Article
Pharmacology & Pharmacy
Hala N. ElShagea, Rana R. Makar, Alaa H. Salama, Nermeen A. Elkasabgy, Emad B. Basalious
Summary: This study focuses on delivering the hydrophilic drug, rasagiline mesylate (RSM), directly to the brain through intranasal administration. Transferosomes were formed to encapsulate RSM and incorporated into an in situ gel. The optimized transferosomal in situ gel showed safety and biocompatibility, with enhanced brain bioavailability and direct nose-to-brain drug delivery.
Article
Biochemistry & Molecular Biology
Mehboob Ur Rehman Kashif, Muhammad Sohail, Shujaat Ali Khan, Muhammad Usman Minhas, Arshad Mahmood, Syed Ahmed Shah, Sabeeh Mohsin
Summary: The study demonstrates that CSG-EH-NPs T-Hgel has an enhanced sustained release drug profile, with approximately 86% and 84% drug released in phosphate buffer saline and simulated nasal fluid respectively throughout 48 hours compared to EH-NPs. In-vivo pharmacokinetic parameters, such as mean residence time (MRT) and area under the curve (AUC(tot)), further establish the superiority of CSG-EH-NPs T-Hgel over EH-NPs.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Chemistry, Medicinal
Fakhara Sabir, Gabor Katona, Ruba Ismail, Bence Sipos, Rita Ambrus, Ildiko Csoka
Summary: The study successfully developed solid lipid nanoparticles loaded with n-propyl gallate in a hydrogel formulation using Transcutol-P as a permeation enhancer. The optimized PG-SLNs-loaded HG showed lower burst effect, sustained release profile, improved antioxidant activity, and enhanced permeation compared to SLNs. The combination of SLNs and HG has the potential to improve nasal absorption of antioxidants due to enhanced stability and mucoadhesive properties.
Article
Pharmacology & Pharmacy
Angela Bonaccorso, Cinzia Cimino, Daniela Erminia Manno, Barbara Tomasello, Antonio Serra, Teresa Musumeci, Giovanni Puglisi, Rosario Pignatello, Claudia Carbone
Summary: This study focuses on the development of nanostructured lipid carriers (NLC) for intranasal delivery of essential oils, showing that NLC formulated with Lavandula or Rosmarinus exhibit more ordered structures and higher cytocompatibility with murine and human fibroblasts. These results suggest that positively charged NLC containing Lavandula or Rosmarinus could be a potential add-on strategy for the treatment of neurodegenerative diseases through intranasal administration.
Article
Biochemistry & Molecular Biology
Yuan Gao, Xiaochen Gong, Shuang Yu, Zheng Jin, Qicheng Ruan, Chunjing Zhang, Kai Zhao
Summary: The study found that N-2-Hydroxypropyl trimethyl ammonium chloride chitosan/N, O-carboxymethyl chitosan nanoparticles (N-2-HACC/CMCS NPs) showed good immunogenicity and no toxicity as a universal vaccine adjuvant/delivery system. The prepared N-2-HACC/OVA/CMCS NPs induced higher levels of antibodies and immune responses in mice, suggesting their potential in enhancing humoral, cellular, and mucosal immune responses.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Instruments & Instrumentation
Bettina Gabold, Friederike Adams, Sophie Brameyer, Kirsten Jung, Christian L. Ried, Thomas Merdan, Olivia M. Merkel
Summary: Nose-to-brain delivery is a promising alternative for delivering high molecular weight drugs. Transferrin-decorated chitosan nanoparticles can efficiently cross the nasal epithelial barrier and enhance cellular uptake in tumor cells. This approach offers a potential improvement in drug bioavailability through targeted ligand binding.
