Article
Engineering, Chemical
Carlos Alberto Arenas-Chavez, Luciana Maria de Hollanda, Arturo A. Arce-Esquivel, Aldo Alvarez-Risco, Shyla Del-Aguila-Arcentales, Jaime A. Yanez, Corina Vera-Gonzales
Summary: This study aims to evaluate the antibacterial and antifungal activity of a nanocomposite, consisting of silver nanoparticles and carboxymethyl chitosan, on Escherichia coli, Staphylococcus aureus, Candida albicans, and Aspergillus niger. The functionalized fabric showed 100% antibacterial activity against E. coli and S. aureus and good antifungal activity against C. albicans and A. niger. This suggests that the functionalized fabric can be used in hospital garments to reduce nosocomial infections.
Article
Polymer Science
Karol K. Klosinski, Radoslaw A. Wach, Malgorzata K. Girek-Bak, Bozena Rokita, Damian Kolat, Zaneta Kaluzinska-Kolat, Barbara Klosinska, Lukasz Duda, Zbigniew W. Pasieka
Summary: Hydrogels formed from CMCS and crosslinking agent via electron beam irradiation showed potential as wound dressings. The gel's elasticity was influenced by component concentrations and irradiation dose. The hydrogels exhibited biocompatibility and could stimulate cell growth. Ionizing radiation proved to be a suitable tool for synthesis and sterilization of CMCS hydrogels.
Article
Engineering, Environmental
Ganeswar Dalei, Subhraseema Das, Soumya Ranjan Jena, Jasmine Nayak, Luna Samanta, Smruti Prava Das
Summary: As the global population increases, the demand for better healthcare grows, requiring the development of smart biomaterials. Cold plasma technology was used to improve CMCS/PVA hydrogels, enhancing their bio-efficacy by improving surface properties, increasing tensile strength, and enabling effective drug release. These hydrogels have potential applications in oral colon-targeted drug delivery systems.
JOURNAL OF POLYMERS AND THE ENVIRONMENT
(2021)
Article
Chemistry, Applied
Qingcong Wei, Jiahao Bai, Huan Wang, Guanglei Ma, Xinjuan Li, Weiwei Zhang, Zhiguo Hu
Summary: In this study, CMCS-based hydrogels with photo-induced cascade reaction were synthesized, showing programmable degradation properties and controlled release profile, indicating great potential in biomedical applications.
CARBOHYDRATE POLYMERS
(2021)
Article
Chemistry, Applied
Chunli Xu, Lidong Cao, Muhammad Bilal, Chong Cao, Pengyue Zhao, Hongjun Zhang, Qiliang Huang
Summary: Carboxymethyl chitosan (CMCS) is a promising biopolymer carrier for controlled release formulations of pesticides. In this study, a manganese-based carboxymethyl chitosan hydrogel was prepared to encapsulate and release fungicide prothioconazole in a controllable manner, with faster release in neutral and slightly alkaline solutions.
CARBOHYDRATE POLYMERS
(2021)
Article
Biochemistry & Molecular Biology
Marek Kozicki, Aleksandra Pawlaczyk, Aleksandra Adamska, Malgorzata Iwona Szynkowska-Jozwik, Elzbieta Sasiadek-Andrzejczak
Summary: This study investigates the potential biomedical applications of golden and silver-golden chitosan hydrogels and hydrogel-modified textiles. The hydrogels are formed through the reaction of chitosan with HAuCl4·xH2O. Different analytical techniques were used to characterize the chitosan-Au structures and quantify the Au content in the hydrogels and modified fabrics. The study also reports the formation of chitosan-Au-Ag hydrogels through the competitive reaction of Au and Ag ions with chitosan macromolecules.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Materials Science, Multidisciplinary
Caimei Zhao, Xinhu Gong, Lan Shen, Yang Wang, Chaoqun Zhang
Summary: Carboxymethyl chitosan hydrogels exhibited ultralow-temperature freezing resistance below -50 degrees C by immersing in a CaCl2 solution. The introduction of electrolyte ions endowed the hydrogels with electrical conductivity, showing stable and reversible sensitivity to human activity. These conductive hydrogels can even be assembled into a two-dimensional integrated array of contact sensors, successfully perceiving the contour and pressure distribution of an object.
