期刊
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
卷 67, 期 -, 页码 323-329出版社
ELSEVIER
DOI: 10.1016/j.ijbiomac.2014.03.030
关键词
Dimompus longan; Polysaccharide; Sulfated modification; Immunomodulation; Antitumor activity
资金
- Natural Science Foundation of China [2010GXNSF013159]
- Guangxi Sci. & Tech. Development Plan, China [12118005-1-2]
- Youth Science Foundation of Guangxi Medical University [02604001015]
A water-soluble polysaccharide fraction (LP1) was prepared from Dimocarpus longan Lour. by hot water extraction, DEAE-cellulose and Sephadex G-100 chromatography. Its sulfated derivative (LP1-S) was prepared by the sulfuric acid method. Preliminary tests in vitro showed LP1 and LP1-S could stimulate murine lymphocytes proliferation, increase pinocytic activity of murine macrophages and production of nitric oxide (NO), interleukin 6 (IL-6), IL-1 beta and tumor necrosis factor-alpha (TNF-alpha) in macrophages. Furthermore, LP1-S exhibited higher antiproliferative activity against human nasopharyngeal carcinoma HONE1 cells in vitro than LP1, which might be caused by the sulfate group in its structures. These results indicated that the LP1-S might be useful for developing safe antitumor drugs or health food. (C) 2014 Elsevier B.V. All rights reserved.
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