Article
Agronomy
Wang Weixia, Zhu Tingheng, Wan Pinjun, Wei Qi, He Jiachun, Lai Fengxiang, Fu Qiang
Summary: This study revealed the importance of serine/threonine phosphatase calcineurin (CN) in the regulation of growth and development in Nilaparvata lugens. Silencing of NlCNA, NlCNB1, and NlCNBH1 genes resulted in a drastic reduction in survival rate, female weight, eclosion rate, and fecundity of the insects. NlCNA was found to be involved in the insect's immune response by regulating phenoloxidase, while NlCNB1 appeared to control growth and development through the 20E signaling pathway.
Article
Multidisciplinary Sciences
Shiqi Chen, Curtis W. Peterson, John A. Parker, Stuart A. Rice, Andrew L. Ferguson, Norbert F. Scherer
Summary: The study introduces a data-driven approach using principal components analysis and harmonic linear discriminant analysis to determine reaction coordinates of non-conservative overdamped systems like optical matter structures. This method can aid in understanding and controlling systems such as optical and active matter systems.
NATURE COMMUNICATIONS
(2021)
Article
Multidisciplinary Sciences
Valentyn Petrychenko, Bee-Zen Peng, Ana C. de A. P. Schwarzer, Frank Peske, Marina V. Rodnina, Niels Fischer
Summary: In this study, the researchers visualized the mechanism of EF-G in the ribosome translocation process using time-resolved cryo-EM, revealing the crucial role of GTP hydrolysis in promoting the movement of the ribosome along mRNA.
NATURE COMMUNICATIONS
(2021)
Article
Chemistry, Physical
R. Horstmann, M. Vogel
Summary: The study shows that water-like models exhibit liquid polyamorphism at various interaction parameters, displaying a dynamic crossover phenomenon with high-temperature dependence in a wide range.
JOURNAL OF CHEMICAL PHYSICS
(2021)
Article
Multidisciplinary Sciences
Moshe Giladi, Michal Lisnyansky Bar-El, Pavla Vankova, Alisa Ferofontov, Emelia Melvin, Suha Alkaderi, Daniel Kavan, Boris Redko, Elvira Haimov, Reuven Wiener, Petr Man, Yoni Haitin
Summary: Isoprenoids are synthesized by the prenyltransferase superfamily, and the correlation between active site volume and product length is not observed in long-chain products and rubber synthases. In the human cis-prenyltransferase complex, elongating products exit through an outlet, and product elongation is closely correlated with membrane association.
Article
Polymer Science
Camilo Febres-Molina, Jorge A. Aguilar-Pineda, Pamela L. Gamero-Begazo, Haruna L. Barazorda-Ccahuana, Diego E. Valencia, Karin J. Vera-Lopez, Gonzalo Davila-Del-Carpio, Badhin Gomez
Summary: In this study, the molecular and energetic affinity of annocatacin B with the human ND1 subunit was evaluated computationally, showing a greater affinity and 35% stronger binding free energy compared to rotenone. The aliphatic chains of annocatacin B played a key role in the molecular coupling. These results support the idea that acetogenins may be good inhibitors of the mitochondrial respiratory complex I.
Article
Materials Science, Ceramics
Liu Zhang, Shaoping Pang, Wenhao Gu, Kai Luo, Rui Tian, Haowei Yang, Yuxing Jiang, Zirun Yang
Summary: This study adopts a combination of theoretical calculation and experiment. The Gibbs free energy enthalpy change of Ti doped B4C/Al composites is calculated, revealing the principle that Ti will form TiB2 with excellent performance by preferentially combining with Al and B4C. The degree of interfacial reaction and diffusion between Al-B4C and Ti/Al-B4C is discussed using pure Al and Ti-Al. The addition of Ti effectively inhibits the interfacial reaction between Al-B4C, and a kinetic equation is established for the diffusion distance and holding time of Al.
