期刊
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
卷 50, 期 1, 页码 157-163出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.ijbiomac.2011.10.013
关键词
Chondroitin sulfate; Interfacial polymerization; Nanocapsule; Drug release
资金
- Yangzhou University [2009CXJ050]
- Key Laboratory of Environmental Materials and Environmental Engineering of Jiangsu Province [017375003579]
In this paper, the method of interfacial polymerization in emulsion was employed to fabricate chondroitin sulfate-methacrylate (ChSMA) nanocapsules, in which poor water-soluble drug of indomethacin (IND) could be effectively encapsulated. The morphology and the size distribution of synthesized nanocapsules were characterized by field emission scanning electron microscopy (FESEM) and dynamic light scattering (DLS) techniques. The quantitative drug loading was investigated. The IND/ChSMA noodle-like self-assemblies were observed with the increase of IND feed concentration, and the interactions between IND and ChSMA were illuminated by FT-IR and XRD measurements. The in vitro drug release of IND-loaded nanocapsules and IND/ChSMA self-assemblies were also carried out in simulated body fluid pH 7.4 at 37 degrees C. (C) 2011 Elsevier B.V. All rights reserved.
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