Article
Ophthalmology
Lasse Jorgensen Cehofski, Kentaro Kojima, Natsuki Kusada, Maja Rasmussen, Danson Vasanthan Muttuvelu, Jakob Grauslund, Henrik Vorum, Bent Honore
Summary: Proteomic analysis of aqueous humor in patients with central retinal vein occlusion (CRVO) revealed differential expression of various proteins that correlated with visual acuity and macular edema severity, including fibrinogen, fibronectin, and immunoglobulins.
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2023)
Article
Biochemistry & Molecular Biology
Lasse Jorgensen Cehofski, Anders Kruse, Mads Odgaard Maeng, Benn Falch Sejergaard, Anders Schlosser, Grith Lykke Sorensen, Jakob Grauslund, Bent Honore, Henrik Vorum
Summary: This study demonstrates the effective treatment of inflammatory response in CRVO using a DEX intravitreal implant. Upregulation of FKBP5 and ubiquilin-4 and downregulation of cell adhesion molecule 3, tumor necrosis factor receptor superfamily member 16, and trans-1,2-dihydrobenzene-1,2-diol dehydrogenase were observed following DEX intervention in CRVO.
Review
Biochemistry & Molecular Biology
Meletia Kallianta, Eftychia Pappa, Heleni Vastardis, Christos Rahiotis
Summary: Mass Spectrometry (MS) is a highly sensitive and universal analytical technique that has rapidly developed in recent decades. It has various applications in dentistry, including research on dental materials and agents, laboratory analysis of biospecimens, and real-time diagnostics in oral surgery and pathology. MS can provide valuable insights into the clinical behavior, toxicity, antimicrobial properties, and biomarkers of dental materials and agents. It is also effective in detecting biomarkers in saliva and providing a comprehensive understanding of cellular functions through metabolite analysis. Additionally, MS shows promising potential for surgical approaches to oral malignant disorders. Overall, MS has revolutionized dental research and has the potential to advance personalized dentistry.
Article
Biochemical Research Methods
Benjamin A. Neely, Magnus Palmblad
Summary: The article discusses the impact of a 1960 protein study by Zuckerkandl, Jones, and Pauling on proteomics and the molecular clock hypothesis, emphasizing the value of framing proteomic results in a larger biological context.
JOURNAL OF PROTEOME RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Sumaiya Nazli, Kip D. Zimmerman, Angelica M. Riojas, Laura A. Cox, Michael Olivier
Summary: The proteomic analysis of plasma has great potential for precision medicine and biomarker identification. However, detecting and quantifying low abundance proteins in plasma is challenging. This study developed a mass spectrometry approach using tandem mass tags (TMT) and a tissue reference sample, which successfully identified and quantified numerous proteins in nonhuman primate plasma samples. The methodology promises to increase the number of putative disease biomarkers by efficiently quantifying plasma proteins released from specific tissues.
Review
Biochemistry & Molecular Biology
Ekaterina Mikhailovna Stakhneva, Evgeniia Vitalievna Striukova, Yulia Igorevna Ragino
Summary: Proteomic studies play a crucial role in investigating atherosclerotic cardiovascular diseases, identifying potential biomarkers, and offering novel diagnostic approaches.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Food Science & Technology
Xin-yue Zhang, Yuan Zhang, Yu Zhou, Zhi-fei Liu, Bin-bin Wei, Xue-song Feng
Summary: Melatonin (MLT) plays a crucial role in maintaining physiological functions and regulating metabolic processes. The global market share of MLT has been increasing due to its abundant functions. However, concerns arise regarding the quality issues and inappropriate or excessive application of MLT. Moreover, the detection of MLT is doubly difficult due to its photosensitivity, oxidation, complex substrate concentration, and trace levels. Therefore, it is essential to develop precise, sensitive, and stable extraction and detection methods. This study provides a comprehensive overview of the distribution, bioactivities, pretreatment, and analysis methods for MLT in food samples since 2010. Commonly used pretreatment methods include traditional techniques and novel ones such as solid-phase extraction, QuEChERS, microextraction by packed sorbent, solid phase microextraction, liquid phase microextraction, and more. Analysis methods include liquid chromatography coupled with different detectors, GC.