ACS APPLIED POLYMER MATERIALS
(2022)
Article
Polymer Science
Chenghong Huang, Hong Tang, Xiaorong Huang, Hongjie Chen, Kang Yang, Qi Yin, Lin Zhang, Xia Li, Xue Mou, Shuangkou Chen, Yuchan Zhang, Yan Hu
Summary: This study demonstrated that ethyl vanillin can be quickly crystallized from carboxymethyl chitosan/ethyl vanillin co-mixture gels via classical swift cooling method and supersaturation. EVA appeared with bulk filament crystals accelerated by a large quantity of nanoconfinement microregions resulted from space-formatted hydrogen network between EVA and CMCS when their concentration exceeds 1:1.4 and may occasionally arise when the concentration is less than 1:0.8。Further investigations found that EVA crystals can be recovered from as-prepared ion-switchable CMCS gels by 0.1 M hydrochloric acid or acetic acid without defects. Consequently, the proposed method may offer an available scheme for a large-scale preparation of API analogs.
Article
Chemistry, Multidisciplinary
Xiaoqian Lin, Jia Lv, Desheng Wang, Kaikai Liu
Summary: In this study, bio-multifunctional melatonin-loaded carboxymethyl chitosan/polyaldehyde dextran (CPM) hydrogels were developed through the dynamic Schiff-base reaction. The CPM hydrogels demonstrated injectability, structural stability, high tissue adhesion, and self-healing features. The hydrogels also exhibited antibacterial properties, slow melatonin release, and promoted cell migration in vitro.
Article
Biochemistry & Molecular Biology
Asmaa M. Mohammed, Khalil T. Hassan, Omar M. Hassan
Summary: This study focuses on synthesizing and characterizing hydrogel and cryogel microspheres doped with green synthesized silver nanoparticles (CS-AgNPs). The antimicrobial activity of these microspheres is compared with commercial antibiotics. SEM and EDX techniques confirm the porous structure of CS and the dispersion of AgNPs, respectively. The results show that CS-AgNPs microspheres exhibit superior antimicrobial activity to antibiotics against both Gram-positive and Gram-negative bacteria. CS-AgNPs microspheres are promising as antimicrobial and biocompatible agents for medical applications.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Materials Science, Paper & Wood
Yi Guo, Chuanyin Zhao, Chao Yan, Li Cui
Summary: In this study, novel cellulose/carboxymethyl chitosan (CMCS) composite hydrogels were successfully prepared and showed good biocompatibility. The compressive strength and equilibrium swelling ratio of the composite hydrogels increased with the content of cellulose and CMCS. These composite hydrogels have potential application as wound dressing materials.
Article
Materials Science, Paper & Wood
Mahmoud H. Abu Elella, Heba M. Abdallah, Heba Gamal, Essam B. Moustafa, Emad S. Goda
Summary: Antimicrobial hydrogels are a major focus for repairing soft tissues and preventing bacterial infections, with new hydrogels designed in this study showing high biocompatibility through physical crosslinking reactions. The hydrogels exhibit significant antibacterial activity against Staphylococcus aureus and Escherichia coli, with those containing high TMC content showing superior inhibition zones compared to pure TMC. Additionally, the cytotoxicity testing on normal cell lines VERO and lung (Wi38) cells demonstrates high cell viability at lower concentrations.
Article
Chemistry, Applied
Kepeng Hu, Erna Jia, Qimeng Zhang, Wei Zheng, Rongjiao Sun, Mengao Qian, Ying Tan, Wanle Hu
Summary: Tea tree oil (TTO) is encapsulated into the hydrogel network via a previous emulsification process, and a tough and antibacterial injectable hydrogel is synthesized by the Schiff base reaction between carboxymethyl chitosan (CMCS) and genipin (GP). The obtained hydrogels exhibit high adhesive strength (about 162.75 kPa), excellent antibacterial properties (over 90%), and great biocompatibility. The heterogeneous hydrogel shows good slow-release properties of TTO for accelerated healing of complex anal fistula wounds according to an anal fistula-like wound healing experiment.
