期刊
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
卷 61, 期 -, 页码 295-301出版社
ELSEVIER
DOI: 10.1016/j.ijbiomac.2013.07.012
关键词
Bleomycin; Drug-DNA interactions; Electrochemical impedance spectroscopy; Mitomycin C; Cis-platin
资金
- Turkish Academy of Sciences (TUBA)
- TUBITAK [111T073]
Surface confined interaction of anti-cancer drug bleomycin (BLM) with nucleic acids: single stranded and double stranded DNA was investigated herein by using electrochemical impedance spectroscopy (EIS) technique in combination with a graphite sensor technology. The experimental conditions were optimized: such as, dsDNA concentration, BLM concentration and interaction time. The main features of impedimetric DNA biosensor, such as its detection limit and the repeatability, were also discussed. The in situ interaction of BLM with dsDNA was also tested impedimetrically in the absence or presence of other chemotherapeutic agents, such as mitomycin C (MC) and cis-platin (cis-DDP) for testing the selectivity. (C) 2013 Elsevier B.V. All rights reserved.
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