Article
Materials Science, Biomaterials
Noura Y. Elmehbad, Nadia A. Mohamed
Summary: The two new hydrogels exhibit varying degrees of swelling at different pH levels and have higher activity against most microbes. Evaluation of their cytotoxicity impact on normal human cells shows they are safe. Their adsorption capacity towards heavy metal ions can be arranged as Co+2 > Ni+2 > Cu+2 > Cd+2.
INTERNATIONAL JOURNAL OF POLYMERIC MATERIALS AND POLYMERIC BIOMATERIALS
(2022)
Article
Polymer Science
Rana A. A. Alharbi, Fahad M. M. Alminderej, Nouf F. F. Al-Harby, Noura Y. Y. Elmehbad, Nadia A. A. Mohamed
Summary: A new series of hydrogels were prepared by incorporating substituted bisuracil linkages between chitosan Schiff's base chains and between chitosan chains. The structure of the hydrogels was confirmed through various techniques. The inhibitory effects of the hydrogels against different microbes were studied, with ZnO nanoparticle composites showing the highest inhibition potency.
Article
Chemistry, Multidisciplinary
Zhixuan Liang, Yiheng Li, Liu He, Zhi Gao, Zhenbin Tang, Yiting Xu, Birong Zeng, Weiang Luo, Guorong Chen, Conghui Yuan, Lizong Dai
Summary: A delayed cross-linking strategy is developed to make hydrogels evolvable. The study shows that mechanical stimulation can strengthen the hydrogels, and the hydrogels can self-evolve in a damage-healing process.
ADVANCED FUNCTIONAL MATERIALS
(2023)
Article
Chemistry, Inorganic & Nuclear
Xuejie Guo, Haocheng Yang, Jun Wang
Summary: A zeolite framework-8/chitosan/melamine sponge adsorbent with superior mechanical and anti-biofouling properties was successfully prepared, showing high adsorption capacity and excellent low-concentration U(vi) adsorption performance. Its practical application potentiality was confirmed in natural seawater (Bohai).
INORGANIC CHEMISTRY FRONTIERS
(2022)
Article
Biochemistry & Molecular Biology
Ran Tao, Yin Lu, Wubing Xia, Changwei Zhang, Chengzhang Wang
Summary: This study successfully prepared a ruthenium coordination polymer composite with chitosan quaternary ammonium polymers and shikimic acid. The composite showed good antibacterial properties, with a strong inhibitory effect against S. aureus and the ability to disrupt their biofilm formation. Further mechanism studies revealed that the composite influenced the cell membrane integrity and intracellular Ca2+ levels of S. aureus.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Chemistry, Applied
Nuraziemah Ahmad, Chua Eng Wee, Lam Kok Wai, Noraziah Mohamad Zin, Fazren Azmi
Summary: Natural antimicrobial peptides (AMPs) are a promising source for new antimicrobial agents, but their clinical application is limited by poor bioavailability and toxicity. This study addresses these limitations by designing a new series of chitosan derivatives that mimic the structure of AMPs, with one derivative showing the most potent antimicrobial activity against Gram-negative bacteria while causing minimal cell death in tested cell lines. The results confirm the importance of cationicity and lipophilicity for selective bacteria targeting with the potential for chitosan nanoparticles as a new class of AMPs mimics effective against Gram-negative bacteria.
CARBOHYDRATE POLYMERS
(2021)
Article
Chemistry, Multidisciplinary
Guiting Yu, Chunqing Niu, Jiali Liu, Jue Wu, Zheng Jin, Yiyu Wang, Kai Zhao
Summary: In this study, a self-cross-linking and biocompatible hydrogel was successfully prepared using N-2-hydroxypropyl trimethyl ammonium chloride chitosan (HACC) and oxidized sodium alginate (OSA). The hydrogel formed a stable and reversible cross-linking network through Schiff base self-cross-linking and hydrogen bonding. By adding a shielding agent (NaCl), the intense electrostatic effect between HACC and OSA was weakened, which solved the problem of flocculation and allowed for the formation of a homogeneous hydrogel. The HACC/OSA hydrogel exhibited a uniform porous structure, enhanced mechanical properties, favorable swelling property, biodegradation, water retention, antibacterial properties, good cytocompatibility, and sustained release effect on rhodamine.
Review
Chemistry, Multidisciplinary
Simona Summonte, Giuseppe Francesco Racaniello, Angela Lopedota, Nunzio Denora, Andreas Bernkop-Schnuerch
Summary: Thiomers, such as thiolated hyaluronic acid and chitosan, are widely studied for their high reactivity in hydrogel synthesis. They exhibit in situ gelling properties and can undergo various click reactions, making them versatile materials for tissue engineering, regenerative medicine, and drug delivery.
