Article
Immunology
Sen Zhang, Huangfu Hui, Qinli Zhao, Yujun Li, Lina Wu
Summary: This study revealed that the long noncoding RNA HCP5 is highly expressed in laryngeal squamous cell carcinoma (LSCC) and plays a role in promoting cancer cell growth, migration, and invasion. HCP5 interacts with miR-216a-5p, and its knockdown inhibits the malignant biological function of LSCC cells. Moreover, miR-216a-5p downregulates the expression of ZEB1, a target gene involved in LSCC progression. These findings suggest that targeting HCP5 may be a potential therapeutic strategy for LSCC.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Oncology
Vittorio Castaldo, Michele Minopoli, Francesca Di Modugno, Andrea Sacconi, Domenico Liguoro, Rachele Frigerio, Arianna Ortolano, Marta Di Martile, Luisa Gesualdi, Gabriele Madonna, Mariaelena Capone, Roberto Cirombella, Angiolina Catizone, Donatella Del Bufalo, Andrea Vecchione, Maria Vincenza Carriero, Paolo Antonio Ascierto, Rita Mancini, Luigi Fattore, Gennaro Ciliberto
Summary: The study demonstrates that miR-4443 and miR-4488 promote enhanced migratory and invasive phenotypes in drug-resistant melanoma cells. Mechanistically, the intermediate filament nestin has been identified as a molecular target of both oncomiRs. Finally, nestin levels have been shown to predict the response to treatment in melanoma patients, suggesting potential for developing miRNA-targeted therapies and identifying novel biomarkers for guiding clinical decisions.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2023)
Article
Oncology
Xiaohui Zhang, Tingyu Li, Ya-Nan Han, Minghui Ge, Pei Wang, Lina Sun, Hao Liu, Tianyu Cao, Yongzhan Nie, Daiming Fan, Hao Guo, Kaichun Wu, Xiaodi Zhao, Yuanyuan Lu
Summary: In this study, we identified a novel mechanism by which miR-125b enhances metastasis in CRC by targeting CFTR and CGN, promoting EMT and uPA expression and secretion, and enhancing RhoA/ROCK signaling pathway. These findings suggest miR-125b as a key functional molecule in CRC and a promising biomarker for the diagnosis and treatment of CRC.
Article
Biochemistry & Molecular Biology
Jing Sui, Qun Zhao, Yanqiu Zhang, Geyu Liang
Summary: The study found that LINC00961 is significantly downregulated in non-small cell lung cancer (NSCLC) tissues, and it inhibits the expression of miR-19a-3p/miR-19b-3p/miR-125b-5p through the PI3K-AKT/MAPK/mTOR signaling pathway, thereby suppressing tumor cell proliferation and migration while promoting apoptosis. This may provide potential biomarkers for the diagnosis and treatment of NSCLC.
DNA AND CELL BIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Ke Li
Summary: This study revealed that miR-509-3-5p regulates the malignancy of colon cancer by suppressing target gene GTSE1. Downregulation of miR-509-3-5p in CC and its overexpression can inhibit the proliferation, migration, and invasion of CC cells. MiR-509-3-5p targets GTSE1, identified as an oncogene in colon cancer.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2021)
Article
Medicine, General & Internal
Zhuo Gao, Jannan Jiang, Lijian Hou, Bin Zhang
Summary: This study reveals the upregulation of RNF187 in colorectal cancer (CRC) and its association with poor prognosis. Inhibition of RNF187 expression suppresses the proliferation, migration, and invasion while promoting apoptosis of CRC cells. miR-144-5p is identified as a direct target of RNF187, and its downregulation in CRC tissues is negatively correlated with RNF187 expression. Restoration of miR-144-5p significantly inhibits CRC cell progression, which can be abolished by overexpression of RNF187.
JOURNAL OF TRANSLATIONAL INTERNAL MEDICINE
(2022)
Article
Biotechnology & Applied Microbiology
Xuehe Wang, Huaqin Sun, Simin Zhu
Summary: The study demonstrated that an aberrant upregulation of PTAR in cervical cancer tissues and cell lines promotes proliferation, migration, and invasion of HeLa cells, while inhibiting apoptosis and downregulating miR-101 expression through direct binding. These findings suggest that PTAR plays a crucial role and may serve as a promising target for cervical cancer diagnosis and therapy.