CERAMICS INTERNATIONAL
(2023)
Article
Biochemistry & Molecular Biology
Colleen M. Noviello, Jakob Kreye, Jinfeng Teng, Harald Pruess, Ryan E. Hibbs
Summary: Autoantibodies targeting neuronal membrane proteins can cause encephalitis and neurological abnormalities. Cryo-electron microscopy structures reveal the inhibitory mechanisms of these antibodies on neurotransmission.
Article
Chemistry, Physical
Justin Engstler, Nicolas Giovambattista
Summary: Water-mediated interactions play important roles in aqueous solutions, affecting processes such as protein folding and nanoparticle aggregation. This study investigates the impact of temperature and pressure on different types of interactions between graphene-based surfaces. The results show that hydrophobic, hydrophilic, and hybrid interactions are all sensitive to pressure, while only hydrophobic interactions are significantly affected by temperature variations. The findings have implications for understanding protein denaturation and biomolecular interactions, as well as for the design of water models for molecular and nanoparticle systems under different thermodynamic conditions.
JOURNAL OF CHEMICAL PHYSICS
(2022)
Article
Chemistry, Multidisciplinary
Hiroyuki Isobe, Yuki Kotani, Taisuke Matsuno, Toshiya M. Fukunaga, Koki Ikemoto
Summary: A molecular version of incommensurate double-wall carbon nanotubes was successfully designed by developing a roadmap for synthesizing cylindrical molecules with chiral indices. The atomic-level study of these unique systems revealed that different-sized molecules with helicity can be synthesized and assembled in a nonstereoselective manner.
COMMUNICATIONS CHEMISTRY
(2022)
Article
Physics, Fluids & Plasmas
Aswin Muthachikavil, Georgios M. Kontogeorgis, Xiaodong Liang, Qun Lei, Baoliang Peng
Summary: The existence of two structural forms in liquid water has been a long-standing point of debate. This study proposes using the average angle between oxygen atoms and their neighbors as an order parameter to describe the structural environment of water molecules, and decomposes the distribution of O-O-O angles to estimate the fractions of the two liquid forms in water. The results show good similarity between the estimated fractions of the locally favored tetrahedral structure (LFTS) and the trends reported in the literature, indicating the accuracy of the proposed order parameter in capturing the structure of the LFTS.
Article
Biochemistry & Molecular Biology
Andrew T. M. Bagshaw, Neil J. Gemmell
Summary: In recent years, scientists have shifted their focus from studying the relationships between adjacent nucleotides to exploring the larger scale structure of DNA. A little-known technique called non-denaturing bisulfite modification of genomic DNA in conjunction with high-throughput sequencing has provided valuable insights. This technique has revealed a gradient in reactivity that increases towards the 5' end of poly-dC:dG mononucleotide repeats, suggesting the presence of positive-roll bending not predicted by existing models. Furthermore, these repeats are enriched at positions relative to the nucleosome dyad that bend towards the major groove, providing important information about DNA packaging.
NUCLEIC ACIDS RESEARCH
(2023)
Article
Chemistry, Physical
Simon Lemcke, Joern H. Appeldorn, Michael Wand, Thomas Speck
Summary: In this paper, the authors demonstrate the identification of metastable states in a small peptide through a neural network that utilizes structural information. They show that an autoencoder architecture, EncoderMap, can effectively find a low-dimensional representation solely based on structural information to identify long-lived molecular conformations. The results contribute to computational strategies for exploring the configuration space of peptides and proteins.
JOURNAL OF CHEMICAL PHYSICS
(2023)
Article
Mechanics
Weibin Wen, Shanyao Deng, Tianhao Liu, Shengyu Duan, Fanglin Huang
Summary: The study presented an improved explicit time integration method based on quartic B-spline interpolation for linear and nonlinear dynamics, achieving high accuracy with the ability to adjust numerical dissipation and precision. Results demonstrated its effectiveness in linear and nonlinear dynamic problems, providing stable and accurate solutions compared to classical explicit methods.
