Article
Biochemistry & Molecular Biology
Jing Cui, Xingxue Pan, Xueqin Duan, Liting Ke, Xiaoping Song, Weimin Zhang, Wuren Ma, Yingqiu Liu, Yunpeng Fan
Summary: The purpose of this study was to investigate the effects and mechanism of miR-4796 in the regulation of immune activity of Kupffer cells (KCs) by ophiopogon polysaccharide liposome (OPL). The results indicate that OPL can regulate the immune activity of KCs by modulating miR-4796 and activating the TLR4-NF-kappa B signaling pathway.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Juan Yu, Xiao-dan Dong, Jian-shuang Jiao, Hai-yu Ji, An-jun Liu
Summary: The Astragalus membranaceus polysaccharide (APS4) shows direct cytotoxicity on various cancer cells and has potential therapeutic effects on solid tumors. Through experiments on S180 tumor-bearing mice, it was found that APS4 can regulate the immune system, inhibit solid tumor growth, and promote apoptosis of tumor cells.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Review
Plant Sciences
Aliya Sheik, Kwanwoo Kim, Ganji Lakshmi Varaprasad, Hoomin Lee, Suheon Kim, Eunsu Kim, Jin-Yong Shin, Seo Yeong Oh, Yun Suk Huh
Summary: Astragalus membranaceus, as a traditional herb with a long history in cancer treatment, has attracted researchers' attention for its immunomodulatory effects and potential in alleviating cancer-related fatigue. Its natural phytoconstituents show high anti-cancer activity and have been studied in clinical trials for overcoming the toxic effects of chemotherapy drugs.
Article
Biochemistry & Molecular Biology
Danping Zhao, Xiuhong Chen, Linyuan Wang, Jianjun Zhang, Zhongpeng Zhao, Na Yue, Yingli Zhu, Wenting Fei, Xinyu Li, Lingyun Tan, Wei He
Summary: Respiratory viral infections, including COVID-19 and influenza, have become a global health concern. Vaccination is crucial for prevention, and this study evaluated the effectiveness of Astragalus polysaccharide (APS) as an immune adjuvant for influenza and COVID-19 vaccines. The results showed that APS facilitated a strong immune response in mice, with increased levels of antibodies and protection against influenza A viruses. APS also demonstrated bidirectional immunomodulation and persistent immunity, making it a promising adjuvant.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Agriculture, Dairy & Animal Science
Adelijiang Wusiman, Sabire Rexiati, Mamat Aziz, Xike Cheng, Zhanhai Mai, Alimire Abulaiti, Abudureheimu Wutikuer, Parhat Rozi, Aytursun Abuduwaili, Saifuding Abula
Summary: This study investigated the preparation and characterization of Lagenaria siceraria polysaccharide and sulfated modified polysaccharide as vaccine adjuvants and demonstrated their immunoenhancing activity on chickens. The results showed that the polysaccharides induced strong and long-lasting immune responses in chickens.
Article
Biochemistry & Molecular Biology
Yanfei He, Xiaoying Hu, Huifang Zhang, Xiangfeng Chen, Hongxiang Sun
Summary: Two polysaccharides from Crocus sativus petals demonstrated immunopotentiatory activity by activating macrophages via the MAPK and NF-KB pathway. This study investigated their adjuvant effects and underlying mechanisms using ovalbumin in mice. The results showed that these polysaccharides enhanced immune responses, triggered the production of cytokines, and facilitated antigen transport, making them promising vaccine adjuvant candidates.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Agriculture, Dairy & Animal Science
Lvyan Liao, Jian Li, Jun Li, Yifan Huang, Yijian Wu
Summary: APS pretreatment can effectively improve intestinal injuries caused by MDRV infection in Muscovy ducklings, promote intestinal morphology restoration, enhance mucosal immune function, and increase secretion of immune-related substances.
Article
Biochemistry & Molecular Biology
Shuwen Xu, Zi'an Feng, Yue Zhang, Haiyu Ni, Zhenguang Liu, Deyun Wang
Summary: This study developed pH-responsive targeting drug delivery carriers using PLGA materials encapsulated with astragalus polysaccharides (APS). The carriers showed good release behavior, low cytotoxicity, and enhanced immune responses.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Biochemistry & Molecular Biology
Ying Peng, Fenbo Ma, Liqiu Hu, Yuqing Deng, Wenqi He, Bin Tang
Summary: This study designed and synthesized a novel polysaccharide compound called APS-Sr, which has therapeutic effects in anti-inflammation and promoting bone formation. The experimental results showed that APS-Sr can effectively inhibit inflammatory factors, promote osteogenic differentiation, and up-regulate bone growth factors.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Biotechnology & Applied Microbiology
Sisi Chen, Liu Yang, Xia Ou, Jin-Yu Li, Cheng-Ting Zi, Hao Wang, Jiang-Miao Hu, Ye Liu
Summary: A newly-identified natural polysaccharide, PRBS, has been found to serve as a versatile platform for constructing diverse types of nanovaccines. By co-assembling with different antigens, PRBS can activate multiple critical immune cells and induce stronger antigen-specific immune responses.