FOOD RESEARCH INTERNATIONAL
(2023)
Article
Immunology
Larissa van der Maas, Maarten Danial, Gideon F. A. Kersten, Bernard Metz, Hugo D. Meiring
Summary: A mass spectrometric method was developed to identify and quantify antigens in DTaP vaccines. The method can be used for both final batch release and in-process control monitoring, potentially reducing the need for animal testing.
Article
Multidisciplinary Sciences
John P. McGee, Pei Su, Kenneth R. Durbin, Michael A. R. Hollas, Nicholas W. Bateman, G. Larry Maxwell, Thomas P. Conrads, Ryan T. Fellers, Rafael D. Melani, Jeannie M. Camarillo, Jared O. Kafader, Neil L. Kelleher
Summary: This study introduces a semi-automated single-ion mass spectrometry workflow for top-down tandem mass spectrometry analysis directly from tissue microenvironments. The results demonstrate that this method can identify multiple proteoforms in tumor samples within a short period of time, and effectively identify proteoform signatures in tumor and stromal regions.
NATURE COMMUNICATIONS
(2023)
Article
Biochemistry & Molecular Biology
Nicolai Bjodstrup Palstrom, Rune Matthiesen, Lars Melholt Rasmussen, Hans Christian Beck
Summary: The human plasma proteome reflects the physiological state of the cardiovascular system and has been used to analyze plasma biomarkers for cardiovascular diseases for decades. However, current plasma biomarkers only address a limited subset of cardiovascular diseases, and there is an urgent need for biomarkers for diseases with increasing incidence like heart failure and abdominal aortic aneurysm. Recent advancements in technologies for analyzing the human plasma proteome are addressing the complexity and facilitating the discovery of novel biomarkers for cardiovascular diseases.
Review
Chemistry, Analytical
Ketki Bagwe, Noah Gould, Kendall R. Johnson, Alexander R. Ivanov
Summary: Tissues and cell populations exhibit high levels of heterogeneity at the cellular level, making it important to analyze smaller sample sizes to capture subtle differences between cells. Capillary electrophoresis coupled with mass spectrometry (CE-MS) is a powerful technique for proteomics and metabolomics analysis at the single-cell level, and this review focuses on its applications and recent advances in sample preparation, separation, MS acquisition, and data analysis.
TRAC-TRENDS IN ANALYTICAL CHEMISTRY
(2023)
Article
Biochemical Research Methods
Laurent Gatto, Ruedi Aebersold, Juergen Cox, Vadim Demichev, Jason Derks, Edward Emmott, Alexander M. Franks, Alexander R. Ivanov, Ryan T. Kelly, Luke Khoury, Andrew Leduc, Michael J. MacCoss, Peter Nemes, David H. Perlman, Aleksandra A. Petelski, Christopher M. Rose, Erwin M. Schoof, Jennifer Van Eyk, Christophe Vanderaa, John R. R. Yates III, Nikolai Slavov
Summary: Analyzing proteins from single cells by tandem mass spectrometry (MS) has the potential to accurately quantify thousands of proteins across thousands of single cells. However, various factors affecting experimental design, sample preparation, data acquisition and analysis may undermine the accuracy and reproducibility of the results. Best practices, quality controls, and data-reporting recommendations are proposed to enhance the reliability of quantitative workflows for single-cell proteomics.
Article
Biochemistry & Molecular Biology
Carsten Schmelter, Kristian Nzogang Fomo, Alina Brueck, Natarajan Perumal, Sascha D. D. Markowitsch, Gokul Govind, Thomas Speck, Norbert Pfeiffer, Franz H. H. Grus
Summary: Glaucoma is a complex optic neuropathy characterized by the loss of retinal ganglion cells (RGCs) and their axons, leading to visual function decline. The exact molecular mechanism of glaucoma remains unclear, and there is an urgent need for therapeutic strategies targeting the neurodegenerative component of this disease. The synthetic CDR1 peptide has shown beneficial effects on RGC viability in a concentration-dependent manner and has been identified as a potential biomarker candidate in glaucoma patients. It specifically interacts with retinal acidic leucine-rich nuclear phosphoprotein 32A (ANP32A) and affects the expression of various proteins related to acetyl-CoA biosynthesis and cytoskeleton regulation. The peptide's interaction with ANP32A's N-terminal leucine-rich repeat (LRR) domain suggests its translational potential for glaucoma treatment.