JOURNAL OF CONTROLLED RELEASE
(2021)
Article
Biochemistry & Molecular Biology
Annie A. Ceron, Lorrane Nascife, Samuel Norte, Silgia A. Costa, Jose Heriberto Oliveira do Nascimento, Fernando Dal Pont Morisso, Julia Baruque-Ramos, Rodrigo C. Oliveira, Sirlene M. Costa
Summary: Chitosan microspheres (CMS) were synthesized and characterized by the emulsion-chemical cross-linking method, with and without lysozyme immobilization. The results showed that the microspheres effectively immobilized lysozyme and exhibited positive antimicrobial activity against Staphylococcus aureus, Enterococcus faecalis, and Pseudomonas aeruginosa.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Biochemistry & Molecular Biology
Noura Y. Elmehbad, Nadia A. Mohamed, Nahed A. Abd El-Ghany, Marwa M. Abdel-Aziz
Summary: Two novel chemically cross-linked chitosan hydrogels, OCsSB and OCs, were prepared by incorporating oxalyl dihydrazide moieties between chitosan Schiff's base chains and between chitosan chains. Addition of ZnO nanoparticles into OCs resulted in the composites OCs/ZnONPs-1% and OCs/ZnONPs-3%. The antimicrobial activity of these compounds was confirmed through various characterization techniques and they exhibited significant inhibitory effects against bacteria and biofilms. Incorporation of oxalyl dihydrazide and ZnO nanoparticles into chitosan greatly enhanced its antimicrobial activity, making it a promising alternative to traditional antibiotics.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Polymer Science
Sayaka Fujita, Hijiri Takeda, Junki Noda, Haruki Wakamori, Hiroyuki Kono
Summary: This study successfully prepared chitosan hydrogels composed entirely of carbohydrates by crosslinking chitosan with oxidized sucrose and then reducing it. The properties of the hydrogels, including thermal stability, dynamic modulus, and antimicrobial activity, were found to be dependent on the degree of crosslinking. The results suggest the potential of these carbohydrate-based hydrogels for various applications in the medical and pharmaceutical fields.
Article
Polymer Science
Ramona Lungu, Maria-Alexandra Paun, Dragos Peptanariu, Daniela Ailincai, Luminita Marin, Mihai-Virgil Nichita, Vladimir-Alexandru Paun, Viorel-Puiu Paun
Summary: This study investigates a supramolecular hydrogel based on chitosan and monoaldehydes as a bioabsorbable wound dressing. The hydrogel's structural and supramolecular properties, as well as its biocompatibility, antimicrobial activity, and biodegradability, were analyzed through various experiments and analyses. The results demonstrate that the hydrogel meets the expected high standards.
Article
Engineering, Multidisciplinary
Alexander Pestov, Yuliya Privar, Arseny Slobodyuk, Andrey Boroda, Svetlana Bratskaya
Summary: This study demonstrates the use of acyclic diethylacetal of acetaldehyde (ADA) with low cytotoxicity for the fabrication of hydrogels. The hydrogels were formed via Schiff bases formation between chitosan and acetaldehyde generated in situ from acetals in chitosan acetate solution. The formed hydrogels showed mechanical stability and insolubility in a broad pH range.
Article
Chemistry, Physical
Maria Demeter, Ion Calina, Anca Scarisoreanu, Valentina Mitran, Marcela Popa, Anisoara Cimpean, Mariana Carmen Chifiriuc, Marin Micutz, Elena Matei, Bogdana Mitu
Summary: Novel biocompatible composite hydrogels with good elastic and antimicrobial properties were synthesized by e-beam cross-linking using chitosan, water-soluble polymers, and silver nanoparticles (AgNP). The composite hydrogels showed high stability, absorption capability specific to infected wounds, and biocompatibility. The antimicrobial activity was influenced by the amount of AgNP and cross-linking degree, with significant inhibition against Gram-negative bacteria.
RADIATION PHYSICS AND CHEMISTRY
(2024)
Article
Chemistry, Multidisciplinary
K. P. Sonu, Le Zhou, Santidan Biswas, John Klier, Anna C. Balazs, Todd Emrick, Shelly R. Peyton
Summary: Hydrogels are water-swollen networks that have various applications in biomaterials and biotechnology. This study successfully synthesized multifunctional polymers to create hydrogels with reversible and irreversible cross-links. These strain-stiffening hydrogels have potential applications as biomaterials, particularly in emerging fields like tissue engineering.
