Article
Oncology
Zhili Ma, Shun Li, Yiqin Wang, Jiaxing Zhang, Xiaofang Zeng
Summary: A novel lncRNA AC104958.2 was found to be upregulated in HCC tissues and associated with MVI, promoting cell viability, metastasis, invasion, and EMT in HCC. The interaction between AC104958.2 and PCBP2 was identified and shown to play a crucial role in HCC development.
EXPERIMENTAL CELL RESEARCH
(2021)
Article
Oncology
Min Hee Yang, Chakrabhavi Dhananjaya Mohan, Amudha Deivasigamani, Arunachalam Chinnathambi, Sulaiman Ali Alharbi, Kanchugarakoppal S. Rangappa, Sang Hoon Jung, Hyejin Ko, Kam Man Hui, Gautam Sethi, Kwang Seok Ahn
Summary: Procaine inhibits the EMT process and c-Met-dependent signaling cascades, suggesting its potential as an anti-metastatic agent for HCC.
Article
Biotechnology & Applied Microbiology
Huiming Zhang, Shuang Liu, Liqiang Chen, Yanliang Sheng, Wenzhe Luo, Gang Zhao
Summary: miR-509-3p inhibits the proliferation, migration, invasion, and EMT of HCC cells by negatively regulating Twist, thereby suppressing HCC development and metastasis.
Article
Pharmacology & Pharmacy
Huaguo Liang, Zexin Chen, Ruihui Yang, Qingsong Huang, Hongmei Chen, Wanting Chen, Li Zou, Peng Wei, Shijie Wei, Yongxia Yang, Yongli Zhang
Summary: The polyphenolic compound Methyl gallate (MG) found in plants can inhibit the proliferation, migration, and invasion of HCC cells both in vitro and in vivo. The therapeutic mechanism of MG potentially involves the regulation of the AMPK/NF-kappa B pathway, which influences the epithelial-mesenchymal transition and MMP expression.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Oncology
Yang Yang, Pengwei Ren, Xiaofeng Liu, Xiaoyan Sun, Chunfeng Zhang, Xiaojuan Du, Baocai Xing
Summary: This study found that PPP1R26 is upregulated in hepatocellular carcinoma (HCC) and is significantly associated with metastasis and poor patient survival. PPP1R26 promotes glycolysis by enhancing the splicing of PKM2 and activates epithelial-mesenchymal transition (EMT) by forming a PPP1R26-PKM2-TGIF2 complex, driving the progression of HCC.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2022)
Article
Oncology
Gang Yang, Guan Wang, Yongfu Xiong, Ji Sun, Weinan Li, Tao Tang, Jingdong Li
Summary: The study demonstrated that CDC20 is highly expressed in HCC and its high expression is associated with poor prognosis. Silencing of CDC20 inhibited the proliferation, migration, and invasion of HCC cells, while increasing the expression of E-cadherin.
MOLECULAR MEDICINE REPORTS
(2021)
Article
Biochemistry & Molecular Biology
Yanhong Wang, Na Li, Yanping Zheng, Anqing Wang, Chunlei Yu, Zhenbo Song, Shuyue Wang, Ying Sun, Lihua Zheng, Guannan Wang, Lei Liu, Jingwen Yi, Yanxin Huang, Muqing Zhang, Yongli Bao, Luguo Sun
Summary: KIAA1217 plays a crucial role in hepatocellular carcinoma (HCC) metastasis by promoting cell migration and invasion through inducing epithelial-mesenchymal transition (EMT), and activating JAK1/2 and STAT3. It interacts with the Notch and Wnt/β-catenin pathways to facilitate HCC metastasis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Oncology
Hongchi Yu, Jia He, Guanyue Su, Yuelong Wang, Fei Fang, Wenxing Yang, Kaiyun Gu, Naiyang Fu, Yunbing Wang, Yang Shen, Xiaoheng Liu
Summary: The study revealed that fluid shear stress facilitated cytoskeleton rearrangement in hepatocellular carcinoma cells, leading to the release of YAP from integrin beta subunit and subsequent activation of EMT-regulating transcription factor SNAI1 and expression of EMT-related genes. FSS-treated HepG2 cells exhibited significantly increased tumorigenesis and metastasis in vivo.