Article
Environmental Sciences
Benjamin Trotter, Magdalena Wilde, Julian Brehm, Evdokia Dafni, Arlinda Aliu, Georg J. Arnold, Thomas Froehlich, Christian Laforsch
Summary: Research on the effects of microplastics on freshwater organisms, particularly Daphnia, has shown that chronic exposure to polystyrene microplastics can lead to decreased body length and offspring numbers in Daphnia magna. Proteomic analysis revealed changes in protein abundance, including alterations in enzymes and important physiological pathways. This study highlights the potential impact of long-term exposure to microplastics on the fitness of aquatic organisms.
SCIENCE OF THE TOTAL ENVIRONMENT
(2021)
Article
Cell Biology
Tian-Yi Zhu, Shang-Tong Li, Dan-Dan Liu, Xiajun Zhang, Lianqi Zhou, Rong Zhou, Bing Yang
Summary: This study quantifies protein changes during aging in different individuals using single-worm mass spectrometry, and reveals the heterogeneity of aging by reconstructing the aging trajectory and proteomic landscape of C. elegans.
Article
Oncology
Martin W. Schoen, Shamia Hoque, Bartlett J. Witherspoon, Benjamin Schooley, Oliver Sartor, Y. Tony Yang, Paul R. Yarnold, Kevin B. Knopf, William J. M. Hrushesky, Michael Dickson, Brian J. Chen, Chadi Nabhan, Charles L. Bennett
INTERNATIONAL JOURNAL OF CANCER
(2020)
Article
Medicine, General & Internal
Lamiaa Shalaby, Menaka Thounaojam, Amany Tawfik, Junnan Li, Khaled Hussein, Wan Jin Jahng, Mohamed Al-Shabrawey, Hang Fai Kwok, Manuela Bartoli, Diana Gutsaeva
JOURNAL OF CLINICAL MEDICINE
(2020)
Article
Chemistry, Multidisciplinary
Faith Pwaniyibo Samson, Weilue He, Srinivas R. Sripathi, Ambrose Teru Patrick, Joshua Madu, Hyewon Chung, Megan C. Frost, Donghyun Jee, Diana R. Gutsaeva, Wan Jin Jahng
Article
Chemistry, Multidisciplinary
Faith Pwaniyibo Samson, Ambrose Teru Patrick, Tosin Esther Fabunmi, Muhammad Falalu Yahaya, Joshua Madu, Weilue He, Srinivas R. Sripathi, Jennifer Tyndall, Hayatu Raji, Donghyun Jee, Diana R. Gutsaeva, Wan Jin Jahng
Article
Biology
James Grutsch, William Hrushesky, Christopher Lis, Robert Levin, Tim Birdsall, Patricia Wood, Dinah Faith Huff, Justin Reynolds, Dennis Pearl, Xiaotong Shen, Digant Gupta, David Blask
Summary: Evening melatonin supplementation improved overall survival rates in advanced non-small cell lung cancer patients, especially those with self-reported normal sleep quality.
BIOLOGICAL RHYTHM RESEARCH
(2022)
Review
Oncology
Charles L. Bennett, Sumimasa Nagai, Andrew C. Bennett, Shamia Hoque, Chadi Nabhan, Martin W. Schoen, William J. Hrushesky, Stefano Luminari, Paul Ray, Paul R. Yarnold, Bart Witherspoon, Josh Riente, Laura Bobolts, John Brusk, Rebecca Tombleson, Kevin Knopf, Marc Fishman, Y. Tony Yang, Kenneth R. Carson, Benjamin Djulbegovic, John Restaino, James O. Armitage, Oliver A. Sartor
Summary: Biosimilars are biologic drug products highly similar to reference products, with uptake varying in the U.S. between different institutions and insurance companies. The understanding and usage of biosimilar epoetin in oncology practice is limited among oncologists and patients.
Article
Chemistry, Multidisciplinary
Faith Pwaniyibo Samson, Tosin Esther Fabunmi, Ambrose Teru Patrick, Donghyun Jee, Diana R. Gutsaeva, Wan Jin Jahng
Summary: The study examined whether specific lipids can control angiogenic reactions and found that specific lipid composition and stoichiometry determine the microenvironment of angiogenesis. Analysis of lipid fragments in the vessel and non-vessel areas revealed distinct lipid compositions in each region.