Article
Materials Science, Biomaterials
Noura Y. Elmehbad, Nadia A. Mohamed
Summary: A new modified chitosan derivative and its metal complexes were successfully prepared and characterized. Among them, the ACsAH-Mn(II) complex showed the highest antimicrobial activity, surpassing some standard drugs.
INTERNATIONAL JOURNAL OF POLYMERIC MATERIALS AND POLYMERIC BIOMATERIALS
(2022)
Article
Materials Science, Biomaterials
Noura Y. Elmehbad, Nadia A. Mohamed
Summary: The two new hydrogels exhibit varying degrees of swelling at different pH levels and have higher activity against most microbes. Evaluation of their cytotoxicity impact on normal human cells shows they are safe. Their adsorption capacity towards heavy metal ions can be arranged as Co+2 > Ni+2 > Cu+2 > Cd+2.
INTERNATIONAL JOURNAL OF POLYMERIC MATERIALS AND POLYMERIC BIOMATERIALS
(2022)
Article
Polymer Science
Noura Y. Elmehbad, Nadia A. Mohamed
Summary: New poly(N-benzoyl-4-(N-itaconimido)-benzhydrazide) (PBIBH) and its metal complexes have been prepared, showing stronger antimicrobial activity against various bacteria and fungi compared to PBIBH alone, with Co displaying the highest potency. Additionally, PBIBH and its metal complexes exhibit higher thermal stabilization efficiency for PVC.
Article
Biochemistry & Molecular Biology
Noura Y. Elmehbad, Nadia A. Mohamed, Nahed A. Abd El-Ghany
Summary: Two novel chitosan derivatives were prepared by incorporating salicylhydrazide into chitosan Schiff base (SCsSB) and chitosan (SCs). Two nanocomposites, SCs/TiO2-1% and SCs/TiO2-3%, were also prepared. Their structures were confirmed using elemental analyses, FTIR, XRD, SEM, EDX and TEM. The new chitosan derivatives exhibited strong antimicrobial and anti-biofilm activities, with low minimum inhibitory concentrations against various bacteria and fungi. This research provides a new approach for the development of new antimicrobial agents.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Materials Science, Paper & Wood
Nouf F. Al-Harby, Mawaheb S. Almarshed, Nadia A. Mohamed
Summary: A chitosan hydrogel crosslinked with trimellitic anhydride isothiocyanate (H-1) and filled with single-walled carbon nanotubes (SWCNTs) (H-1/SWCNTs) was synthesized. The adsorption capacity of H-1/SWCNTs for Basic red 12 (BR 12) dye was significantly higher than that of H-1. The adsorption process followed pseudo-second-order kinetics and the Langmuir isotherm model. The inclusion of SWCNTs improved the features of H-1 and the composite showed high-performance adsorbing characteristic for cationic dyes removal.
CELLULOSE CHEMISTRY AND TECHNOLOGY
(2023)
Article
Engineering, Chemical
Nouf F. Al-Harby, Ruwayda S. Almutairi, Noura Y. Elmehbad, Nadia A. Mohamed
Summary: In this study, the O-Carboxymethyl chitosan (O-CM-chitosan) hydrogel was used for the first time as an adsorbent to remove Basic Red 12 (BR 12) dye. The adsorption capacity and removal efficiency decreased with increasing temperature and decreasing solution pH. Increasing the initial dye concentration led to an increase in adsorption capacity but a decrease in removal efficiency. The results suggest that O-CM-chitosan hydrogel has potential as an effective adsorbent for the removal of BR 12 and similar dyes from aqueous media.
POLYMER ENGINEERING AND SCIENCE
(2023)
Article
Polymer Science
Rana A. A. Alharbi, Fahad M. M. Alminderej, Nouf F. F. Al-Harby, Noura Y. Y. Elmehbad, Nadia A. A. Mohamed
Summary: A new series of hydrogels were prepared by incorporating substituted bisuracil linkages between chitosan Schiff's base chains and between chitosan chains. The structure of the hydrogels was confirmed through various techniques. The inhibitory effects of the hydrogels against different microbes were studied, with ZnO nanoparticle composites showing the highest inhibition potency.