DRUG DELIVERY AND TRANSLATIONAL RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Guohua Hou, Yuan Li, Qimeng Wang, Huijuan Zhang, Shuang Liang, Bin Liu, Wenbiao Shi
Summary: This study developed a nanocomposite that can co-deliver Cur and Mel for potential treatment of solid tumors. The nanocomposite incorporated the advantages of each component, such as efficient compound loading, improved cellular uptake, tumor accumulation, and synergistic anti-tumor effects.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Biochemistry & Molecular Biology
Nida Nehal, Bushra Nabi, Saleha Rehman, Ankita Pathak, Ashif Iqubal, Saif Ahmad Khan, M. Shahar Yar, Suhel Parvez, Sanjula Baboota, Javed Ali
Summary: The research developed a Ropinirole hydrochloride nanoemulsion for Parkinson's disease treatment, showing promising results in in vitro release and permeation studies. The formulation exhibited enhanced transmittance and stable pH, suggesting potential for improved management of PD symptoms.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Biochemistry & Molecular Biology
Zhi Zhao, Jinyu Han, Shangen Xu, Zheng Jin, Tan Hui Yin, Kai Zhao
Summary: This report presents the encapsulation of amoxicillin in N-2-Hydroxypropyl trimethyl ammonium chloride chitosan and N,O-carboxymethyl chitosan nanoparticles for biomedical applications. The synthesized nanoparticles demonstrated sustained drug release, good cytocompatibility and broad-spectrum antimicrobial activity.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Polymer Science
Yu Kang, Zhi Liu, Yingyun Long, Baolong Wang, Xu Yang, Di Sha, Kai Shi, Xiangling Ji, Bai Li, Yonggang Liu
Summary: A two-step method was used to synthesize N,N,N-trimethyl chitosan (TMC) from chitosan, with molecular weight ranging from 29 to 136 kg/mol and quaternization degree from 70% to 82%. Size exclusion chromatography (SEC) coupled with multiangle laser light scattering was employed to analyze the molecular weight and chain conformation, showing a significant increase in chain flexibility upon N-methylation, possibly due to the breakage of intramolecular hydrogen bonds between chitosan repeating units.
JOURNAL OF APPLIED POLYMER SCIENCE
(2021)
Article
Biochemistry & Molecular Biology
Mariacristina Gagliardi, Sara Chiarugi, Chiara De Cesari, Giulia Di Gregorio, Alessandra Diodati, Laura Baroncelli, Marco Cecchini, Ilaria Tonazzini
Summary: The study presents a method to obtain stable and cytocompatible crosslinked chitosan nanoparticles for intranasal drug delivery. The nanoparticles showed a stable size and surface charge, and exhibited good cytocompatibility in vitro. This synthetic system has potential as a drug carrier for intranasal delivery.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Nanoscience & Nanotechnology
Natalia N. Porfiryeva, Irina I. Semina, Ilgiz A. Salakhov, Rouslan I. Moustafine, Vitaliy V. Khutoryanskiy
Summary: Nasal drug delivery systems based on cationic and anionic Eudragit copolymers were designed, resulting in nanoparticles with mucoadhesive or mucus-penetrating properties for delivering haloperidol to the brain. Analysis on sheep nasal mucosa and rats in vivo confirmed the effectiveness of these nanoparticles in drug delivery.
NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE
(2021)
Review
Nanoscience & Nanotechnology
Pallavi Kiran, Sujit Kumar Debnath, Suditi Neekhra, Vaishali Pawar, Amreen Khan, Faith Dias, Shubham Pallod, Rohit Srivastava
Summary: The article discusses the treatment options, limitations, and new trends in nanotherapeutics for Parkinson's disease, emphasizing nasal delivery as a more effective way to manage PD.
WILEY INTERDISCIPLINARY REVIEWS-NANOMEDICINE AND NANOBIOTECHNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Kessily B. Rufato, Paulo R. Souza, Ariel C. de Oliveira, Sharise B. R. Berton, Roberta M. Sabino, Edvani C. Muniz, Ketul C. Popat, Eduardo Radovanovic, Matt J. Kipper, Alessandro F. Martins