Review
Hematology
Charles L. Bennett, Daniele Focosi, Mariana P. Socal, Julia C. Bian, Chadi Nabhan, William J. Hrushesky, Andrew C. Bennett, Martin W. Schoen, Joseph R. Berger, James O. Armitage
Summary: Progressive multifocal leukoencephalopathy (PML) is a serious CNS infection caused by the John Cunningham virus, with CD4+ and CD8+ T-cell lymphopenia being primary risk factors. The use of the immunomodulatory anti-CD20 monoclonal antibody, rituximab, has been associated with an increased risk of PML infection. Reassuringly, pharmacovigilance efforts have shown rituximab-associated PML to be a rare clinical event with specific causal factors after 20 years of monitoring.
LANCET HAEMATOLOGY
(2021)
Article
Chemistry, Multidisciplinary
Doris Tabansi, Daniel Dahiru, Ambrose Teru Patrick, Wan Jin Jahng
Summary: In this study, the antiatherosclerotic and antihyperlipidemic effects of Terminalia catappa fruit extracts were tested using a diet-induced atherosclerosis rat model. The results showed that the extracts contained bioactive molecules and had a significant effect in reversing the atherogenic lipid profile. This suggests that Terminalia catappa fruit extracts could be a potential natural source for the treatment of atherosclerosis.
Article
Chemistry, Multidisciplinary
Seong-Jin Choi, Gwang-Hwan Ahn, Kyung Hae Lee, Wan Jin Jahng
Summary: The study discovered a synthetic method for 1-(2,2-dimethylpropyl)-cyclopropene(1-DCP) as a cyclopropene derivative to inhibit ethylene action in fruit ripening and senescence. The synthesized 1-DCP effectively delayed flesh softening and peel degreening in persimmon and banana fruits, which are representative phenomena of fruit ripening and senescence induced by ethylene. This research is of great importance for maintaining the quality of agricultural products.
Article
Medicine, General & Internal
Charles L. Bennett, Shamia Hoque, Nancy Olivieri, Matthew A. Taylor, David Aboulafia, Courtney Lubaczewski, Andrew C. Bennett, Jay Vemula, Benjamin Schooley, Bartlett J. Witherspoon, Ashley C. Godwin, Paul S. Ray, Paul R. Yarnold, Henry C. Ausdenmoore, Marc Fishman, Georgne Herring, Anne Ventrone, Juan Aldaco, William J. Hrushesky, John Restaino, Henrik S. Thomsen, Robert Marx, Cesar Migliorati, Salvatore Ruggiero, Chadi Nabhan, Kenneth R. Carson, June M. McKoy, Y. Tony Yang, Martin W. Schoen, Kevin Knopf, Linda Martin, Oliver Sartor, Steven Rosen, William K. Smith
Summary: This study examined very serious ADRs associated with 15 drugs and one device reported between 1997 and 2019, leading to 753,900 injured persons. It found that 11 out of 18 clinicians reported harms, including verbal threats and loss of positions. Sales decreased significantly post-FDA Advisory Committee meetings, and manufacturers faced criminal fines for failing to inform about ADRs.
Article
Nanoscience & Nanotechnology
Immaculata O. Onuigbo, Garba N. Abdulrahman, Chukwuma Onwujiuba, Oscar Iwu, Muhammed Falalu Yahaya, Wan Jin Jahng
Summary: The study explored the synergy between specific metal doping and plant chromophore-based solar cells, using a titanium dioxide electrode. The presence of magnesium as a doping agent significantly improved the performance of henna dye-sensitized solar cells, enhancing electron transport and light-harvesting capabilities.
INTERNATIONAL NANO LETTERS
(2021)
Article
Energy & Fuels
David John, Chikaodili E. Chukwuneke, Immaculata O. Onuigbo, Muhammad Falalu Yahaya, Bolade O. Agboola, Wan Jin Jahng
Summary: This study explored the use of potash as a catalyst for low-temperature catalytic cracking of waste plastics to generate carbon fuels, achieving energy recovery and carbon recycling. Potash catalyst showed high efficiency in converting waste plastics into valuable liquid products within a low temperature range, demonstrating potential as a renewable fuel source for carbon recycling.