Article
Polymer Science
Rana A. Alharbi, Fahad M. Alminderej, Nouf F. Al-Harby, Noura Y. Elmehbad, Nadia A. Mohamed
Summary: A new hydrogel based on chitosan crosslinked with 2-chlorophenyl-bis(6-amino-1,3-dimethyluracil-5-yl) methane has been developed and proven through various techniques. Its efficiency in removing anionic Congo red dye in industrial wastewater was studied, and the optimal conditions for removal were investigated. The hydrogel showed a high adsorption capacity for the dye and had potential as a reusable adsorbent for industrial wastewater remediation.
Article
Chemistry, Physical
Jehan Y. Al-Humaidi, Sobhi M. Gomha, Nahed A. Abd El-Ghany, Basant Farag, Magdi E. A. Zaki, Tariq Z. Abolibda, Nadia A. Mohamed
Summary: In this study, an ecofriendly biopolymeric catalyst was prepared and used for the synthesis of novel thiazole and thiadiazole derivatives. The catalyst showed mild reaction conditions, quick reaction durations, and high reaction yields. It also retained its potency after multiple reuses.
Article
Materials Science, Paper & Wood
Noura Y. Elmehbad, Nadia A. Mohamed, Nahed A. Abd El-Ghany, Marwa M. Abdel-Aziz
Summary: A crosslinked sodium alginate (SA)/carboxymethyl xanthan gum (CMXG) hydrogel was prepared, and two nanocomposites were prepared by dispersing silver nanoparticles (AgNPs) into the hydrogel. The AgNP composites exhibited strong inhibition activity, and their efficacy increased with increasing AgNPs content. Moreover, the SA/CMXG/AgNPs composites showed higher inhibition efficiency against H. pylori than the standard drug Clarithromycin, especially at lower concentrations.
CELLULOSE CHEMISTRY AND TECHNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Wei-Han Hui, Yen-Lin Chen, Shu-Wei Chang
Summary: Crosslinking affects the mechanical behavior and tissue metabolism of collagen-based tissues. Aging and diabetes alter the crosslinking type and density, thus changing tissue properties. High-connectivity enzymatic crosslinking and advanced-glycation end-products result in uniform deformation under daily activity, while low-connectivity enzymatic crosslinking does not. High-connectivity model displays more sliding, while AGEs induce instability in structures near the binding sites.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Yao-Bin Ma, Xiao-Qiu Zhou, Wei-Dan Jiang, Pei Wu, Yang Liu, Shu-Wei Li, Ling Tang, Lu Zhang, Hai-Feng Mi, Lin Feng
Summary: Tea polyphenols (TPs) are an inexpensive feed additive that can protect the gill function of fish against Flavobacterium columnare (F. columnare) through various mechanisms, including suppression of oxidative stress, apoptosis, and inflammation.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Yan-Jia Guo, Jing-Ru Pang, Yu Zhang, Zhong-Rui Li, Xiao-Lin Zi, Hong-Min Liu, Ning Wang, Li-Juan Zhao, Ya Gao, Bo Wang, Piet Herdewijn, Cheng-Yun Jin, Ying Liu, Yi-Chao Zheng
Summary: This study identifies the conjugation of NEDD8 to LSD1 and its impact on GC cells, revealing the significance of LSD1 neddylation in GC.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Review
Biochemistry & Molecular Biology
Geum-Jae Jeong, Fazlurrahman Khan, Nazia Tabassum, Young-Mog Kim
Summary: Vibrio species are motile gram-negative bacteria commonly found in aquatic environments. They can adapt to environmental fluctuations and develop protective mechanisms against host immune systems. Different types of sigma and anti-sigma factors play important roles in regulating gene expression and virulence in Vibrio species.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Zahra Mohammadbagheri, Behrooz Movahedi, Shaghayegh Saeedi, Abbas Rahmati
Summary: In this study, a reusable biobased composite hydrogel was successfully synthesized and used for the removal of Tl(I) from aqueous solutions. The hydrogel exhibited high adsorption capacity and thermal stability, and the adsorption process was found to be thermodynamically spontaneous. The results demonstrated that the hydrogel can be reused multiple times without significant loss of its adsorption capacity.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Iqra Batool, Muhammad Imran, Ayesha Anwar, Farhan Ahmed Khan, Afrah E. Mohammed, Ashwag Shami, Hafiz Iqbal
Summary: Enzyme immobilization on ZnO/SnO2 and ZnO/SnO2/SA nanocomposites was studied, and the catalytic and biochemical characteristics of the immobilized enzyme were investigated. The results showed that ZnO/SnO2 and ZnO/SnO2/SA nanostructures are suitable carriers for enzyme immobilization.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Elias Mosaffa, Dhruvi Patel, Nasim Amiri Ramsheh, Rishikumar Indravadan Patel, Atanu Banerjee, Hossein Ghafuri