CARBOHYDRATE POLYMERS
(2023)
Article
Chemistry, Applied
Yang Zhou, Zhenghao Zhai, Yimin Yao, John C. Stant, Sarah L. Landrum, Michael J. Bortner, Charles E. Frazier, Kevin J. Edgar
Summary: Polysaccharide-based Schiff base hydrogels prepared by reacting oxidized hydroxypropyl cellulose (Ox-HPC) with carboxymethyl chitosan (CMCS) exhibit pH-responsive, injectable, and self-healing properties. The reversible nature of the imine bonds allows for an injectable and self-healing hydrogel. The incorporation of the model amine-containing drug phenylalanine within the hydrogel showed pH sensitivity, releasing faster in the extracellular space around tumors (pH 6.8) compared to normal tissues (pH 7.4).
CARBOHYDRATE POLYMERS
(2023)
Article
Environmental Sciences
Qirun Li, Shanxue Jiang, Wenting Jia, Fang Wang, Zeru Wang, Xinyue Cao, Xianbao Shen, Zhiliang Yao
Summary: Novel biodegradable antibacterial membranes based on silver-modified carboxymethyl chitosan (Ag-CMCS) were prepared in this study. The membranes were characterized and showed effective antibacterial properties, killing almost 100% of bacteria under certain conditions. This research provides new ideas for the development of efficient and environmentally friendly antibacterial food packaging membranes.
Article
Biochemistry & Molecular Biology
Wei-Han Hui, Yen-Lin Chen, Shu-Wei Chang
Summary: Crosslinking affects the mechanical behavior and tissue metabolism of collagen-based tissues. Aging and diabetes alter the crosslinking type and density, thus changing tissue properties. High-connectivity enzymatic crosslinking and advanced-glycation end-products result in uniform deformation under daily activity, while low-connectivity enzymatic crosslinking does not. High-connectivity model displays more sliding, while AGEs induce instability in structures near the binding sites.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Yao-Bin Ma, Xiao-Qiu Zhou, Wei-Dan Jiang, Pei Wu, Yang Liu, Shu-Wei Li, Ling Tang, Lu Zhang, Hai-Feng Mi, Lin Feng
Summary: Tea polyphenols (TPs) are an inexpensive feed additive that can protect the gill function of fish against Flavobacterium columnare (F. columnare) through various mechanisms, including suppression of oxidative stress, apoptosis, and inflammation.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Yan-Jia Guo, Jing-Ru Pang, Yu Zhang, Zhong-Rui Li, Xiao-Lin Zi, Hong-Min Liu, Ning Wang, Li-Juan Zhao, Ya Gao, Bo Wang, Piet Herdewijn, Cheng-Yun Jin, Ying Liu, Yi-Chao Zheng
Summary: This study identifies the conjugation of NEDD8 to LSD1 and its impact on GC cells, revealing the significance of LSD1 neddylation in GC.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Review
Biochemistry & Molecular Biology
Geum-Jae Jeong, Fazlurrahman Khan, Nazia Tabassum, Young-Mog Kim
Summary: Vibrio species are motile gram-negative bacteria commonly found in aquatic environments. They can adapt to environmental fluctuations and develop protective mechanisms against host immune systems. Different types of sigma and anti-sigma factors play important roles in regulating gene expression and virulence in Vibrio species.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Zahra Mohammadbagheri, Behrooz Movahedi, Shaghayegh Saeedi, Abbas Rahmati
Summary: In this study, a reusable biobased composite hydrogel was successfully synthesized and used for the removal of Tl(I) from aqueous solutions. The hydrogel exhibited high adsorption capacity and thermal stability, and the adsorption process was found to be thermodynamically spontaneous. The results demonstrated that the hydrogel can be reused multiple times without significant loss of its adsorption capacity.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Iqra Batool, Muhammad Imran, Ayesha Anwar, Farhan Ahmed Khan, Afrah E. Mohammed, Ashwag Shami, Hafiz Iqbal
Summary: Enzyme immobilization on ZnO/SnO2 and ZnO/SnO2/SA nanocomposites was studied, and the catalytic and biochemical characteristics of the immobilized enzyme were investigated. The results showed that ZnO/SnO2 and ZnO/SnO2/SA nanostructures are suitable carriers for enzyme immobilization.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Elias Mosaffa, Dhruvi Patel, Nasim Amiri Ramsheh, Rishikumar Indravadan Patel, Atanu Banerjee, Hossein Ghafuri