INTERNATIONAL JOURNAL OF ENERGY AND ENVIRONMENTAL ENGINEERING
(2021)
Article
Energy & Fuels
Peter E. Nwankwor, Immaculata O. Onuigbo, Chikaodili E. Chukwuneke, Muhammad Falalu Yahaya, Bolade O. Agboola, Wan Jin Jahng
Summary: The study investigated the carbon recycling application of waste materials by synthesizing gasoline-range hydrocarbon fuels from used plastics through thermal catalytic cracking reactions. It was found that the optimal catalyst-polymer ratio can enhance the liquid yield, and gas chromatography-mass spectrometry analysis revealed gasoline-range hydrocarbon molecules as the main products.
INTERNATIONAL JOURNAL OF ENERGY AND ENVIRONMENTAL ENGINEERING
(2021)
Article
Oncology
Michael Retsky, Romano Demicheli, William Hrushesky, Ted James, Rick Rogers, Michael Baums, Jayant S. Vaidya, Osaro Erhabor, Patrice Forget
ECANCERMEDICALSCIENCE
(2020)
Article
Biochemistry & Molecular Biology
Wei-Han Hui, Yen-Lin Chen, Shu-Wei Chang
Summary: Crosslinking affects the mechanical behavior and tissue metabolism of collagen-based tissues. Aging and diabetes alter the crosslinking type and density, thus changing tissue properties. High-connectivity enzymatic crosslinking and advanced-glycation end-products result in uniform deformation under daily activity, while low-connectivity enzymatic crosslinking does not. High-connectivity model displays more sliding, while AGEs induce instability in structures near the binding sites.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Yao-Bin Ma, Xiao-Qiu Zhou, Wei-Dan Jiang, Pei Wu, Yang Liu, Shu-Wei Li, Ling Tang, Lu Zhang, Hai-Feng Mi, Lin Feng
Summary: Tea polyphenols (TPs) are an inexpensive feed additive that can protect the gill function of fish against Flavobacterium columnare (F. columnare) through various mechanisms, including suppression of oxidative stress, apoptosis, and inflammation.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Yan-Jia Guo, Jing-Ru Pang, Yu Zhang, Zhong-Rui Li, Xiao-Lin Zi, Hong-Min Liu, Ning Wang, Li-Juan Zhao, Ya Gao, Bo Wang, Piet Herdewijn, Cheng-Yun Jin, Ying Liu, Yi-Chao Zheng
Summary: This study identifies the conjugation of NEDD8 to LSD1 and its impact on GC cells, revealing the significance of LSD1 neddylation in GC.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Review
Biochemistry & Molecular Biology
Geum-Jae Jeong, Fazlurrahman Khan, Nazia Tabassum, Young-Mog Kim
Summary: Vibrio species are motile gram-negative bacteria commonly found in aquatic environments. They can adapt to environmental fluctuations and develop protective mechanisms against host immune systems. Different types of sigma and anti-sigma factors play important roles in regulating gene expression and virulence in Vibrio species.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Zahra Mohammadbagheri, Behrooz Movahedi, Shaghayegh Saeedi, Abbas Rahmati
Summary: In this study, a reusable biobased composite hydrogel was successfully synthesized and used for the removal of Tl(I) from aqueous solutions. The hydrogel exhibited high adsorption capacity and thermal stability, and the adsorption process was found to be thermodynamically spontaneous. The results demonstrated that the hydrogel can be reused multiple times without significant loss of its adsorption capacity.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Iqra Batool, Muhammad Imran, Ayesha Anwar, Farhan Ahmed Khan, Afrah E. Mohammed, Ashwag Shami, Hafiz Iqbal
Summary: Enzyme immobilization on ZnO/SnO2 and ZnO/SnO2/SA nanocomposites was studied, and the catalytic and biochemical characteristics of the immobilized enzyme were investigated. The results showed that ZnO/SnO2 and ZnO/SnO2/SA nanostructures are suitable carriers for enzyme immobilization.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Elias Mosaffa, Dhruvi Patel, Nasim Amiri Ramsheh, Rishikumar Indravadan Patel, Atanu Banerjee, Hossein Ghafuri
Summary: In this study, a unique 3D bead structure of adsorbent, composed of bacterial cellulose microfilaments reinforced chitosan adorned with melamine 2D plates, was synthesized for anionic dye removal. The adsorbent showed high specific surface area and abundant functional groups, resulting in exceptional adsorption capacity. The characteristics and optimal conditions of the adsorbent were assessed and analyzed.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Carolina Gismene, Jorge Enrique Hernandez Gonzalez, Marilia de Freitas Calmon, Andrey Fabricio Ziem Nascimento, Angela Rocio Nino Santisteban, Felipe Antunes Calil, Alana Della Torre da Silva, Paula Rahal, Rejane Maira Goes, Raghuvir Krishnaswamy Arni, Ricardo Barros Mariutti