Summary: In this study, a unique 3D bead structure of adsorbent, composed of bacterial cellulose microfilaments reinforced chitosan adorned with melamine 2D plates, was synthesized for anionic dye removal. The adsorbent showed high specific surface area and abundant functional groups, resulting in exceptional adsorption capacity. The characteristics and optimal conditions of the adsorbent were assessed and analyzed.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Carolina Gismene, Jorge Enrique Hernandez Gonzalez, Marilia de Freitas Calmon, Andrey Fabricio Ziem Nascimento, Angela Rocio Nino Santisteban, Felipe Antunes Calil, Alana Della Torre da Silva, Paula Rahal, Rejane Maira Goes, Raghuvir Krishnaswamy Arni, Ricardo Barros Mariutti
Summary: Mammaliicoccus sciuri, a bacterium of clinical and veterinary relevance, expresses the virulence factor Exfoliative Toxin C (ExhC), which binds specifically to desmoglein-1 (Dsg1) and plays a role in tissue integrity. This study investigates the necrotic activity of ExhC and identifies a variant lacking necrotic potential but retaining enzymatic activity through mutagenesis experiments and crystal structure determination.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Bibhas K. Bhunia, Ashutosh Bandyopadhyay, Souradeep Dey, Biman B. Mandal
Summary: Intervertebral disc degeneration is a major cause of chronic low back pain and disability. Researchers have developed a bioactive silk-based hybrid hydrogel system functionalized with decellularized human Wharton's jelly extracellular matrix as bioactive cues. The hydrogels mimic the rheological and mechanical properties of the native nucleus pulposus tissue and support cell viability, proliferation, and tissue maturation.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Qun Zhang, Yonggan Yan, Zhao Li, Jing Du, Kai Zhang, Liguo Zhang, Ting Wang, Alberto Bianco, Shaohua Ge, Baojin Ma
Summary: A new crosslinking strategy has been devised to construct injectable sodium alginate hydrogels, which can be regulated for injectability and have great potential in biomedical applications.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Seong Eun Hong, Ji-Soo Lee, Hyeon Gyu Lee
Summary: The potential of multi-layer nanoemulsions for improving the cellular uptake, antioxidant activity, and in vitro bioaccessibility of alpha-tocopherol was examined. The results showed that the multi-layer nanoemulsions significantly enhanced the cellular uptake and antioxidant activity of alpha-tocopherol compared to free coumarin 6. Furthermore, the use of chitosan and dextran sulfate as wall materials in the multi-layer nanoemulsions led to even higher cellular uptake, in vitro bioaccessibility, and antioxidant activity of alpha-tocopherol.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Jingjing Yu, Yanhui Zhang, Ruoning Zhang, Yanxiang Gao, Like Mao
Summary: High internal phase emulsions (HIPEs) based on beeswax (BW) oleogels and octenyl succinic acid starch (OSA starch) were prepared by a simple one-step method. The results showed that oleogelation improved the stability and encapsulation capability of the HIPEs, which is significant for the development of novel healthy food.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Review
Biochemistry & Molecular Biology
Bi-Feng Yao, Xiu-Ju Luo, Jun Peng
Summary: The balanced and continuous fission and fusion of mitochondria, regulated by OPA1, are important for maintaining mitochondrial dynamics in cardiovascular disorders. Understanding the role of OPA1 in mitochondrial fusion can provide insights into the pathogenesis of cardiovascular diseases.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Review
Biochemistry & Molecular Biology
Gokul Paramasivam, Anandhavelu Sanmugam, Vishnu Vardhan Palem, Murugan Sevanan, Ananda Babu Sairam, Nachiappan Nachiappan, Buhyun Youn, Jung Sub Lee, Muthuchamy Nallal, Kang Hyun Park
Summary: Nanomaterials are being used to deliver therapeutic agents in living systems. Different nanotechnological applications such as immunosensors, immune assays, and drug delivery are being implemented using nanotechnology. Genomics plays a crucial role in selecting appropriate drugs for personalized cancer therapy. It helps in analyzing gene and protein expression, disease classification, and designing disease models. Delivering drugs to specific areas using nanoparticles is a challenging issue.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Jing Li, Wei Wang, Han Wu, Feng Peng, Hui Gao, Ying Guan
Summary: In this study, CMH-based CPF films were prepared and their thermal and barrier properties were successfully regulated. The tensile strength and water vapor barrier property of CPF films were significantly improved, making them promising for food packaging applications.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