Summary: This study demonstrates that polysaccharide-based polyelectrolyte multilayers prepared using the layer-by-layer approach can provide stability and durability for free-standing gels, as well as antimicrobial properties and cytocompatibility.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Biochemistry & Molecular Biology
Renas Rzgar Jalal, Twana Mohammed M. Ways, Mahmoud H. Abu Elella, Diyar Ahmed Hassan, Vitaliy V. Khutoryanskiy
Summary: Mucoadhesive nanoparticles based on methacrylated chitosan (MeCHI) were designed and compared with unmodified chitosan nanoparticles for the delivery of ciprofloxacin. The MeCHI nanoparticles showed smaller particle size, lower polydispersity index, higher encapsulation efficiency, and sustained drug release compared to their chitosan counterpart. The mucoadhesion study also demonstrated that the ciprofloxacin-loaded MeCHI nanoparticles had better retention on the mucosal surface.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Engineering, Chemical
Prashant B. Jade, Raju O. Sonawane, Savita D. Patil, Pradum P. Ige, Chandrakantsing V. Pardeshi
PARTICULATE SCIENCE AND TECHNOLOGY
(2017)
Article
Biotechnology & Applied Microbiology
Chandrakantsing Vijaysing Pardeshi, Veena Shailendra Belgamwar
ARTIFICIAL CELLS NANOMEDICINE AND BIOTECHNOLOGY
(2017)
Review
Biochemistry & Molecular Biology
Abhijeet D. Kulkarni, Aditya A. Joshi, Chirag L. Patil, Prasad D. Amale, Harun M. Patel, Sanjay J. Surana, Veena S. Belgamwar, Kapil S. Chaudhari, Chandrakantsing V. Pardeshi
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2017)
Review
Education, Scientific Disciplines
Chandrakantsing Vijaysing Pardeshi, Abhijeet Dattatraya Kulkarni, Raju Onkar Sonawane, Veena Shailendra Belgamwar, Prashant Jagannath Chaudhari, Sanjay Javerilal Surana
INDIAN JOURNAL OF PHARMACEUTICAL EDUCATION AND RESEARCH
(2019)
Article
Materials Science, Multidisciplinary
Chandrakantsing Pardeshi, Veena S. Belgamwar
MATERIALS TECHNOLOGY
(2020)
Article
Materials Science, Multidisciplinary
Chandrakantsing V. Pardeshi, Rahul N. Dhangar, Vilas R. Jagatap, Raju O. Sonawane
Summary: The study investigated the mucoadhesion and gelling behavior of mucilage from Eulophia herbacea tubers, as well as the possibility of enhanced brain targetability through cationic neuronanoemulsions (cNNEs) in a hydrogel formulation. The results showed that the hydrogel had high bioadhesion potential and promising drug delivery approach after extensive preclinical characterization.
MATERIALS TECHNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Chandrakantsing Pardeshi, Vinit V. Agnihotri, Kusumakar Y. Patil, Sagar R. Pardeshi, Sanjay J. Surana
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2020)
Article
Materials Science, Multidisciplinary
Komal Sudhakar Joshi, Raju Onkar Sonawane, Chandrakantsing Vijaysing Pardeshi
Summary: This study developed extended release pellets using κ-carrageenan-montmorillonite (κ-Carr-MMT) polyelectrolyte complex (PEC) hydrogel. The prepared pellets exhibited sustained and stable drug release, making them a potential alternative to conventional pain management formulations.
MATERIALS TECHNOLOGY
(2022)
Article
Engineering, Chemical
Sagar Pardeshi, Mahesh More, Pritam Patil, Chandrakantsing Pardeshi, Prashant Deshmukh, Arun Mujumdar, Jitendra Naik
Summary: The article discusses the importance of pharmaceutical powder drying and the application of different particle engineering technologies, emphasizing the advancement and potential applications of drying in drug delivery systems. It provides information on commercial, regulatory, and scale-up strategies to help readers, researchers, and industrialists address key issues in drying operations.
Article
Engineering, Chemical
Raju Onkar Sonawane, Savita Dattatraya Patil, Chandrakantsing Vijaysing Pardeshi, Hitendra Shaligram Mahajan, Pankaj Padmakar Nerkar
Summary: This study aimed to develop zaltoprofen-loaded extended-release pellets using a novel matrix-forming polymer GPS complex. The optimized formulation showed a cumulative drug release of 99.03% in 14 hours. In vivo study demonstrated decreased C-max and increased t(1/2) compared to bulk zaltoprofen, indicating the potential of GPS-based formulations for extended-release drug delivery.