Summary: Mammaliicoccus sciuri, a bacterium of clinical and veterinary relevance, expresses the virulence factor Exfoliative Toxin C (ExhC), which binds specifically to desmoglein-1 (Dsg1) and plays a role in tissue integrity. This study investigates the necrotic activity of ExhC and identifies a variant lacking necrotic potential but retaining enzymatic activity through mutagenesis experiments and crystal structure determination.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Bibhas K. Bhunia, Ashutosh Bandyopadhyay, Souradeep Dey, Biman B. Mandal
Summary: Intervertebral disc degeneration is a major cause of chronic low back pain and disability. Researchers have developed a bioactive silk-based hybrid hydrogel system functionalized with decellularized human Wharton's jelly extracellular matrix as bioactive cues. The hydrogels mimic the rheological and mechanical properties of the native nucleus pulposus tissue and support cell viability, proliferation, and tissue maturation.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Qun Zhang, Yonggan Yan, Zhao Li, Jing Du, Kai Zhang, Liguo Zhang, Ting Wang, Alberto Bianco, Shaohua Ge, Baojin Ma
Summary: A new crosslinking strategy has been devised to construct injectable sodium alginate hydrogels, which can be regulated for injectability and have great potential in biomedical applications.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Seong Eun Hong, Ji-Soo Lee, Hyeon Gyu Lee
Summary: The potential of multi-layer nanoemulsions for improving the cellular uptake, antioxidant activity, and in vitro bioaccessibility of alpha-tocopherol was examined. The results showed that the multi-layer nanoemulsions significantly enhanced the cellular uptake and antioxidant activity of alpha-tocopherol compared to free coumarin 6. Furthermore, the use of chitosan and dextran sulfate as wall materials in the multi-layer nanoemulsions led to even higher cellular uptake, in vitro bioaccessibility, and antioxidant activity of alpha-tocopherol.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Jingjing Yu, Yanhui Zhang, Ruoning Zhang, Yanxiang Gao, Like Mao
Summary: High internal phase emulsions (HIPEs) based on beeswax (BW) oleogels and octenyl succinic acid starch (OSA starch) were prepared by a simple one-step method. The results showed that oleogelation improved the stability and encapsulation capability of the HIPEs, which is significant for the development of novel healthy food.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Review
Biochemistry & Molecular Biology
Bi-Feng Yao, Xiu-Ju Luo, Jun Peng
Summary: The balanced and continuous fission and fusion of mitochondria, regulated by OPA1, are important for maintaining mitochondrial dynamics in cardiovascular disorders. Understanding the role of OPA1 in mitochondrial fusion can provide insights into the pathogenesis of cardiovascular diseases.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Review
Biochemistry & Molecular Biology
Gokul Paramasivam, Anandhavelu Sanmugam, Vishnu Vardhan Palem, Murugan Sevanan, Ananda Babu Sairam, Nachiappan Nachiappan, Buhyun Youn, Jung Sub Lee, Muthuchamy Nallal, Kang Hyun Park
Summary: Nanomaterials are being used to deliver therapeutic agents in living systems. Different nanotechnological applications such as immunosensors, immune assays, and drug delivery are being implemented using nanotechnology. Genomics plays a crucial role in selecting appropriate drugs for personalized cancer therapy. It helps in analyzing gene and protein expression, disease classification, and designing disease models. Delivering drugs to specific areas using nanoparticles is a challenging issue.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Jing Li, Wei Wang, Han Wu, Feng Peng, Hui Gao, Ying Guan
Summary: In this study, CMH-based CPF films were prepared and their thermal and barrier properties were successfully regulated. The tensile strength and water vapor barrier property of CPF films were significantly improved, making them promising for food packaging applications.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)