JOURNAL OF NANOBIOTECHNOLOGY
(2022)
Article
Immunology
Qianqian Liu, Xinnan Zhang, Dongkun Chai, Hangyu Li, Sheng Li, Daiyan Wu, Linzi Zhang, Ziwei Liu, Yangyang Feng, Feng Tang, Haibo Feng
Summary: CD-205 receptor-mediated dendritic cell targeting liposomes are widely used as a delivery system to induce a strong immune response or specific immune tolerance. They can carry both antigen and adjuvant, modulating dendritic cell maturation and activating T-cell response. Our experiments showed that the CD-205 antibody successfully binds to the corresponding cell receptor, indicating the targeting efficiency of the liposomes.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Beibei Xiong, Xiangfeng Chen, Jue Tu, Ziyi Han, Xiang Meng, Hongxiang Sun
Summary: This study demonstrates for the first time the role of lncRNAs in regulating the adjuvant activity of polysaccharides and its mechanisms. These findings expand our current understanding of the mechanism of action of adjuvants and provide a new target for the design and development of vaccine adjuvants.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Biochemistry & Molecular Biology
Yang Wang, Xiaoyan Shen, Kaiyue Yin, Changqing Miao, Yanlong Sun, Shumei Mao, Dongmei Liu, Jiwen Sheng
Summary: Polysaccharides extracted from Athyrium Multidentatum show remarkable immune enhancement activities by promoting macrophage proliferation, enhancing phagocytosis, and increasing the production of various cytokines.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Nutrition & Dietetics
Xinlei Yan, Jing Miao, Bao Zhang, Huan Liu, Huifang Ma, Yufei Sun, Pufang Liu, Xiujuan Zhang, Ruigang Wang, Juntao Kan, Feiyun Yang, Qiming Wu
Summary: This study aimed to extract Astragalus polysaccharide (APS) using a semi-bionic extraction method and evaluate its anti-aging activities. The results showed that this method significantly improved the yield of APS and exhibited anti-aging activity in rats. These findings highlight the potential applications of APS.
FRONTIERS IN NUTRITION
(2023)
Article
Biochemistry & Molecular Biology
Xiang Weng, Bing Zhao, Rang Li, Quanxiao Li, Ailian Zhang
Summary: This study investigated the adjuvant features of CARP2 polysaccharide component in the IVV vaccine and its mechanism in DCs. CARP2 enhanced the production of antibodies and T cells, lasted for 275 days without adverse effects, and achieved a ten-fold dose-sparing effect. CARP2 activated DCs and Tregs, promoted Th1/Th2 cytokine production, and activated the TLR4/MyD88/TRAF/NF-kappa B pathway in DCs.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Biochemistry & Molecular Biology
Wei-Han Hui, Yen-Lin Chen, Shu-Wei Chang
Summary: Crosslinking affects the mechanical behavior and tissue metabolism of collagen-based tissues. Aging and diabetes alter the crosslinking type and density, thus changing tissue properties. High-connectivity enzymatic crosslinking and advanced-glycation end-products result in uniform deformation under daily activity, while low-connectivity enzymatic crosslinking does not. High-connectivity model displays more sliding, while AGEs induce instability in structures near the binding sites.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Yao-Bin Ma, Xiao-Qiu Zhou, Wei-Dan Jiang, Pei Wu, Yang Liu, Shu-Wei Li, Ling Tang, Lu Zhang, Hai-Feng Mi, Lin Feng
Summary: Tea polyphenols (TPs) are an inexpensive feed additive that can protect the gill function of fish against Flavobacterium columnare (F. columnare) through various mechanisms, including suppression of oxidative stress, apoptosis, and inflammation.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Yan-Jia Guo, Jing-Ru Pang, Yu Zhang, Zhong-Rui Li, Xiao-Lin Zi, Hong-Min Liu, Ning Wang, Li-Juan Zhao, Ya Gao, Bo Wang, Piet Herdewijn, Cheng-Yun Jin, Ying Liu, Yi-Chao Zheng
Summary: This study identifies the conjugation of NEDD8 to LSD1 and its impact on GC cells, revealing the significance of LSD1 neddylation in GC.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Review
Biochemistry & Molecular Biology
Geum-Jae Jeong, Fazlurrahman Khan, Nazia Tabassum, Young-Mog Kim
Summary: Vibrio species are motile gram-negative bacteria commonly found in aquatic environments. They can adapt to environmental fluctuations and develop protective mechanisms against host immune systems. Different types of sigma and anti-sigma factors play important roles in regulating gene expression and virulence in Vibrio species.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Zahra Mohammadbagheri, Behrooz Movahedi, Shaghayegh Saeedi, Abbas Rahmati
Summary: In this study, a reusable biobased composite hydrogel was successfully synthesized and used for the removal of Tl(I) from aqueous solutions. The hydrogel exhibited high adsorption capacity and thermal stability, and the adsorption process was found to be thermodynamically spontaneous. The results demonstrated that the hydrogel can be reused multiple times without significant loss of its adsorption capacity.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Iqra Batool, Muhammad Imran, Ayesha Anwar, Farhan Ahmed Khan, Afrah E. Mohammed, Ashwag Shami, Hafiz Iqbal