EUROPEAN JOURNAL OF MECHANICS A-SOLIDS
(2022)
Article
Physiology
Aswathy M. Cheriyan, Adaku C. Ume, Cynthia E. Francis, Keyona N. King, Valerie A. Linck, Yun Bai, Hui Cai, Robert S. Hoover, Heping P. Ma, Jennifer L. Gooch, Clintoria R. Williams
Summary: CnA alpha deficiency stimulates Nox2 upregulation, and NF-kappa B serves as a novel CnA alpha-regulated transcription factor that mediates Nox2 and ROS regulation. These findings suggest potential for selective CNIs to improve long-term outcomes by mitigating renal side effects.
AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Wei-Han Hui, Yen-Lin Chen, Shu-Wei Chang
Summary: Crosslinking affects the mechanical behavior and tissue metabolism of collagen-based tissues. Aging and diabetes alter the crosslinking type and density, thus changing tissue properties. High-connectivity enzymatic crosslinking and advanced-glycation end-products result in uniform deformation under daily activity, while low-connectivity enzymatic crosslinking does not. High-connectivity model displays more sliding, while AGEs induce instability in structures near the binding sites.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Yao-Bin Ma, Xiao-Qiu Zhou, Wei-Dan Jiang, Pei Wu, Yang Liu, Shu-Wei Li, Ling Tang, Lu Zhang, Hai-Feng Mi, Lin Feng
Summary: Tea polyphenols (TPs) are an inexpensive feed additive that can protect the gill function of fish against Flavobacterium columnare (F. columnare) through various mechanisms, including suppression of oxidative stress, apoptosis, and inflammation.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Yan-Jia Guo, Jing-Ru Pang, Yu Zhang, Zhong-Rui Li, Xiao-Lin Zi, Hong-Min Liu, Ning Wang, Li-Juan Zhao, Ya Gao, Bo Wang, Piet Herdewijn, Cheng-Yun Jin, Ying Liu, Yi-Chao Zheng
Summary: This study identifies the conjugation of NEDD8 to LSD1 and its impact on GC cells, revealing the significance of LSD1 neddylation in GC.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Review
Biochemistry & Molecular Biology
Geum-Jae Jeong, Fazlurrahman Khan, Nazia Tabassum, Young-Mog Kim
Summary: Vibrio species are motile gram-negative bacteria commonly found in aquatic environments. They can adapt to environmental fluctuations and develop protective mechanisms against host immune systems. Different types of sigma and anti-sigma factors play important roles in regulating gene expression and virulence in Vibrio species.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Zahra Mohammadbagheri, Behrooz Movahedi, Shaghayegh Saeedi, Abbas Rahmati
Summary: In this study, a reusable biobased composite hydrogel was successfully synthesized and used for the removal of Tl(I) from aqueous solutions. The hydrogel exhibited high adsorption capacity and thermal stability, and the adsorption process was found to be thermodynamically spontaneous. The results demonstrated that the hydrogel can be reused multiple times without significant loss of its adsorption capacity.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Iqra Batool, Muhammad Imran, Ayesha Anwar, Farhan Ahmed Khan, Afrah E. Mohammed, Ashwag Shami, Hafiz Iqbal
Summary: Enzyme immobilization on ZnO/SnO2 and ZnO/SnO2/SA nanocomposites was studied, and the catalytic and biochemical characteristics of the immobilized enzyme were investigated. The results showed that ZnO/SnO2 and ZnO/SnO2/SA nanostructures are suitable carriers for enzyme immobilization.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Elias Mosaffa, Dhruvi Patel, Nasim Amiri Ramsheh, Rishikumar Indravadan Patel, Atanu Banerjee, Hossein Ghafuri
Summary: In this study, a unique 3D bead structure of adsorbent, composed of bacterial cellulose microfilaments reinforced chitosan adorned with melamine 2D plates, was synthesized for anionic dye removal. The adsorbent showed high specific surface area and abundant functional groups, resulting in exceptional adsorption capacity. The characteristics and optimal conditions of the adsorbent were assessed and analyzed.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Carolina Gismene, Jorge Enrique Hernandez Gonzalez, Marilia de Freitas Calmon, Andrey Fabricio Ziem Nascimento, Angela Rocio Nino Santisteban, Felipe Antunes Calil, Alana Della Torre da Silva, Paula Rahal, Rejane Maira Goes, Raghuvir Krishnaswamy Arni, Ricardo Barros Mariutti
