期刊
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
卷 64, 期 -, 页码 6-10出版社
ELSEVIER
DOI: 10.1016/j.ijbiomac.2013.11.015
关键词
EFO; sIgA; IgA(+) cells
资金
- National Science & Technology Pillar Program of China [2011BAD34B02]
- National Natural Science Foundation of China [31272596]
- Priority Academic Program Development of Jiangsu Higher Education Institutions
A previous study found that epimedium polysaccharide (EP)-propolis flavonoid (PF) injection (EPI) produced reliable immunoenhancement. In this study, we investigate the effects of EP-PF oral liquid (EFO) on mucosal immunity in the chicken small intestine while using EPI, EP and PF as controls. Groups of fourteen-day-old chickens were given EFO orally at one of the three doses when they were vaccinated with ND vaccine. On days 7, 21 and 35 after the first vaccination, six chickens were selected randomly from each group for measurements of the sIgA and IL-17 contents of the washing liquors of the duodenum and jejunum, counts of the lymphocytes in the duodenal endothelium and counts of the IgA(+) cells in the jejunal endothelium and cecum tonsil. The results indicated that EFO significantly promoted the secretion of sIgA and IL-17 and increased the numbers of lymphocyte and IgA(+) cells. Furthermore, EFO was more efficient than EPI at the high and medium doses. These findings indicate that EPO may enhance intestinal mucosal immunity and may be exploited as an oral immunopotentiator. (C) 2013 Elsevier B.V. All rights reserved.
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