PARTICULATE SCIENCE AND TECHNOLOGY
(2022)
Review
Pharmacology & Pharmacy
Fouad Damiri, Satish Rojekar, Yahya Bachra, Rajender S. Varma, Swetha Andra, Satheeshkumar Balu, Chandrakantsing Vijaysing Pardeshi, Paras J. Patel, Hitendra M. Patel, Ana Claudia Paiva-Santos, Mohammed Berrada, Monica C. Garcia
Summary: The biomedical, biotech, and food industries utilize polysaccharides as essential biomolecules for a wide range of applications. Polysaccharide-based nanogels have gained significant attention as carriers for different bioactive agents due to their unique versatile groups, controlled delivery capabilities, and desirable physico-chemical properties. The incorporation of hydrophilic or hydrophobic molecules, including drugs, proteins, genetic material, and nanoparticles, into the 3D polymer network of nanogels offers promising potential for drug delivery systems.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2023)
Review
Pharmacology & Pharmacy
Vivek P. Chavda, Vrashabh V. Sugandhi, Chandrakantsing V. Pardeshi, Rahul Jaywant Patil, Mit Joshi, Bhoomika Patel, Avinash Khadela, Rajashri Bezbaruah, Bedanta Bhattacharjee, Pankti C. Balar, Lalitkumar K. Vora
Summary: Exosomes are multivesicular bodies that release their cargo into surrounding body fluids by fusing with the plasma membrane. They transfer various biomolecules between cells, making them potential therapeutic drug delivery systems. The use of exosomes for cancer detection and prognosis has gained considerable interest. In addition to existing engineering approaches, novel methodologies for exosomal alteration show promise in advancing therapeutic medicines for cancer. This review highlights the theranostic potential of exosomes in various types of cancer.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2023)
Review
Chemistry, Medicinal
Rahul Dhangar, Kusumakar Patil, Chandrakant Pardeshi
INDO AMERICAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2019)
Review
Chemistry, Applied
Abhijeet D. Kulkarni, Harun M. Patel, Sanjay J. Surana, Yogesh H. Vanjari, Veena S. Belgamwar, Chandrakantsing V. Pardeshi
CARBOHYDRATE POLYMERS
(2017)
Article
Biochemistry & Molecular Biology
Wei-Han Hui, Yen-Lin Chen, Shu-Wei Chang
Summary: Crosslinking affects the mechanical behavior and tissue metabolism of collagen-based tissues. Aging and diabetes alter the crosslinking type and density, thus changing tissue properties. High-connectivity enzymatic crosslinking and advanced-glycation end-products result in uniform deformation under daily activity, while low-connectivity enzymatic crosslinking does not. High-connectivity model displays more sliding, while AGEs induce instability in structures near the binding sites.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Yao-Bin Ma, Xiao-Qiu Zhou, Wei-Dan Jiang, Pei Wu, Yang Liu, Shu-Wei Li, Ling Tang, Lu Zhang, Hai-Feng Mi, Lin Feng
Summary: Tea polyphenols (TPs) are an inexpensive feed additive that can protect the gill function of fish against Flavobacterium columnare (F. columnare) through various mechanisms, including suppression of oxidative stress, apoptosis, and inflammation.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Yan-Jia Guo, Jing-Ru Pang, Yu Zhang, Zhong-Rui Li, Xiao-Lin Zi, Hong-Min Liu, Ning Wang, Li-Juan Zhao, Ya Gao, Bo Wang, Piet Herdewijn, Cheng-Yun Jin, Ying Liu, Yi-Chao Zheng
Summary: This study identifies the conjugation of NEDD8 to LSD1 and its impact on GC cells, revealing the significance of LSD1 neddylation in GC.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Review
Biochemistry & Molecular Biology
Geum-Jae Jeong, Fazlurrahman Khan, Nazia Tabassum, Young-Mog Kim
Summary: Vibrio species are motile gram-negative bacteria commonly found in aquatic environments. They can adapt to environmental fluctuations and develop protective mechanisms against host immune systems. Different types of sigma and anti-sigma factors play important roles in regulating gene expression and virulence in Vibrio species.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Zahra Mohammadbagheri, Behrooz Movahedi, Shaghayegh Saeedi, Abbas Rahmati
Summary: In this study, a reusable biobased composite hydrogel was successfully synthesized and used for the removal of Tl(I) from aqueous solutions. The hydrogel exhibited high adsorption capacity and thermal stability, and the adsorption process was found to be thermodynamically spontaneous. The results demonstrated that the hydrogel can be reused multiple times without significant loss of its adsorption capacity.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Iqra Batool, Muhammad Imran, Ayesha Anwar, Farhan Ahmed Khan, Afrah E. Mohammed, Ashwag Shami, Hafiz Iqbal
Summary: Enzyme immobilization on ZnO/SnO2 and ZnO/SnO2/SA nanocomposites was studied, and the catalytic and biochemical characteristics of the immobilized enzyme were investigated. The results showed that ZnO/SnO2 and ZnO/SnO2/SA nanostructures are suitable carriers for enzyme immobilization.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Elias Mosaffa, Dhruvi Patel, Nasim Amiri Ramsheh, Rishikumar Indravadan Patel, Atanu Banerjee, Hossein Ghafuri