Summary: Enzyme immobilization on ZnO/SnO2 and ZnO/SnO2/SA nanocomposites was studied, and the catalytic and biochemical characteristics of the immobilized enzyme were investigated. The results showed that ZnO/SnO2 and ZnO/SnO2/SA nanostructures are suitable carriers for enzyme immobilization.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Elias Mosaffa, Dhruvi Patel, Nasim Amiri Ramsheh, Rishikumar Indravadan Patel, Atanu Banerjee, Hossein Ghafuri
Summary: In this study, a unique 3D bead structure of adsorbent, composed of bacterial cellulose microfilaments reinforced chitosan adorned with melamine 2D plates, was synthesized for anionic dye removal. The adsorbent showed high specific surface area and abundant functional groups, resulting in exceptional adsorption capacity. The characteristics and optimal conditions of the adsorbent were assessed and analyzed.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Carolina Gismene, Jorge Enrique Hernandez Gonzalez, Marilia de Freitas Calmon, Andrey Fabricio Ziem Nascimento, Angela Rocio Nino Santisteban, Felipe Antunes Calil, Alana Della Torre da Silva, Paula Rahal, Rejane Maira Goes, Raghuvir Krishnaswamy Arni, Ricardo Barros Mariutti
Summary: Mammaliicoccus sciuri, a bacterium of clinical and veterinary relevance, expresses the virulence factor Exfoliative Toxin C (ExhC), which binds specifically to desmoglein-1 (Dsg1) and plays a role in tissue integrity. This study investigates the necrotic activity of ExhC and identifies a variant lacking necrotic potential but retaining enzymatic activity through mutagenesis experiments and crystal structure determination.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Bibhas K. Bhunia, Ashutosh Bandyopadhyay, Souradeep Dey, Biman B. Mandal
Summary: Intervertebral disc degeneration is a major cause of chronic low back pain and disability. Researchers have developed a bioactive silk-based hybrid hydrogel system functionalized with decellularized human Wharton's jelly extracellular matrix as bioactive cues. The hydrogels mimic the rheological and mechanical properties of the native nucleus pulposus tissue and support cell viability, proliferation, and tissue maturation.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Qun Zhang, Yonggan Yan, Zhao Li, Jing Du, Kai Zhang, Liguo Zhang, Ting Wang, Alberto Bianco, Shaohua Ge, Baojin Ma
Summary: A new crosslinking strategy has been devised to construct injectable sodium alginate hydrogels, which can be regulated for injectability and have great potential in biomedical applications.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Seong Eun Hong, Ji-Soo Lee, Hyeon Gyu Lee
Summary: The potential of multi-layer nanoemulsions for improving the cellular uptake, antioxidant activity, and in vitro bioaccessibility of alpha-tocopherol was examined. The results showed that the multi-layer nanoemulsions significantly enhanced the cellular uptake and antioxidant activity of alpha-tocopherol compared to free coumarin 6. Furthermore, the use of chitosan and dextran sulfate as wall materials in the multi-layer nanoemulsions led to even higher cellular uptake, in vitro bioaccessibility, and antioxidant activity of alpha-tocopherol.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Jingjing Yu, Yanhui Zhang, Ruoning Zhang, Yanxiang Gao, Like Mao
Summary: High internal phase emulsions (HIPEs) based on beeswax (BW) oleogels and octenyl succinic acid starch (OSA starch) were prepared by a simple one-step method. The results showed that oleogelation improved the stability and encapsulation capability of the HIPEs, which is significant for the development of novel healthy food.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Review
Biochemistry & Molecular Biology
Bi-Feng Yao, Xiu-Ju Luo, Jun Peng
Summary: The balanced and continuous fission and fusion of mitochondria, regulated by OPA1, are important for maintaining mitochondrial dynamics in cardiovascular disorders. Understanding the role of OPA1 in mitochondrial fusion can provide insights into the pathogenesis of cardiovascular diseases.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Review
Biochemistry & Molecular Biology
Gokul Paramasivam, Anandhavelu Sanmugam, Vishnu Vardhan Palem, Murugan Sevanan, Ananda Babu Sairam, Nachiappan Nachiappan, Buhyun Youn, Jung Sub Lee, Muthuchamy Nallal, Kang Hyun Park
Summary: Nanomaterials are being used to deliver therapeutic agents in living systems. Different nanotechnological applications such as immunosensors, immune assays, and drug delivery are being implemented using nanotechnology. Genomics plays a crucial role in selecting appropriate drugs for personalized cancer therapy. It helps in analyzing gene and protein expression, disease classification, and designing disease models. Delivering drugs to specific areas using nanoparticles is a challenging issue.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Jing Li, Wei Wang, Han Wu, Feng Peng, Hui Gao, Ying Guan
Summary: In this study, CMH-based CPF films were prepared and their thermal and barrier properties were successfully regulated. The tensile strength and water vapor barrier property of CPF films were significantly improved, making them promising for food packaging applications.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)