MOLECULAR ONCOLOGY
(2021)
Article
Chemistry, Medicinal
Ying Liu, Dao-Hai Cheng, Ke-Dao Lai, Hua Su, Guo-Shou Lu, Li Wang, Ji-Hua Lv
Summary: Ventilagolin suppresses the migration, invasion, and EMT of HCC cells by downregulating Pim-1, showing potential therapeutic effects. In vivo experiments demonstrate that Ventilagolin effectively inhibits HCC tumor growth and regulates the expression of Pim-1 and EMT-related proteins.
DRUG DESIGN DEVELOPMENT AND THERAPY
(2021)
Article
Oncology
Rongzhong Xu, Liubing Lin, Bo Zhang, Jian Wang, Fanchen Zhao, Xiaolin Liu, Yiping Li, Yan Li
Summary: The study found that BIRC5 was highly expressed in HCC samples and associated with poor prognosis. Through WGCNA, 180 module genes were screened, overlapped with 241 DEGs, ultimately obtaining 33 candidate genes. Cox regression analyses identified 8 genes which were used to construct a risk signature, showing high accuracy in predicting clinical outcomes and closely related to clinicopathological characteristics of HCC patients. IPA suggested these 8 genes were enriched in cancer and immune-related pathways.
Article
Biotechnology & Applied Microbiology
Qiannan Zhao, Fen Jiang, Hui Zhuang, Yanfeng Chu, Fang Zhang, Chenghong Wang
Summary: miR-124-3p inhibits HCC proliferation and epithelial-mesenchymal transition (EMT) by targeting ARRDC1.
Article
Oncology
Gongmin Zhu, Hongwei Xia, Qiulin Tang, Feng Bi
Summary: The study identified an EMT-related 5-gene signature (PDCD6, TCOF1, TRIM28, EZH2 and FAM83D) for predicting the prognosis of HCC patients. The signature accurately and independently predicted HCC prognosis, and its predictive capacity was validated in external cohorts. Functional experiments revealed that PDCD6 promoted cell migration and invasion in HCC.
CANCER CELL INTERNATIONAL
(2021)
Article
Pharmacology & Pharmacy
Weihao Kong, Zhongxiang Mao, Chen Han, Zhenxing Ding, Qianqian Yuan, Gaosong Zhang, Chong Li, Xuesheng Wu, Jia Chen, Manyu Guo, Shaocheng Hong, Feng Yu, Rongqiang Liu, Xingyu Wang, Jianlin Zhang
Summary: In this study, a nine-gene signature related to epithelial-mesenchymal transition (EMT) was identified to predict the survival outcome of hepatocellular carcinoma (HCC) patients. The predictive nomogram based on the EMT risk score showed good distinguishing ability and consistency. The EMT risk score was also found to be correlated with immune infiltration.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Azusa Kitao, Osamu Matsui, Yu Zhang, Takahiro Ogi, Satoko Nakada, Yasunori Sato, Kenichi Harada, Norihide Yoneda, Kazuto Kozaka, Dai Inoue, Kotaro Yoshida, Wataru Koda, Taro Yamashita, Tatsuya Yamashita, Shuichi Kaneko, Satoshi Kobayashi, Toshifumi Gabata
Summary: Imaging characteristics of P53-mutated hepatocellular carcinoma (HCC) can be determined using dynamic CT and gadoxetic acid-enhanced MRI, and they are correlated with clinical features, pathologic findings, and prognosis. Dilated vasculature at the arterial phase of dynamic CT and a lower relative enhancement ratio at the hepatobiliary phase of gadoxetic acid-enhanced MRI are useful markers for predicting P53-mutated HCC.
Article
Medicine, General & Internal
Xianjue Wang, Ping Wei, Ling Yang, Fangyuan Liu, Xin Tong, Xiaoyu Yang, Liya Su
Summary: The study revealed that miR-20a-5p is significantly upregulated in HCC tissues, promoting cell proliferation, migration, and invasion while suppressing apoptosis through regulating the EMT process. Additionally, by downregulating RUNX3, miR-20a-5p activates the EMT pathway, enhancing the malignant behavior of HCC cells.
CHINESE MEDICAL JOURNAL
(2022)