. Siddique, Jacquelyn K. Kuriger, Shrawan K. Mishra, Johng S. Rhim, Heather H. Nelson, Hiroyuki Aburatani, Badrinath R. Konety, Shahriar Koochekpour, Mohammad Saleem
INTERNATIONAL JOURNAL OF CANCER
(2014)
Article
Multidisciplinary Sciences
Hifzur Rahman Siddique, Aijaz Parray, Weixiong Zhong, R. Jeffery Karnes, Eric J. Bergstralh, Shahriar Koochekpour, Johng S. Rhim, Badrinath R. Konety, Mohammad Saleem
Article
Multidisciplinary Sciences
Hifzur Rahman Siddique, Aijaz Parray, Rohinton S. Tarapore, Lei Wang, Hasan Mukhtar, R. Jeffery Karnes, Yibin Deng, Badrinath R. Konety, Mohammad Saleem
Article
Multidisciplinary Sciences
Abeer M. Mahmoud, Tian Zhu, Aijaz Parray, Hifzur R. Siddique, Wancai Yang, Mohammad Saleem, Maarten C. Bosland
Article
Cell Biology
Lei Wang, Hua Xiong, Fengxia Wu, Yingjie Zhang, Ji Wang, Liyan Zhao, Xiaolan Guo, Li-Ju Chang, Yong Zhang, M. James You, Shahriar Koochekpour, Mohammad Saleem, Haojie Huang, Junxuan Lu, Yibin Deng
Article
Biochemistry & Molecular Biology
Arsheed A. Ganaie, Hifzur R. Siddique, Ishfaq A. Sheikh, Aijaz Parray, Lei Wang, Jayanth Panyam, Peter W. Villalta, Yibin Deng, Badrinath R. Konety, Mohammad Saleem
MOLECULAR CARCINOGENESIS
(2020)
Article
Oncology
Arsheed A. Ganaie, Adrian P. Mansini, Tabish Hussain, Arpit Rao, Hifzur R. Siddique, Ashraf Shabaneh, Marina G. Ferrari, Paari Murugan, Jorg Klingelhofer, Jinhua Wang, Noona Ambartsumian, Christopher A. Warlick, Badrinath R. Konety, Mohammad Saleem
MOLECULAR CANCER THERAPEUTICS
(2020)
Article
Oncology
Rofaida Gaballa, Hamdy E. A. Ali, Mohamed O. Mahmoud, Johng S. Rhim, Hamed Ali, Heba F. Salem, Mohammad Saleem, Mohamed A. Kandeil, Stefan Ambs, Zakaria Y. Abd Elmageed
Article
Biotechnology & Applied Microbiology
Ateeq M. Khaliq, Cihat Erdogan, Zeyneb Kurt, Sultan Sevgi Turgut, Miles W. Grunvald, Tim Rand, Sonal Khare, Jeffrey A. Borgia, Dana M. Hayden, Sam G. Pappas, Henry R. Govekar, Audrey E. Kam, Jochen Reiser, Kiran Turaga, Milan Radovich, Yong Zang, Yingjie Qiu, Yunlong Liu, Melissa L. Fishel, Anita Turk, Vineet Gupta, Ram Al-Sabti, Janakiraman Subramanian, Timothy M. Kuzel, Anguraj Sadanandam, Levi Waldron, Arif Hussain, Mohammad Saleem, Bassel El-Rayes, Ameen A. Salahudeen, Ashiq Masood
Summary: Colorectal cancer (CRC) consensus molecular subtypes (CMS) exhibit distinct immunological, stromal cell, and clinicopathological characteristics. Single-cell characterization of CMS subtype tumor microenvironments reveals significant intratumoral heterogeneity. Different cancer-associated fibroblasts (CAFs) and C1Q+ tumor-associated macrophages (TAMs) within tumor microenvironments can predict patient prognosis with greater precision and may influence immunotherapy responses in CRC patients.