期刊
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
卷 50, 期 1, 页码 1-6出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.ijbiomac.2011.08.016
关键词
cAMP; cAMP binding motif; cAMP receptor protein; Conformational change
资金
- National Natural Science Foundation of China [30970631]
- National Basic Research Program of China [2007CB914304]
- Pujiang Program of Shanghai City [09PJD007]
- Shanghai Leading Academic Discipline Project [B109]
The cAMP receptor protein (CRP) requires CAMP for an allosteric change and regulates more than 150 genes in Escherichia coli, In this study, the modular half of cAMP receptor protein was used to investigate the allosteric signal transmission pathway induced by cAMP binding. The activation of CRP upon cAMP binding is indicated to be realignment of the two subunits within the CRP dimer. The interaction of loop 3 and Phe136 do not involve in signal transmission. (C) 2011 Elsevier B.V. All rights reserved.
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