Article
Oncology
Shasha Zhu, Xiangbing Kong, Mengru Song, Mingyang Chi, Yitong Liu, Peng Zhang, Qiao Zhang, Pingping Shang, Feifei Feng
Summary: miR-223-3p attenuates the migration and invasion of NSCLC cells by regulating NLRP3.
FRONTIERS IN ONCOLOGY
(2022)
Article
Oncology
Hongfeng Zhao, Minping Bi, Meng Lou, Xiaowei Yang, Liwen Sun
Summary: LncRNA SOX2-OT is highly expressed in HCC cells and tissues, with poor prognosis in patients. Inhibiting SOX2-OT decreased malignant behaviors of HCC cells and promoted MSI2 expression by binding to miR-143-3p. Nude mouse tumorigenesis experiments confirmed the role of SOX2-OT in promoting proliferation and invasion of HCC cells.
FRONTIERS IN ONCOLOGY
(2021)
Article
Medicine, Research & Experimental
Ignacio Fernando Hall, Montserrat Climent, Chiara Viviani Anselmi, Laura Papa, Vinicius Tragante, Luca Lambroia, Floriana Maria Farina, Marcus E. Kleber, Winfried Maerz, Carlo Biguori, Gianluigi Condorelli, Leonardo Elia
Summary: The study identifies a SNP, rs41291957 (A), near the miR-143/145 cluster that upregulates miR-143 and miR-145, modulating vascular smooth cell phenotype and acting as a protective factor against coronary artery disease.
EMBO MOLECULAR MEDICINE
(2021)
Article
Medicine, Research & Experimental
Yunxia Liu, Xia Liu, Yanhua Zhou, Tingting Liu, Jie Li
Summary: The study revealed that high expression of miR-27a in cholangiocarcinoma patients is associated with lymph node metastasis, TNM stages, and poorer overall survival. Overexpression of miR-27a promotes cell proliferation, migration, and invasion in CCA, while knockdown suppresses these processes. These findings suggest the potential utility of miR-27a in prognosis and progression of CCA.
CLINICAL AND EXPERIMENTAL MEDICINE
(2021)
Article
Oncology
Neng Tang, Xiaolin Dou, Xing You, Yixiong Li, Xi Li, Guodong Liu
Summary: The study revealed that androgen receptor can suppress HCC cells invasion and migration capacities via miR-122-5p/RABL6 signaling, providing a new potential therapeutic target for better treatment of HCC.
FRONTIERS IN ONCOLOGY
(2021)
Article
Pharmacology & Pharmacy
J-X Xu, C-M Liu, C-P Ma
Summary: This study revealed that miR-99b is downregulated in NSCLC tissues, and its overexpression inhibits the invasion and migration capacities of NSCLC cells. NIPBL was identified as a direct target of miR-99b and plays a role in the suppressive effects on NSCLC cell invasion and migration mediated by miR-99b. These findings suggest that the miR-99b/NIPBL axis may serve as novel biomarkers for NSCLC treatments.
EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES
(2021)
Article
Cell Biology
Lei Yang, Wenliang Tan, Yingcheng Wei, Zhiqin Xie, Wenxin Li, Xiaowu Ma, Qingbin Wang, Huilong Li, Ziyu Zhang, Changzhen Shang, Yajin Chen
Summary: This study demonstrates the tumor-suppressive role of circLIFR in hepatocellular carcinoma (HCC) by regulating miR-624-5p and inactivating the GSK-3 beta/beta-catenin signaling pathway.
CELL DEATH & DISEASE
(2022)
Article
Cell Biology
Xi Chen, Qing-Qing Tan, Xin-Rui Tan, Shi-Jun Li, Xing-Xing Zhang
Summary: In NAFLD models, circ_0057558 was found to increase while miR-206 decreased. miR-206 directly inhibited lipogenesis and TG secretion by binding to ROCK1 3'-UTR, and circ_0057558 bound to miR-206 to de-repress ROCK1/AMPK signaling. Knockdown of circ_0057558 or overexpression of miR-206 inhibited lipogenesis and TG secretion. ROCK1 knockdown reversed the effects of circ_0057558 overexpression.
CELL DEATH & DISEASE
(2021)