期刊
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
卷 62, 期 -, 页码 35-43出版社
ELSEVIER
DOI: 10.1016/j.ijbiomac.2013.08.013
关键词
Chitin; PCL; Composite nanogels; Cancer nanomedicine; Drug delivery; Lung cancer
资金
- Department of Biotechnology, Government of India, under Nanoscience and Nanotechnology Initiative program
- Council of Scientific and Industrial Research (CSIR) [9/963 (0017)2K11-EMR-1]
In this work, we developed a pH responsive chitin-poly(caprolactone) composite nanogels (chitin-PCL CNGs) system for non-small cell lung cancer (NSCLC). A hydrophilic drug, doxorubicin (Dox) was loaded in Chitin-PCL CNGs (Dox-chitin-PCL CNGs). Both control and drug loaded systems were analyzed by DLS, SEM, FTIR and TG/DTA. The size ranges of the control composite nanogels and their drug loaded counterparts were found to be 70 +/- 20 and 240 +/- 20 nm, respectively. The control chitin-PCL CNGs and Dox-chitin-PCL CNGs showed higher swelling and degradation in acidic pH. Drug entrapment efficiency and in-vitro drug release studies were carried out and showed a higher drug release at acidic pH compared to neutral pH. Cellular internalization of the nanogel systems was confirmed by fluorescent microscopy. Dox-Chitin-PCLCNGs showed dose dependent cytotoxicity toward A549 (adenocarcinomic human alveolar basal epithelial cells) cancer cells. Furthermore, the results of in-vitro hemolytic assay and coagulation assay substantiate the blood compatibility of the system. These results indicate that chitin-PCL CNGs is a novel carrier for delivery of anticancer drugs. (C) 2013 Elsevier B.V. All rights reserved.
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