Summary: In this study, a unique 3D bead structure of adsorbent, composed of bacterial cellulose microfilaments reinforced chitosan adorned with melamine 2D plates, was synthesized for anionic dye removal. The adsorbent showed high specific surface area and abundant functional groups, resulting in exceptional adsorption capacity. The characteristics and optimal conditions of the adsorbent were assessed and analyzed.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Carolina Gismene, Jorge Enrique Hernandez Gonzalez, Marilia de Freitas Calmon, Andrey Fabricio Ziem Nascimento, Angela Rocio Nino Santisteban, Felipe Antunes Calil, Alana Della Torre da Silva, Paula Rahal, Rejane Maira Goes, Raghuvir Krishnaswamy Arni, Ricardo Barros Mariutti
Summary: Mammaliicoccus sciuri, a bacterium of clinical and veterinary relevance, expresses the virulence factor Exfoliative Toxin C (ExhC), which binds specifically to desmoglein-1 (Dsg1) and plays a role in tissue integrity. This study investigates the necrotic activity of ExhC and identifies a variant lacking necrotic potential but retaining enzymatic activity through mutagenesis experiments and crystal structure determination.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Bibhas K. Bhunia, Ashutosh Bandyopadhyay, Souradeep Dey, Biman B. Mandal
Summary: Intervertebral disc degeneration is a major cause of chronic low back pain and disability. Researchers have developed a bioactive silk-based hybrid hydrogel system functionalized with decellularized human Wharton's jelly extracellular matrix as bioactive cues. The hydrogels mimic the rheological and mechanical properties of the native nucleus pulposus tissue and support cell viability, proliferation, and tissue maturation.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Qun Zhang, Yonggan Yan, Zhao Li, Jing Du, Kai Zhang, Liguo Zhang, Ting Wang, Alberto Bianco, Shaohua Ge, Baojin Ma
Summary: A new crosslinking strategy has been devised to construct injectable sodium alginate hydrogels, which can be regulated for injectability and have great potential in biomedical applications.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Seong Eun Hong, Ji-Soo Lee, Hyeon Gyu Lee
Summary: The potential of multi-layer nanoemulsions for improving the cellular uptake, antioxidant activity, and in vitro bioaccessibility of alpha-tocopherol was examined. The results showed that the multi-layer nanoemulsions significantly enhanced the cellular uptake and antioxidant activity of alpha-tocopherol compared to free coumarin 6. Furthermore, the use of chitosan and dextran sulfate as wall materials in the multi-layer nanoemulsions led to even higher cellular uptake, in vitro bioaccessibility, and antioxidant activity of alpha-tocopherol.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Jingjing Yu, Yanhui Zhang, Ruoning Zhang, Yanxiang Gao, Like Mao
Summary: High internal phase emulsions (HIPEs) based on beeswax (BW) oleogels and octenyl succinic acid starch (OSA starch) were prepared by a simple one-step method. The results showed that oleogelation improved the stability and encapsulation capability of the HIPEs, which is significant for the development of novel healthy food.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Review
Biochemistry & Molecular Biology
Bi-Feng Yao, Xiu-Ju Luo, Jun Peng
Summary: The balanced and continuous fission and fusion of mitochondria, regulated by OPA1, are important for maintaining mitochondrial dynamics in cardiovascular disorders. Understanding the role of OPA1 in mitochondrial fusion can provide insights into the pathogenesis of cardiovascular diseases.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Review
Biochemistry & Molecular Biology
Gokul Paramasivam, Anandhavelu Sanmugam, Vishnu Vardhan Palem, Murugan Sevanan, Ananda Babu Sairam, Nachiappan Nachiappan, Buhyun Youn, Jung Sub Lee, Muthuchamy Nallal, Kang Hyun Park
Summary: Nanomaterials are being used to deliver therapeutic agents in living systems. Different nanotechnological applications such as immunosensors, immune assays, and drug delivery are being implemented using nanotechnology. Genomics plays a crucial role in selecting appropriate drugs for personalized cancer therapy. It helps in analyzing gene and protein expression, disease classification, and designing disease models. Delivering drugs to specific areas using nanoparticles is a challenging issue.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Jing Li, Wei Wang, Han Wu, Feng Peng, Hui Gao, Ying Guan
Summary: In this study, CMH-based CPF films were prepared and their thermal and barrier properties were successfully regulated. The tensile strength and water vapor barrier property of CPF films were significantly improved, making them promising for food packaging applications.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)