Summary: In this study, a unique 3D bead structure of adsorbent, composed of bacterial cellulose microfilaments reinforced chitosan adorned with melamine 2D plates, was synthesized for anionic dye removal. The adsorbent showed high specific surface area and abundant functional groups, resulting in exceptional adsorption capacity. The characteristics and optimal conditions of the adsorbent were assessed and analyzed.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Carolina Gismene, Jorge Enrique Hernandez Gonzalez, Marilia de Freitas Calmon, Andrey Fabricio Ziem Nascimento, Angela Rocio Nino Santisteban, Felipe Antunes Calil, Alana Della Torre da Silva, Paula Rahal, Rejane Maira Goes, Raghuvir Krishnaswamy Arni, Ricardo Barros Mariutti
Summary: Mammaliicoccus sciuri, a bacterium of clinical and veterinary relevance, expresses the virulence factor Exfoliative Toxin C (ExhC), which binds specifically to desmoglein-1 (Dsg1) and plays a role in tissue integrity. This study investigates the necrotic activity of ExhC and identifies a variant lacking necrotic potential but retaining enzymatic activity through mutagenesis experiments and crystal structure determination.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Bibhas K. Bhunia, Ashutosh Bandyopadhyay, Souradeep Dey, Biman B. Mandal
Summary: Intervertebral disc degeneration is a major cause of chronic low back pain and disability. Researchers have developed a bioactive silk-based hybrid hydrogel system functionalized with decellularized human Wharton's jelly extracellular matrix as bioactive cues. The hydrogels mimic the rheological and mechanical properties of the native nucleus pulposus tissue and support cell viability, proliferation, and tissue maturation.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Qun Zhang, Yonggan Yan, Zhao Li, Jing Du, Kai Zhang, Liguo Zhang, Ting Wang, Alberto Bianco, Shaohua Ge, Baojin Ma
Summary: A new crosslinking strategy has been devised to construct injectable sodium alginate hydrogels, which can be regulated for injectability and have great potential in biomedical applications.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Seong Eun Hong, Ji-Soo Lee, Hyeon Gyu Lee
Summary: The potential of multi-layer nanoemulsions for improving the cellular uptake, antioxidant activity, and in vitro bioaccessibility of alpha-tocopherol was examined. The results showed that the multi-layer nanoemulsions significantly enhanced the cellular uptake and antioxidant activity of alpha-tocopherol compared to free coumarin 6. Furthermore, the use of chitosan and dextran sulfate as wall materials in the multi-layer nanoemulsions led to even higher cellular uptake, in vitro bioaccessibility, and antioxidant activity of alpha-tocopherol.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Jingjing Yu, Yanhui Zhang, Ruoning Zhang, Yanxiang Gao, Like Mao
Summary: High internal phase emulsions (HIPEs) based on beeswax (BW) oleogels and octenyl succinic acid starch (OSA starch) were prepared by a simple one-step method. The results showed that oleogelation improved the stability and encapsulation capability of the HIPEs, which is significant for the development of novel healthy food.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Review
Biochemistry & Molecular Biology
Bi-Feng Yao, Xiu-Ju Luo, Jun Peng
Summary: The balanced and continuous fission and fusion of mitochondria, regulated by OPA1, are important for maintaining mitochondrial dynamics in cardiovascular disorders. Understanding the role of OPA1 in mitochondrial fusion can provide insights into the pathogenesis of cardiovascular diseases.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Review
Biochemistry & Molecular Biology
Gokul Paramasivam, Anandhavelu Sanmugam, Vishnu Vardhan Palem, Murugan Sevanan, Ananda Babu Sairam, Nachiappan Nachiappan, Buhyun Youn, Jung Sub Lee, Muthuchamy Nallal, Kang Hyun Park
Summary: Nanomaterials are being used to deliver therapeutic agents in living systems. Different nanotechnological applications such as immunosensors, immune assays, and drug delivery are being implemented using nanotechnology. Genomics plays a crucial role in selecting appropriate drugs for personalized cancer therapy. It helps in analyzing gene and protein expression, disease classification, and designing disease models. Delivering drugs to specific areas using nanoparticles is a challenging issue.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Jing Li, Wei Wang, Han Wu, Feng Peng, Hui Gao, Ying Guan
Summary: In this study, CMH-based CPF films were prepared and their thermal and barrier properties were successfully regulated. The tensile strength and water vapor barrier property of CPF films were significantly improved, making them promising for food packaging applications.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)