Summary: Mammaliicoccus sciuri, a bacterium of clinical and veterinary relevance, expresses the virulence factor Exfoliative Toxin C (ExhC), which binds specifically to desmoglein-1 (Dsg1) and plays a role in tissue integrity. This study investigates the necrotic activity of ExhC and identifies a variant lacking necrotic potential but retaining enzymatic activity through mutagenesis experiments and crystal structure determination.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Bibhas K. Bhunia, Ashutosh Bandyopadhyay, Souradeep Dey, Biman B. Mandal
Summary: Intervertebral disc degeneration is a major cause of chronic low back pain and disability. Researchers have developed a bioactive silk-based hybrid hydrogel system functionalized with decellularized human Wharton's jelly extracellular matrix as bioactive cues. The hydrogels mimic the rheological and mechanical properties of the native nucleus pulposus tissue and support cell viability, proliferation, and tissue maturation.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Qun Zhang, Yonggan Yan, Zhao Li, Jing Du, Kai Zhang, Liguo Zhang, Ting Wang, Alberto Bianco, Shaohua Ge, Baojin Ma
Summary: A new crosslinking strategy has been devised to construct injectable sodium alginate hydrogels, which can be regulated for injectability and have great potential in biomedical applications.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Seong Eun Hong, Ji-Soo Lee, Hyeon Gyu Lee
Summary: The potential of multi-layer nanoemulsions for improving the cellular uptake, antioxidant activity, and in vitro bioaccessibility of alpha-tocopherol was examined. The results showed that the multi-layer nanoemulsions significantly enhanced the cellular uptake and antioxidant activity of alpha-tocopherol compared to free coumarin 6. Furthermore, the use of chitosan and dextran sulfate as wall materials in the multi-layer nanoemulsions led to even higher cellular uptake, in vitro bioaccessibility, and antioxidant activity of alpha-tocopherol.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Jingjing Yu, Yanhui Zhang, Ruoning Zhang, Yanxiang Gao, Like Mao
Summary: High internal phase emulsions (HIPEs) based on beeswax (BW) oleogels and octenyl succinic acid starch (OSA starch) were prepared by a simple one-step method. The results showed that oleogelation improved the stability and encapsulation capability of the HIPEs, which is significant for the development of novel healthy food.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Review
Biochemistry & Molecular Biology
Bi-Feng Yao, Xiu-Ju Luo, Jun Peng
Summary: The balanced and continuous fission and fusion of mitochondria, regulated by OPA1, are important for maintaining mitochondrial dynamics in cardiovascular disorders. Understanding the role of OPA1 in mitochondrial fusion can provide insights into the pathogenesis of cardiovascular diseases.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Review
Biochemistry & Molecular Biology
Gokul Paramasivam, Anandhavelu Sanmugam, Vishnu Vardhan Palem, Murugan Sevanan, Ananda Babu Sairam, Nachiappan Nachiappan, Buhyun Youn, Jung Sub Lee, Muthuchamy Nallal, Kang Hyun Park
Summary: Nanomaterials are being used to deliver therapeutic agents in living systems. Different nanotechnological applications such as immunosensors, immune assays, and drug delivery are being implemented using nanotechnology. Genomics plays a crucial role in selecting appropriate drugs for personalized cancer therapy. It helps in analyzing gene and protein expression, disease classification, and designing disease models. Delivering drugs to specific areas using nanoparticles is a challenging issue.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Jing Li, Wei Wang, Han Wu, Feng Peng, Hui Gao, Ying Guan
Summary: In this study, CMH-based CPF films were prepared and their thermal and barrier properties were successfully regulated. The tensile strength and water vapor barrier property of CPF films were significantly improved, making them promising for food packaging applications.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)